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The map label for this gene is hemB [H]

Identifier: 197116808

GI number: 197116808

Start: 486824

End: 487843

Strand: Direct

Name: hemB [H]

Synonym: Gbem_0410

Alternate gene names: 197116808

Gene position: 486824-487843 (Clockwise)

Preceding gene: 308535161

Following gene: 197116810

Centisome position: 10.55

GC content: 58.73

Gene sequence:

>1020_bases
ATGTTCTACCCACTGTACAGAGCGAGAAGGATCCGGGGCAAAGAAGTCTTCAGAAACATGGTCAGGGAGACCTCGCTTTC
CGCCAATGACCTCATATACCCGATGTTTTCCGCCTTCGGCAAAGGGATCAAGAAAGAGATCTCCTCCATGCCCGGCATCT
ATCAGCAGTCCATCGAGAACATCGTCGAGGAGGCGCAGGAAGTTTACGAGCTGGGTGTTCCCGCCGTCATCCTCTTCGGC
ATTCCCGAGCAGAAGGACGCCATGGGGACCGACGCCTACTCCGACACCGGGATCATCCAGGAGACCATTCGCGCCATCAA
GAAATCCGTTCCCAAGCTCGCCGTCATCACCGACGTCTGCATGTGCGAGTACACCGATCACGGCCATTGCGGCGTGATCA
AAAACGGCGACGTCGACAACGACGAGACCCTGGAGCTGCTCGCCAAAGAAGCCCTTTCCCATGCCAAGGCCGGTGCCGAC
ATGGTCGCACCCTCCGACATGATGGACGGGCGCGTCGCAGCCATCCGCGAGTCTTTGGACAACAACGGCTTCAACCAGAT
CCCGCTGATGAGCTACGCCGTCAAGTACGCTTCCGGGTACTATGGTCCGTTCAGGGAAGCCGCCGAGTCCACGCCGCAGT
TCGGCGACCGTCGTTCCTACCAGATGGATCCGGCTAACCGGCTCGAAGCCATCCGCGAAGCACGCATGGACGTCGAAGAA
GGCGCCGACATCCTCATGGTGAAACCCGGCCTTCCCTACCTCGACATCGTGCGCGAGGTGAGGAACGAGTTCAACCTCCC
GACCGCCGTGTACAACGTCTCCGGCGAGTACAGCATGATCAAGTCCGCCGCCAAGATGGGTTGGATCGACGAAGACCGCG
TCATTATGGAGACCATGATGTCCTTCAAGCGTGCCGGTGCCGACCTGATCCTGACCTATCACTCCAAAGAAGTAGCCAAG
CTTTTGAGGAAAGGGTACGAAGCCGACATCAGCGATCGCTGCGGCTGCGGCTGCAGGTAA

Upstream 100 bases:

>100_bases
CTTTAGCTGTATCAGGTGGCCGCAGGTCCCCTCGCCCAGCGGGAGAGGGACAGGGTGAGGGAAGGTTTTAAAGGCAACAA
CAGACAAAAAGGAGAGATCA

Downstream 100 bases:

>100_bases
GCCAGGCAAGGCTAAAAGCTCACCACAGAGGTTCACAGAGGTACACAGAGGAAAAGGCAGAAACAACAAGGGGCGCAGAT
ATACTCGTTTCGAGCATCTG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYPLYRARRIRGKEVFRNMVRETSLSANDLIYPMFSAFGKGIKKEISSMPGIYQQSIENIVEEAQEVYELGVPAVILFG
IPEQKDAMGTDAYSDTGIIQETIRAIKKSVPKLAVITDVCMCEYTDHGHCGVIKNGDVDNDETLELLAKEALSHAKAGAD
MVAPSDMMDGRVAAIRESLDNNGFNQIPLMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRLEAIREARMDVEE
GADILMVKPGLPYLDIVREVRNEFNLPTAVYNVSGEYSMIKSAAKMGWIDEDRVIMETMMSFKRAGADLILTYHSKEVAK
LLRKGYEADISDRCGCGCR

Sequences:

>Translated_339_residues
MFYPLYRARRIRGKEVFRNMVRETSLSANDLIYPMFSAFGKGIKKEISSMPGIYQQSIENIVEEAQEVYELGVPAVILFG
IPEQKDAMGTDAYSDTGIIQETIRAIKKSVPKLAVITDVCMCEYTDHGHCGVIKNGDVDNDETLELLAKEALSHAKAGAD
MVAPSDMMDGRVAAIRESLDNNGFNQIPLMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRLEAIREARMDVEE
GADILMVKPGLPYLDIVREVRNEFNLPTAVYNVSGEYSMIKSAAKMGWIDEDRVIMETMMSFKRAGADLILTYHSKEVAK
LLRKGYEADISDRCGCGCR
>Mature_339_residues
MFYPLYRARRIRGKEVFRNMVRETSLSANDLIYPMFSAFGKGIKKEISSMPGIYQQSIENIVEEAQEVYELGVPAVILFG
IPEQKDAMGTDAYSDTGIIQETIRAIKKSVPKLAVITDVCMCEYTDHGHCGVIKNGDVDNDETLELLAKEALSHAKAGAD
MVAPSDMMDGRVAAIRESLDNNGFNQIPLMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRLEAIREARMDVEE
GADILMVKPGLPYLDIVREVRNEFNLPTAVYNVSGEYSMIKSAAKMGWIDEDRVIMETMMSFKRAGADLILTYHSKEVAK
LLRKGYEADISDRCGCGCR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=328, Percent_Identity=44.5121951219512, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=48.5981308411215, Blast_Score=302, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=40.8945686900958, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=40.3973509933775, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37895; Mature: 37895

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYPLYRARRIRGKEVFRNMVRETSLSANDLIYPMFSAFGKGIKKEISSMPGIYQQSIEN
CCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IVEEAQEVYELGVPAVILFGIPEQKDAMGTDAYSDTGIIQETIRAIKKSVPKLAVITDVC
HHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
MCEYTDHGHCGVIKNGDVDNDETLELLAKEALSHAKAGADMVAPSDMMDGRVAAIRESLD
HHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHC
NNGFNQIPLMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRLEAIREARMDVEE
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GADILMVKPGLPYLDIVREVRNEFNLPTAVYNVSGEYSMIKSAAKMGWIDEDRVIMETMM
CCCEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHH
SFKRAGADLILTYHSKEVAKLLRKGYEADISDRCGCGCR
HHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFYPLYRARRIRGKEVFRNMVRETSLSANDLIYPMFSAFGKGIKKEISSMPGIYQQSIEN
CCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IVEEAQEVYELGVPAVILFGIPEQKDAMGTDAYSDTGIIQETIRAIKKSVPKLAVITDVC
HHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
MCEYTDHGHCGVIKNGDVDNDETLELLAKEALSHAKAGADMVAPSDMMDGRVAAIRESLD
HHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHC
NNGFNQIPLMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRLEAIREARMDVEE
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GADILMVKPGLPYLDIVREVRNEFNLPTAVYNVSGEYSMIKSAAKMGWIDEDRVIMETMM
CCCEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHH
SFKRAGADLILTYHSKEVAKLLRKGYEADISDRCGCGCR
HHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]