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The map label for this gene is kup [H]

Identifier: 197120012

GI number: 197120012

Start: 4179598

End: 4181418

Strand: Direct

Name: kup [H]

Synonym: Gbem_3651

Alternate gene names: 197120012

Gene position: 4179598-4181418 (Clockwise)

Preceding gene: 197120009

Following gene: 197120016

Centisome position: 90.56

GC content: 58.48

Gene sequence:

>1821_bases
ATGACCCACAAAACTCAGGATTCATTCTGGGGCGGAATCGTGAAAGCACTCGGCCTCGTCTTTGGTGACATCGGCACGAG
CCCCATATACACACTCACCGTCGTTTTCACCTTGACCAAGCCGACCCATGCCAATGTCTACGGCATCCTCTGTCTTGTAT
TCTGGACCATGACCATTCTGGTGACTGCGGAGTACGCCTGGCTCGCCATGAGCCTCGGCAAGAAGGGGCAAGGCGGCGAG
ATCGTGCTTCGGGAAATCATCATCAAGCTCTTCAAGCAGGGGCGGGTGCTGGCCTTCGCCGGGTTTCTCTCCTTCCTCGG
GGTTTCGCTTCTCTTGGGGGACGGGGTCATCACCCCCGCCATCTCCATACTCTCCGCCGTCGAGGGCCTTTTGCTGATAC
CGGGGCTGGAGGCGACGAGGCAGGGGGTGCTGGTCGTCATCGCGGCACTGATCGCCTTCACGCTCTTCTTCTTCCAGTCG
CGCGGCACGGACAAGATGGCCGGGGTCTTCGGGCCGATCATGATCCTTTACTTCGGTTCGCTCCTCGTGTCGGGGCTCGT
CTCCATCTCCGGCACCCCCGGCATCGTCGCGGCCATCAATCCGATGTACGCCATCGACTTCTTCCGCGAAAACGGCATCG
CCGGCTACTTCGTCCTCTCCGAGGTGATCCTTTGCTCCACCGGCGGCGAGGCGCTCTACGCCGACATGGGGCACCTGGGG
AAGAAGCCCATCATCCGGGCCTGGTACTTCGTTTTCGCCGCGCTTTACTTGAACTATCTGGGTCAAGGGGCCTTCCTGCT
CAAGCACCCGGACACGAAGAACATCCTTTTCGGCATGATCCAGGAGCAGTCAAGCCTGCTCTACATCCCGTTCCTGCTTT
TGACCATCATGGCCACCATCATCGCGTCGCAATCGATCATCAGCGGCGTCTTCTCCATCGTCTACCAGGGGATCACCACG
CGGCTCATGCCGCTATTCAAGGTGGACTACACCTCCAAGCACATCCAGTCCCAGATCTACATCGGCGTGGTCAACTGGAC
GCTCATGTGCGCGGTCATCTTCGTCATGTTTTTCTTTCAGAAATCGGTGAACCTCGCCGCCGCCTACGGCATGGCCGTCA
CCGGATCGATGACCATCACGGCGCTGATGATGATCATGGTCTTCTCCAAGACCACGAAGAAATGGAAGGTTCCGGTCGTT
GCCGTCATCGCCGTCATCGACCTCATCTACTTCACCTCGACCTTCCCGAAATTCGTGCACGGTGCCTATTGGTCCATCGC
GCTCGCCTCGGTACCGTTCATCACCATCCAGGTCTGGACCAAGGGGCAGCGCCAGCTGTACCGCGCACTGCGCCCGCTGG
ACCTCGACATCTTCATGCTTTCCTACGAGCAGATCTACGGCAAGAACAAGAACATCCCGGGGACAGCGCTCTTCTTCCTC
AAGGCGCTCGACGTCATCCCCCCCTACATCGTCCATTGCATGATCCGCTCTAACATCATCTACGAGCGGAACATCCTGAT
CTCCATCATCCGCACCGACGAGCCGTTCGGCAACATCGCCCGGCACAAGAAGGACGTGGGGACCGGGCTCGAATTCTTCC
AGATCAGCGCCGGCTACATGGAACTACTCGACATCGAGAAGCAGTTGAAGGAACACGGTATCGTGGAGAAGGTGATCTTC
TACGGCATCGAGGACATCGAGACCAGGAACCCGGTCTGGAAGCTGTTCGCGCTGATGAAGAAGCTGACCCCGAACTTCGT
GCAGTTCAACAAGCTTCCCGCGACCAAGCTGCAGGGGGTCATGACCCGGGTGGAGATGTAA

Upstream 100 bases:

>100_bases
GGCAAACGCCGACGGAATGGTGTATATAGCGTTGGCGCCGTGGCACTTGGCACTGCTTTTACCTTACGCCGCCAGCGTGT
CACTGTCTCAAAGGAGTTCT

Downstream 100 bases:

>100_bases
AAAAGGAAGGGGATCTCAAATCGGTAAAGGGAAAGACAAAAAAAGGCCGCATCGCCAACAACGATGCGGCCTTTTCAGTT
TCGATGCCTGGAAGACCCCT

Product: Kup system potassium transporter

Products: K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MTHKTQDSFWGGIVKALGLVFGDIGTSPIYTLTVVFTLTKPTHANVYGILCLVFWTMTILVTAEYAWLAMSLGKKGQGGE
IVLREIIIKLFKQGRVLAFAGFLSFLGVSLLLGDGVITPAISILSAVEGLLLIPGLEATRQGVLVVIAALIAFTLFFFQS
RGTDKMAGVFGPIMILYFGSLLVSGLVSISGTPGIVAAINPMYAIDFFRENGIAGYFVLSEVILCSTGGEALYADMGHLG
KKPIIRAWYFVFAALYLNYLGQGAFLLKHPDTKNILFGMIQEQSSLLYIPFLLLTIMATIIASQSIISGVFSIVYQGITT
RLMPLFKVDYTSKHIQSQIYIGVVNWTLMCAVIFVMFFFQKSVNLAAAYGMAVTGSMTITALMMIMVFSKTTKKWKVPVV
AVIAVIDLIYFTSTFPKFVHGAYWSIALASVPFITIQVWTKGQRQLYRALRPLDLDIFMLSYEQIYGKNKNIPGTALFFL
KALDVIPPYIVHCMIRSNIIYERNILISIIRTDEPFGNIARHKKDVGTGLEFFQISAGYMELLDIEKQLKEHGIVEKVIF
YGIEDIETRNPVWKLFALMKKLTPNFVQFNKLPATKLQGVMTRVEM

Sequences:

>Translated_606_residues
MTHKTQDSFWGGIVKALGLVFGDIGTSPIYTLTVVFTLTKPTHANVYGILCLVFWTMTILVTAEYAWLAMSLGKKGQGGE
IVLREIIIKLFKQGRVLAFAGFLSFLGVSLLLGDGVITPAISILSAVEGLLLIPGLEATRQGVLVVIAALIAFTLFFFQS
RGTDKMAGVFGPIMILYFGSLLVSGLVSISGTPGIVAAINPMYAIDFFRENGIAGYFVLSEVILCSTGGEALYADMGHLG
KKPIIRAWYFVFAALYLNYLGQGAFLLKHPDTKNILFGMIQEQSSLLYIPFLLLTIMATIIASQSIISGVFSIVYQGITT
RLMPLFKVDYTSKHIQSQIYIGVVNWTLMCAVIFVMFFFQKSVNLAAAYGMAVTGSMTITALMMIMVFSKTTKKWKVPVV
AVIAVIDLIYFTSTFPKFVHGAYWSIALASVPFITIQVWTKGQRQLYRALRPLDLDIFMLSYEQIYGKNKNIPGTALFFL
KALDVIPPYIVHCMIRSNIIYERNILISIIRTDEPFGNIARHKKDVGTGLEFFQISAGYMELLDIEKQLKEHGIVEKVIF
YGIEDIETRNPVWKLFALMKKLTPNFVQFNKLPATKLQGVMTRVEM
>Mature_605_residues
THKTQDSFWGGIVKALGLVFGDIGTSPIYTLTVVFTLTKPTHANVYGILCLVFWTMTILVTAEYAWLAMSLGKKGQGGEI
VLREIIIKLFKQGRVLAFAGFLSFLGVSLLLGDGVITPAISILSAVEGLLLIPGLEATRQGVLVVIAALIAFTLFFFQSR
GTDKMAGVFGPIMILYFGSLLVSGLVSISGTPGIVAAINPMYAIDFFRENGIAGYFVLSEVILCSTGGEALYADMGHLGK
KPIIRAWYFVFAALYLNYLGQGAFLLKHPDTKNILFGMIQEQSSLLYIPFLLLTIMATIIASQSIISGVFSIVYQGITTR
LMPLFKVDYTSKHIQSQIYIGVVNWTLMCAVIFVMFFFQKSVNLAAAYGMAVTGSMTITALMMIMVFSKTTKKWKVPVVA
VIAVIDLIYFTSTFPKFVHGAYWSIALASVPFITIQVWTKGQRQLYRALRPLDLDIFMLSYEQIYGKNKNIPGTALFFLK
ALDVIPPYIVHCMIRSNIIYERNILISIIRTDEPFGNIARHKKDVGTGLEFFQISAGYMELLDIEKQLKEHGIVEKVIFY
GIEDIETRNPVWKLFALMKKLTPNFVQFNKLPATKLQGVMTRVEM

