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The map label for this gene is gcvP-1

Identifier: 197116795

GI number: 197116795

Start: 472129

End: 473466

Strand: Direct

Name: gcvP-1

Synonym: Gbem_0397

Alternate gene names: 197116795

Gene position: 472129-473466 (Clockwise)

Preceding gene: 197116794

Following gene: 197116796

Centisome position: 10.23

GC content: 64.05

Gene sequence:

>1338_bases
ATGGGATACTGTCCCAACACACCGGACGAGATCCGGGAGATGCTCGCCGTGATCGGCGCGGGTAGCATCGAGGAGCTCTT
CGCTCCCATCCCGGCGGAACTGCGCGCCAAGTCTTTCGACCTCCCCCCCGGCATGTCCGAGTTCGAGCTGATGCGGATCA
TGAGGGAGAAGGCCGCGGCCGGGGGGGCGGAGATCGTCCCCTTCATCGGCGGCGGCATCTACGACCACATCATACCGGCG
GCGGTGGACCACCTCTCCTCGCGCGCCGAATTCTACACCGCCTACACCCCTTACCAGCCGGAGTGCTCGCAAGGGACGCT
GCAGGCGCTCTTCGAATACCAGAGCGTGATCTGCCGGCTGACCGGGATGGAGGCATCCAACGCCTCGCTCTATGACGGCG
GAACCGCGGTGGCCGAGGCGGCCCTCATGTCGCTCCGCATCACCGAGCGCAACCGAGTGGTCCTGGACGCCTCGATCAAT
CCGCTGCACCGCGAGATCGTGACTGGATACCTGCACGGGCTTTCCGCGGAAGCGGTCGAGGTGGCTCCCGACGGCTGCGG
CTCGGACCTAAAAAGGCTCATCGATTCAATCGACGAGGAGACGGCCGCGGTGATCGTGCAGAACCCGAACTTCTTCGGGA
GCGTGCAGGACTTCTCCGAACTCGCCGTTAAGGCCCACGAGAAAGGGGCACTCCTAATCATCTCCGGCTACCCCATCGCC
CTGGGCCTCGTAGCGAGCCCGGGCGAGATGGGAGCCGACATCGCGGTCGGCGACGGCCAGAGCCTCGGCAACCCGCTCTC
CTTCGGCGGCCCCTATTTCGGGTTCATCGCCACGCGCAAGCGCTTCATCCGCAACCTCCCCGGCAGGATCGTGGGCGAGA
CCATCGACAACCAGGGGCGCCGCGGCTACGTGCTGACCCTCCAGGCGCGCGAGCAGCACATAAAAAGGCACAAGGCGACC
TCCAACATCTGCAGCAACCAGAGCCTGTGCGCCCTGCGCGGATTAATCTTCTGCGCCTCGCTCGGTCGAAAGGGTTTCGA
AGAGCTGGCAGTTTTGAACTACGACAAGGCGCAGTACGCGAAGTCCCGCCTTACCGGCGTCAAGGGAGTGAGCGTGATGA
ACGCCGGGACCACCTTCAACGAGTTCACCCTATCGCTTCCCAAAGACGCGGCGCCAGTGGTGGAGAAACTCCTAGCCTGC
GGAGTAGCCGCTGGCGTGCCGCTGGTACAGTACTATCCGGGCATGGATAACGCGCTGACGGTAACGGTAACGGAGAAACG
GAGCAAGGCGGAGATCGACCGACTGGCAGCTCTCTTGGAGGAGGCGCTATGCAGCTGA

Upstream 100 bases:

>100_bases
GCGAAGGGTGGATCTGCAGGCTGGAAGGTGTTGACGCCTCCGAGCTTGGTGCGCTCCTGGATGCAGCGGCGTACGCCAAG
TACCTGGAAGGACTGTAGGG

Downstream 100 bases:

>100_bases
TATTCGAAAAATCGGTGCCGGGACGCAACGGGGTGCGGGTTCCCCTCTCCGACGTCCCGAAGGCGTCCCCCTTCCCCGAT
GCGCTTCGGCGCAAGGAGCC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MGYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAAGGAEIVPFIGGGIYDHIIPA
AVDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQSVICRLTGMEASNASLYDGGTAVAEAALMSLRITERNRVVLDASIN
PLHREIVTGYLHGLSAEAVEVAPDGCGSDLKRLIDSIDEETAAVIVQNPNFFGSVQDFSELAVKAHEKGALLIISGYPIA
LGLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIATRKRFIRNLPGRIVGETIDNQGRRGYVLTLQAREQHIKRHKAT
SNICSNQSLCALRGLIFCASLGRKGFEELAVLNYDKAQYAKSRLTGVKGVSVMNAGTTFNEFTLSLPKDAAPVVEKLLAC
GVAAGVPLVQYYPGMDNALTVTVTEKRSKAEIDRLAALLEEALCS

Sequences:

>Translated_445_residues
MGYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAAGGAEIVPFIGGGIYDHIIPA
AVDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQSVICRLTGMEASNASLYDGGTAVAEAALMSLRITERNRVVLDASIN
PLHREIVTGYLHGLSAEAVEVAPDGCGSDLKRLIDSIDEETAAVIVQNPNFFGSVQDFSELAVKAHEKGALLIISGYPIA
LGLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIATRKRFIRNLPGRIVGETIDNQGRRGYVLTLQAREQHIKRHKAT
SNICSNQSLCALRGLIFCASLGRKGFEELAVLNYDKAQYAKSRLTGVKGVSVMNAGTTFNEFTLSLPKDAAPVVEKLLAC
GVAAGVPLVQYYPGMDNALTVTVTEKRSKAEIDRLAALLEEALCS
>Mature_444_residues
GYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAAGGAEIVPFIGGGIYDHIIPAA
VDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQSVICRLTGMEASNASLYDGGTAVAEAALMSLRITERNRVVLDASINP
LHREIVTGYLHGLSAEAVEVAPDGCGSDLKRLIDSIDEETAAVIVQNPNFFGSVQDFSELAVKAHEKGALLIISGYPIAL
GLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIATRKRFIRNLPGRIVGETIDNQGRRGYVLTLQAREQHIKRHKATS
NICSNQSLCALRGLIFCASLGRKGFEELAVLNYDKAQYAKSRLTGVKGVSVMNAGTTFNEFTLSLPKDAAPVVEKLLACG
VAAGVPLVQYYPGMDNALTVTVTEKRSKAEIDRLAALLEEALCS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=353, Percent_Identity=37.1104815864023, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1789269, Length=353, Percent_Identity=31.4447592067989, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535605, Length=351, Percent_Identity=36.7521367521368, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6323843, Length=356, Percent_Identity=35.3932584269663, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24645648, Length=347, Percent_Identity=35.7348703170029, Blast_Score=212, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_GEOBB (B5EAW7)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137222.1
- GeneID:   6783223
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0397
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47702; Mature: 47571

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAA
CCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
GGAEIVPFIGGGIYDHIIPAAVDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQSVICRL
CCCEEEHHHCCCHHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
TGMEASNASLYDGGTAVAEAALMSLRITERNRVVLDASINPLHREIVTGYLHGLSAEAVE
CCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
VAPDGCGSDLKRLIDSIDEETAAVIVQNPNFFGSVQDFSELAVKAHEKGALLIISGYPIA
ECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCEE
LGLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIATRKRFIRNLPGRIVGETIDNQGR
EEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCHHCCCCC
RGYVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFCASLGRKGFEELAVLNYDKAQYA
CEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHH
KSRLTGVKGVSVMNAGTTFNEFTLSLPKDAAPVVEKLLACGVAAGVPLVQYYPGMDNALT
HHHHCCCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEE
VTVTEKRSKAEIDRLAALLEEALCS
EEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAA
CCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
GGAEIVPFIGGGIYDHIIPAAVDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQSVICRL
CCCEEEHHHCCCHHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
TGMEASNASLYDGGTAVAEAALMSLRITERNRVVLDASINPLHREIVTGYLHGLSAEAVE
CCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
VAPDGCGSDLKRLIDSIDEETAAVIVQNPNFFGSVQDFSELAVKAHEKGALLIISGYPIA
ECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCEE
LGLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIATRKRFIRNLPGRIVGETIDNQGR
EEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCHHCCCCC
RGYVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFCASLGRKGFEELAVLNYDKAQYA
CEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHH
KSRLTGVKGVSVMNAGTTFNEFTLSLPKDAAPVVEKLLACGVAAGVPLVQYYPGMDNALT
HHHHCCCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEE
VTVTEKRSKAEIDRLAALLEEALCS
EEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA