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The map label for this gene is msrA [H]

Identifier: 209694033

GI number: 209694033

Start: 467069

End: 467719

Strand: Reverse

Name: msrA [H]

Synonym: VSAL_I0432

Alternate gene names: 209694033

Gene position: 467719-467069 (Counterclockwise)

Preceding gene: 209694041

Following gene: 209694031

Centisome position: 14.07

GC content: 38.86

Gene sequence:

>651_bases
ATGGTAATTTACTCGTTTTATAGAGTAGCACAAGGCAAATGTCTTCTAAATTACTCAGTTAAAGGATGCGACATGACGAT
GGAAAAACACACAGTACAGCCACTACATTTTATTTCTCAGCATGATATAGAATCAATTCCTACTGGTTGTGAGCAAATAC
TCTTTGGCATGGGATGCTTTTGGGGTACTGAACGTTTATTTTGGAAACTAACTGGCGTTTACTCCACAGCAGTAGGTTAC
AGCGGTGGTAAAACCAAGATCCCAACATACAAAGACGTTTGCTCAGGTTCAACTGACCACGTAGAAGTCGTCAAAGTAGT
TTTTAACCCGGCGCTCATTTCCTTAGAAGAATTGCTTCACTCTTTTTGGCAAACGCATAACCCAACCCAAGGAATGCGCC
AAGGAAATGATATTGGAACTCAATATAGATCCGTTATTTACACCTATGATAAAAACCAGCAAGAAATAGCAACACACACG
AAAAAACAATACCAACACGCTCTATCTCAACAGGGAATAGAAGAACCAATAACAACCGAGATTACTCCTGCAAATGATTT
TTATTTCGCAGAAGAATACCATCAACAATATTTAGCCAAAAATCCAAATGGTTACTGTGGATTAAGCGGAACTGGCGTGT
GTTTTCTTTAA

Upstream 100 bases:

>100_bases
ACGTTAGATGAAATGGCAAACAAACAAAATGTAAAAAAGAGGGATAACTTCTTGGTCATACTTATAATTATTCTATTGAT
TCAGTTATGCATTATATGTC

Downstream 100 bases:

>100_bases
TTCTTTTTATAGCATAAAAAAGGTGCCCATTATTGAGCACCTTTTTTATTAATAATTTTATTACGCTACTATGCAGGCAT
CAGAGAAAGCTGGCGAATAT

Product: peptide methionine sulfoxide reductase MSRA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MVIYSFYRVAQGKCLLNYSVKGCDMTMEKHTVQPLHFISQHDIESIPTGCEQILFGMGCFWGTERLFWKLTGVYSTAVGY
SGGKTKIPTYKDVCSGSTDHVEVVKVVFNPALISLEELLHSFWQTHNPTQGMRQGNDIGTQYRSVIYTYDKNQQEIATHT
KKQYQHALSQQGIEEPITTEITPANDFYFAEEYHQQYLAKNPNGYCGLSGTGVCFL

Sequences:

>Translated_216_residues
MVIYSFYRVAQGKCLLNYSVKGCDMTMEKHTVQPLHFISQHDIESIPTGCEQILFGMGCFWGTERLFWKLTGVYSTAVGY
SGGKTKIPTYKDVCSGSTDHVEVVKVVFNPALISLEELLHSFWQTHNPTQGMRQGNDIGTQYRSVIYTYDKNQQEIATHT
KKQYQHALSQQGIEEPITTEITPANDFYFAEEYHQQYLAKNPNGYCGLSGTGVCFL
>Mature_216_residues
MVIYSFYRVAQGKCLLNYSVKGCDMTMEKHTVQPLHFISQHDIESIPTGCEQILFGMGCFWGTERLFWKLTGVYSTAVGY
SGGKTKIPTYKDVCSGSTDHVEVVKVVFNPALISLEELLHSFWQTHNPTQGMRQGNDIGTQYRSVIYTYDKNQQEIATHT
KKQYQHALSQQGIEEPITTEITPANDFYFAEEYHQQYLAKNPNGYCGLSGTGVCFL

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=178, Percent_Identity=58.9887640449438, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=58.2417582417582, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=61.2068965517241, Blast_Score=148, Evalue=3e-36,
Organism=Escherichia coli, GI1790665, Length=199, Percent_Identity=51.2562814070352, Blast_Score=203, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=38.7755102040816, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=40.4624277456647, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664627, Length=174, Percent_Identity=36.2068965517241, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24664631, Length=174, Percent_Identity=35.632183908046, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=40.4255319148936, Blast_Score=103, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24481; Mature: 24481

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIYSFYRVAQGKCLLNYSVKGCDMTMEKHTVQPLHFISQHDIESIPTGCEQILFGMGCF
CEEEEEEHHHCCCEEEEEEECCCCEEHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHH
WGTERLFWKLTGVYSTAVGYSGGKTKIPTYKDVCSGSTDHVEVVKVVFNPALISLEELLH
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
SFWQTHNPTQGMRQGNDIGTQYRSVIYTYDKNQQEIATHTKKQYQHALSQQGIEEPITTE
HHHHCCCCCHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ITPANDFYFAEEYHQQYLAKNPNGYCGLSGTGVCFL
CCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEEC
>Mature Secondary Structure
MVIYSFYRVAQGKCLLNYSVKGCDMTMEKHTVQPLHFISQHDIESIPTGCEQILFGMGCF
CEEEEEEHHHCCCEEEEEEECCCCEEHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHH
WGTERLFWKLTGVYSTAVGYSGGKTKIPTYKDVCSGSTDHVEVVKVVFNPALISLEELLH
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
SFWQTHNPTQGMRQGNDIGTQYRSVIYTYDKNQQEIATHTKKQYQHALSQQGIEEPITTE
HHHHCCCCCHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ITPANDFYFAEEYHQQYLAKNPNGYCGLSGTGVCFL
CCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA