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The map label for this gene is atoC [H]

Identifier: 197118192

GI number: 197118192

Start: 2091750

End: 2093114

Strand: Direct

Name: atoC [H]

Synonym: Gbem_1807

Alternate gene names: 197118192

Gene position: 2091750-2093114 (Clockwise)

Preceding gene: 197118191

Following gene: 197118193

Centisome position: 45.32

GC content: 63.3

Gene sequence:

>1365_bases
GTGAAAAAACTATTGATTGTCGACGACAACGACGATATCAGGCAGCAGTTGAAGTGGGGCCTGAACCAGGAATTCCAGGT
GCTTTTGGCGGCCGATGGCAGAGAGGCGCTGCAGCAGTTCAAAAGCGAGAAGCCCGACGTGGTGGTGCTCGACCTGGGCC
TTCCCCCCTACGCCGACAGTTCGGTGGAGGGGTTCCGCTGCCTGGACGAGATGCTCGGGCTGAACCCGGCGGCGAAGGTG
ATCATGCTGACCGGGAACAACGAACGGGAAAACGCCTTGAAGGCGATGCGCATGGGGGCCTTCGACTTTTACGCCAAGCC
CCCGGTTTTGAGCGAGCTGAAGGTGATCATCACCCGCGCCTTTCACCTGGCCAACATCGACGAGCAGAACCTGAGGCAGG
TATCGTCCCAGAGCGAGGACGGCGAGCAGTGGGGCATGGTCGGCTCCTGCCCCGAGATGCAGGCCGTCTTTCACACCATC
CGCAAGGTTGCCGGCTCCAACGCCCCGATCCTCATCACCGGCGAAAGCGGCACCGGAAAGGAACTGGTGGCGGGCGCCAT
CCACGAGGCGAGCTCTCGCAACAAGGGGCCGCTGGTGGCCATCAACTGCGGCGCTATTCCCGAGAACCTCCTGGAGAGCG
AGCTCTTCGGCCACGAGAAGGGGGCCTTCACCGGCGCCCACGCAGCGGTCAGGGGGAAGCTCCAGTTCGCCCACAAAGGG
ACGCTCTTTCTCGATGAAATAGGCGAGCTCCCGGTGAACCTCCAGGTGAAGCTTTTGCGCTTCTTGCAGGAGGGGACCAT
CCAGCGGGTCGGGGGGCGGGAGGAAATCGCCATCGACGCCCGCACCACCTGCGCCACCAACGTGGACATCGCCAAGGCGA
TCGAGGAAGGGCGCTTTAGGGAGGACCTCTACTACCGCATCGGGGTGATCAACATCAAGCTGCCTCCCTTGCGCGAACGC
GGCGACGACATCCTCCTGATCGCGGAGAACTTCCTGCGGCTCTACTGCAAAGAGAACAAGAAGAAGACGGTCCGCTTCTC
CACCGCCGCCGTCGCTTTCCTCAAGCGCCACAACTGGCCCGGCAACGTGCGCGAGCTGAAGAACCGGGTACAGCGCGCGG
TGATCATGTGCGACGGCGCGAGCATAGGACCGCTCGACCTTGGCTGCGACGTGGAGCCTGCGGCGATGCCGGTTCCCTCC
GGTGACGGGGTCTCGCTGAAGGCCGCCCGCGAGCGGATGGAGCGCGAGATGATACAGCAGGCGATCGAGCGCCAGCAGGG
GAATATCATGAAGGCGGCCGAGGAACTCGGGGTGAGCCGCCCGACGCTGTACGACCTGATGAAGAAGCTCTCCATCCACC
CGTAG

Upstream 100 bases:

>100_bases
TGCAGCGTAGAGGGGGAGGGGACCGTGTTCACGGTATGGTTCCCGTCCCCTGCGCTAGGCGCGGAACGGGTCATCACACA
GCCGGCATGAGGGGGTGGTA

Downstream 100 bases:

>100_bases
GCAGACGAAGAAAGGTAACGCATGAGCGTCAATGGGAACCTGGCCGAGCGCGTGCAGCAGGAATCCGCTTTTCTGGCAGG
CGTCGTCTCCGCGGTGGAAA

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKKLLIVDDNDDIRQQLKWGLNQEFQVLLAADGREALQQFKSEKPDVVVLDLGLPPYADSSVEGFRCLDEMLGLNPAAKV
IMLTGNNERENALKAMRMGAFDFYAKPPVLSELKVIITRAFHLANIDEQNLRQVSSQSEDGEQWGMVGSCPEMQAVFHTI
RKVAGSNAPILITGESGTGKELVAGAIHEASSRNKGPLVAINCGAIPENLLESELFGHEKGAFTGAHAAVRGKLQFAHKG
TLFLDEIGELPVNLQVKLLRFLQEGTIQRVGGREEIAIDARTTCATNVDIAKAIEEGRFREDLYYRIGVINIKLPPLRER
GDDILLIAENFLRLYCKENKKKTVRFSTAAVAFLKRHNWPGNVRELKNRVQRAVIMCDGASIGPLDLGCDVEPAAMPVPS
GDGVSLKAARERMEREMIQQAIERQQGNIMKAAEELGVSRPTLYDLMKKLSIHP

Sequences:

>Translated_454_residues
MKKLLIVDDNDDIRQQLKWGLNQEFQVLLAADGREALQQFKSEKPDVVVLDLGLPPYADSSVEGFRCLDEMLGLNPAAKV
IMLTGNNERENALKAMRMGAFDFYAKPPVLSELKVIITRAFHLANIDEQNLRQVSSQSEDGEQWGMVGSCPEMQAVFHTI
RKVAGSNAPILITGESGTGKELVAGAIHEASSRNKGPLVAINCGAIPENLLESELFGHEKGAFTGAHAAVRGKLQFAHKG
TLFLDEIGELPVNLQVKLLRFLQEGTIQRVGGREEIAIDARTTCATNVDIAKAIEEGRFREDLYYRIGVINIKLPPLRER
GDDILLIAENFLRLYCKENKKKTVRFSTAAVAFLKRHNWPGNVRELKNRVQRAVIMCDGASIGPLDLGCDVEPAAMPVPS
GDGVSLKAARERMEREMIQQAIERQQGNIMKAAEELGVSRPTLYDLMKKLSIHP
>Mature_454_residues
MKKLLIVDDNDDIRQQLKWGLNQEFQVLLAADGREALQQFKSEKPDVVVLDLGLPPYADSSVEGFRCLDEMLGLNPAAKV
IMLTGNNERENALKAMRMGAFDFYAKPPVLSELKVIITRAFHLANIDEQNLRQVSSQSEDGEQWGMVGSCPEMQAVFHTI
RKVAGSNAPILITGESGTGKELVAGAIHEASSRNKGPLVAINCGAIPENLLESELFGHEKGAFTGAHAAVRGKLQFAHKG
TLFLDEIGELPVNLQVKLLRFLQEGTIQRVGGREEIAIDARTTCATNVDIAKAIEEGRFREDLYYRIGVINIKLPPLRER
GDDILLIAENFLRLYCKENKKKTVRFSTAAVAFLKRHNWPGNVRELKNRVQRAVIMCDGASIGPLDLGCDVEPAAMPVPS
GDGVSLKAARERMEREMIQQAIERQQGNIMKAAEELGVSRPTLYDLMKKLSIHP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=41.7748917748918, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=41.8502202643172, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=35.8050847457627, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=37.8619153674833, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082117, Length=314, Percent_Identity=42.0382165605096, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=43.4375, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=42.4148606811146, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789087, Length=316, Percent_Identity=41.4556962025316, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=41.9254658385093, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=39.5638629283489, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1787583, Length=309, Percent_Identity=38.1877022653722, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87081858, Length=304, Percent_Identity=33.2236842105263, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789828, Length=259, Percent_Identity=36.6795366795367, Blast_Score=134, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50203; Mature: 50203

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLIVDDNDDIRQQLKWGLNQEFQVLLAADGREALQQFKSEKPDVVVLDLGLPPYADS
CCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
SVEGFRCLDEMLGLNPAAKVIMLTGNNERENALKAMRMGAFDFYAKPPVLSELKVIITRA
CCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHH
FHLANIDEQNLRQVSSQSEDGEQWGMVGSCPEMQAVFHTIRKVAGSNAPILITGESGTGK
HHHCCCCHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
ELVAGAIHEASSRNKGPLVAINCGAIPENLLESELFGHEKGAFTGAHAAVRGKLQFAHKG
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEECC
TLFLDEIGELPVNLQVKLLRFLQEGTIQRVGGREEIAIDARTTCATNVDIAKAIEEGRFR
CEEEHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCCH
EDLYYRIGVINIKLPPLRERGDDILLIAENFLRLYCKENKKKTVRFSTAAVAFLKRHNWP
HCEEEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCC
GNVRELKNRVQRAVIMCDGASIGPLDLGCDVEPAAMPVPSGDGVSLKAARERMEREMIQQ
CCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIERQQGNIMKAAEELGVSRPTLYDLMKKLSIHP
HHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKKLLIVDDNDDIRQQLKWGLNQEFQVLLAADGREALQQFKSEKPDVVVLDLGLPPYADS
CCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
SVEGFRCLDEMLGLNPAAKVIMLTGNNERENALKAMRMGAFDFYAKPPVLSELKVIITRA
CCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHH
FHLANIDEQNLRQVSSQSEDGEQWGMVGSCPEMQAVFHTIRKVAGSNAPILITGESGTGK
HHHCCCCHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
ELVAGAIHEASSRNKGPLVAINCGAIPENLLESELFGHEKGAFTGAHAAVRGKLQFAHKG
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEECC
TLFLDEIGELPVNLQVKLLRFLQEGTIQRVGGREEIAIDARTTCATNVDIAKAIEEGRFR
CEEEHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCCH
EDLYYRIGVINIKLPPLRERGDDILLIAENFLRLYCKENKKKTVRFSTAAVAFLKRHNWP
HCEEEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCC
GNVRELKNRVQRAVIMCDGASIGPLDLGCDVEPAAMPVPSGDGVSLKAARERMEREMIQQ
CCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIERQQGNIMKAAEELGVSRPTLYDLMKKLSIHP
HHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]