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The map label for this gene is pdxA

Identifier: 194333552

GI number: 194333552

Start: 765961

End: 766977

Strand: Reverse

Name: pdxA

Synonym: Paes_0718

Alternate gene names: 194333552

Gene position: 766977-765961 (Counterclockwise)

Preceding gene: 194333553

Following gene: 194333551

Centisome position: 30.52

GC content: 53.69

Gene sequence:

>1017_bases
ATGAAGACCACAGCATGGACAATTGGCGACATCCACGGTATCGGACCGGAAATCATTCTGAAAACGTTTGATGAATCGCT
GCGCTCAACCGGTCAGCCAGAAGAAAAACCAATCGTTATCGGCTCGGCTGAAGCGCTTCTTTACTACAGCAAACGCCTCG
GTCTGTCTATCGATATCCGTACCATCGATGCACCCGAAAAAGCCGCAGCATATCCTCAGGGAGTATTGCCGGTTATCAGC
GTCGGAGAGCCATCCTCTCCTCTGCAGCCGGGCACCATCAGTGCCGAAGCAGGCCGGCTCTCAATGCTTGCAATTGAAAA
AGCGGCCAATCTCTGCCTTGAAGGACGCTGTGCGGCTATGGTGACCGCCCCGATTCACAAAGAGGCCGTTGCCAGAGCAG
GCTATCCCCATACCGGTCACACCGATTTTCTCGCCGACCTGTGCGCAACAGATAATCCGACCATGCTCTTCAGAGACCCT
GTATCAGGACTGATGGTCGCTCTGGCGACAATTCACGTGGCGTTGCATAGAGTCCCTGAACTGATCAGATCTATGGATAT
GAGCGCGTTCTTCAGCAACCTCAACCGCTCACTTCAGTCAGATTTCAGAATTGAGCAGCCCAGGATCGCGGTTCTCGGAC
TCAACCCCCACGCCTCTGACGGCGGGGTCATGGGCAGGGAAGAAAAAGAGATCATTCTTCCATGCATTGACGCGCTCGCA
GACAGACAGAATATTGAAGGTCCTTTTGCCGCTGATGGATTTTTCGGGTCAGGGAAATACAGGAACTACGATGTCACTGT
CGCCATGTATCATGACCAGGGACTGCTTCCATTCAAAGTACTGGCATTCGACACCGGTATCAACGTCACGCTCGGCCTCC
CTCTTGTCAGGACATCACCCGATCACGGCACAAGTTTCGACATTGCAGGCCAGGGCAGGGCATCACACCGAAGCTTCAGC
GAAGCGGCAAAACTGGCTTGGGAAATTGCGTTCAACCGCCTCATGGAGCACTCATAG

Upstream 100 bases:

>100_bases
CAGGGTTCTTCGTCCTTATCCCTGAACCACTGCTTTTCTGGCTCGCGATGAAAGGGATACAGAAAGACGAAAAAATTGCT
ACCGCCTATAAACGACTCTG

Downstream 100 bases:

>100_bases
AGCGCACACTCCCCCTGAAACGTCCGGCAATCGTTCAACGAATCAACAAATAAACCTTTCGCATGATATCATTTGTCAAT
GTAGACCTTGAACTCGGCAA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRTIDAPEKAAAYPQGVLPVIS
VGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMVTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDP
VSGLMVALATIHVALHRVPELIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALA
DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSPDHGTSFDIAGQGRASHRSFS
EAAKLAWEIAFNRLMEHS

Sequences:

>Translated_338_residues
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRTIDAPEKAAAYPQGVLPVIS
VGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMVTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDP
VSGLMVALATIHVALHRVPELIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALA
DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSPDHGTSFDIAGQGRASHRSFS
EAAKLAWEIAFNRLMEHS
>Mature_338_residues
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRTIDAPEKAAAYPQGVLPVIS
VGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMVTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDP
VSGLMVALATIHVALHRVPELIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALA
DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSPDHGTSFDIAGQGRASHRSFS
EAAKLAWEIAFNRLMEHS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=327, Percent_Identity=35.7798165137615, Blast_Score=190, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_PROA2 (B4S6L0)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015412.1
- ProteinModelPortal:   B4S6L0
- GeneID:   6459914
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0718
- HOGENOM:   HBG451136
- OMA:   VTLVTIH
- ProtClustDB:   CLSK637382
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36521; Mature: 36521

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: BINDING 140-140 BINDING 141-141 BINDING 279-279 BINDING 288-288 BINDING 297-297

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIR
CCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEHHHCCCEEEEE
TIDAPEKAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAM
ECCCCHHHHCCCCCCCEEEECCCCCCCCCCCEECCCCCCEEHHHHHHHHHHEECCCEEEE
VTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPE
EECCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
LIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSP
HHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCEEEECCEEEECCC
DHGTSFDIAGQGRASHRSFSEAAKLAWEIAFNRLMEHS
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIR
CCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEHHHCCCEEEEE
TIDAPEKAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAM
ECCCCHHHHCCCCCCCEEEECCCCCCCCCCCEECCCCCCEEHHHHHHHHHHEECCCEEEE
VTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPE
EECCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
LIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSP
HHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCEEEECCEEEECCC
DHGTSFDIAGQGRASHRSFSEAAKLAWEIAFNRLMEHS
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA