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The map label for this gene is bkdB [H]

Identifier: 197116858

GI number: 197116858

Start: 553413

End: 554375

Strand: Direct

Name: bkdB [H]

Synonym: Gbem_0460

Alternate gene names: 197116858

Gene position: 553413-554375 (Clockwise)

Preceding gene: 197116857

Following gene: 197116859

Centisome position: 11.99

GC content: 66.67

Gene sequence:

>963_bases
ATGGCGCAACTGAACATGGTACAGGCGATAAACCAGGCCCTCGCCGACGAGATGGCGCGCGACGACCGGGTGGTGCTCCT
CGGGGAGGACGTGGGGCGGGACGGCGGGGTGTTCCGGGTCACGGATGGGCTCCAGGACCGGTTCGGAGCGGAACGGGTGC
TGGATACCCCACTGTGCGAATCGGCCATCATGGGGGCCGCCATCGGGATGGCCGCTTATGGGCTCCGCCCGGTGCCGGAG
ATCCAGTTCATGGGTTTCACCTACTCCGCCTTCGAGCAGCTCTTCGCCCATGCGGCAAGGCTTCGCTCCCGGTCCCGCGG
GCGTTACAGCTGTCCGCTGGTGGTCCGCACACCCTACGGCGGCGGAATCAAGGCGCCGGAGCTGCACGAGGAAAGTACGG
AGGCGATCTTCTGCCATATCCCCGGCCTCAAGGTGGTGGTGCCGTCCGGTCCCTACAACGCCAAGGGGCTGCTTCTGGCG
GCCCTGCGCGACCCGGACCCTGTTTTGTTCCTGGAGCCGACCCGGCTTTACCGCATGGTGAAGGAGGAGGTGCCGGAGGG
GGATTATCAGCTGGAGTTGGGGAAGGCGCGGGTAGCGCGCAAAGGCTCCGCCGTTACCGTCGTCGCCTGGGGGAGCATGC
TGGAGCGGGTGCTGAGGGCCATCGACGGCTACGACGCCGAGGTGATAGACCTCCTCACCCTGAACCCGCTGGACCTGGAG
GCGCTGCTTTCTTCGGTGCAGAAAACCGGCAGGGCGGTCATCGTTCACGAGGCGATCAAGACCTGCGGGCTCGGCGCCGA
GATTGCGGCGACCCTGGCGGAAGAGGCGATGCTGCACCTGCGCGCGCCGATTCTGAGGGTGACTGCCCCCGATGTGCCGG
TACCGTTGGCGAAGTTGATCGATCAGTACCTGCCGGGCCCCGACCGGATACGGGCCGCGCTGGACGAGGTGCTGAAGTAC
TGA

Upstream 100 bases:

>100_bases
GAGATGGAGGCTGTACCGCCCCCCGACCCGGCAGAACTCTTCGACGCGACCCTGGCGGCACTCACACCGCGGCAGGCCGG
GCAAAGAAAGGGACGCTGAC

Downstream 100 bases:

>100_bases
CAAAAGCCGGAGCAAACGGCGAAATGCGGAACACAGAGGGCACGGGGGTTCACGAAGGCCACAGAGGTTTTCTCGGGAAA
AGCAAAGGCTCTCACCACAG

Product: branched-chain 2-oxoacid dehydrogenase complex, E1 protein subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MAQLNMVQAINQALADEMARDDRVVLLGEDVGRDGGVFRVTDGLQDRFGAERVLDTPLCESAIMGAAIGMAAYGLRPVPE
IQFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYGGGIKAPELHEESTEAIFCHIPGLKVVVPSGPYNAKGLLLA
ALRDPDPVLFLEPTRLYRMVKEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLRAIDGYDAEVIDLLTLNPLDLE
ALLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLIDQYLPGPDRIRAALDEVLKY

Sequences:

>Translated_320_residues
MAQLNMVQAINQALADEMARDDRVVLLGEDVGRDGGVFRVTDGLQDRFGAERVLDTPLCESAIMGAAIGMAAYGLRPVPE
IQFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYGGGIKAPELHEESTEAIFCHIPGLKVVVPSGPYNAKGLLLA
ALRDPDPVLFLEPTRLYRMVKEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLRAIDGYDAEVIDLLTLNPLDLE
ALLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLIDQYLPGPDRIRAALDEVLKY
>Mature_319_residues
AQLNMVQAINQALADEMARDDRVVLLGEDVGRDGGVFRVTDGLQDRFGAERVLDTPLCESAIMGAAIGMAAYGLRPVPEI
QFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYGGGIKAPELHEESTEAIFCHIPGLKVVVPSGPYNAKGLLLAA
LRDPDPVLFLEPTRLYRMVKEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLRAIDGYDAEVIDLLTLNPLDLEA
LLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLIDQYLPGPDRIRAALDEVLKY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=42.0245398773006, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=42.0245398773006, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=36.697247706422, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=35.7798165137615, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=44.1717791411043, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=38.109756097561, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=38.0368098159509, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=41.2307692307692, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=41.2307692307692, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI21358145, Length=327, Percent_Identity=38.2262996941896, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24650940, Length=327, Percent_Identity=38.2262996941896, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=43.956043956044, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=43.956043956044, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34826; Mature: 34695

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLNMVQAINQALADEMARDDRVVLLGEDVGRDGGVFRVTDGLQDRFGAERVLDTPLCE
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHCHHHHHCCHHHH
SAIMGAAIGMAAYGLRPVPEIQFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYG
HHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCC
GGIKAPELHEESTEAIFCHIPGLKVVVPSGPYNAKGLLLAALRDPDPVLFLEPTRLYRMV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLRAIDGYDAEVIDLLTLNPLDLE
HHHCCCCCEEEEECHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
ALLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLI
HHHHHHHHCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHH
DQYLPGPDRIRAALDEVLKY
HHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQLNMVQAINQALADEMARDDRVVLLGEDVGRDGGVFRVTDGLQDRFGAERVLDTPLCE
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHCHHHHHCCHHHH
SAIMGAAIGMAAYGLRPVPEIQFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYG
HHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCC
GGIKAPELHEESTEAIFCHIPGLKVVVPSGPYNAKGLLLAALRDPDPVLFLEPTRLYRMV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLRAIDGYDAEVIDLLTLNPLDLE
HHHCCCCCEEEEECHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
ALLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLI
HHHHHHHHCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHH
DQYLPGPDRIRAALDEVLKY
HHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]