Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 195952996

GI number: 195952996

Start: 555160

End: 555486

Strand: Direct

Name: trxA [H]

Synonym: HY04AAS1_0621

Alternate gene names: 195952996

Gene position: 555160-555486 (Clockwise)

Preceding gene: 195952995

Following gene: 195952997

Centisome position: 35.6

GC content: 41.28

Gene sequence:

>327_bases
ATGGCACAAAATGTTGTTGAACTTACAGACGCCAACTGGGAAAATGAGGTCATAAACTCCTCAGTTCCAGTTTTGGTTGA
TTTTTGGGCACCTTGGTGTGGGCCCTGCAGAATCATAGCCCCAGTCGTTGAGAAACTAGCCGGTGAATTTGCTGGCCAAA
TAAAGGTAGGTAAGCTAAACACAGACGATAACCCAGGTGTATCCATGAGATACGGTATAAGAGCTATACCTACTATAATG
ATGTTTAAAAATGGCGAAGTGGTAGATACAAGAGTTGGTGTACAACCAGAAGATGGCTTAAGAAAGATGATCAAAAACAA
TTTATGA

Upstream 100 bases:

>100_bases
GGTATTGTAGGATGGAAAAGAGAAGGACCTATAATATGTTATTTTATCAAGGACAAAAGAGCTATAGAAGTTTATAATTT
ATTGTTTAAGGAGGTTCAAG

Downstream 100 bases:

>100_bases
TAAACACTCATAAAATTTACGATTGTATAATAGTTGGTGGAGGTCCGGCCGGTCTTACAGCCGGGCTTTATTGTGCTAGA
GCCAAGATGGATGTAATACT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MAQNVVELTDANWENEVINSSVPVLVDFWAPWCGPCRIIAPVVEKLAGEFAGQIKVGKLNTDDNPGVSMRYGIRAIPTIM
MFKNGEVVDTRVGVQPEDGLRKMIKNNL

Sequences:

>Translated_108_residues
MAQNVVELTDANWENEVINSSVPVLVDFWAPWCGPCRIIAPVVEKLAGEFAGQIKVGKLNTDDNPGVSMRYGIRAIPTIM
MFKNGEVVDTRVGVQPEDGLRKMIKNNL
>Mature_107_residues
AQNVVELTDANWENEVINSSVPVLVDFWAPWCGPCRIIAPVVEKLAGEFAGQIKVGKLNTDDNPGVSMRYGIRAIPTIMM
FKNGEVVDTRVGVQPEDGLRKMIKNNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=40, Blast_Score=96, Evalue=7e-21,
Organism=Homo sapiens, GI21361657, Length=104, Percent_Identity=33.6538461538462, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI5031973, Length=81, Percent_Identity=38.2716049382716, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20070125, Length=91, Percent_Identity=31.8681318681319, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=45.3703703703704, Blast_Score=123, Evalue=3e-30,
Organism=Escherichia coli, GI1788936, Length=83, Percent_Identity=49.3975903614458, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI87081747, Length=103, Percent_Identity=33.9805825242718, Blast_Score=82, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=40.2061855670103, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=41.9753086419753, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17549970, Length=98, Percent_Identity=40.8163265306122, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=84, Percent_Identity=39.2857142857143, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=95, Percent_Identity=37.8947368421053, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=104, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=81, Percent_Identity=41.9753086419753, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=40.2298850574713, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=40.2298850574713, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=87, Percent_Identity=40.2298850574713, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=37.5, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=90, Percent_Identity=35.5555555555556, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=86, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=104, Percent_Identity=31.7307692307692, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=103, Percent_Identity=34.9514563106796, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=105, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=103, Percent_Identity=27.1844660194175, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=36.1702127659575, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=38.8888888888889, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=36.9047619047619, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=40.7407407407407, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=36.4705882352941, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=36.4705882352941, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=32.183908045977, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=92, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11928; Mature: 11797

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNVVELTDANWENEVINSSVPVLVDFWAPWCGPCRIIAPVVEKLAGEFAGQIKVGKLN
CCCCEEEECCCCCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCC
TDDNPGVSMRYGIRAIPTIMMFKNGEVVDTRVGVQPEDGLRKMIKNNL
CCCCCCEEEECCHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AQNVVELTDANWENEVINSSVPVLVDFWAPWCGPCRIIAPVVEKLAGEFAGQIKVGKLN
CCCEEEECCCCCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCC
TDDNPGVSMRYGIRAIPTIMMFKNGEVVDTRVGVQPEDGLRKMIKNNL
CCCCCCEEEECCHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]