Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 194735902

GI number: 194735902

Start: 1853786

End: 1854733

Strand: Direct

Name: prs [H]

Synonym: SeSA_A1919

Alternate gene names: 194735902

Gene position: 1853786-1854733 (Clockwise)

Preceding gene: 194736140

Following gene: 194734827

Centisome position: 39.37

GC content: 54.64

Gene sequence:

>948_bases
GTGCCTGATATGAAGCTTTTTGCTGGTAACGCCACCCCGGAACTAGCACAACGTATTGCCAACCGCCTGTACACTTCTCT
CGGCGACGCCGCCGTAGGTCGCTTTAGCGACGGCGAAGTCAGCGTACAAATCAACGAAAATGTACGCGGTGGTGATATTT
TCATCATCCAGTCCACTTGTGCCCCAACCAACGACAACCTGATGGAATTGGTCGTTATGGTTGATGCCCTGCGTCGTGCT
TCCGCAGGTCGTATCACCGCCGTTATCCCCTACTTTGGCTATGCACGTCAGGACCGTCGCGTACGTTCCGCCCGTGTGCC
GATTACCGCAAAAGTTGTCGCTGACTTCCTGTCCAGCGTCGGCGTTGACCGCGTTCTCACCGTAGATCTGCATGCTGAAC
AGATCCAGGGCTTCTTTGACGTTCCGGTTGATAACGTGTTCGGTAGCCCAATCCTGCTCGAAGATATGCTGCAACTGAAT
CTGGATAACCCGATCGTGGTTTCCCCGGATATTGGCGGCGTGGTTCGTGCCCGCGCTATCGCTAAGCTGCTGAACGATAC
CGATATGGCTATCATTGATAAACGTCGTCCGCGCGCGAACGTTTCTCAGGTGATGCACATCATCGGCGACGTCGCTGGCC
GTGACTGCGTGCTGGTTGATGATATGATCGATACCGGCGGTACTCTGTGCAAAGCAGCAGAAGCATTGAAAGAACGTGGC
GCTAAACGCGTGTTTGCCTACGCGACGCACCCGATCTTCTCAGGCAATGCGGCAAACAACCTGCGCAACTCCGTCATTGA
TGAAGTCGTTGTCTGCGACACCATTCCGCTGACCGACGAAATCAAAGCGCTGCCGAACGTGCGTACCTTGACCCTGTCAG
GTATGCTGGCCGAAGCGATTCGCCGTATCAGCAACGAAGAATCGATTTCCGCCATGTTCGAGCATTGA

Upstream 100 bases:

>100_bases
ATCGCGCTCTTTAATACACCGCCTGGATAGGATTTTGCCTGGCCCGCACAGTTTTCGGCAGATTCTTTCCACCAATGGAC
GCATGCCTGAGGTTCTTCTC

Downstream 100 bases:

>100_bases
TCGAACCCGGATCTGAAACCCGCTGCGGCGGGTTTTTTTGTCTGTAACACCCTTTTGTATGACTTATGCCTCCTTCACCT
GCCATTTAGTTGACAGATGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLN
LDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAIRRISNEESISAMFEH

Sequences:

>Translated_315_residues
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLN
LDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAIRRISNEESISAMFEH
>Mature_314_residues
PDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNL
DNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGA
KRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAIRRISNEESISAMFEH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=318, Percent_Identity=48.4276729559748, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=48.2649842271293, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=47.9623824451411, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=47.3186119873817, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.1516034985423, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.734693877551, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI310128524, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115209, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310118259, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310119946, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=99.3650793650794, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=46.6876971608833, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=46.6876971608833, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=46.6876971608833, Blast_Score=294, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=46.474358974359, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=34.2182890855457, Blast_Score=194, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=46.5189873417722, Blast_Score=271, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=319, Percent_Identity=47.3354231974922, Blast_Score=269, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=46.031746031746, Blast_Score=268, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=40.2912621359223, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=40, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=47.0031545741325, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=44.1176470588235, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651462, Length=376, Percent_Identity=33.5106382978723, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24651464, Length=376, Percent_Identity=33.5106382978723, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI45552010, Length=376, Percent_Identity=33.5106382978723, Blast_Score=190, Evalue=8e-49,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34217; Mature: 34086

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAI
CCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
AKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHCC
AKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAI
CCEEEEEECCCEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEHHHHHHHHH
RRISNEESISAMFEH
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
PDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTC
CCCEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAI
CCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
AKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHCC
AKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAI
CCEEEEEECCCEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEHHHHHHHHH
RRISNEESISAMFEH
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]