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The map label for this gene is lpxB [H]

Identifier: 197117236

GI number: 197117236

Start: 997900

End: 999042

Strand: Direct

Name: lpxB [H]

Synonym: Gbem_0844

Alternate gene names: 197117236

Gene position: 997900-999042 (Clockwise)

Preceding gene: 197117235

Following gene: 197117237

Centisome position: 21.62

GC content: 63.25

Gene sequence:

>1143_bases
TTGCAAGAAAAACCAAAGTCCGTGATGATCGTCGCCGGTGAGGCTTCCGGCGAGATGTACGGCGCGAGCATCGCGACCGA
GATACGTGCCCTCGCCCCGGAGACCAGGTTCTTCGGGATGGGGGGCGGCAACATGCGCAAGGCCGGCGTCGAGACGCTGG
TCGACGCGGACACCATGGCCGTGATGGGGCTGGTCGAGGTGGTCGCGCACCTTCCGGTGATCGTCAACGGTTTCAACACC
CTCAAGAACAAGCTCCGCAGCGATCTTCCCGACCTGTTGATCCTGATCGATTACCCCGACTTCAACCTGAGGCTCGCCAA
GGTGGCCAAGAAGGCCGGCGTCAAGGTGCTCTACTTCATCTCCCCGCAGGTGTGGGCCTGGAGAAGCGGACGCGTCAAGG
GTATCGGCCGTGTGGTCGACATGATGGCCGTCCTCTTCCCGTTCGAGGTCCCCTTCTACCAAAACGCCGGCGTGCCGGTC
ACCTTCGTCGGGCATCCGCTGCTCGACCTGGTGCGCCCCACCATGAAAAGGGACGAGGCGCTTTCCTCCCTGGGGCTCGA
CCCGCAGCGGCGCTGCGTAGGCCTTTTCCCGGGGAGCCGGAAGTCCGAGATCGGCAAGCTCTTGGGGATCATCCTTGAGT
CCGCCGAGATCCTGAAAAAGAGGATGCCGGAGCTGCAGTTCGTGCTCCCGCTCGCCTCGTCGCTGCGCCGGGAGGATCTC
GACCCGTACCTCTCCGGCTCCAAGGTCGAGGTAAGGGTGGTCTCCGGCCGCAACCACGACGTGATGACCGCCTGCGACGC
CGCCGTTTGCGCCTCCGGGACCGTGGTGATGGAGATGGCGCTGGTCGGGACCCCGCACCTGATCATCTACAAGATGTCCA
CCTTCACCTACGAGGTCGGCAAAAGGGTGATCAACGTGCCGCACATAGGGATCAGCAACATCGTGGCCGAAAAAAGGATG
GTGCGGGAACTGGTCCAGCACGAGGCGGAGCCCGTCGCCATCGCGGACGAAGTAGACGCGCTTTTGAACGACGCGGCGTA
TGCAACAGAGATGCGGGAAGGTTTCGCCGCGATGAGAGTCAAGTTAGGCAGCGGAGGCGCCCTAGGGAGGGTGGCCCGGC
TGGCCATGGAGATGATGAGATGA

Upstream 100 bases:

>100_bases
GTGGTGCTGAGATTGATGTTAAGAATTACGCAAGGTTTTTCTCAATCTTAATCTTAATCTTAATCTCAATCTGCCTTTAA
GCTGTCTTTCAGAGGTTTGT

Downstream 100 bases:

>100_bases
GTGCAGTAAACGAGAAAGCAAAGGACGCTTTCCAAAGACTTCTGGCATACAGCCGCCCCTACTGGTGGCGCATCGCCGTG
GCGGCGCTCGGATCACTGGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MQEKPKSVMIVAGEASGEMYGASIATEIRALAPETRFFGMGGGNMRKAGVETLVDADTMAVMGLVEVVAHLPVIVNGFNT
LKNKLRSDLPDLLILIDYPDFNLRLAKVAKKAGVKVLYFISPQVWAWRSGRVKGIGRVVDMMAVLFPFEVPFYQNAGVPV
TFVGHPLLDLVRPTMKRDEALSSLGLDPQRRCVGLFPGSRKSEIGKLLGIILESAEILKKRMPELQFVLPLASSLRREDL
DPYLSGSKVEVRVVSGRNHDVMTACDAAVCASGTVVMEMALVGTPHLIIYKMSTFTYEVGKRVINVPHIGISNIVAEKRM
VRELVQHEAEPVAIADEVDALLNDAAYATEMREGFAAMRVKLGSGGALGRVARLAMEMMR

Sequences:

>Translated_380_residues
MQEKPKSVMIVAGEASGEMYGASIATEIRALAPETRFFGMGGGNMRKAGVETLVDADTMAVMGLVEVVAHLPVIVNGFNT
LKNKLRSDLPDLLILIDYPDFNLRLAKVAKKAGVKVLYFISPQVWAWRSGRVKGIGRVVDMMAVLFPFEVPFYQNAGVPV
TFVGHPLLDLVRPTMKRDEALSSLGLDPQRRCVGLFPGSRKSEIGKLLGIILESAEILKKRMPELQFVLPLASSLRREDL
DPYLSGSKVEVRVVSGRNHDVMTACDAAVCASGTVVMEMALVGTPHLIIYKMSTFTYEVGKRVINVPHIGISNIVAEKRM
VRELVQHEAEPVAIADEVDALLNDAAYATEMREGFAAMRVKLGSGGALGRVARLAMEMMR
>Mature_380_residues
MQEKPKSVMIVAGEASGEMYGASIATEIRALAPETRFFGMGGGNMRKAGVETLVDADTMAVMGLVEVVAHLPVIVNGFNT
LKNKLRSDLPDLLILIDYPDFNLRLAKVAKKAGVKVLYFISPQVWAWRSGRVKGIGRVVDMMAVLFPFEVPFYQNAGVPV
TFVGHPLLDLVRPTMKRDEALSSLGLDPQRRCVGLFPGSRKSEIGKLLGIILESAEILKKRMPELQFVLPLASSLRREDL
DPYLSGSKVEVRVVSGRNHDVMTACDAAVCASGTVVMEMALVGTPHLIIYKMSTFTYEVGKRVINVPHIGISNIVAEKRM
VRELVQHEAEPVAIADEVDALLNDAAYATEMREGFAAMRVKLGSGGALGRVARLAMEMMR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=332, Percent_Identity=34.3373493975904, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41498; Mature: 41498

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKPKSVMIVAGEASGEMYGASIATEIRALAPETRFFGMGGGNMRKAGVETLVDADTMA
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
VMGLVEVVAHLPVIVNGFNTLKNKLRSDLPDLLILIDYPDFNLRLAKVAKKAGVKVLYFI
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEE
SPQVWAWRSGRVKGIGRVVDMMAVLFPFEVPFYQNAGVPVTFVGHPLLDLVRPTMKRDEA
CCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
LSSLGLDPQRRCVGLFPGSRKSEIGKLLGIILESAEILKKRMPELQFVLPLASSLRREDL
HHHCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCC
DPYLSGSKVEVRVVSGRNHDVMTACDAAVCASGTVVMEMALVGTPHLIIYKMSTFTYEVG
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEHHHHHHHH
KRVINVPHIGISNIVAEKRMVRELVQHEAEPVAIADEVDALLNDAAYATEMREGFAAMRV
HHEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHEEEE
KLGSGGALGRVARLAMEMMR
EECCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MQEKPKSVMIVAGEASGEMYGASIATEIRALAPETRFFGMGGGNMRKAGVETLVDADTMA
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
VMGLVEVVAHLPVIVNGFNTLKNKLRSDLPDLLILIDYPDFNLRLAKVAKKAGVKVLYFI
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEE
SPQVWAWRSGRVKGIGRVVDMMAVLFPFEVPFYQNAGVPVTFVGHPLLDLVRPTMKRDEA
CCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
LSSLGLDPQRRCVGLFPGSRKSEIGKLLGIILESAEILKKRMPELQFVLPLASSLRREDL
HHHCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCC
DPYLSGSKVEVRVVSGRNHDVMTACDAAVCASGTVVMEMALVGTPHLIIYKMSTFTYEVG
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEHHHHHHHH
KRVINVPHIGISNIVAEKRMVRELVQHEAEPVAIADEVDALLNDAAYATEMREGFAAMRV
HHEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHEEEE
KLGSGGALGRVARLAMEMMR
EECCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA