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The map label for this gene is glsA

Identifier: 209694129

GI number: 209694129

Start: 591928

End: 592848

Strand: Direct

Name: glsA

Synonym: VSAL_I0536

Alternate gene names: 209694129

Gene position: 591928-592848 (Clockwise)

Preceding gene: 209694128

Following gene: 209694137

Centisome position: 17.8

GC content: 41.69

Gene sequence:

>921_bases
ATGAAGCCAACAAAACAAATATTAGAAGATATTTTGAATGAAGTGCGTCCTCTTATTGGACAAGGAGAGGTTGCCGATTA
CATTCCAGCACTTGCTTGTGTACCGAGTAATAAACTGGGTATTGCTGTCTATACTAATGATGGTGAAATGATCACAGCAG
GCGATGCAAACGAACGATTTTCGATTCAGTCAATCTCTAAGGCACTGAGTTTAACGCTTGCTATGGAGCTGTATCAGCCC
GAAGAACTCTGGCATAGAGTTGGAAAAGAACCTTCTGGACAAGCGTTTAACTCATTGATCCAGTTGGAAATGGAACAAGG
GGTTCCTCGTAATCCGTTCATCAATGCGGGGGCGATTGTTGTGGCAGATATGCTGTTTAGTCGCTTTTCTGCTCCGAAAC
ATCGCTTATTAGAATTTGTACGTAAGCTCTCTGGCAATGAACATATTATTTATGATCGTGTCGTCGCTAATTCGGAGATG
GATCATAGTGATCGAAATGCATCAATTGCTTATTTAATGCGATCATTTGGTAACTTTGAGAATGAAGTGATGCCCGTATT
AAAGAACTATTTTCATGCGTGTTCACTGAATATGAGCTGTGTTGATTTAGCGAAAACGTTTGGTTATTTAGCGAATAAAG
GCATTCAACCAGAGACAAATGAATTCATTATCACACCTATGCAAAGTAAACAAATTAATGCACTGATGGCGACGTGTGGT
TTATATGATGGTGCAGGGGAATTTGCTTATCGTGTTGGTATGCCGGGTAAATCCGGTGTCGGTGGCGGAATTATCGCAAT
TGTTCCGGGTGAAATGACGATTGCAGTATGGTCACCAGAGTTGGACCCATCAGGCAACTCGCTAGCAGGAACCCAAGCGT
TAGAATTGCTTTCAGAGCGTATTGGACGTTCGATATTTTAA

Upstream 100 bases:

>100_bases
TCAGTAGTAAACTGATGCAGTGTCTAATACATTGCTTATAAATTTAAAGCCAACCTCTGTGTTGGCTTTTTTGTCCTTGC
TGTGAAAGGAAGTAAAAATA

Downstream 100 bases:

>100_bases
GGTAAGAGCAGGTTTCAGGACGGTCGCAAGCTCCCTAAAGGTTTCAGGAAAAGATTGTTAAGCTCTTACTGAAACCTTTA
AGCGAAGCGATCTGAACCCT

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERFSIQSISKALSLTLAMELYQP
EELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIVVADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEM
DHSDRNASIAYLMRSFGNFENEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCG
LYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSERIGRSIF

Sequences:

>Translated_306_residues
MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERFSIQSISKALSLTLAMELYQP
EELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIVVADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEM
DHSDRNASIAYLMRSFGNFENEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCG
LYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSERIGRSIF
>Mature_306_residues
MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERFSIQSISKALSLTLAMELYQP
EELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIVVADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEM
DHSDRNASIAYLMRSFGNFENEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCG
LYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSERIGRSIF

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=273, Percent_Identity=37.3626373626374, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI20336214, Length=296, Percent_Identity=34.4594594594595, Blast_Score=171, Evalue=6e-43,
Organism=Escherichia coli, GI1787804, Length=300, Percent_Identity=66.6666666666667, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1786693, Length=303, Percent_Identity=36.963696369637, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17507019, Length=301, Percent_Identity=37.5415282392027, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI193204073, Length=299, Percent_Identity=38.1270903010033, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193204075, Length=301, Percent_Identity=37.8737541528239, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17532727, Length=290, Percent_Identity=35.5172413793103, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653162, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363241, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI116008307, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24653164, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363239, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24653156, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24653158, Length=304, Percent_Identity=35.5263157894737, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24653166, Length=304, Percent_Identity=35.5263157894737, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_ALISL (B6EMU2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262057.1
- ProteinModelPortal:   B6EMU2
- GeneID:   6989321
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0536
- HOGENOM:   HBG512335
- OMA:   RNASIAY
- ProtClustDB:   PRK00971
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33483; Mature: 33483

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCC
SIQSISKALSLTLAMELYQPEELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
VADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEMDHSDRNASIAYLMRSFGNFE
HHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCH
NEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHC
LYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSER
CCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
IGRSIF
HCCCCC
>Mature Secondary Structure
MKPTKQILEDILNEVRPLIGQGEVADYIPALACVPSNKLGIAVYTNDGEMITAGDANERF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCC
SIQSISKALSLTLAMELYQPEELWHRVGKEPSGQAFNSLIQLEMEQGVPRNPFINAGAIV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
VADMLFSRFSAPKHRLLEFVRKLSGNEHIIYDRVVANSEMDHSDRNASIAYLMRSFGNFE
HHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCH
NEVMPVLKNYFHACSLNMSCVDLAKTFGYLANKGIQPETNEFIITPMQSKQINALMATCG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHC
LYDGAGEFAYRVGMPGKSGVGGGIIAIVPGEMTIAVWSPELDPSGNSLAGTQALELLSER
CCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
IGRSIF
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA