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The map label for this gene is lktA [H]

Identifier: 197104477

GI number: 197104477

Start: 1123889

End: 1126297

Strand: Direct

Name: lktA [H]

Synonym: PHZ_c1011

Alternate gene names: 197104477

Gene position: 1123889-1126297 (Clockwise)

Preceding gene: 197104474

Following gene: 197104483

Centisome position: 28.12

GC content: 71.65

Gene sequence:

>2409_bases
TTGCGGGCGCGAGGCCTCGCGCGACGGAGCCAGACCGTGCCGCAATCCTTCAACGTCCAGGGAATCTCGCTCTCGACCTA
CAGCGCCGGCGGCTACGCCGACTCCCGCGTGGTCGAGCTCATCGACCGGGCCGCACAGAACGGCGCGACCCACGTGGTGT
TCAGCAACGTGGCGCTCGCCGACCTGCGGACCGGCGCCATCGGCGAGGTGATCGAGAACGGCCAGAACCAGACCGCCAGC
CTGGCCGACGTCGGCCGCGCCGTCGCCGCCGCCAAGGCCGAGGGGCTGCAGGTGGTGCTGAAGCCGCAGCTGGTCGTCCA
CGACCCAGCCTTCGACCAGTACAACAGCGCGTCCTGGATCAACATGGTCAATCCGGACCTGACGATCTCGAACCCGGACG
CCTTCTTCGCCGCCTACAAGGCCCACATCCTGGACTGGGCGCGGCTGGCCCAGGCCCAGGGCGCGGACGTGCTGAGCATC
GGCAACGAGATGGTGGCCGCCACCAAGCCGCAGTACACGGCCTACTGGAACGACATCATCGATGCGGTGCGCGGCGTCTA
CGGCGGCCAGCTGACCTACGCCGCCCTCGCGCCTGTGGCGGTCGGCGCGCCGGTGAACGAGATCACCCAGATCGGCTTCT
GGGACCGGCTGGACGTCGCCGGCTTCGACGTCTTCCCCAGCCTCACCAGCAACACCGATCCCACCGTCGCCGAGCTGAAG
GCGGGCTGGCGCGACGCCCAGGTGTTCGGCCAGCAGCAGGACTATGTCGAGTTCCTCGGGCGGATGGCCGCCCACGTCGG
CAAGCCGGTGATCTTCACCGAGACCGGACTGCCCAGCTTCGACGGCGCGTCGGACAGGATCGCCACCTCGGACGGCTTCA
TCGGGACGGGCGCGCGGGCCGCCGACCAGGGCGAGCAGGCCGACTGGTGGCAGGCCTTCTTCGAGACCTGGGCCGTGAGC
AAGCCCGCCTGGCTGCAGGGCGTGTGGCTGATCAACAACGACCCCGGCCGCCTCGGGACCTACTACGATCAGAACTACAA
CATCGACGGCAAGCTGGCCGAGGCGGTGGTCACCGCCTGGTTCGGCGGCGAAACGACCATAGGCGGCGGCTCGGGCGATG
CGGCCCTGACCGGCAGCGCCGCCGGCGACCGGCTCTTCCTGTACGGCCCCGACGCGCCGCAGGCGGCCCGGCTCGCCGAC
AGCCTCGAGACGACCGTCACGGTGGACGTCACCGGCGCGCTGTCCGGCGGCCAGGCGCCGACGATCCGCATCTGGATCAA
CGGCGTCGACCGCGGGACGGCGGCCCTCAAGCCGCTCGACAGCGGCTACGTCAACGGCGAGGGCGTGCGCTTCACCCAGA
CCCAGACCTTCACCTTCGAGCTGCCGGGCCTGACGCGGATCGACCAGCTGCGGATCGCGCCGGAAGGAAGCGGCAACGTC
TTCTTCCACGGCGTTCAGGTGAACGGCGTGCCGCTGACCGGGACGTCCGGGGCGGGCGGGGCCACGACCTTCGACCCCGG
CGCCTGGAACGCGGCGCTCGCCACGCGGGCCGTGGGCACGGCCGGCAATCCCATCGTGGTCGACGGCCAGGGCGGGTTCG
ACACGGTCCATGTCCTCGGGCGCGCGGACCAGTACGCCGTGCAGGCGCTCCCCGACGGCAGCGTGCGCCTGACCGAAACC
AGCGGCCTCAATCAGAACGCGATCCTGAAGGGCGTCTCGGTCGTGGTCTTCGCCGATGGGTCGCGGATCGCGCTTTCCGA
CCTCGCCGCCGGCCCGGGCGCCGGTCCGGCCGGCCCGCGCGAGCTGGCCGGCGACCTCGGCGACACGCGGCTCATCGGCA
CGGACGCCGACGAGATCATCCGCGATCCCGGCGGACGGAACTTCCTGCGCGGCGGGGGCGGCGACGACCGAATCTACGGC
GGGTCGGGCTTCGACGACGCCCACGGCAACCTCGGGAACGACACCGTCTCGGGCGGGGAGGGCGACGACTGGGTGGTCGG
CGGCCAGGGCAACGACCTGCTGAACGGCGAGGGCGGCCACGACGTCGTCTACGGGAACCTGGGCGACGACACCCTGCACG
GCGGCCTGGGAAGCGACTGGGTCCGCGGCGGCCAGGGCGACGACCTGATCTACGCGGGCGGCGGCGACGACTGGATCTCG
GGCGACATGGGCAGCGACACCATCACCGGCGGGGCGGGGGCCGACCTCTTCCACACCCACGGGAACGCCGGCCTCGACCG
GGTGCTCGACTTCAGTTTCGCCCAGGGCGACCGGGTGAACGTGCTGGCGGGGACGGGCTACGAAGCCCTGCAGGTCGGCG
CCGATACGGTGATCCGCATGACCGGCGGGGGCGAGATGTCGCTGGCGGGCGTCCGCCTGGCCGACCTGCCCCCCGGCTGG
ATCGTCTGA

Upstream 100 bases:

>100_bases
CCAGAGGCCCCATCACATCGCGTCCTTCAGGCCAAACGCGTCCTTAAGGAACGTCACCCCCCAATGACAGCGCAGCCGCG
CATCCCGCGAGCCCCTCGGT

Downstream 100 bases:

>100_bases
CGGCGGGGCGCCGTTCCCCGGCGGCTAGTTCGCCGGGACGACCGGCAGCTCGATGGACGAGGCGGCCCCGCGGGTGTGGA
ACACGCGCTGGGTCGCCTTC

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MRARGLARRSQTVPQSFNVQGISLSTYSAGGYADSRVVELIDRAAQNGATHVVFSNVALADLRTGAIGEVIENGQNQTAS
LADVGRAVAAAKAEGLQVVLKPQLVVHDPAFDQYNSASWINMVNPDLTISNPDAFFAAYKAHILDWARLAQAQGADVLSI
GNEMVAATKPQYTAYWNDIIDAVRGVYGGQLTYAALAPVAVGAPVNEITQIGFWDRLDVAGFDVFPSLTSNTDPTVAELK
AGWRDAQVFGQQQDYVEFLGRMAAHVGKPVIFTETGLPSFDGASDRIATSDGFIGTGARAADQGEQADWWQAFFETWAVS
KPAWLQGVWLINNDPGRLGTYYDQNYNIDGKLAEAVVTAWFGGETTIGGGSGDAALTGSAAGDRLFLYGPDAPQAARLAD
SLETTVTVDVTGALSGGQAPTIRIWINGVDRGTAALKPLDSGYVNGEGVRFTQTQTFTFELPGLTRIDQLRIAPEGSGNV
FFHGVQVNGVPLTGTSGAGGATTFDPGAWNAALATRAVGTAGNPIVVDGQGGFDTVHVLGRADQYAVQALPDGSVRLTET
SGLNQNAILKGVSVVVFADGSRIALSDLAAGPGAGPAGPRELAGDLGDTRLIGTDADEIIRDPGGRNFLRGGGGDDRIYG
GSGFDDAHGNLGNDTVSGGEGDDWVVGGQGNDLLNGEGGHDVVYGNLGDDTLHGGLGSDWVRGGQGDDLIYAGGGDDWIS
GDMGSDTITGGAGADLFHTHGNAGLDRVLDFSFAQGDRVNVLAGTGYEALQVGADTVIRMTGGGEMSLAGVRLADLPPGW
IV

Sequences:

>Translated_802_residues
MRARGLARRSQTVPQSFNVQGISLSTYSAGGYADSRVVELIDRAAQNGATHVVFSNVALADLRTGAIGEVIENGQNQTAS
LADVGRAVAAAKAEGLQVVLKPQLVVHDPAFDQYNSASWINMVNPDLTISNPDAFFAAYKAHILDWARLAQAQGADVLSI
GNEMVAATKPQYTAYWNDIIDAVRGVYGGQLTYAALAPVAVGAPVNEITQIGFWDRLDVAGFDVFPSLTSNTDPTVAELK
AGWRDAQVFGQQQDYVEFLGRMAAHVGKPVIFTETGLPSFDGASDRIATSDGFIGTGARAADQGEQADWWQAFFETWAVS
KPAWLQGVWLINNDPGRLGTYYDQNYNIDGKLAEAVVTAWFGGETTIGGGSGDAALTGSAAGDRLFLYGPDAPQAARLAD
SLETTVTVDVTGALSGGQAPTIRIWINGVDRGTAALKPLDSGYVNGEGVRFTQTQTFTFELPGLTRIDQLRIAPEGSGNV
FFHGVQVNGVPLTGTSGAGGATTFDPGAWNAALATRAVGTAGNPIVVDGQGGFDTVHVLGRADQYAVQALPDGSVRLTET
SGLNQNAILKGVSVVVFADGSRIALSDLAAGPGAGPAGPRELAGDLGDTRLIGTDADEIIRDPGGRNFLRGGGGDDRIYG
GSGFDDAHGNLGNDTVSGGEGDDWVVGGQGNDLLNGEGGHDVVYGNLGDDTLHGGLGSDWVRGGQGDDLIYAGGGDDWIS
GDMGSDTITGGAGADLFHTHGNAGLDRVLDFSFAQGDRVNVLAGTGYEALQVGADTVIRMTGGGEMSLAGVRLADLPPGW
IV
>Mature_802_residues
MRARGLARRSQTVPQSFNVQGISLSTYSAGGYADSRVVELIDRAAQNGATHVVFSNVALADLRTGAIGEVIENGQNQTAS
LADVGRAVAAAKAEGLQVVLKPQLVVHDPAFDQYNSASWINMVNPDLTISNPDAFFAAYKAHILDWARLAQAQGADVLSI
GNEMVAATKPQYTAYWNDIIDAVRGVYGGQLTYAALAPVAVGAPVNEITQIGFWDRLDVAGFDVFPSLTSNTDPTVAELK
AGWRDAQVFGQQQDYVEFLGRMAAHVGKPVIFTETGLPSFDGASDRIATSDGFIGTGARAADQGEQADWWQAFFETWAVS
KPAWLQGVWLINNDPGRLGTYYDQNYNIDGKLAEAVVTAWFGGETTIGGGSGDAALTGSAAGDRLFLYGPDAPQAARLAD
SLETTVTVDVTGALSGGQAPTIRIWINGVDRGTAALKPLDSGYVNGEGVRFTQTQTFTFELPGLTRIDQLRIAPEGSGNV
FFHGVQVNGVPLTGTSGAGGATTFDPGAWNAALATRAVGTAGNPIVVDGQGGFDTVHVLGRADQYAVQALPDGSVRLTET
SGLNQNAILKGVSVVVFADGSRIALSDLAAGPGAGPAGPRELAGDLGDTRLIGTDADEIIRDPGGRNFLRGGGGDDRIYG
GSGFDDAHGNLGNDTVSGGEGDDWVVGGQGNDLLNGEGGHDVVYGNLGDDTLHGGLGSDWVRGGQGDDLIYAGGGDDWIS
GDMGSDTITGGAGADLFHTHGNAGLDRVLDFSFAQGDRVNVLAGTGYEALQVGADTVIRMTGGGEMSLAGVRLADLPPGW
IV

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 83214; Mature: 83214

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARGLARRSQTVPQSFNVQGISLSTYSAGGYADSRVVELIDRAAQNGATHVVFSNVALA
CCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECEEEE
DLRTGAIGEVIENGQNQTASLADVGRAVAAAKAEGLQVVLKPQLVVHDPAFDQYNSASWI
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECEEEEECCCCCCCCCCCEE
NMVNPDLTISNPDAFFAAYKAHILDWARLAQAQGADVLSIGNEMVAATKPQYTAYWNDII
EECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCHHHHHHHHH
DAVRGVYGGQLTYAALAPVAVGAPVNEITQIGFWDRLDVAGFDVFPSLTSNTDPTVAELK
HHHHHHCCCCCHHHHHHHECCCCCHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCHHHHH
AGWRDAQVFGQQQDYVEFLGRMAAHVGKPVIFTETGLPSFDGASDRIATSDGFIGTGARA
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCEECCCCC
ADQGEQADWWQAFFETWAVSKPAWLQGVWLINNDPGRLGTYYDQNYNIDGKLAEAVVTAW
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEECCCCCCCCHHHHHHEEEE
FGGETTIGGGSGDAALTGSAAGDRLFLYGPDAPQAARLADSLETTVTVDVTGALSGGQAP
ECCCEEECCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHCCCEEEEEEEEEECCCCCCC
TIRIWINGVDRGTAALKPLDSGYVNGEGVRFTQTQTFTFELPGLTRIDQLRIAPEGSGNV
EEEEEEECCCCCCHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEEECCCCCCCE
FFHGVQVNGVPLTGTSGAGGATTFDPGAWNAALATRAVGTAGNPIVVDGQGGFDTVHVLG
EEEEEEECCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCEEEEEC
RADQYAVQALPDGSVRLTETSGLNQNAILKGVSVVVFADGSRIALSDLAAGPGAGPAGPR
CCCCEEEEECCCCCEEEEECCCCCCCCEECCEEEEEEECCCEEEEHHCCCCCCCCCCCHH
ELAGDLGDTRLIGTDADEIIRDPGGRNFLRGGGGDDRIYGGSGFDDAHGNLGNDTVSGGE
HHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GDDWVVGGQGNDLLNGEGGHDVVYGNLGDDTLHGGLGSDWVRGGQGDDLIYAGGGDDWIS
CCCEEECCCCCCCCCCCCCCEEEEECCCCCHHCCCCCCHHHCCCCCCCEEEECCCCCCCC
GDMGSDTITGGAGADLFHTHGNAGLDRVLDFSFAQGDRVNVLAGTGYEALQVGADTVIRM
CCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCEEEEEECCCHHHEEECCCEEEEE
TGGGEMSLAGVRLADLPPGWIV
ECCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MRARGLARRSQTVPQSFNVQGISLSTYSAGGYADSRVVELIDRAAQNGATHVVFSNVALA
CCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECEEEE
DLRTGAIGEVIENGQNQTASLADVGRAVAAAKAEGLQVVLKPQLVVHDPAFDQYNSASWI
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECEEEEECCCCCCCCCCCEE
NMVNPDLTISNPDAFFAAYKAHILDWARLAQAQGADVLSIGNEMVAATKPQYTAYWNDII
EECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCHHHHHHHHH
DAVRGVYGGQLTYAALAPVAVGAPVNEITQIGFWDRLDVAGFDVFPSLTSNTDPTVAELK
HHHHHHCCCCCHHHHHHHECCCCCHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCHHHHH
AGWRDAQVFGQQQDYVEFLGRMAAHVGKPVIFTETGLPSFDGASDRIATSDGFIGTGARA
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCEECCCCC
ADQGEQADWWQAFFETWAVSKPAWLQGVWLINNDPGRLGTYYDQNYNIDGKLAEAVVTAW
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEECCCCCCCCHHHHHHEEEE
FGGETTIGGGSGDAALTGSAAGDRLFLYGPDAPQAARLADSLETTVTVDVTGALSGGQAP
ECCCEEECCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHCCCEEEEEEEEEECCCCCCC
TIRIWINGVDRGTAALKPLDSGYVNGEGVRFTQTQTFTFELPGLTRIDQLRIAPEGSGNV
EEEEEEECCCCCCHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEEECCCCCCCE
FFHGVQVNGVPLTGTSGAGGATTFDPGAWNAALATRAVGTAGNPIVVDGQGGFDTVHVLG
EEEEEEECCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCEEEEEC
RADQYAVQALPDGSVRLTETSGLNQNAILKGVSVVVFADGSRIALSDLAAGPGAGPAGPR
CCCCEEEEECCCCCEEEEECCCCCCCCEECCEEEEEEECCCEEEEHHCCCCCCCCCCCHH
ELAGDLGDTRLIGTDADEIIRDPGGRNFLRGGGGDDRIYGGSGFDDAHGNLGNDTVSGGE
HHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GDDWVVGGQGNDLLNGEGGHDVVYGNLGDDTLHGGLGSDWVRGGQGDDLIYAGGGDDWIS
CCCEEECCCCCCCCCCCCCCEEEEECCCCCHHCCCCCCHHHCCCCCCCEEEECCCCCCCC
GDMGSDTITGGAGADLFHTHGNAGLDRVLDFSFAQGDRVNVLAGTGYEALQVGADTVIRM
CCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCEEEEEECCCHHHEEECCCEEEEE
TGGGEMSLAGVRLADLPPGWIV
ECCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]