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The map label for this gene is nadB1 [H]

Identifier: 194333536

GI number: 194333536

Start: 748077

End: 749672

Strand: Reverse

Name: nadB1 [H]

Synonym: Paes_0702

Alternate gene names: 194333536

Gene position: 749672-748077 (Counterclockwise)

Preceding gene: 194333537

Following gene: 194333532

Centisome position: 29.83

GC content: 50.44

Gene sequence:

>1596_bases
ATGACTGAAGACATACAAACCGATGTCCTGGTTATCGGCAGCGGCATCGGGGGACTCTACTTTGCGCTGAACATAGCCGA
CCATGCCAGGGTAACCATCATCACAAAAAAAGAGAGCTGCGAATCCAACACCAACTGGGCTCAAGGAGGCATAGCAGCAA
CCATTGATCAGAATGACAGCGCTGAACTCCATATCAATGATACCCTCGATGCCGGAGCAGGTCTCTGCAACAAACCGATG
GTTGAAGTAATGGTTAACGAGGGGCCTCAGCATATCCGGAAACTTATAGAACTGGGCGTACAGTTTACGACAACCGATAA
CGACCATCTCGACCTTGGGCGTGAAGGTGGACACTCGCGAAAAAGAATCGTCCATGCCAGTGATCTCACCGGTCAGGAGG
TTGAACACGCACTGCTCGAACGGGTCAACCAGCACCCCAACATCACCCTCCTCGAACACCATTTCGCCATTGAACTGCTC
ACTGAGCATCATGTGCATATCAAAACCAACGAGATCAGCTGCTATGGGGCCTTCGTGCTCGATACCCAAAACCGGAAGCT
CAAAAAAGTTCTTTCGAAAGTCACCATGCTTGCCTCGGGCGGGCTCGGCCATGTCTATCTTCACACCACCAATCCTGATA
TCGCCACCGGCGACGGAATCGCCATGGCCTATCGCGCAGGTGCGTTGATCGCAAACATGGAGTTCATCCAGTTTCACCCG
ACATCACTCTTTCACCCCAAAGCAAAATCATTCCTTATCTCTGAAGCGGTAAGGGGGTTCGGGGGCATTCTGCGGCTTAA
AAACGGCCAGGCATTCATGAAAAAATATGACCCCAGAGAAAATCTCGCGCCCCGCGATATCGTCGCCCGGGCTATAGACT
CTGAAATGAAAAAGACAGGGGATGAATGCGTCTTTCTCGATGTAACCCATCTTGAGCCAGAAAAAACCATCCAGCATTTC
CCGAATATTTATGAGACCTGTCTGGAATTCGGTATTGACATGACAAAAGAGATGATCCCCGTTGTCCCGGCAGCGCATTA
CTCATGCGGCGGCATAAAAACCGACGATGTAGGACGCAGCTCAATCAATCGCCTGTACGCCTGTGGAGAAACAAGCTGCA
CCGGCGTCCACGGAGCCAACAGGCTTGCCAGCAATTCACTGCTTGAAGCGCTGGTGTTCGCCTACAGGTCCTATAAGGAT
ATCAAGCAGACGCTGCACACCATTCACAATAACCTCCCATTCCCGGACTGGGACGACAGCGGGACGACCAACCCTGAAGA
GTGGATTCTTGTTTCTCACAATAAAAAAGAAGCTCAGCAGGTTATGAACGACTACGTCGGCATTGTCCGCAGCGACCTGA
GACTTCAGAGAGCAAAACGGAGAATCGAATTCCTGAAAGAGGAAACAGAAGCCTACTATAAACGAACACGGATCACGACA
GAGATTCTTGAACTGCGAAACATTATCAAAGTCGCAAGCCTTATCATTGAAAGTGCCATAAAAAGAAGAGAATCGCGCGG
GTTGCACTATACGACCGACTACCCGTCGAAAGACGACAAACACTTTCTCATCGATACCGAACTGCGGTCGTTCTGA

Upstream 100 bases:

>100_bases
GTAACGGGTGTCGGCCTCGTGCTCATACTGGAATTGACTGCAGGCAGAAAGCAGGGCGCCCTGAAGCAATACTCATCGTA
ACATCAGCAAATCACATTCA

Downstream 100 bases:

>100_bases
ACAACCCGGTCAGACAGTTGCCTGCCAGTCCCTGGCATACCTGAAATCGATGCCGGGGGTTCTGGATGATATTTTAGCAA
TAACAGGCATCATCCGCTTA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTEDIQTDVLVIGSGIGGLYFALNIADHARVTIITKKESCESNTNWAQGGIAATIDQNDSAELHINDTLDAGAGLCNKPM
VEVMVNEGPQHIRKLIELGVQFTTTDNDHLDLGREGGHSRKRIVHASDLTGQEVEHALLERVNQHPNITLLEHHFAIELL
TEHHVHIKTNEISCYGAFVLDTQNRKLKKVLSKVTMLASGGLGHVYLHTTNPDIATGDGIAMAYRAGALIANMEFIQFHP
TSLFHPKAKSFLISEAVRGFGGILRLKNGQAFMKKYDPRENLAPRDIVARAIDSEMKKTGDECVFLDVTHLEPEKTIQHF
PNIYETCLEFGIDMTKEMIPVVPAAHYSCGGIKTDDVGRSSINRLYACGETSCTGVHGANRLASNSLLEALVFAYRSYKD
IKQTLHTIHNNLPFPDWDDSGTTNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRIEFLKEETEAYYKRTRITT
EILELRNIIKVASLIIESAIKRRESRGLHYTTDYPSKDDKHFLIDTELRSF

Sequences:

>Translated_531_residues
MTEDIQTDVLVIGSGIGGLYFALNIADHARVTIITKKESCESNTNWAQGGIAATIDQNDSAELHINDTLDAGAGLCNKPM
VEVMVNEGPQHIRKLIELGVQFTTTDNDHLDLGREGGHSRKRIVHASDLTGQEVEHALLERVNQHPNITLLEHHFAIELL
TEHHVHIKTNEISCYGAFVLDTQNRKLKKVLSKVTMLASGGLGHVYLHTTNPDIATGDGIAMAYRAGALIANMEFIQFHP
TSLFHPKAKSFLISEAVRGFGGILRLKNGQAFMKKYDPRENLAPRDIVARAIDSEMKKTGDECVFLDVTHLEPEKTIQHF
PNIYETCLEFGIDMTKEMIPVVPAAHYSCGGIKTDDVGRSSINRLYACGETSCTGVHGANRLASNSLLEALVFAYRSYKD
IKQTLHTIHNNLPFPDWDDSGTTNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRIEFLKEETEAYYKRTRITT
EILELRNIIKVASLIIESAIKRRESRGLHYTTDYPSKDDKHFLIDTELRSF
>Mature_530_residues
TEDIQTDVLVIGSGIGGLYFALNIADHARVTIITKKESCESNTNWAQGGIAATIDQNDSAELHINDTLDAGAGLCNKPMV
EVMVNEGPQHIRKLIELGVQFTTTDNDHLDLGREGGHSRKRIVHASDLTGQEVEHALLERVNQHPNITLLEHHFAIELLT
EHHVHIKTNEISCYGAFVLDTQNRKLKKVLSKVTMLASGGLGHVYLHTTNPDIATGDGIAMAYRAGALIANMEFIQFHPT
SLFHPKAKSFLISEAVRGFGGILRLKNGQAFMKKYDPRENLAPRDIVARAIDSEMKKTGDECVFLDVTHLEPEKTIQHFP
NIYETCLEFGIDMTKEMIPVVPAAHYSCGGIKTDDVGRSSINRLYACGETSCTGVHGANRLASNSLLEALVFAYRSYKDI
KQTLHTIHNNLPFPDWDDSGTTNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRIEFLKEETEAYYKRTRITTE
ILELRNIIKVASLIIESAIKRRESRGLHYTTDYPSKDDKHFLIDTELRSF

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=528, Percent_Identity=31.4393939393939, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1788928, Length=512, Percent_Identity=48.046875, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1790597, Length=539, Percent_Identity=31.7254174397032, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1786942, Length=563, Percent_Identity=29.8401420959147, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=536, Percent_Identity=30.410447761194, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=29.7597042513863, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71986328, Length=467, Percent_Identity=27.8372591006424, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=538, Percent_Identity=31.2267657992565, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=534, Percent_Identity=29.9625468164794, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320788, Length=479, Percent_Identity=27.348643006263, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322511, Length=488, Percent_Identity=26.0245901639344, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17137288, Length=543, Percent_Identity=29.8342541436464, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24655642, Length=543, Percent_Identity=29.8342541436464, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24655647, Length=543, Percent_Identity=29.8342541436464, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24663005, Length=541, Percent_Identity=30.1293900184843, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59594; Mature: 59462

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDIQTDVLVIGSGIGGLYFALNIADHARVTIITKKESCESNTNWAQGGIAATIDQNDS
CCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
AELHINDTLDAGAGLCNKPMVEVMVNEGPQHIRKLIELGVQFTTTDNDHLDLGREGGHSR
CEEEECCCCCCCCCCCCCCHHEEEECCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCH
KRIVHASDLTGQEVEHALLERVNQHPNITLLEHHFAIELLTEHHVHIKTNEISCYGAFVL
HEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHEEEEECCCCEEEEECCEEEEEEEEE
DTQNRKLKKVLSKVTMLASGGLGHVYLHTTNPDIATGDGIAMAYRAGALIANMEFIQFHP
ECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHCCHHEECCEEEEECC
TSLFHPKAKSFLISEAVRGFGGILRLKNGQAFMKKYDPRENLAPRDIVARAIDSEMKKTG
CCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
DECVFLDVTHLEPEKTIQHFPNIYETCLEFGIDMTKEMIPVVPAAHYSCGGIKTDDVGRS
CCEEEEEEECCCHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCHH
SINRLYACGETSCTGVHGANRLASNSLLEALVFAYRSYKDIKQTLHTIHNNLPFPDWDDS
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GTTNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRIEFLKEETEAYYKRTRITT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EILELRNIIKVASLIIESAIKRRESRGLHYTTDYPSKDDKHFLIDTELRSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCHHCC
>Mature Secondary Structure 
TEDIQTDVLVIGSGIGGLYFALNIADHARVTIITKKESCESNTNWAQGGIAATIDQNDS
CCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
AELHINDTLDAGAGLCNKPMVEVMVNEGPQHIRKLIELGVQFTTTDNDHLDLGREGGHSR
CEEEECCCCCCCCCCCCCCHHEEEECCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCH
KRIVHASDLTGQEVEHALLERVNQHPNITLLEHHFAIELLTEHHVHIKTNEISCYGAFVL
HEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHEEEEECCCCEEEEECCEEEEEEEEE
DTQNRKLKKVLSKVTMLASGGLGHVYLHTTNPDIATGDGIAMAYRAGALIANMEFIQFHP
ECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHCCHHEECCEEEEECC
TSLFHPKAKSFLISEAVRGFGGILRLKNGQAFMKKYDPRENLAPRDIVARAIDSEMKKTG
CCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
DECVFLDVTHLEPEKTIQHFPNIYETCLEFGIDMTKEMIPVVPAAHYSCGGIKTDDVGRS
CCEEEEEEECCCHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCHH
SINRLYACGETSCTGVHGANRLASNSLLEALVFAYRSYKDIKQTLHTIHNNLPFPDWDDS
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GTTNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRIEFLKEETEAYYKRTRITT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EILELRNIIKVASLIIESAIKRRESRGLHYTTDYPSKDDKHFLIDTELRSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]