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The map label for this gene is lolE-1 [H]

Identifier: 197117229

GI number: 197117229

Start: 990156

End: 991406

Strand: Direct

Name: lolE-1 [H]

Synonym: Gbem_0837

Alternate gene names: 197117229

Gene position: 990156-991406 (Clockwise)

Preceding gene: 197117228

Following gene: 197117230

Centisome position: 21.45

GC content: 60.51

Gene sequence:

>1251_bases
ATGCCCTTCGAGCTCTTCATAGGGCTGCGCTACCTTAAGGCCAAGCGCAAATCGACCTTCATCTCCCTGATCACCCTGAT
CTCCGTGGCAGGGGTCGCCTTGGGCGTCATGGCGCTCATCATCGTCCTCGCCGTGATGACCGGGTTCGAGGAGCAGCTCA
AGGAGAAGATCCTGGGGACCAACGCGCACATCGTGGTCCTTAGCAGCCTCGGGGCGGTACATGATTACCCCCAGGTCATC
AAGAAGCTGGAAGGGATGGACGGCGTGGTAGCCGCCACCCCGTTCATCTACAACCAGGTCATGCTCTCCACCGGCAAGAA
CGTCTCCGGCGTGGTGCTGCGCGGCATCGACGTGAAAAGCGACGCCAAGGTCACCAACCTCCAGAAGTCCATGGTCGAGG
GGAAGCTCGACACCCTGGAGAGCGAGGTCGGGAAGACGCCGGGACTGGTGGTCGGCAAGGAGCTGGCAAAGAACCTGGGG
CTCTTCCTGGGCGACACGGTGGACGTGATCTCCCCCATGGGGAACATCACGCCGCTTGGCATGATGCCCAAGCTGAACCG
CTTCCGCATCACCGGCATCTTCAATACCGGCATGTTCGAGTACGACTCGACGCTCGCCTACGTTTCGCTCAAGGAGGCCC
AGCAGTTCCTCGATCTGGGCGACGTGGTGACCGGTGTGCAGCTCAAGGTGCGGGACGTCTACAAGTCGGACCAACTGGCG
CAAAAGATCAACCAGGAGCTAGGCCCTCCGTACCACGCCCGCGACTGGATGCAGATGAACAAGAACATCCTCTTCGCGCT
TAAGACCGAAAAAAGCGTGATGTTCATCATCCTGACCCTGATCGTGCTGGTGGCCGCCTTCGGCATCGCCTCGACGCTCT
TCATGGTGGTCATGGAGAAGACCCGCGACATCGCCATCCTGAAGTCGATGGGGGCGACCAGCCGCAGCATCATGCGCATC
TTCGTCTTCGAGGGGGTAATCATCGGCGTCTTAGGCACCGCAATCGGCGTGCTGGGCGGATTGCTGGTTGCGCTCAACAT
GGAATCGATCGTGACCGTGGTGCAGAAGGTGACCGGCTTCGAGCTTTTCAGCAAGGACATCTACTACCTGGACCACTTCC
CCTCCCAGGTGATACCGTCCGACGTGGTGCTGATCAGCATCACGGCGGTACTGATCTCCTTTGCCGCGACGCTCTATCCT
TCCTGGGCCGCCTCGCGCATGGCCCCCGCGGAGGCGCTCCGTTATGAGTAG

Upstream 100 bases:

>100_bases
CGAGGGGATCGGCATCGACCGCCTGGTCATGCTCTTGACCGACTCCCCGTCCATCCGCGACGTCATCCTGTTCCCGCAGT
TAAGGAAAGAGGCGAAATAG

Downstream 100 bases:

>100_bases
CCTTCTCGAGGTGAAGAACCTCTACAAGTCCTACGGCGAGGCCGCGGCCAAGGTCGAGGTGCTGAAGGGAATCGATCTCT
GCGTGGAATCGGGCGACACC

Product: lipoprotein release ABC transporter membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MPFELFIGLRYLKAKRKSTFISLITLISVAGVALGVMALIIVLAVMTGFEEQLKEKILGTNAHIVVLSSLGAVHDYPQVI
KKLEGMDGVVAATPFIYNQVMLSTGKNVSGVVLRGIDVKSDAKVTNLQKSMVEGKLDTLESEVGKTPGLVVGKELAKNLG
LFLGDTVDVISPMGNITPLGMMPKLNRFRITGIFNTGMFEYDSTLAYVSLKEAQQFLDLGDVVTGVQLKVRDVYKSDQLA
QKINQELGPPYHARDWMQMNKNILFALKTEKSVMFIILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATSRSIMRI
FVFEGVIIGVLGTAIGVLGGLLVALNMESIVTVVQKVTGFELFSKDIYYLDHFPSQVIPSDVVLISITAVLISFAATLYP
SWAASRMAPAEALRYE

Sequences:

>Translated_416_residues
MPFELFIGLRYLKAKRKSTFISLITLISVAGVALGVMALIIVLAVMTGFEEQLKEKILGTNAHIVVLSSLGAVHDYPQVI
KKLEGMDGVVAATPFIYNQVMLSTGKNVSGVVLRGIDVKSDAKVTNLQKSMVEGKLDTLESEVGKTPGLVVGKELAKNLG
LFLGDTVDVISPMGNITPLGMMPKLNRFRITGIFNTGMFEYDSTLAYVSLKEAQQFLDLGDVVTGVQLKVRDVYKSDQLA
QKINQELGPPYHARDWMQMNKNILFALKTEKSVMFIILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATSRSIMRI
FVFEGVIIGVLGTAIGVLGGLLVALNMESIVTVVQKVTGFELFSKDIYYLDHFPSQVIPSDVVLISITAVLISFAATLYP
SWAASRMAPAEALRYE
>Mature_415_residues
PFELFIGLRYLKAKRKSTFISLITLISVAGVALGVMALIIVLAVMTGFEEQLKEKILGTNAHIVVLSSLGAVHDYPQVIK
KLEGMDGVVAATPFIYNQVMLSTGKNVSGVVLRGIDVKSDAKVTNLQKSMVEGKLDTLESEVGKTPGLVVGKELAKNLGL
FLGDTVDVISPMGNITPLGMMPKLNRFRITGIFNTGMFEYDSTLAYVSLKEAQQFLDLGDVVTGVQLKVRDVYKSDQLAQ
KINQELGPPYHARDWMQMNKNILFALKTEKSVMFIILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATSRSIMRIF
VFEGVIIGVLGTAIGVLGGLLVALNMESIVTVVQKVTGFELFSKDIYYLDHFPSQVIPSDVVLISITAVLISFAATLYPS
WAASRMAPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=30.9927360774818, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1787360, Length=421, Percent_Identity=33.2541567695962, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45343; Mature: 45211

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFELFIGLRYLKAKRKSTFISLITLISVAGVALGVMALIIVLAVMTGFEEQLKEKILGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
NAHIVVLSSLGAVHDYPQVIKKLEGMDGVVAATPFIYNQVMLSTGKNVSGVVLRGIDVKS
CCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHHHCCCCCCCEEEECCCCCC
DAKVTNLQKSMVEGKLDTLESEVGKTPGLVVGKELAKNLGLFLGDTVDVISPMGNITPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCHHHHHCCCCCCCCCC
MMPKLNRFRITGIFNTGMFEYDSTLAYVSLKEAQQFLDLGDVVTGVQLKVRDVYKSDQLA
CCCCCCCEEEEEEEECCCEEECCHHHEEEHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHH
QKINQELGPPYHARDWMQMNKNILFALKTEKSVMFIILTLIVLVAAFGIASTLFMVVMEK
HHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRDIAILKSMGATSRSIMRIFVFEGVIIGVLGTAIGVLGGLLVALNMESIVTVVQKVTGF
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELFSKDIYYLDHFPSQVIPSDVVLISITAVLISFAATLYPSWAASRMAPAEALRYE
HHHHCCHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCC
>Mature Secondary Structure 
PFELFIGLRYLKAKRKSTFISLITLISVAGVALGVMALIIVLAVMTGFEEQLKEKILGT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
NAHIVVLSSLGAVHDYPQVIKKLEGMDGVVAATPFIYNQVMLSTGKNVSGVVLRGIDVKS
CCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHHHCCCCCCCEEEECCCCCC
DAKVTNLQKSMVEGKLDTLESEVGKTPGLVVGKELAKNLGLFLGDTVDVISPMGNITPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCHHHHHCCCCCCCCCC
MMPKLNRFRITGIFNTGMFEYDSTLAYVSLKEAQQFLDLGDVVTGVQLKVRDVYKSDQLA
CCCCCCCEEEEEEEECCCEEECCHHHEEEHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHH
QKINQELGPPYHARDWMQMNKNILFALKTEKSVMFIILTLIVLVAAFGIASTLFMVVMEK
HHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRDIAILKSMGATSRSIMRIFVFEGVIIGVLGTAIGVLGGLLVALNMESIVTVVQKVTGF
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELFSKDIYYLDHFPSQVIPSDVVLISITAVLISFAATLYPSWAASRMAPAEALRYE
HHHHCCHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]