Click here to switch to the map view.

The map label for this gene is fbp

Identifier: 209693950

GI number: 209693950

Start: 377275

End: 378285

Strand: Reverse

Name: fbp

Synonym: VSAL_I0346

Alternate gene names: 209693950

Gene position: 378285-377275 (Counterclockwise)

Preceding gene: 209693958

Following gene: 209693922

Centisome position: 11.38

GC content: 38.28

Gene sequence:

>1011_bases
ATGTCAGAAATAAGAACTTTAGGTGAGTTTATCGTCGCTAAACAGCACGATTTCCCTCATGCAAGTGGAGAGTTGTCATC
ATTGATCGGTTCCATTAAATTGGCAGCCAAAATAGTAAACCGAGAAATAAATAAAGCAGGGCTGGTTGATATTACAGGGG
CTTCTGGTGATGAAAATATTCAAGGTGAACAACAACAAAAATTAGATATCTACGCCAATGATAAATTTAAAGCCGCATTA
GAAAATCGAGACCAAGTGTGTGGTGTCGCAAGTGAAGAGGAAGATGAAGCGGTTGCGTTTAATAAAGAACTGAATAAAAA
CGCAAAGTATGTCGTGTTAATGGATCCATTGGATGGTTCTTCAAATATCGATGTTAATGTTTCTGTCGGTACTATTTTCT
CCATTTATCGTCGTATTTCACCAATAGGCTCACCGGCAACCGAAGAAGATTTTCTACAGCCAGGAAATAAACAAGTGGCT
GCTGGTTATATTATTTATGGTTCTTCTACCATGCTGGTTTATACCACAGGGAACGGCGTTCACGGCTTTACTTACGATCC
ATCTCTTGGTGTCTTCTGTTTATCTCATGAAGACATGAAAATTCCACAAGATGGTAATATATACTCCATTAATGAAGGGA
ATTACATACGTTTCCCTGAAGGAGTGAAGCAATATTTAAAATATTGCCAAGAAATAAAACCTGCAGAAAATCGCCCATAT
ACATCACGTTATATCGGGTCTCTCGTTGCTGACTTCCATCGTAATCTACTAAAGGGAGGGATTTATCTGTACCCAAGTAC
TCAAGCTTACCCAAATGGAAAATTAAGATTACTTTATGAATGTAACCCAATGGCAATGTTAATTGAAGAGGCGGGAGGAA
AAGCGACAAGTGGAGAAGAGCGGATCTTAGATATTACTCCGACCGAATTGCATCAACGTGTACCTTTCTTTGTTGGTTCA
ATCAATATGGTCGATAAAGTACAAAATTTTCTTGATGAATGGCAAGATTAA

Upstream 100 bases:

>100_bases
TTATAAAGATAAATTGCACTCGTTTTATATTGGATTATAAATTGTAACTGACCCCATCCACCGTTGATATCTAATAACAT
GAGAATAAAAGGAATAACCC

Downstream 100 bases:

>100_bases
CAATATTTAGATACAAAAAAACCGAGTCCTAAGACTCGGTTTTTTATTGAAACTACTTACTAATTACTCAGCTGCAGCTT
CTACTTCTGGGCGATCTACA

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSEIRTLGEFIVAKQHDFPHASGELSSLIGSIKLAAKIVNREINKAGLVDITGASGDENIQGEQQQKLDIYANDKFKAAL
ENRDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRISPIGSPATEEDFLQPGNKQVA
AGYIIYGSSTMLVYTTGNGVHGFTYDPSLGVFCLSHEDMKIPQDGNIYSINEGNYIRFPEGVKQYLKYCQEIKPAENRPY
TSRYIGSLVADFHRNLLKGGIYLYPSTQAYPNGKLRLLYECNPMAMLIEEAGGKATSGEERILDITPTELHQRVPFFVGS
INMVDKVQNFLDEWQD

Sequences:

>Translated_336_residues
MSEIRTLGEFIVAKQHDFPHASGELSSLIGSIKLAAKIVNREINKAGLVDITGASGDENIQGEQQQKLDIYANDKFKAAL
ENRDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRISPIGSPATEEDFLQPGNKQVA
AGYIIYGSSTMLVYTTGNGVHGFTYDPSLGVFCLSHEDMKIPQDGNIYSINEGNYIRFPEGVKQYLKYCQEIKPAENRPY
TSRYIGSLVADFHRNLLKGGIYLYPSTQAYPNGKLRLLYECNPMAMLIEEAGGKATSGEERILDITPTELHQRVPFFVGS
INMVDKVQNFLDEWQD
>Mature_335_residues
SEIRTLGEFIVAKQHDFPHASGELSSLIGSIKLAAKIVNREINKAGLVDITGASGDENIQGEQQQKLDIYANDKFKAALE
NRDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRISPIGSPATEEDFLQPGNKQVAA
GYIIYGSSTMLVYTTGNGVHGFTYDPSLGVFCLSHEDMKIPQDGNIYSINEGNYIRFPEGVKQYLKYCQEIKPAENRPYT
SRYIGSLVADFHRNLLKGGIYLYPSTQAYPNGKLRLLYECNPMAMLIEEAGGKATSGEERILDITPTELHQRVPFFVGSI
NMVDKVQNFLDEWQD

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=334, Percent_Identity=45.2095808383234, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI16579888, Length=334, Percent_Identity=45.2095808383234, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI22907028, Length=336, Percent_Identity=43.75, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1790679, Length=333, Percent_Identity=72.972972972973, Blast_Score=516, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17508131, Length=331, Percent_Identity=46.2235649546828, Blast_Score=309, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6323409, Length=334, Percent_Identity=42.5149700598802, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI45550998, Length=330, Percent_Identity=46.6666666666667, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI19921562, Length=330, Percent_Identity=46.6666666666667, Blast_Score=300, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_ALISL (B6EPV3)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002261878.1
- GeneID:   6989160
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0346
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- ProtClustDB:   PRK09293
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37288; Mature: 37157

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00124 FBPASE

Important sites: BINDING 211-211 BINDING 244-244 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIRTLGEFIVAKQHDFPHASGELSSLIGSIKLAAKIVNREINKAGLVDITGASGDENI
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
QGEQQQKLDIYANDKFKAALENRDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGS
CCCCCCCEEEEECCCHHHHHCCCHHCCCCCCCCCCCCEEECHHCCCCCCEEEEECCCCCC
SNIDVNVSVGTIFSIYRRISPIGSPATEEDFLQPGNKQVAAGYIIYGSSTMLVYTTGNGV
CCEEEEEEHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEEEECCCEEEEEEECCCC
HGFTYDPSLGVFCLSHEDMKIPQDGNIYSINEGNYIRFPEGVKQYLKYCQEIKPAENRPY
CCEEECCCCCEEEECCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCCCCCCCCH
TSRYIGSLVADFHRNLLKGGIYLYPSTQAYPNGKLRLLYECNPMAMLIEEAGGKATSGEE
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCC
RILDITPTELHQRVPFFVGSINMVDKVQNFLDEWQD
EEEECCHHHHHHCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEIRTLGEFIVAKQHDFPHASGELSSLIGSIKLAAKIVNREINKAGLVDITGASGDENI
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
QGEQQQKLDIYANDKFKAALENRDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGS
CCCCCCCEEEEECCCHHHHHCCCHHCCCCCCCCCCCCEEECHHCCCCCCEEEEECCCCCC
SNIDVNVSVGTIFSIYRRISPIGSPATEEDFLQPGNKQVAAGYIIYGSSTMLVYTTGNGV
CCEEEEEEHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEEEECCCEEEEEEECCCC
HGFTYDPSLGVFCLSHEDMKIPQDGNIYSINEGNYIRFPEGVKQYLKYCQEIKPAENRPY
CCEEECCCCCEEEECCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCCCCCCCCH
TSRYIGSLVADFHRNLLKGGIYLYPSTQAYPNGKLRLLYECNPMAMLIEEAGGKATSGEE
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCC
RILDITPTELHQRVPFFVGSINMVDKVQNFLDEWQD
EEEECCHHHHHHCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA