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The map label for this gene is ttcA [H]

Identifier: 194735405

GI number: 194735405

Start: 1720489

End: 1721424

Strand: Direct

Name: ttcA [H]

Synonym: SeSA_A1777

Alternate gene names: 194735405

Gene position: 1720489-1721424 (Clockwise)

Preceding gene: 194738149

Following gene: 194734500

Centisome position: 36.54

GC content: 49.57

Gene sequence:

>936_bases
ATGCAAGAAATTCAAAAGAATACAAAGAAAGAACAATACAACCTGAACAAGTTGCAAAAGCGCCTGCGCCGTAACGTTGG
CGAAGCGATTGCCGATTTTAATATGATTGAAGAAGGCGATCGCATTATGGTTTGCCTTTCTGGCGGCAAAGATAGCTATA
CGATGCTGGAAATTTTACGTAATTTGCAGCAAAGCGCTCCGATCAATTTTTCACTGGTCGCCGTCAACCTCGATCAAAAG
CAGCCAGGTTTTCCGGAGCATATCCTGCCAGCCTACCTTGAGCAGCTGGGCGTAGAATATAAAATCGTCGAAGAAAACAC
CTATGGCATTGTGAAAGAAAAGATTCCGGAAGGAAAAACCACCTGCTCGCTGTGCTCGCGTTTACGTCGGGGTATCCTGT
ATCGTACGGCGACTGAATTGGGCGCGACCAAAATCGCCCTGGGCCACCATCGCGACGATATTCTGCAAACCCTGTTTCTG
AATATGTTCTATGGCGGAAAAATGAAAGGGATGCCGCCGAAGCTGATGAGCGATGATGGCAAACATATCGTGATCCGCCC
GCTGGCTTACTGCCGCGAGAAAGATATTATCCGTTTTGCTGAGGCCAAAGCCTTTCCTATCATTCCTTGTAATCTGTGCG
GTTCGCAACCCAACCTGCAACGCCAGGTGATTGCCGACATGCTACGCGACTGGGATAAGCGCTATCCTGGACGGATCGAG
ACGATGTTTAGCGCCATGCAGAATGTCGTGCCGTCTCACCTTTGTGACACTAACCTGTTCGATTTCAAAGGGATCACTCA
CGGTTCCGAGGTCGTCGACGGCGGTGATTTAGCGTTCGATCGTGAAGAGATTCCCTTGCAGCCCGCTGGCTGGCAGCCGG
AAGAAGATGACACCTCCTTAGAGGCGTTGCGGCTTGATGTTATCGAAGTGAAATAA

Upstream 100 bases:

>100_bases
TGACATGAACGACGAACAGGTAGCGATGTTGAATGCGCGGTTATCGTAGTTGCAAAGTTTGCCCCCAATTTGCCCCATTT
AGTACCAGAGAACTGAAATA

Downstream 100 bases:

>100_bases
TCTGCAGGCGTCTCAGCACTCCGCTGAGACGCCATACTATCGATCATTTTAATAGCCGTACCCGGCATGACTTGCCTTTG
ATCTTCCCGTTTTGCAACTG

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSLEALRLDVIEVK

Sequences:

>Translated_311_residues
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSLEALRLDVIEVK
>Mature_311_residues
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSLEALRLDVIEVK

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=311, Percent_Identity=94.5337620578778, Blast_Score=615, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI193211090, Length=250, Percent_Identity=31.6, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17540090, Length=235, Percent_Identity=27.2340425531915, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 35374; Mature: 35374

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKT
HHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
CEEEECCHHHHCHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
EALRLDVIEVK
HHHEEEEEECC
>Mature Secondary Structure
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKT
HHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
CEEEECCHHHHCHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
EALRLDVIEVK
HHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA