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The map label for this gene is ilvC

Identifier: 194333575

GI number: 194333575

Start: 791637

End: 792629

Strand: Reverse

Name: ilvC

Synonym: Paes_0741

Alternate gene names: 194333575

Gene position: 792629-791637 (Counterclockwise)

Preceding gene: 194333576

Following gene: 194333574

Centisome position: 31.54

GC content: 50.45

Gene sequence:

>993_bases
ATGAATGTCTACTATGAGCAGGATGCAGATTTAAAGCACCTGCAAGGAAAAAATATCGCTGTTCTCGGATACGGCAGTCA
GGGCCATGCCCATGCGCTCAACCTTAAAGAGAGCGGCCTGAACGTCTGTGTCGGTCTTCGTACCGACAGCTCATCCTGCG
CAAAAGCAAGACAAGCCGGCCTGGAGGTCAACACCATTGCCGATGCCGTCAAATGGGCTGACATCATCATGATTCTTCTT
CCGGACCAGTACCAGAAAGCCATCTACGAGACAGAAATTGCACCGAATCTCGAAACGGGCAACACCCTCGCGTTTGCTCA
TGGATTCAATATCCATTACAAGCAGATCGTCCCTCCCGAGACGGTCAACGTCATCATGATCGCCCCGAAAAGTCCAGGCC
ACCTGGTTCGCCGTACCTTCACCGAAGGCAATGGTGTTCCCTGTCTGATTGCTGTCCACCAGGATTACACCGGCAATGCC
AAAGAGCAGGCTCTTGCATGGGCAAAAGGTCTTGGCGGCGCAAAAGCAGGCGTTATTGAAACCACAATCAAAGACGAAAC
CGAAACCGATCTTTTCGGCGAACAGGCTGTCCTTTGCGGCGGCTCTGCTGAATTGATCAAGGCTGGCTTCGAAACGCTGG
TTGAAGCAGGTTACCCTGAGGAACTTGCATATTTTGAATGTCTGCACGAACTGAAACTGATCGTCGATCTCTACTATGAA
GGCGGTCTGTCACGCATGAACTATTCAGTCAGTGACACCGCTGAGTACGGCGGGATGACACGCGGCCCTCGTCTCATTAC
GCCTGCAGTCAAGGCTGAAATGAAAAAAATTCTCGAGGAAGTGCAGGATGGAAGGTTTGCAAAAGAGTTCATTGATGAAT
GCAATTCGGGGTACAAAAACCTTACCAGCCTTCGCGAATCAAATACGAACCACCCCATCGAGAAAGTCGGGGCAAAACTC
CGCAACATGATGAGCTGGCTCATTAAAAAATAA

Upstream 100 bases:

>100_bases
GAGATAGCCCGTTCCGGCACGGTTGCCCTGCACCGCGGGGAGAACTGAACGGGTTATTCTTTTCATTACGTCATATCTCA
TAACATTAAAGATAGATCAC

Downstream 100 bases:

>100_bases
GTGATCAAGCATGTTCAAGATTGTCTCTATACCCGGTGACGGGATTGGACCGGAAGTGGTGGCAAGTGCCATCCGGGTCA
TCAATACGCTTGCCCGACAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNVYYEQDADLKHLQGKNIAVLGYGSQGHAHALNLKESGLNVCVGLRTDSSSCAKARQAGLEVNTIADAVKWADIIMILL
PDQYQKAIYETEIAPNLETGNTLAFAHGFNIHYKQIVPPETVNVIMIAPKSPGHLVRRTFTEGNGVPCLIAVHQDYTGNA
KEQALAWAKGLGGAKAGVIETTIKDETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECLHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNSGYKNLTSLRESNTNHPIEKVGAKL
RNMMSWLIKK

Sequences:

>Translated_330_residues
MNVYYEQDADLKHLQGKNIAVLGYGSQGHAHALNLKESGLNVCVGLRTDSSSCAKARQAGLEVNTIADAVKWADIIMILL
PDQYQKAIYETEIAPNLETGNTLAFAHGFNIHYKQIVPPETVNVIMIAPKSPGHLVRRTFTEGNGVPCLIAVHQDYTGNA
KEQALAWAKGLGGAKAGVIETTIKDETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECLHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNSGYKNLTSLRESNTNHPIEKVGAKL
RNMMSWLIKK
>Mature_330_residues
MNVYYEQDADLKHLQGKNIAVLGYGSQGHAHALNLKESGLNVCVGLRTDSSSCAKARQAGLEVNTIADAVKWADIIMILL
PDQYQKAIYETEIAPNLETGNTLAFAHGFNIHYKQIVPPETVNVIMIAPKSPGHLVRRTFTEGNGVPCLIAVHQDYTGNA
KEQALAWAKGLGGAKAGVIETTIKDETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECLHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNSGYKNLTSLRESNTNHPIEKVGAKL
RNMMSWLIKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=318, Percent_Identity=32.0754716981132, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=328, Percent_Identity=32.6219512195122, Blast_Score=136, Evalue=6e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PROA2 (B4S6N3)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015435.1
- ProteinModelPortal:   B4S6N3
- SMR:   B4S6N3
- GeneID:   6459796
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0741
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36216; Mature: 36216

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYYEQDADLKHLQGKNIAVLGYGSQGHAHALNLKESGLNVCVGLRTDSSSCAKARQAG
CCCEECCCCCHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHC
LEVNTIADAVKWADIIMILLPDQYQKAIYETEIAPNLETGNTLAFAHGFNIHYKQIVPPE
CCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCC
TVNVIMIAPKSPGHLVRRTFTEGNGVPCLIAVHQDYTGNAKEQALAWAKGLGGAKAGVIE
CEEEEEECCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
TTIKDETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECLHELKLIVDLYYE
EECCCCCHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNSGYKN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
LTSLRESNTNHPIEKVGAKLRNMMSWLIKK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVYYEQDADLKHLQGKNIAVLGYGSQGHAHALNLKESGLNVCVGLRTDSSSCAKARQAG
CCCEECCCCCHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHC
LEVNTIADAVKWADIIMILLPDQYQKAIYETEIAPNLETGNTLAFAHGFNIHYKQIVPPE
CCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCC
TVNVIMIAPKSPGHLVRRTFTEGNGVPCLIAVHQDYTGNAKEQALAWAKGLGGAKAGVIE
CEEEEEECCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
TTIKDETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECLHELKLIVDLYYE
EECCCCCHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNSGYKN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
LTSLRESNTNHPIEKVGAKLRNMMSWLIKK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA