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The map label for this gene is ahcY [H]

Identifier: 194333640

GI number: 194333640

Start: 883638

End: 885056

Strand: Reverse

Name: ahcY [H]

Synonym: Paes_0807

Alternate gene names: 194333640

Gene position: 885056-883638 (Counterclockwise)

Preceding gene: 194333641

Following gene: 194333639

Centisome position: 35.22

GC content: 51.73

Gene sequence:

>1419_bases
ATGATGACTACTGACACTGCAGTCCTCGACTACAAAGTGGCAGATATCTCGCTGGCTGAATGGGGCAGAAAAGAGATTGA
AATCGCGGAAAAAGAGATGCCCGGGCTGATGGCCACAAGAGCCAAGTATGAAGGGCAGCAACCACTGAAGGGAGCCCGCA
TCACAGGTTCGCTTCATATGACCATTCAGACTGCGGTTTTGATTGAAACCCTGGTTGAACTGGGCGCTGAAGTCCGCTGG
GCGAGCTGCAATATTTTCTCCACCCAGGATCATGCCGCTGCAGCTATTGCAGCAGCAGGGGTTCCGGTTTTTGCCTGGAA
AGGGGAAACCCTTGAAGAGTACTGGTGGTGCACTCGCCAGGCGCTTGCTTTCGATGGCGGTAAAGGGCCAAACATGATTG
TCGATGACGGTGGCGATGCTACGCTGATGATCATCCTCGGCTACAAAATCGAAAACAATCCTGCACTGCTCGATGTCACC
CCCGGCAACGCCGAGGAAAAAGCGCTTTACGGCCAGCTCAAAGAGGTGTTCGAAAGCGACAACCAGCACTGGCACAAAGT
TGCAGCTGAAATCAAGGGCGTTTCCGAGGAAACAACCACCGGCGTACACAGACTCTACCAGATGATGGAAAAAGGCGAAC
TGCTCTTCCCTGCCATCAACGTCAACGACTCGGTCACCAAATCGAAGTTTGACAACCTGTACGGCTGTCGTGAATCGCTT
GCTGACGGCATCAAGCGTGCAACTGACGTTATGTTAGCAGGAAAAATCGTTGTTGTGCTGGGATACGGTGATGTCGGAAA
GGGCTGTGCCCACTCCATGCGCACCTATGGCTCACGCGTCATTGTGACAGAAATCGATCCGATCTGTGCCCTTCAGGCAT
CGATGGAAGGCTTTGAGGTCACGACCATGGAAGAAGCCGTCAAAGAAGGCAACATTTTTGTCACCACGACAGGCAACAAA
GACGTCATTACCCTTGAGCACATGAAACAGATGAGGGACGAAGCCATCATCTGCAATATCGGCCATTTCGACAATGAAAT
CCAGGTCGATATGCTCAACAACTTCGAAGGTGCATCAAGAACCAACATCAAACCGCAGGTCGACAAATACACCTTTGAAG
ATGGGCGTTCTATCTACCTGCTTGCTGAAGGTCGCCTGGTCAACCTTGGCTGTGCTACCGGTCACCCGTCGTTCGTCATG
AGCAACTCGTTCACGAACCAGACCCTTGCTCAGCTTGAACTCTGGACAAAAGAGTACGAAACCGGTGTCTACCGTCTTCC
TAAAGAACTGGACGAGGAGGTTGCACGACTTCACCTCGGACAGATTGGTGTAAAACTCACCACACTGTCAAAAGAACAGG
CCGATTATATCGGCGTCCCTGTCGAAGGCCCTTATAAACCAGAGCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
ACGCGATATCTTCCCATGGGAAAAAACCGATAAGGTTGAAGAACTCAAAAAAGCCTTCAACCTCTGATACGATATTACTT
AAAGACACAAAACAAAGACT

Downstream 100 bases:

>100_bases
TTGAAAGGTTTTCCACATACGACCAACAGCCCGGCACCATCCGGGCTGTTGGTGTTTACGGCAGGTTGAGGTGATTGGTG
ATTAGTGATTAGTGATTAGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MMTTDTAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRAKYEGQQPLKGARITGSLHMTIQTAVLIETLVELGAEVRW
ASCNIFSTQDHAAAAIAAAGVPVFAWKGETLEEYWWCTRQALAFDGGKGPNMIVDDGGDATLMIILGYKIENNPALLDVT
PGNAEEKALYGQLKEVFESDNQHWHKVAAEIKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESL
ADGIKRATDVMLAGKIVVVLGYGDVGKGCAHSMRTYGSRVIVTEIDPICALQASMEGFEVTTMEEAVKEGNIFVTTTGNK
DVITLEHMKQMRDEAIICNIGHFDNEIQVDMLNNFEGASRTNIKPQVDKYTFEDGRSIYLLAEGRLVNLGCATGHPSFVM
SNSFTNQTLAQLELWTKEYETGVYRLPKELDEEVARLHLGQIGVKLTTLSKEQADYIGVPVEGPYKPEHYRY

Sequences:

>Translated_472_residues
MMTTDTAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRAKYEGQQPLKGARITGSLHMTIQTAVLIETLVELGAEVRW
ASCNIFSTQDHAAAAIAAAGVPVFAWKGETLEEYWWCTRQALAFDGGKGPNMIVDDGGDATLMIILGYKIENNPALLDVT
PGNAEEKALYGQLKEVFESDNQHWHKVAAEIKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESL
ADGIKRATDVMLAGKIVVVLGYGDVGKGCAHSMRTYGSRVIVTEIDPICALQASMEGFEVTTMEEAVKEGNIFVTTTGNK
DVITLEHMKQMRDEAIICNIGHFDNEIQVDMLNNFEGASRTNIKPQVDKYTFEDGRSIYLLAEGRLVNLGCATGHPSFVM
SNSFTNQTLAQLELWTKEYETGVYRLPKELDEEVARLHLGQIGVKLTTLSKEQADYIGVPVEGPYKPEHYRY
>Mature_472_residues
MMTTDTAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRAKYEGQQPLKGARITGSLHMTIQTAVLIETLVELGAEVRW
ASCNIFSTQDHAAAAIAAAGVPVFAWKGETLEEYWWCTRQALAFDGGKGPNMIVDDGGDATLMIILGYKIENNPALLDVT
PGNAEEKALYGQLKEVFESDNQHWHKVAAEIKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESL
ADGIKRATDVMLAGKIVVVLGYGDVGKGCAHSMRTYGSRVIVTEIDPICALQASMEGFEVTTMEEAVKEGNIFVTTTGNK
DVITLEHMKQMRDEAIICNIGHFDNEIQVDMLNNFEGASRTNIKPQVDKYTFEDGRSIYLLAEGRLVNLGCATGHPSFVM
SNSFTNQTLAQLELWTKEYETGVYRLPKELDEEVARLHLGQIGVKLTTLSKEQADYIGVPVEGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=63.9484978540773, Blast_Score=581, Evalue=1e-166,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=63.5746606334842, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=48.9270386266094, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=48.9270386266094, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=48.9270386266094, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=48.9270386266094, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=47.4248927038627, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=64.882226980728, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=60, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=64.8706896551724, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24656245, Length=467, Percent_Identity=48.1798715203426, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=48.3870967741936, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=48.2758620689655, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52259; Mature: 52259

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTTDTAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRAKYEGQQPLKGARITGSLHM
CCCCCCEEEEEEEEEEEHHHCCCHHEEEHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEEE
TIQTAVLIETLVELGAEVRWASCNIFSTQDHAAAAIAAAGVPVFAWKGETLEEYWWCTRQ
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
ALAFDGGKGPNMIVDDGGDATLMIILGYKIENNPALLDVTPGNAEEKALYGQLKEVFESD
HEEECCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCC
NQHWHKVAAEIKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ADGIKRATDVMLAGKIVVVLGYGDVGKGCAHSMRTYGSRVIVTEIDPICALQASMEGFEV
HHHHHHHHHHEEECEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCEE
TTMEEAVKEGNIFVTTTGNKDVITLEHMKQMRDEAIICNIGHFDNEIQVDMLNNFEGASR
EHHHHHHHCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCC
TNIKPQVDKYTFEDGRSIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQLELWTKEYE
CCCCCCCCCEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHC
TGVYRLPKELDEEVARLHLGQIGVKLTTLSKEQADYIGVPVEGPYKPEHYRY
CCHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMTTDTAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRAKYEGQQPLKGARITGSLHM
CCCCCCEEEEEEEEEEEHHHCCCHHEEEHHHHCCCHHHHHHHCCCCCCCCCCEEEEEEEE
TIQTAVLIETLVELGAEVRWASCNIFSTQDHAAAAIAAAGVPVFAWKGETLEEYWWCTRQ
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
ALAFDGGKGPNMIVDDGGDATLMIILGYKIENNPALLDVTPGNAEEKALYGQLKEVFESD
HEEECCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCC
NQHWHKVAAEIKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ADGIKRATDVMLAGKIVVVLGYGDVGKGCAHSMRTYGSRVIVTEIDPICALQASMEGFEV
HHHHHHHHHHEEECEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCEE
TTMEEAVKEGNIFVTTTGNKDVITLEHMKQMRDEAIICNIGHFDNEIQVDMLNNFEGASR
EHHHHHHHCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCC
TNIKPQVDKYTFEDGRSIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQLELWTKEYE
CCCCCCCCCEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHC
TGVYRLPKELDEEVARLHLGQIGVKLTTLSKEQADYIGVPVEGPYKPEHYRY
CCHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA