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The map label for this gene is capL-2 [H]

Identifier: 197118190

GI number: 197118190

Start: 2088294

End: 2089643

Strand: Direct

Name: capL-2 [H]

Synonym: Gbem_1805

Alternate gene names: 197118190

Gene position: 2088294-2089643 (Clockwise)

Preceding gene: 197118189

Following gene: 197118191

Centisome position: 45.25

GC content: 63.19

Gene sequence:

>1350_bases
ATGGAACTGCAGCGCGATAAATTCATTTTGGCGGCCTTGGTGCCGCAATTTCAGGAGGACGACTTGACGGTAGAGCGCAT
TGTCTCAGTGGTAGGGCTAGGGTACGTGGGGCTTCCGGTAGCGGTTGCCTTCGGCAAGGTGCGCCGCGCCATAGGCTTCG
ACATCAATGGCACCAGGATCAAGGAGCTGTGCGAGGGGTACGACCGGACCGCCGAGGTGGAGGCGGGGGATCTGGCTCAA
GCGGACATCCTGTTCACCGACCGGGTCGAGGACCTGGCTCAGGCCAATTTCCACATCGTGGCGGTCCCGACCCCCATCGA
CGAGGCGAACCAGCCGGACCTGAGCCTCGTCTGCCGGGCCAGCGAGACCGTGGGGAAGGCGCTTAAAAAGGGCGACATCG
TGGTCTACGAATCCACCGTCTACCCGGGGGTAACCGAGGACGAATGCGTCCCGGTCCTGGAGCGGGTCTCCGGCCTCAAA
GGCGGTATCGACTTCAAGGTGGGATACAGCCCGGAGCGGATCAACCCCGGCGACAAGGAGCACACCTTCACCAAGATCAA
GAAGGTGGTCTCCGGCCAGGACAGTGAGACCCTGGAGGTGGTGGCGGAGGTCTACAGCTCGGTGGTGACGGCGGGGGTGT
TCCGCGCCTCCTCCATCAAGGTGGCGGAAGCGGCCAAGGTGATCGAGAACACCCAGCGCGACCTGAACATCGCCCTCATG
AACGAACTGGCGCTCATCTTCGACCGCCTGGGGATCGACACCTCCGAGGTGCTGGCGGCAGCCGGGAGCAAGTGGAACTT
CCTCAAGTTCTCCCCCGGTCTGGTCGGCGGGCACTGCATCGGCGTCGACCCTTACTACCTCACCCACAAGGCGGAGAAGT
TAGGCTACATCCCGCAGGTGATCCTGGCGGGGCGGCGCATCAACGACGGCATGGGGAAATTCGTGGCGCAGCGCGCCGTG
AAGGAGATCATCAGGGCCGGGCACCCGGTGCTGAACGCGGTGGTCACGGTGCTGGGGATCACCTTCAAGGAAAACTGCCC
CGACATCAGGAACTCCAAGGTCATCGACATCGTCAAGGAGCTCAAGGATTACGGGATGCAGGTCCAGGTCTGCGATCCTA
TGGCCGACCCGGAGGAGACGCTGCACGAGTACGGGGTGCGGCTCACCCCGAGGGAGCAGTTAAAGCCCGCAGTGGCGGTG
GTGGCCGCCGTGGCCCACGCTGAATTCGCCTCCCTCGCGGCACCTGAACTCTTGGCGCTCATGGGTCCCAACCCGGTCTT
GATCGACGTGAAGAGCATGTTCGACCGGGAGCGGGTTGAAGAGGCCGGTGTCAAGGTCTGGGCGTTATAA

Upstream 100 bases:

>100_bases
AAGGAGTTCCTCCCGGCGATACGGACCTTCCTGCCGAGCTGAGCCTCCCGGCGCGGCTCTCCATCTGCCTCATGGCGATG
GCGGCGCGGGTAGGGCGGCA

Downstream 100 bases:

>100_bases
AGGGTTGAATCCCAGAGGGGAACATGGCGCTTTCGCTTGTTGCGATCATCTTGCTTTTGTTTGCCATGCTGAGGATAATC
CGGCTGGAGCGCAAAAGCGC

Product: UDP-N-acetyl-D-galactosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MELQRDKFILAALVPQFQEDDLTVERIVSVVGLGYVGLPVAVAFGKVRRAIGFDINGTRIKELCEGYDRTAEVEAGDLAQ
ADILFTDRVEDLAQANFHIVAVPTPIDEANQPDLSLVCRASETVGKALKKGDIVVYESTVYPGVTEDECVPVLERVSGLK
GGIDFKVGYSPERINPGDKEHTFTKIKKVVSGQDSETLEVVAEVYSSVVTAGVFRASSIKVAEAAKVIENTQRDLNIALM
NELALIFDRLGIDTSEVLAAAGSKWNFLKFSPGLVGGHCIGVDPYYLTHKAEKLGYIPQVILAGRRINDGMGKFVAQRAV
KEIIRAGHPVLNAVVTVLGITFKENCPDIRNSKVIDIVKELKDYGMQVQVCDPMADPEETLHEYGVRLTPREQLKPAVAV
VAAVAHAEFASLAAPELLALMGPNPVLIDVKSMFDRERVEEAGVKVWAL

Sequences:

>Translated_449_residues
MELQRDKFILAALVPQFQEDDLTVERIVSVVGLGYVGLPVAVAFGKVRRAIGFDINGTRIKELCEGYDRTAEVEAGDLAQ
ADILFTDRVEDLAQANFHIVAVPTPIDEANQPDLSLVCRASETVGKALKKGDIVVYESTVYPGVTEDECVPVLERVSGLK
GGIDFKVGYSPERINPGDKEHTFTKIKKVVSGQDSETLEVVAEVYSSVVTAGVFRASSIKVAEAAKVIENTQRDLNIALM
NELALIFDRLGIDTSEVLAAAGSKWNFLKFSPGLVGGHCIGVDPYYLTHKAEKLGYIPQVILAGRRINDGMGKFVAQRAV
KEIIRAGHPVLNAVVTVLGITFKENCPDIRNSKVIDIVKELKDYGMQVQVCDPMADPEETLHEYGVRLTPREQLKPAVAV
VAAVAHAEFASLAAPELLALMGPNPVLIDVKSMFDRERVEEAGVKVWAL
>Mature_449_residues
MELQRDKFILAALVPQFQEDDLTVERIVSVVGLGYVGLPVAVAFGKVRRAIGFDINGTRIKELCEGYDRTAEVEAGDLAQ
ADILFTDRVEDLAQANFHIVAVPTPIDEANQPDLSLVCRASETVGKALKKGDIVVYESTVYPGVTEDECVPVLERVSGLK
GGIDFKVGYSPERINPGDKEHTFTKIKKVVSGQDSETLEVVAEVYSSVVTAGVFRASSIKVAEAAKVIENTQRDLNIALM
NELALIFDRLGIDTSEVLAAAGSKWNFLKFSPGLVGGHCIGVDPYYLTHKAEKLGYIPQVILAGRRINDGMGKFVAQRAV
KEIIRAGHPVLNAVVTVLGITFKENCPDIRNSKVIDIVKELKDYGMQVQVCDPMADPEETLHEYGVRLTPREQLKPAVAV
VAAVAHAEFASLAAPELLALMGPNPVLIDVKSMFDRERVEEAGVKVWAL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=29.1358024691358, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560350, Length=467, Percent_Identity=24.4111349036403, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=23.3261339092873, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48853; Mature: 48853

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQRDKFILAALVPQFQEDDLTVERIVSVVGLGYVGLPVAVAFGKVRRAIGFDINGTRI
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHH
KELCEGYDRTAEVEAGDLAQADILFTDRVEDLAQANFHIVAVPTPIDEANQPDLSLVCRA
HHHHCCCCCCCCCCCCCCCCHHEEEHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEEC
SETVGKALKKGDIVVYESTVYPGVTEDECVPVLERVSGLKGGIDFKVGYSPERINPGDKE
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCH
HTFTKIKKVVSGQDSETLEVVAEVYSSVVTAGVFRASSIKVAEAAKVIENTQRDLNIALM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NELALIFDRLGIDTSEVLAAAGSKWNFLKFSPGLVGGHCIGVDPYYLTHKAEKLGYIPQV
HHHHHHHHHHCCCHHHHHHHCCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCHHH
ILAGRRINDGMGKFVAQRAVKEIIRAGHPVLNAVVTVLGITFKENCPDIRNSKVIDIVKE
HHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LKDYGMQVQVCDPMADPEETLHEYGVRLTPREQLKPAVAVVAAVAHAEFASLAAPELLAL
HHHCCCEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGPNPVLIDVKSMFDRERVEEAGVKVWAL
CCCCCEEEEHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MELQRDKFILAALVPQFQEDDLTVERIVSVVGLGYVGLPVAVAFGKVRRAIGFDINGTRI
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHH
KELCEGYDRTAEVEAGDLAQADILFTDRVEDLAQANFHIVAVPTPIDEANQPDLSLVCRA
HHHHCCCCCCCCCCCCCCCCHHEEEHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEEC
SETVGKALKKGDIVVYESTVYPGVTEDECVPVLERVSGLKGGIDFKVGYSPERINPGDKE
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCH
HTFTKIKKVVSGQDSETLEVVAEVYSSVVTAGVFRASSIKVAEAAKVIENTQRDLNIALM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NELALIFDRLGIDTSEVLAAAGSKWNFLKFSPGLVGGHCIGVDPYYLTHKAEKLGYIPQV
HHHHHHHHHHCCCHHHHHHHCCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCHHH
ILAGRRINDGMGKFVAQRAVKEIIRAGHPVLNAVVTVLGITFKENCPDIRNSKVIDIVKE
HHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LKDYGMQVQVCDPMADPEETLHEYGVRLTPREQLKPAVAVVAAVAHAEFASLAAPELLAL
HHHCCCEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGPNPVLIDVKSMFDRERVEEAGVKVWAL
CCCCCEEEEHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]