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The map label for this gene is cqsS [H]

Identifier: 194333505

GI number: 194333505

Start: 710429

End: 713002

Strand: Reverse

Name: cqsS [H]

Synonym: Paes_0671

Alternate gene names: 194333505

Gene position: 713002-710429 (Counterclockwise)

Preceding gene: 194333507

Following gene: 194333504

Centisome position: 28.37

GC content: 45.07

Gene sequence:

>2574_bases
ATGATTCGAGATGATGCGATGACCAAACAGTCACTCCAGGATATGCTCTGGGCTAAAACCAGGAATACCCTTGAACATGC
TGAACCAAACATTCCGGTTATGGGAATATTTGGTCTGATAGGCTTCCCCCTGTTCTTTTATGTCTGGGCATATGTTTTCC
CGCAGCCATATGAAAACCTGGGATTCCGTCTGATCATCGCCTTGCTGAGTATCCCCTGGGTTCTTTACCACCGTCTGCCC
TCGCACTTCAAAGCAATTTTTCCGGTCTACATGATTATCTCCTGCTGGATCATGATTCCGTTTTTTTTCAGCTTTATGCT
CCTCAAAAACGACTGGAATATGGTCTGGGCAATATCGACGATGGCCGGCCTTTCCCTGCTGATTCTTCTCTTGAATGACT
GGGTGCTTCTGACCGTGCTTATTGTATCGGCATATGCTGCCGCAGAGATCTCTGTCTCTTTTCTTTACGGCAGCACGACA
GGGTATGCTGATTTTCAACTTGAATACATCCCGCTTTTCCTTTTCGGTATCGTTGGAAGTATCATCTTCAGTCATAAGCG
CCAGATAGCCCAGCAGTCCAAAATATCACTGCTGCACAGCCTGAGCGGCAGCATCGCTCATGAAATGCGAAATCCTTTGA
GTACCATCACCAATGCAATGGGCTCAATCCAGACCATTCTTCCCGACAAACCCAAAGCAGGAGAACACAACTCGCACTAC
AATCTCAGTCGTTCCGGACTGATCAGCTTGCACAGCGTAATCGATGAAAGCAGCGAAATCGTCACCAGGGCAAATAAAAT
AATCGATTCCATACTGGCAAGCATGCAGGGAAAGTCTATCGACCCTGCCAACTTCAAGCGACTCTCGATCAAAACAACAA
CGAGCTATGCAATTAACAGCTACAGTTATGCATCGCGAGACGAGAAAGAACTGATTCACGATTCCACAATAGATGATTTT
GAGTTTTTCGGAGACAAGGACCTCTTCAGCTATGTCATATTCAATCTCCTGAAAAACGCCCTGCACTACAAAAACTCACC
GGGCTTCAGAATTGATATTTTTTCCATCAAAGGCCCCATTGATAACATTATCAAAATCAGGGATACGGGTCCGGGTATTG
CCTCAGGCAAGCTCCACATGATTTTTGACAGTTTTTATACATCGGGCAAAAAAGGAGGTATCGGTCTTGGCCTGTCATTC
TGTAAACGAGTCATTGAAGCATTTGGCGGAACCATCGTATGCGATTCGAAGGAAAAAGAATGGACAGAATTCACCATTAC
ACTTCCGGATTACACCAGCAAGGAAACTGAAAAACTGAAAAAAAATGCACTATCAGAAAAAAAGATTCTCGTTGTCGATG
ATAATGCAACAACGAGAACATTCCACTCCAAACTGCTCACGGAATGGAAATGCCGGGTTGATCAGGCAATCAATGGCGTT
GCAGCAATCCAGAACATAACGGACAATGAGTATGATCTGGTACTCATGGACATTGAAATGCCGGTTTTAGATGGTGACGA
AGCAACTCAACAGATACGTTCAGAAATAGACACTAACGCATCGCTCGAATACTACTTGAAAAACGTACCAATTATTGGGA
TTTCATCACTCCCACAAGAGACCGGCCGCAAAAGATCCATTAATTCCGGTATGAATGATTTCATACCCAAGCCGCTCACA
AAAAACGACATCATCAACCTGTTCGAAAAATACTTTTTCTCCGAAAAAAATCCTGTCATCTATGAAACCAGCCCATGTCT
GGAAGAATCGACAATCCTGCTTGTCGATGATAATACAACAAGCAGAAAATTCATGAGCATCATGCTTGAGCGTATGGGAG
CTCATGTCATCCAGGCCGAAAACGGACAAGAAGCAATTGAGTGTCTTGAGCAAAAAACAGTCGACCTGGTCTTCATGGAC
ATGGAAATGCCGGTCCTCAACGGCGTAGAGGCAACAAAAATAATTCGATCGGGCAAACCCTTTACTCGCTTCAGCAAATT
CCGGGAGCTTCCGATTATCGCCCTTACCGGCAATACCGACAGTAAAAACATAGCGATCGTCAAACAAAGCGGCATGAATG
CGCACCTTGGAAAGCCCGTATCAAAGGACGATCTTGTTTCCGTGTTCTGTCACTGGCTAAAGGACAAAACATCTGAATCA
TCCCTTCCAAACAACCATTCAACAGCAAACACGACAGCCATGGATACTCTTCTCAAAGACGTCGAAAAAGAACAGATCCT
CAATTCCGAAACGATTGAGATGCTCCGTGAAACAGGCGGAAACGAGTTGCTGGAAGAACTCATCCGCATCTATATCGACG
ACGCTCAAAAGCTCATCGACGGGATTGTCGAAGCCGAGAAAAACAACGACAACCACGCATTGAATCAGTTGAGCCATACC
CTGAAAGGCTCTTCCGGCAGCGTAGGCGCCCAGAAAATGCATATTTTTGCAACCCATCTCAACCATCTTTCAAAAATCGG
GGACCAGAAAGACTATAGCCAATGGGTGTCGTCTCTTCACCGGATCTTTGAAGAGACCATTGTTGAATTCGAAAACCTCA
AGACAAGCAACTGA