Specific function: Transport of potassium into the cell [H]

COG id: COG3158

COG function: function code P; K+ transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAK/KUP transporter (TC 2.A.72) family [H]

Homologues:

Organism=Escherichia coli, GI48994960, Length=633, Percent_Identity=32.3854660347551, Blast_Score=299, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003855
- InterPro:   IPR023051 [H]

Pfam domain/function: PF02705 K_trans [H]

EC number: NA

Molecular weight: Translated: 67368; Mature: 67237

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHKTQDSFWGGIVKALGLVFGDIGTSPIYTLTVVFTLTKPTHANVYGILCLVFWTMTIL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VTAEYAWLAMSLGKKGQGGEIVLREIIIKLFKQGRVLAFAGFLSFLGVSLLLGDGVITPA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
ISILSAVEGLLLIPGLEATRQGVLVVIAALIAFTLFFFQSRGTDKMAGVFGPIMILYFGS
HHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LLVSGLVSISGTPGIVAAINPMYAIDFFRENGIAGYFVLSEVILCSTGGEALYADMGHLG
HHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCC
KKPIIRAWYFVFAALYLNYLGQGAFLLKHPDTKNILFGMIQEQSSLLYIPFLLLTIMATI
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHH
IASQSIISGVFSIVYQGITTRLMPLFKVDYTSKHIQSQIYIGVVNWTLMCAVIFVMFFFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHH
KSVNLAAAYGMAVTGSMTITALMMIMVFSKTTKKWKVPVVAVIAVIDLIYFTSTFPKFVH
HCCCHHHHHCHHEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GAYWSIALASVPFITIQVWTKGQRQLYRALRPLDLDIFMLSYEQIYGKNKNIPGTALFFL
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCHHHHEEHHHHHHCCCCCCCHHHHHHH
KALDVIPPYIVHCMIRSNIIYERNILISIIRTDEPFGNIARHKKDVGTGLEFFQISAGYM
HHHHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCHHHHHHHHHHCCCCHHEEECHHHH
ELLDIEKQLKEHGIVEKVIFYGIEDIETRNPVWKLFALMKKLTPNFVQFNKLPATKLQGV
HHHHHHHHHHHCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHH
MTRVEM
HHHHCC
>Mature Secondary Structure 
THKTQDSFWGGIVKALGLVFGDIGTSPIYTLTVVFTLTKPTHANVYGILCLVFWTMTIL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VTAEYAWLAMSLGKKGQGGEIVLREIIIKLFKQGRVLAFAGFLSFLGVSLLLGDGVITPA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
ISILSAVEGLLLIPGLEATRQGVLVVIAALIAFTLFFFQSRGTDKMAGVFGPIMILYFGS
HHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LLVSGLVSISGTPGIVAAINPMYAIDFFRENGIAGYFVLSEVILCSTGGEALYADMGHLG
HHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCC
KKPIIRAWYFVFAALYLNYLGQGAFLLKHPDTKNILFGMIQEQSSLLYIPFLLLTIMATI
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHH
IASQSIISGVFSIVYQGITTRLMPLFKVDYTSKHIQSQIYIGVVNWTLMCAVIFVMFFFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHH
KSVNLAAAYGMAVTGSMTITALMMIMVFSKTTKKWKVPVVAVIAVIDLIYFTSTFPKFVH
HCCCHHHHHCHHEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GAYWSIALASVPFITIQVWTKGQRQLYRALRPLDLDIFMLSYEQIYGKNKNIPGTALFFL
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCHHHHEEHHHHHHCCCCCCCHHHHHHH
KALDVIPPYIVHCMIRSNIIYERNILISIIRTDEPFGNIARHKKDVGTGLEFFQISAGYM
HHHHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCHHHHHHHHHHCCCCHHEEECHHHH
ELLDIEKQLKEHGIVEKVIFYGIEDIETRNPVWKLFALMKKLTPNFVQFNKLPATKLQGV
HHHHHHHHHHHCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHH
MTRVEM
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: K (I) [Periplasm] [C]

Specific reaction: K (I) [Periplasm] = K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA