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The map label for this gene is shc [H]

Identifier: 197119724

GI number: 197119724

Start: 3861485

End: 3863527

Strand: Direct

Name: shc [H]

Synonym: Gbem_3360

Alternate gene names: 197119724

Gene position: 3861485-3863527 (Clockwise)

Preceding gene: 197119720

Following gene: 197119725

Centisome position: 83.67

GC content: 62.21

Gene sequence:

>2043_bases
GTGACCTCCCCTTTCAAGCACCCCATATCAAACGCACTCACCTCATTCAACGGTAACGTTGCAGAGCCAGAGCAAAGCGT
CGAGCAACAGAGTGGAGCAAAGGTGCACCACCTTCCTGCTTCAATCTGGAAGCGGAAGATGGGCAGGGCTAAGAGCCCCC
TGGATGTGGCCATTGAAGGAAGCCGCGATTTTTTCTTTCAGGAACAGCTACCCAAAGGTTATTGGTGGGCAGAACTCGAA
TCCAATGTCACCATCACCGCCGAATACATCATGCTGTTCCATTTCCTTGGGCTGGTTGATCCTGAGCGCCAGCGCAAGAT
GTCAACCTACCTGCTCTCTAAACAGACCGAAGAAGGTTTCTGGACCATCTATTACGGCGGACCTGGCGATCTCTCTACCA
CCATAGAGGCCTATTTCGCCCTGAAACTCTCCGGTTACCCGGAGGACCACCCGGCCCTGGCGAAGGCGCGCGCCTTCATC
CTGGAGCAGGGGGGGGTCGTCAAGAGCCGCGTCTTCACCAAGATCTTCCTGGCGCTCTTCGGCGAGTTCGACTGGCAGGG
GATCCCGAGCATGCCGGTTGAGCTGAACCTCCTGCCGGACTGGGCCTACATCAACATCTACGAATTCTCCAGTTGGGCCA
GGGCGACCATTGTCCCGCTTTCCGTGGTGATGCACAGCCGCCCGGTGCGCCGCGTCCCCCCTTCCGCGCGGGTACAGGAA
CTCTTCGTGCGGCAGCCCACGGCGGCGGACTACAGCTTCGCCAAAAACGACGGCCTCTTCACCTGGGAGAAATTTTTCCT
AGGTCTCGACCGCGTGCTCAAGGTGTACGAGAAGAGCCCGCTGCGCCCGTTCAAGAAGACGGCGCTGGCCAAGGCGGAGG
AGTGGGTGCTGGAGCACCAGGAACCGACCGGCGACTGGGGAGGCATCCAGCCTGCCATGCTGAACGCCATCCTTGCGCTC
AACGTGCTGGGGTACCGGAACGACCACCCCGCGGTGGAACAGGGGTTGAGGGCGCTGGCGAACTTCTGCATCGAGACCGA
GGACCAGCTGGTGCTGCAGTCCTGCGTCTCCCCGGTGTGGGACACGGCGCTGGCGTTAAAGGCGCTATTGGATGCGGGCG
TTCCTCCCGACCACCCCTCCCTGGTGAAGGGGGCCCAGTGGCTTCTGGACAAGGAGGTGACCCGGGCAGGCGACTGGCGC
GTCAAGTCCCCCAACCTGGAAGCCGGCGGTTGGGCCTTCGAATTCCTGAACGACTGGTACCCGGACGTGGACGACTCCGG
CTTCGTCATGATCGCCCTGAAGGGGATCCAGGTGAAGGACCACAAGGCCATGGACGCCGCCATCAAGCGCGGCATCAACT
GGTGCCTGGGGATGCAGAGCAAGAACGGCGGCTGGGGGGCGTTCGACAAGGACAACACCAAGCACGTACTGAACAAGATC
CCCTTTGCCGATCTGGAGGCGCTCATCGATCCCCCAACCGCGGACCTGACCGGCCGCATGCTGGAGCTGATGGGAACCTT
CGACTACCCTGTCACCTTCCCTGCGGCGCAGCGCGCCATCGAATTCCTGAAGAAGAACCAGGAGCCGGAGGGGCCCTGGT
GGGGGCGCTGGGGGGTCAACTACCTTTACGGCACCTGGTCCGTCCTTTGCGGGCTGGCCGCCATAGGCGAAGACATGGAT
CAGCCTTACATCCGCAAGGCGGTGAACTGGATCAAGTCGCGCCAGAACATCGACGGCGGGTGGGGCGAGACCTGCCAGTC
GTACCACGACCGGACCCTGGCAGGGGTCGGCGAGAGCACCCCTTCCCAGACGGGATGGGCGCTCCTAAGCCTTCTGGCGG
CCGGCGAGATGCACTCGGCGACCGTGGTGCGTGGGGTGCAGTACCTGATCTCGACCCAGAACAGCGACGGGACCTGGGAC
GAGCAGCAGTACACCGGGACCGGGTTCCCCAAGTACTTCATGATCAAGTACCACATCTACCGCAACTGCTTCCCGCTCAT
GGCCCTGGGGACCTACCGCACCCTGACCAGGACGCAGCCGTGA

Upstream 100 bases:

>100_bases
ACCTTTTAGGAAAACCGTGTTAAGTTCCGGCACTTGTAACAATTAGAGAAAGAGGCTACACTCTGTTAGCTTTAGCCAAT
CTGACAGAAAGGAGTACGTT

Downstream 100 bases:

>100_bases
CCGGAGCGCGCGGATGAAAGCATTCGTCACAGGCGCCACCGGGTTCATCGGCGCGAGCATCGTGCGCGAATTGTTGAAGG
ACGGCTGGGAGGTACGGGTG

Product: squalene cyclase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTSPFKHPISNALTSFNGNVAEPEQSVEQQSGAKVHHLPASIWKRKMGRAKSPLDVAIEGSRDFFFQEQLPKGYWWAELE
SNVTITAEYIMLFHFLGLVDPERQRKMSTYLLSKQTEEGFWTIYYGGPGDLSTTIEAYFALKLSGYPEDHPALAKARAFI
LEQGGVVKSRVFTKIFLALFGEFDWQGIPSMPVELNLLPDWAYINIYEFSSWARATIVPLSVVMHSRPVRRVPPSARVQE
LFVRQPTAADYSFAKNDGLFTWEKFFLGLDRVLKVYEKSPLRPFKKTALAKAEEWVLEHQEPTGDWGGIQPAMLNAILAL
NVLGYRNDHPAVEQGLRALANFCIETEDQLVLQSCVSPVWDTALALKALLDAGVPPDHPSLVKGAQWLLDKEVTRAGDWR
VKSPNLEAGGWAFEFLNDWYPDVDDSGFVMIALKGIQVKDHKAMDAAIKRGINWCLGMQSKNGGWGAFDKDNTKHVLNKI
PFADLEALIDPPTADLTGRMLELMGTFDYPVTFPAAQRAIEFLKKNQEPEGPWWGRWGVNYLYGTWSVLCGLAAIGEDMD
QPYIRKAVNWIKSRQNIDGGWGETCQSYHDRTLAGVGESTPSQTGWALLSLLAAGEMHSATVVRGVQYLISTQNSDGTWD
EQQYTGTGFPKYFMIKYHIYRNCFPLMALGTYRTLTRTQP

Sequences:

>Translated_680_residues
MTSPFKHPISNALTSFNGNVAEPEQSVEQQSGAKVHHLPASIWKRKMGRAKSPLDVAIEGSRDFFFQEQLPKGYWWAELE
SNVTITAEYIMLFHFLGLVDPERQRKMSTYLLSKQTEEGFWTIYYGGPGDLSTTIEAYFALKLSGYPEDHPALAKARAFI
LEQGGVVKSRVFTKIFLALFGEFDWQGIPSMPVELNLLPDWAYINIYEFSSWARATIVPLSVVMHSRPVRRVPPSARVQE
LFVRQPTAADYSFAKNDGLFTWEKFFLGLDRVLKVYEKSPLRPFKKTALAKAEEWVLEHQEPTGDWGGIQPAMLNAILAL
NVLGYRNDHPAVEQGLRALANFCIETEDQLVLQSCVSPVWDTALALKALLDAGVPPDHPSLVKGAQWLLDKEVTRAGDWR
VKSPNLEAGGWAFEFLNDWYPDVDDSGFVMIALKGIQVKDHKAMDAAIKRGINWCLGMQSKNGGWGAFDKDNTKHVLNKI
PFADLEALIDPPTADLTGRMLELMGTFDYPVTFPAAQRAIEFLKKNQEPEGPWWGRWGVNYLYGTWSVLCGLAAIGEDMD
QPYIRKAVNWIKSRQNIDGGWGETCQSYHDRTLAGVGESTPSQTGWALLSLLAAGEMHSATVVRGVQYLISTQNSDGTWD
EQQYTGTGFPKYFMIKYHIYRNCFPLMALGTYRTLTRTQP
>Mature_679_residues
TSPFKHPISNALTSFNGNVAEPEQSVEQQSGAKVHHLPASIWKRKMGRAKSPLDVAIEGSRDFFFQEQLPKGYWWAELES
NVTITAEYIMLFHFLGLVDPERQRKMSTYLLSKQTEEGFWTIYYGGPGDLSTTIEAYFALKLSGYPEDHPALAKARAFIL
EQGGVVKSRVFTKIFLALFGEFDWQGIPSMPVELNLLPDWAYINIYEFSSWARATIVPLSVVMHSRPVRRVPPSARVQEL
FVRQPTAADYSFAKNDGLFTWEKFFLGLDRVLKVYEKSPLRPFKKTALAKAEEWVLEHQEPTGDWGGIQPAMLNAILALN
VLGYRNDHPAVEQGLRALANFCIETEDQLVLQSCVSPVWDTALALKALLDAGVPPDHPSLVKGAQWLLDKEVTRAGDWRV
KSPNLEAGGWAFEFLNDWYPDVDDSGFVMIALKGIQVKDHKAMDAAIKRGINWCLGMQSKNGGWGAFDKDNTKHVLNKIP
FADLEALIDPPTADLTGRMLELMGTFDYPVTFPAAQRAIEFLKKNQEPEGPWWGRWGVNYLYGTWSVLCGLAAIGEDMDQ
PYIRKAVNWIKSRQNIDGGWGETCQSYHDRTLAGVGESTPSQTGWALLSLLAAGEMHSATVVRGVQYLISTQNSDGTWDE
QQYTGTGFPKYFMIKYHIYRNCFPLMALGTYRTLTRTQP

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=687, Percent_Identity=24.0174672489083, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI47933397, Length=687, Percent_Identity=24.0174672489083, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI224177558, Length=643, Percent_Identity=24.5723172628305, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI224177556, Length=568, Percent_Identity=25.3521126760563, Blast_Score=161, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321863, Length=676, Percent_Identity=24.7041420118343, Blast_Score=154, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 76549; Mature: 76418

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPFKHPISNALTSFNGNVAEPEQSVEQQSGAKVHHLPASIWKRKMGRAKSPLDVAIEG
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEEEEC
SRDFFFQEQLPKGYWWAELESNVTITAEYIMLFHFLGLVDPERQRKMSTYLLSKQTEEGF
CCCHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCE
WTIYYGGPGDLSTTIEAYFALKLSGYPEDHPALAKARAFILEQGGVVKSRVFTKIFLALF
EEEEECCCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GEFDWQGIPSMPVELNLLPDWAYINIYEFSSWARATIVPLSVVMHSRPVRRVPPSARVQE
CCCCCCCCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
LFVRQPTAADYSFAKNDGLFTWEKFFLGLDRVLKVYEKSPLRPFKKTALAKAEEWVLEHQ
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
EPTGDWGGIQPAMLNAILALNVLGYRNDHPAVEQGLRALANFCIETEDQLVLQSCVSPVW
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DTALALKALLDAGVPPDHPSLVKGAQWLLDKEVTRAGDWRVKSPNLEAGGWAFEFLNDWY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHCC
PDVDDSGFVMIALKGIQVKDHKAMDAAIKRGINWCLGMQSKNGGWGAFDKDNTKHVLNKI
CCCCCCCEEEEEEECCEECCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCHHHHHHHC
PFADLEALIDPPTADLTGRMLELMGTFDYPVTFPAAQRAIEFLKKNQEPEGPWWGRWGVN
CHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCH
YLYGTWSVLCGLAAIGEDMDQPYIRKAVNWIKSRQNIDGGWGETCQSYHDRTLAGVGEST
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCCC
PSQTGWALLSLLAAGEMHSATVVRGVQYLISTQNSDGTWDEQQYTGTGFPKYFMIKYHIY
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHHH
RNCFPLMALGTYRTLTRTQP
HCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSPFKHPISNALTSFNGNVAEPEQSVEQQSGAKVHHLPASIWKRKMGRAKSPLDVAIEG
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEEEEC
SRDFFFQEQLPKGYWWAELESNVTITAEYIMLFHFLGLVDPERQRKMSTYLLSKQTEEGF
CCCHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCE
WTIYYGGPGDLSTTIEAYFALKLSGYPEDHPALAKARAFILEQGGVVKSRVFTKIFLALF
EEEEECCCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GEFDWQGIPSMPVELNLLPDWAYINIYEFSSWARATIVPLSVVMHSRPVRRVPPSARVQE
CCCCCCCCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
LFVRQPTAADYSFAKNDGLFTWEKFFLGLDRVLKVYEKSPLRPFKKTALAKAEEWVLEHQ
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
EPTGDWGGIQPAMLNAILALNVLGYRNDHPAVEQGLRALANFCIETEDQLVLQSCVSPVW
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DTALALKALLDAGVPPDHPSLVKGAQWLLDKEVTRAGDWRVKSPNLEAGGWAFEFLNDWY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHCC
PDVDDSGFVMIALKGIQVKDHKAMDAAIKRGINWCLGMQSKNGGWGAFDKDNTKHVLNKI
CCCCCCCEEEEEEECCEECCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCHHHHHHHC
PFADLEALIDPPTADLTGRMLELMGTFDYPVTFPAAQRAIEFLKKNQEPEGPWWGRWGVN
CHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCH
YLYGTWSVLCGLAAIGEDMDQPYIRKAVNWIKSRQNIDGGWGETCQSYHDRTLAGVGEST
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCCC
PSQTGWALLSLLAAGEMHSATVVRGVQYLISTQNSDGTWDEQQYTGTGFPKYFMIKYHIY
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHHH
RNCFPLMALGTYRTLTRTQP
HCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]