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The map label for this gene is obgE [H]

Identifier: 194738014

GI number: 194738014

Start: 3369350

End: 3370522

Strand: Reverse

Name: obgE [H]

Synonym: SeSA_A3493

Alternate gene names: 194738014

Gene position: 3370522-3369350 (Counterclockwise)

Preceding gene: 194734771

Following gene: 194734364

Centisome position: 71.58

GC content: 55.24

Gene sequence:

>1173_bases
ATGAAGTTTGTTGATGAAGCATCGATTCTGGTCGTTGCAGGCGATGGCGGTAATGGCTGTGTGAGCTTCCGCCGCGAAAA
ATATATCCCGAAAGGCGGCCCGGACGGCGGTGATGGCGGCGACGGCGGCGACGTCTGGATGGAAGCCGATGAAAACCTGA
ATACGCTGATCGATTACCGCTTTGAAAAATCATTCCGCGCTGAACGTGGTCAGAATGGCGCGAGCCGCGACTGTACCGGT
AAACGCGGTAAAGACGTGACCATCAAAGTGCCGGTCGGTACGCGCGTTATCGACCAGGGAACCGGTGAAACGATGGGCGA
CATGACCAAACACGGTCAGCGTCTGTTGGTCGCGAAGGGCGGCTGGCATGGGTTAGGCAATACCCGTTTTAAATCCTCGG
TTAACCGTACGCCGCGCCAGAAAACCAATGGTACGCCGGGCGATAAGCGCGACCTGCTGCTGGAACTGATGCTGCTGGCG
GATGTCGGGATGCTGGGGATGCCAAACGCCGGTAAATCAACGTTCATTCGTGCGGTATCGGCAGCAAAACCGAAAGTCGC
GGACTATCCGTTTACCACGCTGGTGCCGAGCCTGGGCGTGGTACGAATGGACAGCGAAAAGAGTTTTGTGGTGGCTGACA
TTCCGGGGTTGATCGAAGGCGCGGCGGAAGGCGCGGGCCTGGGGATTCGCTTCCTGAAGCACCTCGAACGTTGCCGCGTA
CTGCTGCACCTCATTGATATCGATCCGATCGACGGTTCCGATCCGGTGGAAAACGCCCGTATCATTATTGGCGAACTGGA
AAAATACAGCCAGGATCTGGCGGCTAAACCGCGCTGGTTAGTGTTCAACAAGATCGATCTGATGGATAAAACCGAAGCGG
AAGAGAAAGCGAAAGCGATCGCCGAAGCGTTGGGCTGGGAAGGGAAATACTATCTGATTTCCGCCGCCAGTCAGCTGGGG
GTGAAAGATCTCTGCTGGGATGTGATGACCTTTATCATCGAGAATCCGATCGCGCAGGCTGAAGAAGCAAAACAGCCGGA
AAAAGTCGAGTTCATGTGGGACGATTATCATCGCCAGCAGTTGGCTGAAGTGGAAGAAGACGCAGACGATGACTGGGATG
ACGACTGGGATGAAGACGACGAAGAAGGCGTCGAGTTCATCTACAAACGTTAA

Upstream 100 bases:

>100_bases
GATGTATTCCGCCATTGGTCATCGTATTTGGGGCGGTTTACGCAAGCATGAAACGGTGGTTTCGCAACCCCGCTCAGGCG
AATGATTTACGGAGAATAAA

Downstream 100 bases:

>100_bases
TCTCGTAGCCGGATGGCGCTAACGCTTATCCGGCCTACAAAAGCCAACGGGCCGCATTTGCGGCCCGTTTTATTATGTTC
GTTGTAGGCCGGATAAGACG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLG
VKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR

Sequences:

>Translated_390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLG
VKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
>Mature_390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLG
VKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=348, Percent_Identity=38.7931034482759, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI111955139, Length=293, Percent_Identity=40.6143344709898, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI111955063, Length=129, Percent_Identity=46.5116279069767, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI58761500, Length=129, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789574, Length=390, Percent_Identity=95.6410256410256, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=31.25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=322, Percent_Identity=38.8198757763975, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=32.1428571428571, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17509631, Length=135, Percent_Identity=34.8148148148148, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=32.2033898305085, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=178, Percent_Identity=37.0786516853933, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129375, Length=285, Percent_Identity=40.7017543859649, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=35.3697749196142, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43104; Mature: 43104

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHH
FEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAI
HHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
AEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQ
HHHHCCCCCEEEEECCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEHHHHHHHH
LAEVEEDADDDWDDDWDEDDEEGVEFIYKR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHH
FEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAI
HHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
AEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQ
HHHHCCCCCEEEEECCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEHHHHHHHH
LAEVEEDADDDWDDDWDEDDEEGVEFIYKR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA