Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 194734815

GI number: 194734815

Start: 234293

End: 236350

Strand: Direct

Name: fhuB [H]

Synonym: SeSA_A0223

Alternate gene names: 194734815

Gene position: 234293-236350 (Clockwise)

Preceding gene: 194735158

Following gene: 194735314

Centisome position: 4.98

GC content: 60.84

Gene sequence:

>2058_bases
GTGAGCAGAAAACGTGAAATGCCGGATGGCGGCGCGAAAAACGCCTTATCCGACCTACGGTTCGGGTGCTTTGTAGGCCG
GATAAGGCGAAGCCGCCATCCGGCGTTGCTGTTATTGGCGCTGTTTGTTGCCGCCTGCTGGCTGACATGGGGTAACTTCT
CCGTTGCGCTACCGCGCAGTCAGTGGCAACAGGCTATCTGGTCACCGGATATCGACATCATTGAGCAGATGATTTTTCAT
TACAGCCTGCTGCCAAGACTGGCGATTTCGCTACTGGTGGGCGCGGGACTTGGGCTGGTAGGTGTCCTGTTCCAGCAAGT
ATTACGTAACCCGCTGGCGGAACCGACCACGCTGGGCGTGGCGACCGGCGCGCAATTGGGGATCACGGTGACTACGCTTT
GGGCGATTCCCGGCGCGCTGGCGACGCAGTTTGCCGCCCTGACGGGAGCCTGCATTGTCGGCGCGCTGGTGTTCGGCGTG
GCGTGGGGCAAACGTCTGTCGCCAGTGACCCTGATCCTCGCCGGGTTGGTGGTTAGCCTCTATTGTGGTGCAATCAACCA
GTTACTGGTGATTTTCCACCACGATCAGTTGCAAAGCATGTTTTTATGGAGCACCGGAACGCTGACACAAACCGACTGGA
GTGGCGTGCAGCGTCTGTGGCCGCAGTTGCTGGGCGGCGTAATGCTCACGTTATTGTTGTTACGTCCGATGACGCTGATG
GGGCTGGATGACGGCGTTGCGCGTAATCTGGGGCTGGCGCTGTCGTTAGCGCGTCTGGCGGCGCTGTCGCTGGCGATTGT
GTTGAGCGCGCTGCTGGTCAACGCGGTGGGCATTATCGGTTTTATCGGCCTGTTTGCGCCGCTGCTGGCGAAAATGCTTG
GCGCAAGACGTCTGCTGGCGCGCCTGATGCTGGCGCCGCTCATTGGGGCGCTTATTTTGTGGCTATCCGATCAGATTATC
CTTTGGCTCACCCGCGTATGGATGGAAGTTTCCACCGGTTCAGTGACGGCGCTAATCGGCGCGCCGCTGCTCCTGTGGCT
GCTGCCGCGGCTTAAAAGCATGAGCGCGCCGGATATGAACGCCAGCGATCGTGTGGCGGCGGAGCGTCGGCATGTCCTCG
CTTTTGCCGTTGCCGGTGGCGCGCTCTTGCTGCTGGCAACATGGGGCGCGCTCTCTTTTGGTCGCGACGCGCACGGCTGG
ACGTGGGCGAGCGGAACGCTGCTTGAGGAACTGATGCCGTGGCGCTGGCCGCGGATACTGGCGGCGTTAATGGCGGGCGT
CATGCTGGCGGTGGCGGGCTGCATTATTCAGCGTCTGACCGGTAATCCAATGGCCAGTCCGGAAGTGCTGGGGATCAGTT
CCGGAGCCGCGTTTGGCGTGGTGTTGATGCTGTTTTTGGTGCCGGGGAATGCCTTCGGTTGGCTACTGCCCGCCGGAAGC
CTGGGCGCGGCGGCGACACTGCTGATTATTATGTTAGCCGCCGGACGCGGCGGTTTCTCGCCACAACGGATGTTGCTGGC
GGGGATGGCGCTCAGCACCGCGTTTACCATGCTGCTAATGATGCTCCAGGCGAGCGGCGACCCGCGGATGGCGGAAGTGT
TGACCTGGATCGCAGGATCTACCTATAACGCCACTGGCGGGCAGGTTACGCGAACCGCGATCGTAATGGTGATTTTGCTG
GCAATTGTGCCGTTGTGTCGCCGCTGGTTAACGATTTTGCCACTGGGCGGCGATGCCGCGCGTGCGGTGGGCATGGCGCT
TACGCCGTCGCGTATCGCGCTGCTGGCGCTGGCGGCTTGTTTGACGGCAACTGCGACGATGACCATTGGGCCGCTGAGTT
TCGTTGGACTGATGGCGCCACATATTGCGCGGATGCTCGGTTTTCGCCGGACGATGCCGCATATGGTCATCTCGGCGCTG
GCAGGGGGCGTTTTACTGGTCTTTGCCGACTGGTGCGGCAGGATGGCGCTATTTCCGTATCAGATCCCGGCGGGACTGCT
TTCAAGCTTTATTGGCGCGCCGTACTTTATCTATTTGCTACGTAAACAGAGCCGCTGA

Upstream 100 bases:

>100_bases
CCGGGCGCTTTCACCGGGTGCCCGCCGTTTGGTTCTATGGCGCGACCCTCTCCACGATGCATTTTGTCCGCATCCTGAAT
AACGTGTTGGGAGGCAAAGC

Downstream 100 bases:

>100_bases
GTTTGCCGGATGGCGGCATAAATGCCTTATCCGGCCTGCGGTGTAGAATGTAGGCCGGGTAAGCGTAAGCGTCACCCGGC
AATTCATCCTTTACAATTTC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MSRKREMPDGGAKNALSDLRFGCFVGRIRRSRHPALLLLALFVAACWLTWGNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALATQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWGALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMLAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWIAGSTYNATGGQVTRTAIVMVILL
AIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Sequences:

>Translated_685_residues
MSRKREMPDGGAKNALSDLRFGCFVGRIRRSRHPALLLLALFVAACWLTWGNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALATQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWGALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMLAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWIAGSTYNATGGQVTRTAIVMVILL
AIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR
>Mature_684_residues
SRKREMPDGGAKNALSDLRFGCFVGRIRRSRHPALLLLALFVAACWLTWGNFSVALPRSQWQQAIWSPDIDIIEQMIFHY
SLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALATQFAALTGACIVGALVFGVA
WGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLMG
LDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQIIL
WLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLAFAVAGGALLLLATWGALSFGRDAHGWT
WASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSL
GAAATLLIIMLAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWIAGSTYNATGGQVTRTAIVMVILLA
IVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALA
GGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=643, Percent_Identity=90.9797822706065, Blast_Score=1033, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=36.101083032491, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.2313167259786, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=32.3741007194245, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=35.7400722021661, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=33.4494773519164, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 73006; Mature: 72875

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKREMPDGGAKNALSDLRFGCFVGRIRRSRHPALLLLALFVAACWLTWGNFSVALPRS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHH
QWQQAIWSPDIDIIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALATQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLAFAVAGGALLLLATWGALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMLAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWIAGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
TYNATGGQVTRTAIVMVILLAIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SRKREMPDGGAKNALSDLRFGCFVGRIRRSRHPALLLLALFVAACWLTWGNFSVALPRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHH
QWQQAIWSPDIDIIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALATQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLAFAVAGGALLLLATWGALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMLAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMAEVLTWIAGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
TYNATGGQVTRTAIVMVILLAIVPLCRRWLTILPLGGDAARAVGMALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]