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The map label for this gene is murA

Identifier: 194333532

GI number: 194333532

Start: 743738

End: 745015

Strand: Reverse

Name: murA

Synonym: Paes_0698

Alternate gene names: 194333532

Gene position: 745015-743738 (Counterclockwise)

Preceding gene: 194333536

Following gene: 194333525

Centisome position: 29.65

GC content: 51.25

Gene sequence:

>1278_bases
ATGGATAAACTGGTTATCAATGGAGGACATCGCCTCACCGGATCGGTGGCAGCGTCCGGCTCGAAAAACTCTGCACTACC
CCTTATTGCAGCCACACTCCTGTGCGACAATGGAACCTGTAGGCTGGAAAGGATCCCGGACCTTAAAGACACACGAACAT
TTCAGGAACTGCTGGCATACCTCGGCGCCGATATCTCCTACAGCGGATCGAGACTGAGCGTCAGCACCCAAAACCTTCGA
GCTATCCAGGCTCCTTATGAACTCGTCAAAAAAATGAGAGCTTCGATCTATGTACTCGGGCCTCTGCTTGCCCGGTTTGG
ACGAGCTGAAGTATCGCTGCCTGGTGGTTGCGCATTCGGACCGCGACCGATTGACCTCCATCTGATGGCAATGGAAAAAC
TGGGCGCATCTATTTCCATAAAAAACGGCTATATCGAGGCCTCGATCGCCAAAGGACGTCTTACTGGAGGACATATAGAG
TTTCCCGTCTCTTCAGTTGGAGCAACAGGCAATGCATTGATGGCCGCATCCCTGGCTGAAGGAACGACAACCATCACCAA
CGCATCGATAGAGCCCGAAATCACTGCCCTCTGCGACTTTCTTATGGCCATGGGAGCTGACATCAAGGGTGCAGGAACAA
CGGCACTCACCATTGAAGGCGTCCCTTCGCTCCATCCGGTCGCATTCACCAATATTTTCGACCGTATCGAAGCAGGAACC
CTTCTTGCCGCTGCAGCCATCACCAAAGGAACTATATCTATCACCGGTATCGACCATACTCACATGGGCGCAGTCCTGAA
AAAATTCAAACAGGCAGGCTGTCGGATCACCATCGATGATGACTCTCTGACACTTCAGAGCCCGGACAGGCTTGAGCCGA
CAGATATCATCGCCAGTCCCTACCCCTTTTTCCCGACAGATATGCAGGCACAGTGGATCGCCCTCATGACCCAGGCAAAC
GGAAGCAGCCGGATCATTGACAAAGTCTATCACGAACGATTCAATCATATCCCGGAACTCAACCGTCTGGGAGCAAAAAT
AGAGATTAATAACAATGAAGCTATCGTGCACGGGCCTCAGTTACTGACCGGCACAACGGTCATGTCTACAGATCTTCGAG
CCTCTGCATGCCTTGTTCTGGCAGGACTGGTCGCCCAAGGGACCACAGAGGTACTCCGAGTCTATCACCTTGACCGTGGT
TACGAAAAAATTGAAGAAAAATTACGTCATCTCGGCGCTGATATACAAAGAGAAAATTATCAGGAGTTCAGCACATAA

Upstream 100 bases:

>100_bases
CCATCATAAGGCTGCCCGAAACAGAAAAGAGCATGAAAGAACTTGCTTTTATCAGGGTGAAATAAGTAAATAACAGCTTT
GACATTTTAAGAGATCTTGT

Downstream 100 bases:

>100_bases
AATTTTACAGAAAAACGCATGAAGGTCTTGTATATTTTCCTCAATAATGTATATTAACAAACTCTGAAGCCGGACGTTGG
CCGGGCCCTTAGCTCAGTTG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAYLGADISYSGSRLSVSTQNLR
AIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFGPRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIE
FPVSSVGATGNALMAASLAEGTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGT
LLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASPYPFFPTDMQAQWIALMTQAN
GSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQLLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRG
YEKIEEKLRHLGADIQRENYQEFST

Sequences:

>Translated_425_residues
MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAYLGADISYSGSRLSVSTQNLR
AIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFGPRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIE
FPVSSVGATGNALMAASLAEGTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGT
LLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASPYPFFPTDMQAQWIALMTQAN
GSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQLLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRG
YEKIEEKLRHLGADIQRENYQEFST
>Mature_425_residues
MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAYLGADISYSGSRLSVSTQNLR
AIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFGPRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIE
FPVSSVGATGNALMAASLAEGTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGT
LLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASPYPFFPTDMQAQWIALMTQAN
GSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQLLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRG
YEKIEEKLRHLGADIQRENYQEFST

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=48.0861244019139, Blast_Score=383, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_PROA2 (B4S6J0)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015392.1
- GeneID:   6460780
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0698
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45561; Mature: 45561

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAY
CCCEEEECCCEEEEEEEECCCCCCCHHHEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
LGADISYSGSRLSVSTQNLRAIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFG
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCCCC
PRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIEFPVSSVGATGNALMAASLAE
CCCCEEEEEEHHHCCCEEEEECCEEEEEEECCCCCCCEEECCHHHCCCCCCCEEEEHHCC
GTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGT
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
LLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASP
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHCCCC
YPFFPTDMQAQWIALMTQANGSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQ
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCEEEECCCEEEEECCE
LLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRGYEKIEEKLRHLGADIQRENY
EEECCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCH
QEFST
HHCCC
>Mature Secondary Structure
MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAY
CCCEEEECCCEEEEEEEECCCCCCCHHHEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
LGADISYSGSRLSVSTQNLRAIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFG
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCCCC
PRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIEFPVSSVGATGNALMAASLAE
CCCCEEEEEEHHHCCCEEEEECCEEEEEEECCCCCCCEEECCHHHCCCCCCCEEEEHHCC
GTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGT
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
LLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASP
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHCCCC
YPFFPTDMQAQWIALMTQANGSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQ
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCEEEECCCEEEEECCE
LLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRGYEKIEEKLRHLGADIQRENY
EEECCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCH
QEFST
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA