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The map label for this gene is czcR [H]

Identifier: 197119976

GI number: 197119976

Start: 4134188

End: 4134862

Strand: Direct

Name: czcR [H]

Synonym: Gbem_3615

Alternate gene names: 197119976

Gene position: 4134188-4134862 (Clockwise)

Preceding gene: 197119975

Following gene: 197119977

Centisome position: 89.58

GC content: 63.26

Gene sequence:

>675_bases
ATGCGCATCCTGATCGTCGAGGACGAACAAAAGGCCGCCAACTATCTCAAGAAGGGGCTCAGCGAAAACGGCTTCAGCGT
GGACATAGCCAACGACGGCGAGGACGGGCTGCACCTGGCCCTGACCGAGGTGTACAGCCTGATCATCCTCGACGTTATGC
TCCCGATACGCGGCGGATGGTCCATCATCAAGGAACTGCGCGCCGCGGGAAACGACGTCCCGGTCATCTTCCTGTCGGCG
CGCGACGAGGTGCACGACCGGGTGCACGGCCTGGAGCTTGGGGCCGACGACTACCTGGTGAAACCCTACGCCTTCTCCGA
GCTTCTGGCCCGCATCCGCATCATACTGCGCCGCTACCCGCTGCAGCAGTCCGAGTCCATGAAGCTGGCCGACCTGGAGC
TGGACCTGATCCGGCACAAGGCCCGGCGCGGCGGCCGCTCGCTCGACCTCACCGTCAAGGAATTCCAGCTCCTCGCCCTG
ATGCTGCACCGGCGCGGCGAGGTCTTGAGCCGCACCACCATCTCCGAGCAGATCTGGGGCATCAACTTCGACACCGACAC
CAACGTGGTGGACGTGGCGATCAGAAGGCTCAGGAAGAAGGTCGACGACCCCTTCCCGGTCAAACTCATCCAAACCATCA
GGGGAGTAGGCTATGTCCTCGACGAGACCGCCTGA

Upstream 100 bases:

>100_bases
GCATCGATACGTTATACTGCGGGACGTGCCGTTTCATGAGAAGCTGCGCGCCCCAGCCGCAGCCCTCCCGCACAAAACGC
CAACGCAGTTTAAGGAACAC

Downstream 100 bases:

>100_bases
ACCCCGCCGCTCCACCTCCATCACCGCGCGCCTGGTCGCCTTCTACCTGATCAGCACCCTTTTGATACTCCTTTGCACCA
ACTGGTTCCAGTTCAAGGCG

Product: winged-helix heavy metal transcriptional response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILIVEDEQKAANYLKKGLSENGFSVDIANDGEDGLHLALTEVYSLIILDVMLPIRGGWSIIKELRAAGNDVPVIFLSA
RDEVHDRVHGLELGADDYLVKPYAFSELLARIRIILRRYPLQQSESMKLADLELDLIRHKARRGGRSLDLTVKEFQLLAL
MLHRRGEVLSRTTISEQIWGINFDTDTNVVDVAIRRLRKKVDDPFPVKLIQTIRGVGYVLDETA

Sequences:

>Translated_224_residues
MRILIVEDEQKAANYLKKGLSENGFSVDIANDGEDGLHLALTEVYSLIILDVMLPIRGGWSIIKELRAAGNDVPVIFLSA
RDEVHDRVHGLELGADDYLVKPYAFSELLARIRIILRRYPLQQSESMKLADLELDLIRHKARRGGRSLDLTVKEFQLLAL
MLHRRGEVLSRTTISEQIWGINFDTDTNVVDVAIRRLRKKVDDPFPVKLIQTIRGVGYVLDETA
>Mature_224_residues
MRILIVEDEQKAANYLKKGLSENGFSVDIANDGEDGLHLALTEVYSLIILDVMLPIRGGWSIIKELRAAGNDVPVIFLSA
RDEVHDRVHGLELGADDYLVKPYAFSELLARIRIILRRYPLQQSESMKLADLELDLIRHKARRGGRSLDLTVKEFQLLAL
MLHRRGEVLSRTTISEQIWGINFDTDTNVVDVAIRRLRKKVDDPFPVKLIQTIRGVGYVLDETA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=55.9633027522936, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=54.5045045045045, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=39.6396396396396, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=38.1818181818182, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.1233480176211, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=38.3561643835616, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=29.8642533936652, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=39.2241379310345, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=37.10407239819, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=35.1351351351351, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=35.2422907488987, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.858407079646, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.8398268398268, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=35.5140186915888, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25401; Mature: 25401

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDEQKAANYLKKGLSENGFSVDIANDGEDGLHLALTEVYSLIILDVMLPIRGGW
CEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
SIIKELRAAGNDVPVIFLSARDEVHDRVHGLELGADDYLVKPYAFSELLARIRIILRRYP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHHHCC
LQQSESMKLADLELDLIRHKARRGGRSLDLTVKEFQLLALMLHRRGEVLSRTTISEQIWG
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
INFDTDTNVVDVAIRRLRKKVDDPFPVKLIQTIRGVGYVLDETA
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure
MRILIVEDEQKAANYLKKGLSENGFSVDIANDGEDGLHLALTEVYSLIILDVMLPIRGGW
CEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
SIIKELRAAGNDVPVIFLSARDEVHDRVHGLELGADDYLVKPYAFSELLARIRIILRRYP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHHHCC
LQQSESMKLADLELDLIRHKARRGGRSLDLTVKEFQLLALMLHRRGEVLSRTTISEQIWG
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
INFDTDTNVVDVAIRRLRKKVDDPFPVKLIQTIRGVGYVLDETA
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]