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The map label for this gene is accD [C]

Identifier: 197116735

GI number: 197116735

Start: 411469

End: 413013

Strand: Direct

Name: accD [C]

Synonym: Gbem_0335

Alternate gene names: 197116735

Gene position: 411469-413013 (Clockwise)

Preceding gene: 197116734

Following gene: 308535158

Centisome position: 8.92

GC content: 63.56

Gene sequence:

>1545_bases
ATGTCCATAGAAGAGAAGATAAAAGCGCTGAACGACAAGAAGAGCAAGCTGAAGCTGGGCGGCGGGCGCTCGAAGATCGA
CCAGCAGCACGCCCAGGGAAGCCTGACCGCCCGGGAGCGGATAGAGGCGCTGGTGGACAAGGACAGCTTCCAGGAAATCG
GCATCTTCGCCAGGCACCGCTGCACCAATTTCGGCATGGCCGGGAAGGAACTGCCGGCCGAAGGGGTGGTCACCGGCGCA
GGGAGCGTGGGCGGGAGGATGGTGCACCTGGCGAGCCAGGATTTCACCGTCGCCGGGGGATCGGCGGGCGAGGTGCACAG
CGACAAGATCGTGCAGGCGATGCTGGGGTCGCTGAAGACCGGAACCCCCTTCGTCTTCATGAACGATTCCGGCGGCGCCA
GGATCCAGGAAGGGATCGACTCGTTAGCCGGCTACGGCAAGGTCTTCTACCACAACGTGATGCTCAGCGGGGTGGTGCCG
CAGATCTCGCTCATCTGCGGCCCCTGTGCCGGGGGCGCGGCCTACAGCCCGGCGCTCACCGATTTCATCATCCAGACCGC
CAAGGCGCGCATGTTCATCACCGGCCCTTCCGTGATCAAGGAGGCGACCGGCGAAGAGATCAGCGCCGAGGAGCTGGGAG
GGCCACTGTCGCAGATGAACCATAGCGGCGTAGCCCATTTCGTGGCGGAGAACGACCTGGTGGCGCTTCGCATCTGCAAG
AAGCTCCTTTCCTACCTCCCCTCCAACAACATCGAGGACCCGCCGCAGTTGGAAAGCGACGACGTCATCGTCCCGGACAA
GACGTTGAACAGCATCGTGCCGTCGGAGCAGAAGAAGGCCTACGACGTGAGGAACGTGATCACGCGCCTGATCGACGGCG
GCGACTTCCTGGAGGTGCAGCCTCTGTTCGCTGCCAACATCGTGGTCGGGTTCGGCAGGATACTCGGGCGGAGCGTCGGC
ATCGTCGCCAATCAGCCGTCGGTCTTGGCGGGGGCGCTGGACATCAACGCTTCGGACAAGGGAGCCAGGTTCGTCCGGTT
CTGCAACGCCTTCAACATCCCGCTGGTGACCCTGGTGGACGTTCCGGGTTTTCTCCCCGGGGTACAGCAGGAGAAGGGGG
GGATCATCCGCCACGGCGCCAAGATGCTCTTCGCCTACGCCGCGGCCACCGTCCCGAAGATAACCGTCATCATGCGCAAG
GCGTACGGCGGCGCCTTCCTCGCCATGTGCGGCAAGGAGTTGGAGACCGATCGGGTTTTCGCCTGGCCCAGCGCCGAGAT
CGCGGTCATGGGACCGCAGGGAGCGGTCAACGTCATCTTCCGGAACGAGATCGCCCAGGCGGAAGATCCCAAGAAAAAGC
GCGACGAGCTGATCGCTTCTTACCAGGGAACCTTCGCCACTCCCTATGCGGCCGCGGCACGCCGCGATGTGGACGACATC
ATCGAGCCCGCCGATACGAGGCGCCACCTCGCCATGACGCTGGACATCCTGAGCACCAAGCGCGAATTCAGGCCCATGAA
GAAGCATGGCCTCATTCCGCTGTAA

Upstream 100 bases:

>100_bases
CCCCGTCACCTACACGGTCACCTTGAGCGGGCAGCCGCACAAGGTGACGGTTGCACCCTACGGCCAGGAATAGGCGCCGC
ACCGACCAAGGAGCGAGCTC

Downstream 100 bases:

>100_bases
GGGGGAAGCCGTGGACGAAGAGATGGAGCAGGAACACGATCCGGAAATCACGCCCGAACTGCTGATGGTGATGTCCGCCG
CGATAGCCGCGTATCTGGGC

Product: biotin-dependent acyl-CoA carboxyltransferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSIEEKIKALNDKKSKLKLGGGRSKIDQQHAQGSLTARERIEALVDKDSFQEIGIFARHRCTNFGMAGKELPAEGVVTGA
GSVGGRMVHLASQDFTVAGGSAGEVHSDKIVQAMLGSLKTGTPFVFMNDSGGARIQEGIDSLAGYGKVFYHNVMLSGVVP
QISLICGPCAGGAAYSPALTDFIIQTAKARMFITGPSVIKEATGEEISAEELGGPLSQMNHSGVAHFVAENDLVALRICK
KLLSYLPSNNIEDPPQLESDDVIVPDKTLNSIVPSEQKKAYDVRNVITRLIDGGDFLEVQPLFAANIVVGFGRILGRSVG
IVANQPSVLAGALDINASDKGARFVRFCNAFNIPLVTLVDVPGFLPGVQQEKGGIIRHGAKMLFAYAAATVPKITVIMRK
AYGGAFLAMCGKELETDRVFAWPSAEIAVMGPQGAVNVIFRNEIAQAEDPKKKRDELIASYQGTFATPYAAAARRDVDDI
IEPADTRRHLAMTLDILSTKREFRPMKKHGLIPL

Sequences:

>Translated_514_residues
MSIEEKIKALNDKKSKLKLGGGRSKIDQQHAQGSLTARERIEALVDKDSFQEIGIFARHRCTNFGMAGKELPAEGVVTGA
GSVGGRMVHLASQDFTVAGGSAGEVHSDKIVQAMLGSLKTGTPFVFMNDSGGARIQEGIDSLAGYGKVFYHNVMLSGVVP
QISLICGPCAGGAAYSPALTDFIIQTAKARMFITGPSVIKEATGEEISAEELGGPLSQMNHSGVAHFVAENDLVALRICK
KLLSYLPSNNIEDPPQLESDDVIVPDKTLNSIVPSEQKKAYDVRNVITRLIDGGDFLEVQPLFAANIVVGFGRILGRSVG
IVANQPSVLAGALDINASDKGARFVRFCNAFNIPLVTLVDVPGFLPGVQQEKGGIIRHGAKMLFAYAAATVPKITVIMRK
AYGGAFLAMCGKELETDRVFAWPSAEIAVMGPQGAVNVIFRNEIAQAEDPKKKRDELIASYQGTFATPYAAAARRDVDDI
IEPADTRRHLAMTLDILSTKREFRPMKKHGLIPL
>Mature_513_residues
SIEEKIKALNDKKSKLKLGGGRSKIDQQHAQGSLTARERIEALVDKDSFQEIGIFARHRCTNFGMAGKELPAEGVVTGAG
SVGGRMVHLASQDFTVAGGSAGEVHSDKIVQAMLGSLKTGTPFVFMNDSGGARIQEGIDSLAGYGKVFYHNVMLSGVVPQ
ISLICGPCAGGAAYSPALTDFIIQTAKARMFITGPSVIKEATGEEISAEELGGPLSQMNHSGVAHFVAENDLVALRICKK
LLSYLPSNNIEDPPQLESDDVIVPDKTLNSIVPSEQKKAYDVRNVITRLIDGGDFLEVQPLFAANIVVGFGRILGRSVGI
VANQPSVLAGALDINASDKGARFVRFCNAFNIPLVTLVDVPGFLPGVQQEKGGIIRHGAKMLFAYAAATVPKITVIMRKA
YGGAFLAMCGKELETDRVFAWPSAEIAVMGPQGAVNVIFRNEIAQAEDPKKKRDELIASYQGTFATPYAAAARRDVDDII
EPADTRRHLAMTLDILSTKREFRPMKKHGLIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=523, Percent_Identity=52.1988527724665, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI295821216, Length=543, Percent_Identity=50.2762430939227, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=34.5924453280318, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI134142062, Length=404, Percent_Identity=22.2772277227723, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679974, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679960, Length=414, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679977, Length=414, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679967, Length=414, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679971, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788655, Length=187, Percent_Identity=29.9465240641711, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=520, Percent_Identity=51.5384615384615, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25147359, Length=520, Percent_Identity=51.5384615384615, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17552936, Length=528, Percent_Identity=35.2272727272727, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71997163, Length=357, Percent_Identity=24.0896358543417, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI133931226, Length=289, Percent_Identity=23.1833910034602, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324343, Length=353, Percent_Identity=24.0793201133144, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323863, Length=315, Percent_Identity=24.4444444444444, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=34.0425531914894, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55090; Mature: 54959

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEEKIKALNDKKSKLKLGGGRSKIDQQHAQGSLTARERIEALVDKDSFQEIGIFARHR
CCHHHHHHHHCCCCHHEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMAGKELPAEGVVTGAGSVGGRMVHLASQDFTVAGGSAGEVHSDKIVQAMLGSLKT
HCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCC
GTPFVFMNDSGGARIQEGIDSLAGYGKVFYHNVMLSGVVPQISLICGPCAGGAAYSPALT
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCHHHH
DFIIQTAKARMFITGPSVIKEATGEEISAEELGGPLSQMNHSGVAHFVAENDLVALRICK
HHHHHHHCCEEEEECHHHHHHCCCCCCCHHHHCCCHHHHCCCCEEEEEECCCCHHHHHHH
KLLSYLPSNNIEDPPQLESDDVIVPDKTLNSIVPSEQKKAYDVRNVITRLIDGGDFLEVQ
HHHHHCCCCCCCCCCCCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
PLFAANIVVGFGRILGRSVGIVANQPSVLAGALDINASDKGARFVRFCNAFNIPLVTLVD
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEC
VPGFLPGVQQEKGGIIRHGAKMLFAYAAATVPKITVIMRKAYGGAFLAMCGKELETDRVF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCEEE
AWPSAEIAVMGPQGAVNVIFRNEIAQAEDPKKKRDELIASYQGTFATPYAAAARRDVDDI
ECCCCCEEEECCCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCHHHH
IEPADTRRHLAMTLDILSTKREFRPMKKHGLIPL
HCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure 
SIEEKIKALNDKKSKLKLGGGRSKIDQQHAQGSLTARERIEALVDKDSFQEIGIFARHR
CHHHHHHHHCCCCHHEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMAGKELPAEGVVTGAGSVGGRMVHLASQDFTVAGGSAGEVHSDKIVQAMLGSLKT
HCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCC
GTPFVFMNDSGGARIQEGIDSLAGYGKVFYHNVMLSGVVPQISLICGPCAGGAAYSPALT
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCHHHH
DFIIQTAKARMFITGPSVIKEATGEEISAEELGGPLSQMNHSGVAHFVAENDLVALRICK
HHHHHHHCCEEEEECHHHHHHCCCCCCCHHHHCCCHHHHCCCCEEEEEECCCCHHHHHHH
KLLSYLPSNNIEDPPQLESDDVIVPDKTLNSIVPSEQKKAYDVRNVITRLIDGGDFLEVQ
HHHHHCCCCCCCCCCCCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
PLFAANIVVGFGRILGRSVGIVANQPSVLAGALDINASDKGARFVRFCNAFNIPLVTLVD
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEC
VPGFLPGVQQEKGGIIRHGAKMLFAYAAATVPKITVIMRKAYGGAFLAMCGKELETDRVF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCEEE
AWPSAEIAVMGPQGAVNVIFRNEIAQAEDPKKKRDELIASYQGTFATPYAAAARRDVDDI
ECCCCCEEEECCCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCHHHH
IEPADTRRHLAMTLDILSTKREFRPMKKHGLIPL
HCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]