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The map label for this gene is glcD [H]

Identifier: 194333542

GI number: 194333542

Start: 753742

End: 755223

Strand: Reverse

Name: glcD [H]

Synonym: Paes_0708

Alternate gene names: 194333542

Gene position: 755223-753742 (Counterclockwise)

Preceding gene: 194333543

Following gene: 194333541

Centisome position: 30.05

GC content: 48.11

Gene sequence:

>1482_bases
ATGCTTTTTAAAACAGATCCATCGCAAATACAGCGATTTCTTGAAGACACCAGCAATATCAGAACAGGCTCTACCCCGGG
AGTCTACTTCCCGCAAAACGCCGATGAGGTCCGTGATATTGTCATCGATGCACAGACAACAGGCAAACGACTCGTTATTG
CAGGAAACGCAACAGGAACGACCGGAGGCAGGATACCATTCGGAGACTATGTCATTTCGACAGAAAAACTCAATCATATC
GGTGAGATTGTCGAAACAGGCAACAATCTGGCAACGCTGACAGCTGGTGCTGGTGTTCTTCTGGAAGATATTCAAAACAA
ATGCCTTGAATCCGGCTGGTTCTATCCTCCCGACCCAACTGAAAAGCTCTGCTTCATCGGCAGTACGATCGCAAATAATT
CCTCCGGGGCAAGAACCTTGAAATACGGCCCCACACGCAACCATATCGCCCGACTGAAACTTCTCCTTTCCACGGGGGAG
ATCCTCGATCTCCGGAGAGGAGAACAGTATGCAGATGCATCGGGTACAATCCGCTGCAACATACCATCAGGAAGAACACT
CGAATTCGACATTGCGCGTTACAGCATGCCTGCGACCTCAAAGCACAATGCCGGTTACTTTTCGGCTCCCGGCATGGACC
TCGTTGATCTGTTTATCGGCTCGGAAGGAACCCTTGGCATCATTCTTGAGGCAGAGCTCGTGCTGCGACCTGCACCGGAA
AAAATCATCTCATTCCTGATTTATTTCAGCACTCTTGACGACCTGTTTTCCTTTGTCTCAAGGGCAAAACAGGGAGACTA
CGGGGTAGAGCCCAGAGCGCTTGAGCTTTTCGAAAAAAACGCGCTGAATTTTCTTCGCAATGTCTATCCCGAAATCCCCC
TTGACACAGCTGGCGCGATATTCCTTGAGCAGGAGGCAACTGAACAAACAGAAGAAATGCTGCTCGAATCATGGTTCGAA
CTGATGGAATCATGCAATGCGATGACTGATGAGTCATGGGTAGCGCTTGACACCGAAGAACAACGTGCCATGAAAGCGTT
TCGTCACGAGCTCCCGGTTCAGGTCAACGAATGGCTCAGCCATCAGGCGGAAAGCAAAATCAGCACTGATATGGCTGTTC
CCGAAGCGTCGTTCAGAGAGTTATTCGACTTTTACAGGAACCGTTGCCAGGAACGAGACTTTCGTTACATTATTTTCGGC
CATGCAGGTAACGCACATGTCCATCTGAATATTCTTCCGAAAAATCATGAGGAGTATCTGGAAGCAAAAAAGCTCTACCT
GGATCTCGTCGATAAAGCGCTTCAACTTGGAGGAACCCTGTCGGCAGAGCATGGAATCGGAAAACTGAAAGCAGAATATC
TGGTAAAAATGTTCGGCCGTGAAGGCATTTTGGAGATGGTACGGATAAAAAAATACCTTGATCCGTTCCTTATGCTCAAT
ATGGGGAACCTGATACCATTAGAATATTACGAAACCTGTTGA

Upstream 100 bases:

>100_bases
GCCGCAACTCCCGCTCGGATAATTGCCACGCAAAACGTTCAGGATTCGGCGCTGACGGCGATCCCCGACAGTCTGAAAAA
GCTCAACAACAACGAGACGA

Downstream 100 bases:

>100_bases
AAACGGAAACAGAACGTGGCTAAACAGCAACAGAAACCACAATATGTAAGCACCATCCTGAACCGCAAGGCAAGGCATGA
GTTCACCATTCTCGAAACAG

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MLFKTDPSQIQRFLEDTSNIRTGSTPGVYFPQNADEVRDIVIDAQTTGKRLVIAGNATGTTGGRIPFGDYVISTEKLNHI
GEIVETGNNLATLTAGAGVLLEDIQNKCLESGWFYPPDPTEKLCFIGSTIANNSSGARTLKYGPTRNHIARLKLLLSTGE
ILDLRRGEQYADASGTIRCNIPSGRTLEFDIARYSMPATSKHNAGYFSAPGMDLVDLFIGSEGTLGIILEAELVLRPAPE
KIISFLIYFSTLDDLFSFVSRAKQGDYGVEPRALELFEKNALNFLRNVYPEIPLDTAGAIFLEQEATEQTEEMLLESWFE
LMESCNAMTDESWVALDTEEQRAMKAFRHELPVQVNEWLSHQAESKISTDMAVPEASFRELFDFYRNRCQERDFRYIIFG
HAGNAHVHLNILPKNHEEYLEAKKLYLDLVDKALQLGGTLSAEHGIGKLKAEYLVKMFGREGILEMVRIKKYLDPFLMLN
MGNLIPLEYYETC

Sequences:

>Translated_493_residues
MLFKTDPSQIQRFLEDTSNIRTGSTPGVYFPQNADEVRDIVIDAQTTGKRLVIAGNATGTTGGRIPFGDYVISTEKLNHI
GEIVETGNNLATLTAGAGVLLEDIQNKCLESGWFYPPDPTEKLCFIGSTIANNSSGARTLKYGPTRNHIARLKLLLSTGE
ILDLRRGEQYADASGTIRCNIPSGRTLEFDIARYSMPATSKHNAGYFSAPGMDLVDLFIGSEGTLGIILEAELVLRPAPE
KIISFLIYFSTLDDLFSFVSRAKQGDYGVEPRALELFEKNALNFLRNVYPEIPLDTAGAIFLEQEATEQTEEMLLESWFE
LMESCNAMTDESWVALDTEEQRAMKAFRHELPVQVNEWLSHQAESKISTDMAVPEASFRELFDFYRNRCQERDFRYIIFG
HAGNAHVHLNILPKNHEEYLEAKKLYLDLVDKALQLGGTLSAEHGIGKLKAEYLVKMFGREGILEMVRIKKYLDPFLMLN
MGNLIPLEYYETC
>Mature_493_residues
MLFKTDPSQIQRFLEDTSNIRTGSTPGVYFPQNADEVRDIVIDAQTTGKRLVIAGNATGTTGGRIPFGDYVISTEKLNHI
GEIVETGNNLATLTAGAGVLLEDIQNKCLESGWFYPPDPTEKLCFIGSTIANNSSGARTLKYGPTRNHIARLKLLLSTGE
ILDLRRGEQYADASGTIRCNIPSGRTLEFDIARYSMPATSKHNAGYFSAPGMDLVDLFIGSEGTLGIILEAELVLRPAPE
KIISFLIYFSTLDDLFSFVSRAKQGDYGVEPRALELFEKNALNFLRNVYPEIPLDTAGAIFLEQEATEQTEEMLLESWFE
LMESCNAMTDESWVALDTEEQRAMKAFRHELPVQVNEWLSHQAESKISTDMAVPEASFRELFDFYRNRCQERDFRYIIFG
HAGNAHVHLNILPKNHEEYLEAKKLYLDLVDKALQLGGTLSAEHGIGKLKAEYLVKMFGREGILEMVRIKKYLDPFLMLN
MGNLIPLEYYETC

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595754, Length=485, Percent_Identity=26.3917525773196, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI37595756, Length=476, Percent_Identity=26.0504201680672, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI119964728, Length=488, Percent_Identity=23.7704918032787, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789351, Length=469, Percent_Identity=23.2409381663113, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787977, Length=506, Percent_Identity=24.3083003952569, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534361, Length=466, Percent_Identity=26.3948497854077, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71992373, Length=495, Percent_Identity=26.2626262626263, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71992381, Length=433, Percent_Identity=26.7898383371824, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=26.5625, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=473, Percent_Identity=24.3128964059197, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320023, Length=497, Percent_Identity=23.5412474849095, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320764, Length=491, Percent_Identity=21.5885947046843, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 55364; Mature: 55364

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKTDPSQIQRFLEDTSNIRTGSTPGVYFPQNADEVRDIVIDAQTTGKRLVIAGNATGT
CCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHEEEECCCCCCEEEEECCCCCC
TGGRIPFGDYVISTEKLNHIGEIVETGNNLATLTAGAGVLLEDIQNKCLESGWFYPPDPT
CCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
EKLCFIGSTIANNSSGARTLKYGPTRNHIARLKLLLSTGEILDLRRGEQYADASGTIRCN
CCEEEEECHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEEE
IPSGRTLEFDIARYSMPATSKHNAGYFSAPGMDLVDLFIGSEGTLGIILEAELVLRPAPE
CCCCCEEEEEHHHCCCCCCCCCCCCEECCCCCHHHHHEECCCCCEEEEEEEEEEECCCHH
KIISFLIYFSTLDDLFSFVSRAKQGDYGVEPRALELFEKNALNFLRNVYPEIPLDTAGAI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
FLEQEATEQTEEMLLESWFELMESCNAMTDESWVALDTEEQRAMKAFRHELPVQVNEWLS
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHH
HQAESKISTDMAVPEASFRELFDFYRNRCQERDFRYIIFGHAGNAHVHLNILPKNHEEYL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHH
EAKKLYLDLVDKALQLGGTLSAEHGIGKLKAEYLVKMFGREGILEMVRIKKYLDPFLMLN
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHEEEC
MGNLIPLEYYETC
CCCCCCCHHHCCC
>Mature Secondary Structure
MLFKTDPSQIQRFLEDTSNIRTGSTPGVYFPQNADEVRDIVIDAQTTGKRLVIAGNATGT
CCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHEEEECCCCCCEEEEECCCCCC
TGGRIPFGDYVISTEKLNHIGEIVETGNNLATLTAGAGVLLEDIQNKCLESGWFYPPDPT
CCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
EKLCFIGSTIANNSSGARTLKYGPTRNHIARLKLLLSTGEILDLRRGEQYADASGTIRCN
CCEEEEECHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEEE
IPSGRTLEFDIARYSMPATSKHNAGYFSAPGMDLVDLFIGSEGTLGIILEAELVLRPAPE
CCCCCEEEEEHHHCCCCCCCCCCCCEECCCCCHHHHHEECCCCCEEEEEEEEEEECCCHH
KIISFLIYFSTLDDLFSFVSRAKQGDYGVEPRALELFEKNALNFLRNVYPEIPLDTAGAI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
FLEQEATEQTEEMLLESWFELMESCNAMTDESWVALDTEEQRAMKAFRHELPVQVNEWLS
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHH
HQAESKISTDMAVPEASFRELFDFYRNRCQERDFRYIIFGHAGNAHVHLNILPKNHEEYL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHH
EAKKLYLDLVDKALQLGGTLSAEHGIGKLKAEYLVKMFGREGILEMVRIKKYLDPFLMLN
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHEEEC
MGNLIPLEYYETC
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]