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The map label for this gene is cvrA [H]

Identifier: 194735060

GI number: 194735060

Start: 1877816

End: 1879549

Strand: Direct

Name: cvrA [H]

Synonym: SeSA_A1943

Alternate gene names: 194735060

Gene position: 1877816-1879549 (Clockwise)

Preceding gene: 194734546

Following gene: 194735382

Centisome position: 39.88

GC content: 54.56

Gene sequence:

>1734_bases
TTGGATGCTGCAACAATTATTAGTCTATTTATTTTAGGTTCCATCCTTGTAACCAGCAGTATCCTGTTAAGTTCATTCTC
ATCGCGACTGGGCATCCCGATTCTGGTCATTTTCCTCGCCATTGGGATGTTAGCGGGTGTGGATGGCATTGGCGGTATTC
CTTTCGATAATTATCCTTTCGCTTATATGGTCAGTAACCTGGCGCTGGCGATTATTTTACTCGATGGCGGCATGCGCACC
CAGGCCAGCTCTTTCCGGGTAGCGCTGGGCCCCGCGCTGTCGCTGGCGACGCTCGGCGTACTGATCACGTCGGGGTTAAC
AGGTATGATGGCCGCCTGGCTGTTTCATCTGGATCTTATTGAAGGTCTGCTCATTGGCGCGATAGTCGGTTCCACTGACG
CCGCAGCGGTCTTTTCTCTGCTTGGCGGCAAAGGGCTAAACGAACGTGTAGGCTCCACGCTGGAGATCGAATCGGGAAGT
AACGACCCGATGGCCGTTTTTCTGACCATTACATTAATTGAGATGATCCAGAAACATGAAACCGGTCTGGACTGGATGTT
TGCCGTCCATATTATCCAGCAGTTCGGTCTCGGTATTGTTTTTGGTCTCGGCGGCGGTTACCTGCTACAGCAGATGATCA
ACCGCATTTCTCTGCCCAGCGGCCTGTATCCGATGTTGGCGCTCAGCGGCGGTATTCTGATTTTTGCTTTGACGACCGCG
CTTGAAGGCAGCGGTATTCTCGCGGTCTATCTGTGCGGATTCCTGTTAGGAAACCGCCCGATTCGCAACCGTTACGGCAT
CCTGCAAAACTTTGACGGACTGGCCTGGCTGGCGCAGATCGCGATGTTCCTGGTCCTGGGGCTGTTGGTGACGCCTTCCG
ATCTGTGGCCGATTGCCGTCCCTGCGCTCATTCTCTCTATCTGGATGATTTTCTTCGCCCGCCCACTGTCGGTGTTTACC
GGCCTGCTGCCATTTCGCGGCTTTAATCTTCGGGAGCGCATTTTCATCAGTTGGGTCGGACTGCGCGGCGCGGTGCCGAT
TATTCTCGCCGTTTTCCCGATGATGGCCGGGCTTGAAAACGCTCGCCTGTTCTTTAATGTCGCTTTCTTTGTGGTACTGG
TGTCACTGCTCCTGCAGGGAACATCGCTGTCATGGGCGGCGAAAAGAGCCAAAGTGGTCGTGCCTCCGGTTGGCTGGCCA
GTATCGCGCGTGGGGCTTGACATCCATCCTGATAATCCGTGGGAGCAATTCATCTATCAGTTGAGCGCCGACAAATGGTG
CGTCGGCGCGGCGTTGCGCGACCTGCATATGCCGAACGAAACCCGCATTGCCGCGCTATTTCGCAATAATGAACTGTTTC
ACCCCACGGGCAGTACTCGCCTGCAGGAAGGCGACGTACTCTGCGTGATTGGCCGGGAGCGCGATCTGCCAGCGCTAGGC
AAATTGTTTAGCCAGTCGCCGCCGGTTTCGTTAGATCAGCGTTTCTTTGGCGATTTTATCCTCGAAGCGAATGCGAAATT
CGCCGACGTGGCGCTTATCTACGGGCTGGAAGAAGGAACGGAATACCGGGATAAACAACAAACCCTCGGTGAAATCATAC
AGCAACTGCTGGGCGCTGCGCCGGTCGTCGGCGATCAGGTGGAGTTTGGCGGCATGATTTGGACGGTAGCTGAAAAAGAA
GATAACGTGGTACGCAAGATTGGGGTACGCGTCGCCGAAGACGAAGCAGAATAA

Upstream 100 bases:

>100_bases
GTAAAAAAAGTCCCCGACAGGCTAAGTAAAACGCTGCCCTGGCCGTTATTATGTTAATGTTAAATAATACGAAGTCGTGT
GAGTCAGGAGATATAAAACG

Downstream 100 bases:

>100_bases
GGTCGTCGGACAACGTCGACCCGCCCCCAAGTGGACCGGTCGACGCCTTAGCCTGAATTAGGTTACGTTGTCACAAACGG
CACACGCGGCGCTACGGCGC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQKHETGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAVPALILSIWMIFFARPLSVFT
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWP
VSRVGLDIHPDNPWEQFIYQLSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALG
KLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAAPVVGDQVEFGGMIWTVAEKE
DNVVRKIGVRVAEDEAE

Sequences:

>Translated_577_residues
MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQKHETGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAVPALILSIWMIFFARPLSVFT
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWP
VSRVGLDIHPDNPWEQFIYQLSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALG
KLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAAPVVGDQVEFGGMIWTVAEKE
DNVVRKIGVRVAEDEAE
>Mature_577_residues
MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQKHETGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAVPALILSIWMIFFARPLSVFT
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWP
VSRVGLDIHPDNPWEQFIYQLSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALG
KLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAAPVVGDQVEFGGMIWTVAEKE
DNVVRKIGVRVAEDEAE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=577, Percent_Identity=92.5476603119584, Blast_Score=989, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 62470; Mature: 62470

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQKHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHHC
TGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTA
CCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PALILSIWMIFFARPLSVFTGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHCCCC
ARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWPVSRVGLDIHPDNPWEQFIYQ
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEECCCCCCHHHCCEECCCCCHHHHHHHH
LSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCCHHHH
KLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAA
HHHCCCCCCCHHHHHHHHHHEECCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
PVVGDQVEFGGMIWTVAEKEDNVVRKIGVRVAEDEAE
CCCCCCEECCCEEEEEECCCCHHHHHHCCEEECCCCC
>Mature Secondary Structure
MDAATIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGIGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFHLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQKHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHHC
TGLDWMFAVHIIQQFGLGIVFGLGGGYLLQQMINRISLPSGLYPMLALSGGILIFALTTA
CCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVTPSDLWPIAV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PALILSIWMIFFARPLSVFTGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHCCCC
ARLFFNVAFFVVLVSLLLQGTSLSWAAKRAKVVVPPVGWPVSRVGLDIHPDNPWEQFIYQ
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEECCCCCCHHHCCEECCCCCHHHHHHHH
LSADKWCVGAALRDLHMPNETRIAALFRNNELFHPTGSTRLQEGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCCHHHH
KLFSQSPPVSLDQRFFGDFILEANAKFADVALIYGLEEGTEYRDKQQTLGEIIQQLLGAA
HHHCCCCCCCHHHHHHHHHHEECCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
PVVGDQVEFGGMIWTVAEKEDNVVRKIGVRVAEDEAE
CCCCCCEECCCEEEEEECCCCHHHHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA