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The map label for this gene is sapD [H]

Identifier: 194735415

GI number: 194735415

Start: 1764553

End: 1765545

Strand: Direct

Name: sapD [H]

Synonym: SeSA_A1824

Alternate gene names: 194735415

Gene position: 1764553-1765545 (Clockwise)

Preceding gene: 194735977

Following gene: 194735207

Centisome position: 37.47

GC content: 52.77

Gene sequence:

>993_bases
ATGCCGTTACTGGATATCCGCAATCTCACCATTGAATTTAAAACCAGCGAAGGTTGGGTAAAAGCGGTCGATCGCGTCAG
TATGACATTAAGCGAAGGCGAAATTCGCGGCCTGGTAGGTGAATCGGGTTCCGGAAAGAGCTTGATTGCTAAAGCTATTT
GCGGCGTCGCGAAAGACAACTGGCGAGTCACTGCCGACCGTATGCGTTTTGATGATATCGATCTGCTGCGCCTCTCCTCT
CGTGAACGGCGTAAGCTGGTCGGGCATAATGTGTCGATGATCTTCCAGGAGCCGCAGTCGTGCCTTGATCCTTCCGAACG
CGTCGGCCGCCAGCTAATGCAAAATATTCCCGCCTGGACCTATAAAGGCCGCTGGTGGCAGCGTTTAGGCTGGCGTAAAC
GGCGTGCTATTGAATTACTGCACCGGGTGGGAATTAAAGATCATAAAGACGCGATGCGCAGTTTTCCCTATGAACTGACC
GATGGCGAGTGTCAGAAAGTCATGATCGCTATCGCGCTGGCGAATCAACCGCGACTCCTGATCGCTGATGAACCCACCAA
CTCAATGGAACCGACGACGCAGGCGCAAATTTTTCGCCTGCTGACCCGACTGAATCAAAACAGTAATACCACCATTCTGT
TGATTAGCCACGACCTGCAAATGCTGAGTCAGTGGGCTGACAAAATCAACGTTTTATACTGCGGCCAGACGGTAGAAACC
GCGCCAAGTAAAGATCTGGTGACGACGCCACATCATCCTTATACGCAGGCGCTTATCCGCGCGATTCCGGATTTTGGCAG
TGCGATGCCGCATAAAAGCCGTCTGAATACGCTGCCGGGCGCGATCCCGCTACTGGAGCAGTTACCGATAGGTTGTCGTC
TGGGGCCGCGCTGCCCTTACGCGCAACGAGAATGCATTATCACGCCACGCTTAACCGGCGCGAAAAATCATCTCTATGCC
TGTCATTTTCCGCTGAATATGGAGAGAGAGTGA

Upstream 100 bases:

>100_bases
GGACCGTTATGCTACCCGGCGCGGCGATAACGCTCAGTGTTTTACTGGTAAACCTGCTCGGAGATGGGATTCGTCGTGCG
ATTATTGCGGGGGTGGAATA

Downstream 100 bases:

>100_bases
TATGGTGGAAACTCTGCTTGAAGTGCGCAACCTGAGTAAAACCTTTCGCTACCGGACAGGATGGTTTCGCCGCCAGACCG
TCGACGCCGTGAAACCATTA

Product: peptide transport system ATP-binding protein SapD

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MPLLDIRNLTIEFKTSEGWVKAVDRVSMTLSEGEIRGLVGESGSGKSLIAKAICGVAKDNWRVTADRMRFDDIDLLRLSS
RERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWTYKGRWWQRLGWRKRRAIELLHRVGIKDHKDAMRSFPYELT
DGECQKVMIAIALANQPRLLIADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVET
APSKDLVTTPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPYAQRECIITPRLTGAKNHLYA
CHFPLNMERE

Sequences:

>Translated_330_residues
MPLLDIRNLTIEFKTSEGWVKAVDRVSMTLSEGEIRGLVGESGSGKSLIAKAICGVAKDNWRVTADRMRFDDIDLLRLSS
RERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWTYKGRWWQRLGWRKRRAIELLHRVGIKDHKDAMRSFPYELT
DGECQKVMIAIALANQPRLLIADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVET
APSKDLVTTPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPYAQRECIITPRLTGAKNHLYA
CHFPLNMERE
>Mature_329_residues
PLLDIRNLTIEFKTSEGWVKAVDRVSMTLSEGEIRGLVGESGSGKSLIAKAICGVAKDNWRVTADRMRFDDIDLLRLSSR
ERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWTYKGRWWQRLGWRKRRAIELLHRVGIKDHKDAMRSFPYELTD
GECQKVMIAIALANQPRLLIADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVETA
PSKDLVTTPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPYAQRECIITPRLTGAKNHLYAC
HFPLNMERE

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4170

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787548, Length=330, Percent_Identity=96.3636363636364, Blast_Score=668, Evalue=0.0,
Organism=Escherichia coli, GI1789963, Length=328, Percent_Identity=43.9024390243902, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1787759, Length=328, Percent_Identity=38.109756097561, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI48994883, Length=324, Percent_Identity=37.037037037037, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1787500, Length=329, Percent_Identity=33.1306990881459, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI145693107, Length=271, Percent_Identity=33.5793357933579, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788506, Length=273, Percent_Identity=35.8974358974359, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787758, Length=314, Percent_Identity=30.8917197452229, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1789962, Length=328, Percent_Identity=29.5731707317073, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1787547, Length=274, Percent_Identity=28.8321167883212, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789890, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI48994997, Length=263, Percent_Identity=28.8973384030418, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786398, Length=290, Percent_Identity=28.6206896551724, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789891, Length=250, Percent_Identity=31.2, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081834, Length=229, Percent_Identity=30.5676855895196, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789873, Length=228, Percent_Identity=30.7017543859649, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789032, Length=249, Percent_Identity=26.1044176706827, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081791, Length=268, Percent_Identity=25.3731343283582, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787712, Length=265, Percent_Identity=25.6603773584906, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787105, Length=248, Percent_Identity=27.0161290322581, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788225, Length=262, Percent_Identity=25.9541984732824, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788450, Length=245, Percent_Identity=25.3061224489796, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790162, Length=260, Percent_Identity=23.4615384615385, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790544, Length=240, Percent_Identity=28.3333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787792, Length=245, Percent_Identity=30.6122448979592, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787029, Length=249, Percent_Identity=22.4899598393574, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786703, Length=241, Percent_Identity=28.2157676348548, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786872, Length=214, Percent_Identity=27.5700934579439, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789672, Length=248, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787089, Length=222, Percent_Identity=27.4774774774775, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789864, Length=257, Percent_Identity=24.5136186770428, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787370, Length=254, Percent_Identity=24.0157480314961, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081709, Length=253, Percent_Identity=23.7154150197628, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788644, Length=139, Percent_Identity=28.0575539568345, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790525, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082268, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48995001, Length=225, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788210, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082267, Length=248, Percent_Identity=22.5806451612903, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788472, Length=228, Percent_Identity=27.1929824561404, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789586, Length=263, Percent_Identity=24.7148288973384, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790739, Length=263, Percent_Identity=24.3346007604563, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 37542; Mature: 37411

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLDIRNLTIEFKTSEGWVKAVDRVSMTLSEGEIRGLVGESGSGKSLIAKAICGVAKDN
CCCCEEECEEEEEECCCCHHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHCCCCC
WRVTADRMRFDDIDLLRLSSRERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWT
CEEEHHHCCCCCCHHHHHCCHHHHHHHCCCHHHEEECCHHHCCHHHHHHHHHHHHCCCCE
YKGRWWQRLGWRKRRAIELLHRVGIKDHKDAMRSFPYELTDGECQKVMIAIALANQPRLL
ECCHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHEEEEEEEECCCCEEE
IADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVET
EEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCEEEEECCCCCC
APSKDLVTTPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPY
CCCCCCEECCCCHHHHHHHHHCCHHCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCCC
AQRECIITPRLTGAKNHLYACHFPLNMERE
CCCCEEEECCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
PLLDIRNLTIEFKTSEGWVKAVDRVSMTLSEGEIRGLVGESGSGKSLIAKAICGVAKDN
CCCEEECEEEEEECCCCHHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHCCCCC
WRVTADRMRFDDIDLLRLSSRERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWT
CEEEHHHCCCCCCHHHHHCCHHHHHHHCCCHHHEEECCHHHCCHHHHHHHHHHHHCCCCE
YKGRWWQRLGWRKRRAIELLHRVGIKDHKDAMRSFPYELTDGECQKVMIAIALANQPRLL
ECCHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHEEEEEEEECCCCEEE
IADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVET
EEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCEEEEECCCCCC
APSKDLVTTPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPY
CCCCCCEECCCCHHHHHHHHHCCHHCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCCC
AQRECIITPRLTGAKNHLYACHFPLNMERE
CCCCEEEECCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]