Click here to switch to the map view.

The map label for this gene is dtd

Identifier: 197116754

GI number: 197116754

Start: 435157

End: 435606

Strand: Reverse

Name: dtd

Synonym: Gbem_0354

Alternate gene names: 197116754

Gene position: 435606-435157 (Counterclockwise)

Preceding gene: 197116755

Following gene: 197116752

Centisome position: 9.44

GC content: 63.33

Gene sequence:

>450_bases
GTGAAGGCAGTAATCCAGCGGGTGAAAGAAGCGAAGGTCTCGGTTGAGGGGAGGGTGGTCGGCGAGATCGGGAAGGGCGT
CCTGGTGCTCTTGGGCGTCGAGATCGGCGACGGCTGCGCCCAGGCGGACTGGATGGCGGAAAAGATCGTCAACCTGAGGA
TTTTTGCTGACAACGAGGGGAAGATGAACCTGGCGCTGCCAGAGGTGAAGGGGGAGATGCTCGCCGTTTCCCAGTTCACC
CTGGCCGGCAACTGCTCCAAGGGGCGCCGCCCTTCCTTCGACACCGCCGCGGCCCCCGAGGAGGCGAACCGCCTTTACAG
CTACTTCATGGGACAGGTATGGGAGCGGGGGGTGCCGGTGCAAAGCGGGATCTTTCAGGCTGATATGGAGGTCTCCCTGG
TGAACGACGGTCCGGTGACCTTCATCCTGGAGACCCCGCCCAAGCGCTAG

Upstream 100 bases:

>100_bases
CCGCACTGGAGGGCTATCCGGACCTGAAAAAGGTGGTCTTCGTCCCCTTTTCGCCCGAGGCGGAACAGATTTATCAAGAG
CTTTTGCAGGAGGTTTTTTC

Downstream 100 bases:

>100_bases
TCACATCAGGGGGCGCACCTCTTCCACCTTGAAGTAGGCCACCCGGGTCACCGCAGCGCTCGCCTGAGGGCTCGCCACCT
GCGCCGTCCTTTCCCTGATG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MKAVIQRVKEAKVSVEGRVVGEIGKGVLVLLGVEIGDGCAQADWMAEKIVNLRIFADNEGKMNLALPEVKGEMLAVSQFT
LAGNCSKGRRPSFDTAAAPEEANRLYSYFMGQVWERGVPVQSGIFQADMEVSLVNDGPVTFILETPPKR

Sequences:

>Translated_149_residues
MKAVIQRVKEAKVSVEGRVVGEIGKGVLVLLGVEIGDGCAQADWMAEKIVNLRIFADNEGKMNLALPEVKGEMLAVSQFT
LAGNCSKGRRPSFDTAAAPEEANRLYSYFMGQVWERGVPVQSGIFQADMEVSLVNDGPVTFILETPPKR
>Mature_149_residues
MKAVIQRVKEAKVSVEGRVVGEIGKGVLVLLGVEIGDGCAQADWMAEKIVNLRIFADNEGKMNLALPEVKGEMLAVSQFT
LAGNCSKGRRPSFDTAAAPEEANRLYSYFMGQVWERGVPVQSGIFQADMEVSLVNDGPVTFILETPPKR

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=150, Percent_Identity=42, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=52.7777777777778, Blast_Score=151, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=41.0596026490066, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319982, Length=150, Percent_Identity=39.3333333333333, Blast_Score=101, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281361569, Length=152, Percent_Identity=39.4736842105263, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_GEOBB (B5EAS6)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137181.1
- GeneID:   6783180
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0354
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16185; Mature: 16185

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIQRVKEAKVSVEGRVVGEIGKGVLVLLGVEIGDGCAQADWMAEKIVNLRIFADNEG
CHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHEEEEEEECCCC
KMNLALPEVKGEMLAVSQFTLAGNCSKGRRPSFDTAAAPEEANRLYSYFMGQVWERGVPV
EEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
QSGIFQADMEVSLVNDGPVTFILETPPKR
CCCEEECCCEEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MKAVIQRVKEAKVSVEGRVVGEIGKGVLVLLGVEIGDGCAQADWMAEKIVNLRIFADNEG
CHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHEEEEEEECCCC
KMNLALPEVKGEMLAVSQFTLAGNCSKGRRPSFDTAAAPEEANRLYSYFMGQVWERGVPV
EEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
QSGIFQADMEVSLVNDGPVTFILETPPKR
CCCEEECCCEEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA