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The map label for this gene is ilvC

Identifier: 197104243

GI number: 197104243

Start: 856887

End: 857906

Strand: Direct

Name: ilvC

Synonym: PHZ_c0777

Alternate gene names: 197104243

Gene position: 856887-857906 (Clockwise)

Preceding gene: 197104240

Following gene: 197104245

Centisome position: 21.44

GC content: 67.55

Gene sequence:

>1020_bases
ATGCGCGTCTACTACGATCGCGACGCCGACCTGTCCCGGATCCTGGACAAGAAGATCGCCATCGTAGGCTATGGCTCGCA
GGGCCGTGCGCATGCGCTGAACCTCGTGGACTCGGGCGTGAAGAACGTGGCCGTGGCGCTGCGCCCCGGCTCGGCCACCG
CCAAGAAGGTCGAGGCCGACGGCCTGAAGGTGATGAGCGTCGCCGAAGCCTCGGCCTGGGCCGACGCGATCATGATCCTG
GCGCCCGACGAACTGCAGGCGCAGATCTACCGCGACGAGATCGCCCCCAACATCAAGGACGGTGCGGCCCTGCTGTTCGC
CCACGGCCTGAACGTCCACTTCGGCCTCATCGAGCCGAAGAAGACCGTCGACGTGCTGATGGTGGCGCCCAAGGGCCCCG
GCCACACCGTCCGCGGCGAGTACCAGAAGGGCGGCGGCGTGCCGTGCCTGATCGCGGTCCACCACGACGCCACGGGCGGC
GCCATGGACTTCGGCCTGGCCTACGCCTCGGCCATCGGCGGCGGCCGCTCGGGCGTCATCGAGACCAACTTCCGCGAGGA
GTGCGAGACCGACCTGTTCGGCGAACAGGCCGTGCTCTGCGGCGGCCTGGTGGAGCTGATCCGCGCCGGCTTCGAAACCC
TGGTCGAGGCGGGCTACGCCCCCGAGATGGCCTATTTCGAGTGCCTGCACGAGGTGAAGCTGATCGTCGACCTCATCTAC
GAGGGCGGCATCGCCAACATGAACTACTCGATCTCCAACACGGCCGAGTACGGCGAGTACGTCACCGGCCCGCGGATCGT
CACCTCCGAGACCAAGGCCGAGATGAAGCGCGTGCTGGAGGACATCCAGTCGGGCCGCTTCGTGCGCGACTTCATGCAGG
AGAACGCGGTGGGCGCCCCGTCCTTCAAGGCCACCCGCCGCCGCAACGCCGAGCATCCCATCGAGGAAGTCGGCGGCCGC
CTGCGCGCCATGATGCCCTGGATCACCAAGAACAAGCTGGTGGATACGGAGCGCAACTGA

Upstream 100 bases:

>100_bases
CTTCGCTTGACCTAAGAGCAAAAAACCGCTTCAGAGCCCCGGCTTTGCTGCACTGCCGTTGCGCAGGCGCGGGCCAAACA
ACGTATCAGGAGAAACAATC

Downstream 100 bases:

>100_bases
TCGCGCAGCGCAAATTCGGAATAGGAAGGCCCGGGGGCGACCCCCGGGCCTTTTTCATGACCGGTGCTTCCCCTGAGGGG
GAACTAGGACTCCTCGTCGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEADGLKVMSVAEASAWADAIMIL
APDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPKKTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGG
AMDFGLAYASAIGGGRSGVIETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAPSFKATRRRNAEHPIEEVGGR
LRAMMPWITKNKLVDTERN

Sequences:

>Translated_339_residues
MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEADGLKVMSVAEASAWADAIMIL
APDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPKKTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGG
AMDFGLAYASAIGGGRSGVIETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAPSFKATRRRNAEHPIEEVGGR
LRAMMPWITKNKLVDTERN
>Mature_339_residues
MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEADGLKVMSVAEASAWADAIMIL
APDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPKKTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGG
AMDFGLAYASAIGGGRSGVIETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAPSFKATRRRNAEHPIEEVGGR
LRAMMPWITKNKLVDTERN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=295, Percent_Identity=37.9661016949153, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=339, Percent_Identity=31.2684365781711, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PHEZH (B4RG67)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129620.1
- GeneID:   6790270
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0777
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36775; Mature: 36775

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEAD
CEEEECCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHCCCC
GLKVMSVAEASAWADAIMILAPDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCC
KTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGGAMDFGLAYASAIGGGRSGVI
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAP
CCCCCCCCCCCCCCHHHCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
SFKATRRRNAEHPIEEVGGRLRAMMPWITKNKLVDTERN
CCHHHHHCCCCCCHHHHCCHHHHHHCHHHCCCCCCCCCC
>Mature Secondary Structure
MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEAD
CEEEECCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHCCCC
GLKVMSVAEASAWADAIMILAPDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCC
KTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGGAMDFGLAYASAIGGGRSGVI
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAP
CCCCCCCCCCCCCCHHHCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
SFKATRRRNAEHPIEEVGGRLRAMMPWITKNKLVDTERN
CCHHHHHCCCCCCHHHHCCHHHHHHCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA