Click here to switch to the map view.

The map label for this gene is lpxA-1 [H]

Identifier: 197117235

GI number: 197117235

Start: 996883

End: 997659

Strand: Direct

Name: lpxA-1 [H]

Synonym: Gbem_0843

Alternate gene names: 197117235

Gene position: 996883-997659 (Clockwise)

Preceding gene: 197117234

Following gene: 197117236

Centisome position: 21.6

GC content: 61.78

Gene sequence:

>777_bases
ATGATTCACAGCACCGCAATAATCCACCCCGGCGCCAAGATCGCCGACGGGGTCGAGATCGGCCCTTATGTAGTCATCGG
CGAAAACGTAAGCATCGGCAAGGGGACCAAGATCGGCCCGCACACCGTGATCGACGGCTGGACCGAGATCGGCGAGGACA
ACAACATCTTCCACATGGCCTCGGTGGGAGCAGTCCCCCAGGACTTGAAGTACAAAGGCGAGAAAACCTGGCTCAAGATC
GGCAACGGCAACACCATCAGGGAGTTCGCCAGCCTGCACCTGGGAACCGTGACCGGCGACGGCGAGACCACCGTCGGCGG
CGGGAACCTCTTCATGGCCTACTCGCACGTGGCCCACGACTGCCACATCGGCAACCATGTCATCATGGCCAACTCGGCCA
CCCTCGCCGGGCACGTCACCGTCGAGGACTACGCCATCATGGGCGGTCTCTCCGCCGTACTGCAGTTCACCAGGATCGGC
GCGCACGTGATGGTCGGCGGCATGACCTCGATCACCCTGGACGTCCCCCCCTACACCATCGTCACCGGCGACCGCAGCGA
GTCGAGGCTAAGGGGATTGAACCTGGTCGGGCTGAAAAGGCGCGGTTTCTCCGAGCAGACCGTCTCCAGCCTGAAGAAGG
CGTACAAGATCCTGTCGCTTTCCGGCATGAAGCTGACCGAGGCGGTGGAGAAGATGAAGAGCGACATCCCCACCTGCCCC
GAGCTAGAGCACTTCATCTCCTTCATAGAATCCGCCAAGCGCGGGGTCACACGATAA

Upstream 100 bases:

>100_bases
CCAAGGCCTACGTCGGCGAGACCCTGATGACCGAAGCCGAGCTTAAGGCGACCCTCGGGAGCAAGTAAGCCCTCTTCAGC
GGGGGATTCAGGAGAAAGAG

Downstream 100 bases:

>100_bases
GGCAGATTAAGAGATAAAGCAGATTAAGATTAAGAGTAAGGCAGATTAAGAGAGTACAGATCAAGATTAAGATGAAGAGA
TCAAGATTAAGATGAAGAGA

Product: acyl-(acyl carrier protein)--UDP-N-acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIHSTAIIHPGAKIADGVEIGPYVVIGENVSIGKGTKIGPHTVIDGWTEIGEDNNIFHMASVGAVPQDLKYKGEKTWLKI
GNGNTIREFASLHLGTVTGDGETTVGGGNLFMAYSHVAHDCHIGNHVIMANSATLAGHVTVEDYAIMGGLSAVLQFTRIG
AHVMVGGMTSITLDVPPYTIVTGDRSESRLRGLNLVGLKRRGFSEQTVSSLKKAYKILSLSGMKLTEAVEKMKSDIPTCP
ELEHFISFIESAKRGVTR

Sequences:

>Translated_258_residues
MIHSTAIIHPGAKIADGVEIGPYVVIGENVSIGKGTKIGPHTVIDGWTEIGEDNNIFHMASVGAVPQDLKYKGEKTWLKI
GNGNTIREFASLHLGTVTGDGETTVGGGNLFMAYSHVAHDCHIGNHVIMANSATLAGHVTVEDYAIMGGLSAVLQFTRIG
AHVMVGGMTSITLDVPPYTIVTGDRSESRLRGLNLVGLKRRGFSEQTVSSLKKAYKILSLSGMKLTEAVEKMKSDIPTCP
ELEHFISFIESAKRGVTR
>Mature_258_residues
MIHSTAIIHPGAKIADGVEIGPYVVIGENVSIGKGTKIGPHTVIDGWTEIGEDNNIFHMASVGAVPQDLKYKGEKTWLKI
GNGNTIREFASLHLGTVTGDGETTVGGGNLFMAYSHVAHDCHIGNHVIMANSATLAGHVTVEDYAIMGGLSAVLQFTRIG
AHVMVGGMTSITLDVPPYTIVTGDRSESRLRGLNLVGLKRRGFSEQTVSSLKKAYKILSLSGMKLTEAVEKMKSDIPTCP
ELEHFISFIESAKRGVTR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=47.6744186046512, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27582; Mature: 27582

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHSTAIIHPGAKIADGVEIGPYVVIGENVSIGKGTKIGPHTVIDGWTEIGEDNNIFHMA
CCCCEEEECCCCCCCCCCEECCEEEECCCEECCCCCCCCCCCEECCHHHCCCCCCEEEEE
SVGAVPQDLKYKGEKTWLKIGNGNTIREFASLHLGTVTGDGETTVGGGNLFMAYSHVAHD
ECCCCCHHHCCCCCEEEEEECCCCHHHHHHHHEEEEEECCCCEEECCCCEEEEEHHHHHE
CHIGNHVIMANSATLAGHVTVEDYAIMGGLSAVLQFTRIGAHVMVGGMTSITLDVPPYTI
EECCCEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEE
VTGDRSESRLRGLNLVGLKRRGFSEQTVSSLKKAYKILSLSGMKLTEAVEKMKSDIPTCP
EECCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
ELEHFISFIESAKRGVTR
CHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIHSTAIIHPGAKIADGVEIGPYVVIGENVSIGKGTKIGPHTVIDGWTEIGEDNNIFHMA
CCCCEEEECCCCCCCCCCEECCEEEECCCEECCCCCCCCCCCEECCHHHCCCCCCEEEEE
SVGAVPQDLKYKGEKTWLKIGNGNTIREFASLHLGTVTGDGETTVGGGNLFMAYSHVAHD
ECCCCCHHHCCCCCEEEEEECCCCHHHHHHHHEEEEEECCCCEEECCCCEEEEEHHHHHE
CHIGNHVIMANSATLAGHVTVEDYAIMGGLSAVLQFTRIGAHVMVGGMTSITLDVPPYTI
EECCCEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEE
VTGDRSESRLRGLNLVGLKRRGFSEQTVSSLKKAYKILSLSGMKLTEAVEKMKSDIPTCP
EECCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
ELEHFISFIESAKRGVTR
CHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA