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The map label for this gene is ilvD [H]

Identifier: 209693683

GI number: 209693683

Start: 56735

End: 58207

Strand: Reverse

Name: ilvD [H]

Synonym: VSAL_I0053

Alternate gene names: 209693683

Gene position: 58207-56735 (Counterclockwise)

Preceding gene: 209693684

Following gene: 209693682

Centisome position: 1.75

GC content: 44.87

Gene sequence:

>1473_bases
ATGTCTACCACTCCTAAAAACAGATACCGTTCAGCTACCACCACTCATGGCCGTAATATGGCTGGCGCACGCGCACTATG
GCGTGCAACTGGCGTAAAAGAAGAAGACTTTGGCAAGCCAATTATTGCCGTAGTGAATTCATTCACCCAATTTGTACCCG
GTCATGTTCATCTTAAAGATATGGGGCAATTAGTGGCAGGCGAGATTGAGAAAGCAGGTGGTATCGCCAAAGAATTCAAT
ACCATTGCTGTCGATGATGGCATCGCAATGGGACACGGAGGCATGTTGTACTCATTGCCATCTCGTGAACTGATCGCAGA
TTCCGTTGAATACATGGTGAATGCACACTGTGCTGATGCCATGGTATGTATTTCAAACTGTGACAAGATTACTCCAGGAA
TGATGATGGCGGCAATGCGTCTAAATATCCCAGTAATTTTCGTCTCTGGCGGCCCAATGGAAGCAGGCAAAACTAAACTT
TCAGATCAAATCATTAAACTTGATTTAGTTGATGCCATGATCCAAGGCGCTGATCCAACGGTTTCTGATGCACAAAGCGA
GCAAATAGAACGTTCAGCGTGTCCAACTTGTGGTTCATGTTCTGGTATGTTTACCGCCAACTCAATGAACTGTTTAACTG
AAGCATTAGGGTTATCTCAACCGGGTAATGGATCAATGCTTGCTACTCATGCCGATCGTGAAGAATTGTTTATCAATGCA
GGTAAACGCATCGTGACTCTAACTAAGCGTTATTACGAGCAAGGCGATGATTCGGCTCTGCCACGTAATATTGCCAACAA
AGCGGCATTTGAAAATGCAATGGCGTTAGATATTGCAATGGGCGGTTCAAGTAATACGGTACTTCACCTAATAGCATCCG
CTCAAGAAGGCGGCCTAGCGGTTCTTTCTGGTAATATCGCGGTTGACGGCTGTATTGTAAAAACAGCCGGTGTTGATGAA
GATAACCTTAAATTCCAAGGTCCTGCCATTGTATTTGAAAGCCAAGATACCGCTGTAGAAAATATTTTAGCCGGAGAAGT
AAAAGCAGGGAATGTGGTTGTTATTCGCTACGAAGGTCCTAAAGGCGGCCCGGGTATGCAAGAAATGTTGTACCCAACCA
CTTACCTAAAATCAATGGGATTAGGTAAAGCATGTGCATTACTTACTGATGGCCGTTTCTCTGGCGGGACTTCTGGTCTT
TCTATTGGTCATGCCTCTCCAGAAGCCGCAAGTGGTGGCACAATTGGTTTAGTCAAAACAGGAGATATCATCACTATTGA
TATTCCAAACCGCTCTATCACGCTTGATGTACCAGAAGCGGAATTAAGCGAGCGTCGTGCAGAGCAAGATAAGTTAGGTT
GGAAGCCTGTTAATCGTCAACGTGAAGTCTCTTTTGCACTAAAAGCTTACGCAATGATGGCGACCAGTGCAGATAAAGGC
GCGGTACGTGATAGATCTAAGTTAGAAGGGTAA

Upstream 100 bases:

>100_bases
GCCTTCTAACAAATCAAATAGAGAAGCTTTGGGACATAACCACCGTTAATGTCGCTACATTACATCGAACATAAGATAAA
AATTTAAAGGATTAAACGAT

Downstream 100 bases:

>100_bases
ATTTATGACAACACCTTCTTATCAAACTGGCGCAGAATACCTGCGTCAGATCTTACGGGCACCGGTCTATGATGTGGCGA
CAGTAACGCAGCTTCAAGAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSTTPKNRYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFN
TIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKL
SDQIIKLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINA
GKRIVTLTKRYYEQGDDSALPRNIANKAAFENAMALDIAMGGSSNTVLHLIASAQEGGLAVLSGNIAVDGCIVKTAGVDE
DNLKFQGPAIVFESQDTAVENILAGEVKAGNVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGL
SIGHASPEAASGGTIGLVKTGDIITIDIPNRSITLDVPEAELSERRAEQDKLGWKPVNRQREVSFALKAYAMMATSADKG
AVRDRSKLEG

Sequences:

>Translated_490_residues
MSTTPKNRYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFN
TIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKL
SDQIIKLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINA
GKRIVTLTKRYYEQGDDSALPRNIANKAAFENAMALDIAMGGSSNTVLHLIASAQEGGLAVLSGNIAVDGCIVKTAGVDE
DNLKFQGPAIVFESQDTAVENILAGEVKAGNVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGL
SIGHASPEAASGGTIGLVKTGDIITIDIPNRSITLDVPEAELSERRAEQDKLGWKPVNRQREVSFALKAYAMMATSADKG
AVRDRSKLEG
>Mature_489_residues
STTPKNRYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNT
IAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLS
DQIIKLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAG
KRIVTLTKRYYEQGDDSALPRNIANKAAFENAMALDIAMGGSSNTVLHLIASAQEGGLAVLSGNIAVDGCIVKTAGVDED
NLKFQGPAIVFESQDTAVENILAGEVKAGNVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLS
IGHASPEAASGGTIGLVKTGDIITIDIPNRSITLDVPEAELSERRAEQDKLGWKPVNRQREVSFALKAYAMMATSADKGA
VRDRSKLEG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=289, Percent_Identity=89.2733564013841, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI2367371, Length=136, Percent_Identity=40.4411764705882, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788157, Length=178, Percent_Identity=36.5168539325843, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786464, Length=138, Percent_Identity=37.6811594202899, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322476, Length=300, Percent_Identity=39.6666666666667, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 51705; Mature: 51573

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTPKNRYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEHHH
MGQLVAGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADA
HHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHCCHHHH
MVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPT
HHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCC
VSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINA
CCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCHHHEEEC
GKRIVTLTKRYYEQGDDSALPRNIANKAAFENAMALDIAMGGSSNTVLHLIASAQEGGLA
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCCEE
VLSGNIAVDGCIVKTAGVDEDNLKFQGPAIVFESQDTAVENILAGEVKAGNVVVIRYEGP
EEECCEEEEEEEEEECCCCCCCCEEECCEEEEECCCHHHHHHHHCCCCCCCEEEEEECCC
KGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVKT
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEEEEC
GDIITIDIPNRSITLDVPEAELSERRAEQDKLGWKPVNRQREVSFALKAYAMMATSADKG
CCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
AVRDRSKLEG
CCCCHHHCCC
>Mature Secondary Structure 
STTPKNRYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEHHH
MGQLVAGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADA
HHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHCCHHHH
MVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPT
HHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCC
VSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINA
CCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCHHHEEEC
GKRIVTLTKRYYEQGDDSALPRNIANKAAFENAMALDIAMGGSSNTVLHLIASAQEGGLA
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCCEE
VLSGNIAVDGCIVKTAGVDEDNLKFQGPAIVFESQDTAVENILAGEVKAGNVVVIRYEGP
EEECCEEEEEEEEEECCCCCCCCEEECCEEEEECCCHHHHHHHHCCCCCCCEEEEEECCC
KGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVKT
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEEEEC
GDIITIDIPNRSITLDVPEAELSERRAEQDKLGWKPVNRQREVSFALKAYAMMATSADKG
CCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
AVRDRSKLEG
CCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA