Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 197104240

GI number: 197104240

Start: 852796

End: 855372

Strand: Direct

Name: clpB [H]

Synonym: PHZ_c0774

Alternate gene names: 197104240

Gene position: 852796-855372 (Clockwise)

Preceding gene: 197104238

Following gene: 197104243

Centisome position: 21.34

GC content: 71.05

Gene sequence:

>2577_bases
ATGAACATCGACATCTATTCCGACCGCGCCAAGCAGGCGATCCAGTCGGCCCAGAGCCTGGCGCTCGCCCGGCGCCACCA
GCAGCTCGGCCCGGAGCACGTCCTGAAGGTGCTGCTGGAGGAGAAGGACGGCCTGTCCCGCGCGCTGATCCAGAGCGCCG
GCGGCCGGCCCGACGCGGCCGACAAGGCGGTGGACGACCTCCTGGGCCGGCTTCCCAAGGTCGAGGGCGGTTCGGGCCAG
CTCTACATGAAGCCCGAGACGGCCCGGGTGTTCGCCGAGGCCGAGGCGGGCGCCAAGGCCGCCGGGGACGCCTTCGTCAC
CACCGAACGCCTGCTGATCGCCATCGCCAAGGAAGGCGGCGAGGCCGCCAACGCCCTCAAGCAGGCCGGCGCCAGTCCCA
AGGGCCTGGAAGAGGCCGCCAGCGCCGTTCGCAAGGGGCGCACGGCGGATTCCGCCTCGGCGGAAGAAGGGTACGACGCC
CTGAAGCGCTACGCCCGCGACCTGACCCAGGCCGCCCGCGACGGCAAGCTCGATCCCGTCATCGGCCGCGACGAGGAGAT
CCGCCGGACCATCCAGGTCCTCTCCCGCCGCACCAAGAACAACCCCGTCCTGATCGGCGAGCCCGGCGTCGGCAAGACCG
CCATCGTCGAGGGCCTGGCCCTGCGCATCGTCAACGGCGACGTGCCCGAGAGCCTGAAGGACAAGCAGCTGCACGCGCTC
GACATGGGCGCGCTGATCGCCGGGGCGAAGTACCGCGGCGAGTTCGAGGAGCGGCTGAAGGCGGTGCTGAACGAGGTCAC
CCAGGCCGAAGGCTCCATCATCCTGTTCATCGACGAGATGCACACCCTGGTCGGCGCCGGGAAGAGCGACGGGGCCATGG
ACGCCTCGAACCTGCTGAAGCCCGCGCTGGCCCGCGGCGAACTGCACTGCGTGGGCGCCACCACGCTCGACGAGTACCGC
AAGCACGTCGAGAAGGACGCGGCCCTGGCCCGCCGCTTCCAGCCGGTGTTCGTCTCCGAGCCGACGGTCGAGGACACCGT
CTCGATCCTGCGCGGCCTGAAGGAGAAGTACGAGGTCCACCACGGCGTGCGGATCTCGGACAGCGCCATCGTGGCCGCCG
CCACCCTCTCCAACCGCTACATCACCGACCGCTTCCTCCCCGACAAGGCCATCGACCTGGTGGACGAGGCGGCCAGCCGC
GTGCGCATGGCGGTGGACTCCAAGCCCGAGGAGCTGGACGAGATCGACCGCCGCGTCGTGCAGCTGAAGATCGAGCGCGA
GGCCCTCGCCAAGGAGACCGACGCGGCCTCGAAGGCGCGCCTCGAGAAGCTCGAGGAGGAGCTGGCCGGGCTCGAGGCGC
AGTCCGCCGAGATGACCGCCCGCTGGCGCGCCGAGAAGGAGAAGGTCTCCTCCGCCGCCCAGGTCCGCGAGGGCCTGGAC
CGGCTGCGGGCCGAACTGACCGCCGCCCAACGGCGCGGCGACCTGCAGCGCGCCTCCGAGATCGCCTACGGGGAGATCCC
GCAGCTGGAGAAGCGGCTCGCCGAGGCCGAGGCCGCCGAGGGCGGCGACGAGGCCATGACGCCCGAGGTCGTCGACGCCG
AGCAGATCGCCGCCGTCGTCTCGCGCTGGACCGGCGTGCCTGTCGAGAAGATGCTGGAGGGCGAGCGCGAGAAGCTGCTC
CAGATGGAGGACGGCCTGCGCCGCCGGGTGGTCGGCCAGGAGGAGGCGCTGGTCGCCGTCTCCGACGCCGTGCGCCGCGC
CCGCGCCGGCCTGAAGGACCCGAACCGGCCGATCGGCTCGTTCCTGTTCTTAGGACCCACCGGCGTCGGCAAGACCGAGC
TGACCAAGGCGCTGGCCGAGTTCCTGTTCGACGACGAGTCCGCCGTGACCCGCCTCGACATGAGCGAGTACATGGAGAAG
CACTCGGTCAGCCGGATGATCGGCGCGCCTCCCGGCTACGTCGGCTACGACGAGGGCGGGGCGCTGACCGAGAGCGTCCG
CCGGCGGCCCTACCAGGTCGTGCTGTTCGACGAGGTCGAGAAGGCCCACCCCGACGTCTTCAACGTGCTGCTGCAGGTGC
TGGACGACGGCCGCCTGACCGACGGCCAGGGCCGCACGGTCGACTTCCGCAATACGCTGATCATCATGACGTCCAACCTC
GGCTCGGAATTCCTGGCCGGCGGCGACGACGTGGAGACGGCGCGTCCGGCGGTCATGGAGGTCGTGCGCCGCCACTTCCG
GCCCGAGTTCCTGAACCGGATCGACGAGGTGATCCTCTTCAAGCGCCTGGGCCGGGCCGAGATGGACGACATCGTCCGCA
TCCAGCTCCAGCGCGTCGAGAAGCTGCTGGCCGACCGGCGCATGGCGCTGGCGCTGGATCCCGCCGCCCTGCACTGGCTG
GGCGACCGGGGCTACGACCCGGTCTACGGGGCGCGGCCGCTGAAGCGGGTGATCCAGAAGGAGCTGGTGGACCCCATCGC
CCGCAAGCTGCTGGCGGGCGAGCTGGAGGACGGCTCGGTCATCGACGTCACCGCCGGCGACGCCGGCCTCGAGATCGGCC
GGGCCAAGGTGCACTGA

Upstream 100 bases:

>100_bases
CCGGAGGCTTGTGTGACCCATATGCCACACTAAATGCGATGGGGTCGGCGGCTGCGCTTGATCAAGGCGGCCGCCCTCAG
TCCGCCTGAGTAGGGGAACC

Downstream 100 bases:

>100_bases
CTTGGCGAATCCTCCCCCTCAGGGGGAGGGGGACCACGAAGTGGTGGAGGGGGCTTCAGCCGTTGAAGCGCCGGATGGAG
CCCCTCGGCCGCTGCGTGAC

Product: ATP-dependent Clp protease, ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 858; Mature: 858

Protein sequence:

>858_residues
MNIDIYSDRAKQAIQSAQSLALARRHQQLGPEHVLKVLLEEKDGLSRALIQSAGGRPDAADKAVDDLLGRLPKVEGGSGQ
LYMKPETARVFAEAEAGAKAAGDAFVTTERLLIAIAKEGGEAANALKQAGASPKGLEEAASAVRKGRTADSASAEEGYDA
LKRYARDLTQAARDGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKQLHAL
DMGALIAGAKYRGEFEERLKAVLNEVTQAEGSIILFIDEMHTLVGAGKSDGAMDASNLLKPALARGELHCVGATTLDEYR
KHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVHHGVRISDSAIVAAATLSNRYITDRFLPDKAIDLVDEAASR
VRMAVDSKPEELDEIDRRVVQLKIEREALAKETDAASKARLEKLEEELAGLEAQSAEMTARWRAEKEKVSSAAQVREGLD
RLRAELTAAQRRGDLQRASEIAYGEIPQLEKRLAEAEAAEGGDEAMTPEVVDAEQIAAVVSRWTGVPVEKMLEGEREKLL
QMEDGLRRRVVGQEEALVAVSDAVRRARAGLKDPNRPIGSFLFLGPTGVGKTELTKALAEFLFDDESAVTRLDMSEYMEK
HSVSRMIGAPPGYVGYDEGGALTESVRRRPYQVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNL
GSEFLAGGDDVETARPAVMEVVRRHFRPEFLNRIDEVILFKRLGRAEMDDIVRIQLQRVEKLLADRRMALALDPAALHWL
GDRGYDPVYGARPLKRVIQKELVDPIARKLLAGELEDGSVIDVTAGDAGLEIGRAKVH

Sequences:

>Translated_858_residues
MNIDIYSDRAKQAIQSAQSLALARRHQQLGPEHVLKVLLEEKDGLSRALIQSAGGRPDAADKAVDDLLGRLPKVEGGSGQ
LYMKPETARVFAEAEAGAKAAGDAFVTTERLLIAIAKEGGEAANALKQAGASPKGLEEAASAVRKGRTADSASAEEGYDA
LKRYARDLTQAARDGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKQLHAL
DMGALIAGAKYRGEFEERLKAVLNEVTQAEGSIILFIDEMHTLVGAGKSDGAMDASNLLKPALARGELHCVGATTLDEYR
KHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVHHGVRISDSAIVAAATLSNRYITDRFLPDKAIDLVDEAASR
VRMAVDSKPEELDEIDRRVVQLKIEREALAKETDAASKARLEKLEEELAGLEAQSAEMTARWRAEKEKVSSAAQVREGLD
RLRAELTAAQRRGDLQRASEIAYGEIPQLEKRLAEAEAAEGGDEAMTPEVVDAEQIAAVVSRWTGVPVEKMLEGEREKLL
QMEDGLRRRVVGQEEALVAVSDAVRRARAGLKDPNRPIGSFLFLGPTGVGKTELTKALAEFLFDDESAVTRLDMSEYMEK
HSVSRMIGAPPGYVGYDEGGALTESVRRRPYQVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNL
GSEFLAGGDDVETARPAVMEVVRRHFRPEFLNRIDEVILFKRLGRAEMDDIVRIQLQRVEKLLADRRMALALDPAALHWL
GDRGYDPVYGARPLKRVIQKELVDPIARKLLAGELEDGSVIDVTAGDAGLEIGRAKVH
>Mature_858_residues
MNIDIYSDRAKQAIQSAQSLALARRHQQLGPEHVLKVLLEEKDGLSRALIQSAGGRPDAADKAVDDLLGRLPKVEGGSGQ
LYMKPETARVFAEAEAGAKAAGDAFVTTERLLIAIAKEGGEAANALKQAGASPKGLEEAASAVRKGRTADSASAEEGYDA
LKRYARDLTQAARDGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKQLHAL
DMGALIAGAKYRGEFEERLKAVLNEVTQAEGSIILFIDEMHTLVGAGKSDGAMDASNLLKPALARGELHCVGATTLDEYR
KHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVHHGVRISDSAIVAAATLSNRYITDRFLPDKAIDLVDEAASR
VRMAVDSKPEELDEIDRRVVQLKIEREALAKETDAASKARLEKLEEELAGLEAQSAEMTARWRAEKEKVSSAAQVREGLD
RLRAELTAAQRRGDLQRASEIAYGEIPQLEKRLAEAEAAEGGDEAMTPEVVDAEQIAAVVSRWTGVPVEKMLEGEREKLL
QMEDGLRRRVVGQEEALVAVSDAVRRARAGLKDPNRPIGSFLFLGPTGVGKTELTKALAEFLFDDESAVTRLDMSEYMEK
HSVSRMIGAPPGYVGYDEGGALTESVRRRPYQVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNL
GSEFLAGGDDVETARPAVMEVVRRHFRPEFLNRIDEVILFKRLGRAEMDDIVRIQLQRVEKLLADRRMALALDPAALHWL
GDRGYDPVYGARPLKRVIQKELVDPIARKLLAGELEDGSVIDVTAGDAGLEIGRAKVH

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=320, Percent_Identity=36.5625, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1788943, Length=845, Percent_Identity=59.0532544378698, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=332, Percent_Identity=46.3855421686747, Blast_Score=285, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=699, Percent_Identity=56.6523605150215, Blast_Score=810, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=857, Percent_Identity=44.4574095682614, Blast_Score=693, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 93858; Mature: 93858

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDIYSDRAKQAIQSAQSLALARRHQQLGPEHVLKVLLEEKDGLSRALIQSAGGRPDAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHH
DKAVDDLLGRLPKVEGGSGQLYMKPETARVFAEAEAGAKAAGDAFVTTERLLIAIAKEGG
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
EAANALKQAGASPKGLEEAASAVRKGRTADSASAEEGYDALKRYARDLTQAARDGKLDPV
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKQLHAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHH
DMGALIAGAKYRGEFEERLKAVLNEVTQAEGSIILFIDEMHTLVGAGKSDGAMDASNLLK
HHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHHH
PALARGELHCVGATTLDEYRKHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVH
HHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HGVRISDSAIVAAATLSNRYITDRFLPDKAIDLVDEAASRVRMAVDSKPEELDEIDRRVV
CCCEECCCCEEEHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QLKIEREALAKETDAASKARLEKLEEELAGLEAQSAEMTARWRAEKEKVSSAAQVREGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAELTAAQRRGDLQRASEIAYGEIPQLEKRLAEAEAAEGGDEAMTPEVVDAEQIAAVV
HHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
SRWTGVPVEKMLEGEREKLLQMEDGLRRRVVGQEEALVAVSDAVRRARAGLKDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELTKALAEFLFDDESAVTRLDMSEYMEKHSVSRMIGAPPGYVGYDEGG
EEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ALTESVRRRPYQVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNL
HHHHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSEFLAGGDDVETARPAVMEVVRRHFRPEFLNRIDEVILFKRLGRAEMDDIVRIQLQRVE
CHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLLADRRMALALDPAALHWLGDRGYDPVYGARPLKRVIQKELVDPIARKLLAGELEDGSV
HHHHCCHHHEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IDVTAGDAGLEIGRAKVH
EEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNIDIYSDRAKQAIQSAQSLALARRHQQLGPEHVLKVLLEEKDGLSRALIQSAGGRPDAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHH
DKAVDDLLGRLPKVEGGSGQLYMKPETARVFAEAEAGAKAAGDAFVTTERLLIAIAKEGG
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
EAANALKQAGASPKGLEEAASAVRKGRTADSASAEEGYDALKRYARDLTQAARDGKLDPV
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKQLHAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHH
DMGALIAGAKYRGEFEERLKAVLNEVTQAEGSIILFIDEMHTLVGAGKSDGAMDASNLLK
HHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHHH
PALARGELHCVGATTLDEYRKHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVH
HHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HGVRISDSAIVAAATLSNRYITDRFLPDKAIDLVDEAASRVRMAVDSKPEELDEIDRRVV
CCCEECCCCEEEHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QLKIEREALAKETDAASKARLEKLEEELAGLEAQSAEMTARWRAEKEKVSSAAQVREGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAELTAAQRRGDLQRASEIAYGEIPQLEKRLAEAEAAEGGDEAMTPEVVDAEQIAAVV
HHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
SRWTGVPVEKMLEGEREKLLQMEDGLRRRVVGQEEALVAVSDAVRRARAGLKDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELTKALAEFLFDDESAVTRLDMSEYMEKHSVSRMIGAPPGYVGYDEGG
EEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ALTESVRRRPYQVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNL
HHHHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSEFLAGGDDVETARPAVMEVVRRHFRPEFLNRIDEVILFKRLGRAEMDDIVRIQLQRVE
CHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLLADRRMALALDPAALHWLGDRGYDPVYGARPLKRVIQKELVDPIARKLLAGELEDGSV
HHHHCCHHHEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IDVTAGDAGLEIGRAKVH
EEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]