Upstream 100 bases:

>100_bases
CAAATGAAAGCATTGCCTCCTCCTGTAACACGCTGTTCAGGAACTTTTGCAACAGCCGGAAAGCATGGGTCTGAAAAAAC
GACCGCCGGCTTGTCATTAA

Downstream 100 bases:

>100_bases
ACGAAATACATGCAGCAGCATCTGCACATTCCGCAACATTTCGATCATGAAAGGCCCGGACTTCTTCTGCAACTACTGGA
AGAACATTCCATTCCTGTCG

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 857; Mature: 857

Protein sequence:

>857_residues
MIRDDAMTKQSLQDMLWAKTRNTLEHAEPNIPVMGIFGLIGFPLFFYVWAYVFPQPYENLGFRLIIALLSIPWVLYHRLP
SHFKAIFPVYMIISCWIMIPFFFSFMLLKNDWNMVWAISTMAGLSLLILLLNDWVLLTVLIVSAYAAAEISVSFLYGSTT
GYADFQLEYIPLFLFGIVGSIIFSHKRQIAQQSKISLLHSLSGSIAHEMRNPLSTITNAMGSIQTILPDKPKAGEHNSHY
NLSRSGLISLHSVIDESSEIVTRANKIIDSILASMQGKSIDPANFKRLSIKTTTSYAINSYSYASRDEKELIHDSTIDDF
EFFGDKDLFSYVIFNLLKNALHYKNSPGFRIDIFSIKGPIDNIIKIRDTGPGIASGKLHMIFDSFYTSGKKGGIGLGLSF
CKRVIEAFGGTIVCDSKEKEWTEFTITLPDYTSKETEKLKKNALSEKKILVVDDNATTRTFHSKLLTEWKCRVDQAINGV
AAIQNITDNEYDLVLMDIEMPVLDGDEATQQIRSEIDTNASLEYYLKNVPIIGISSLPQETGRKRSINSGMNDFIPKPLT
KNDIINLFEKYFFSEKNPVIYETSPCLEESTILLVDDNTTSRKFMSIMLERMGAHVIQAENGQEAIECLEQKTVDLVFMD
MEMPVLNGVEATKIIRSGKPFTRFSKFRELPIIALTGNTDSKNIAIVKQSGMNAHLGKPVSKDDLVSVFCHWLKDKTSES
SLPNNHSTANTTAMDTLLKDVEKEQILNSETIEMLRETGGNELLEELIRIYIDDAQKLIDGIVEAEKNNDNHALNQLSHT
LKGSSGSVGAQKMHIFATHLNHLSKIGDQKDYSQWVSSLHRIFEETIVEFENLKTSN

Sequences:

>Translated_857_residues
MIRDDAMTKQSLQDMLWAKTRNTLEHAEPNIPVMGIFGLIGFPLFFYVWAYVFPQPYENLGFRLIIALLSIPWVLYHRLP
SHFKAIFPVYMIISCWIMIPFFFSFMLLKNDWNMVWAISTMAGLSLLILLLNDWVLLTVLIVSAYAAAEISVSFLYGSTT
GYADFQLEYIPLFLFGIVGSIIFSHKRQIAQQSKISLLHSLSGSIAHEMRNPLSTITNAMGSIQTILPDKPKAGEHNSHY
NLSRSGLISLHSVIDESSEIVTRANKIIDSILASMQGKSIDPANFKRLSIKTTTSYAINSYSYASRDEKELIHDSTIDDF
EFFGDKDLFSYVIFNLLKNALHYKNSPGFRIDIFSIKGPIDNIIKIRDTGPGIASGKLHMIFDSFYTSGKKGGIGLGLSF
CKRVIEAFGGTIVCDSKEKEWTEFTITLPDYTSKETEKLKKNALSEKKILVVDDNATTRTFHSKLLTEWKCRVDQAINGV
AAIQNITDNEYDLVLMDIEMPVLDGDEATQQIRSEIDTNASLEYYLKNVPIIGISSLPQETGRKRSINSGMNDFIPKPLT
KNDIINLFEKYFFSEKNPVIYETSPCLEESTILLVDDNTTSRKFMSIMLERMGAHVIQAENGQEAIECLEQKTVDLVFMD
MEMPVLNGVEATKIIRSGKPFTRFSKFRELPIIALTGNTDSKNIAIVKQSGMNAHLGKPVSKDDLVSVFCHWLKDKTSES
SLPNNHSTANTTAMDTLLKDVEKEQILNSETIEMLRETGGNELLEELIRIYIDDAQKLIDGIVEAEKNNDNHALNQLSHT
LKGSSGSVGAQKMHIFATHLNHLSKIGDQKDYSQWVSSLHRIFEETIVEFENLKTSN
>Mature_857_residues
MIRDDAMTKQSLQDMLWAKTRNTLEHAEPNIPVMGIFGLIGFPLFFYVWAYVFPQPYENLGFRLIIALLSIPWVLYHRLP
SHFKAIFPVYMIISCWIMIPFFFSFMLLKNDWNMVWAISTMAGLSLLILLLNDWVLLTVLIVSAYAAAEISVSFLYGSTT
GYADFQLEYIPLFLFGIVGSIIFSHKRQIAQQSKISLLHSLSGSIAHEMRNPLSTITNAMGSIQTILPDKPKAGEHNSHY
NLSRSGLISLHSVIDESSEIVTRANKIIDSILASMQGKSIDPANFKRLSIKTTTSYAINSYSYASRDEKELIHDSTIDDF
EFFGDKDLFSYVIFNLLKNALHYKNSPGFRIDIFSIKGPIDNIIKIRDTGPGIASGKLHMIFDSFYTSGKKGGIGLGLSF
CKRVIEAFGGTIVCDSKEKEWTEFTITLPDYTSKETEKLKKNALSEKKILVVDDNATTRTFHSKLLTEWKCRVDQAINGV
AAIQNITDNEYDLVLMDIEMPVLDGDEATQQIRSEIDTNASLEYYLKNVPIIGISSLPQETGRKRSINSGMNDFIPKPLT
KNDIINLFEKYFFSEKNPVIYETSPCLEESTILLVDDNTTSRKFMSIMLERMGAHVIQAENGQEAIECLEQKTVDLVFMD
MEMPVLNGVEATKIIRSGKPFTRFSKFRELPIIALTGNTDSKNIAIVKQSGMNAHLGKPVSKDDLVSVFCHWLKDKTSES
SLPNNHSTANTTAMDTLLKDVEKEQILNSETIEMLRETGGNELLEELIRIYIDDAQKLIDGIVEAEKNNDNHALNQLSHT
LKGSSGSVGAQKMHIFATHLNHLSKIGDQKDYSQWVSSLHRIFEETIVEFENLKTSN

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=32, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=543, Percent_Identity=21.9152854511971, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=411, Percent_Identity=25.3041362530414, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=493, Percent_Identity=21.501014198783, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=279, Percent_Identity=26.1648745519713, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=123, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788393, Length=134, Percent_Identity=32.089552238806, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=383, Percent_Identity=26.6318537859008, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322000, Length=148, Percent_Identity=38.5135135135135, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 96591; Mature: 96591

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS00061 ADH_SHORT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDDAMTKQSLQDMLWAKTRNTLEHAEPNIPVMGIFGLIGFPLFFYVWAYVFPQPYENL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GFRLIIALLSIPWVLYHRLPSHFKAIFPVYMIISCWIMIPFFFSFMLLKNDWNMVWAIST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
MAGLSLLILLLNDWVLLTVLIVSAYAAAEISVSFLYGSTTGYADFQLEYIPLFLFGIVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEHHHHHHHHHHHHHH
IIFSHKRQIAQQSKISLLHSLSGSIAHEMRNPLSTITNAMGSIQTILPDKPKAGEHNSHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NLSRSGLISLHSVIDESSEIVTRANKIIDSILASMQGKSIDPANFKRLSIKTTTSYAINS
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEECC
YSYASRDEKELIHDSTIDDFEFFGDKDLFSYVIFNLLKNALHYKNSPGFRIDIFSIKGPI
CCCCCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
DNIIKIRDTGPGIASGKLHMIFDSFYTSGKKGGIGLGLSFCKRVIEAFGGTIVCDSKEKE
CCEEEEECCCCCCCCCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCC
WTEFTITLPDYTSKETEKLKKNALSEKKILVVDDNATTRTFHSKLLTEWKCRVDQAINGV
CEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAIQNITDNEYDLVLMDIEMPVLDGDEATQQIRSEIDTNASLEYYLKNVPIIGISSLPQE
HHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEECCCCCHH
TGRKRSINSGMNDFIPKPLTKNDIINLFEKYFFSEKNPVIYETSPCLEESTILLVDDNTT
HCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCC
SRKFMSIMLERMGAHVIQAENGQEAIECLEQKTVDLVFMDMEMPVLNGVEATKIIRSGKP
HHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCEEEEEECCCCHHCCCHHHHHHHCCCC
FTRFSKFRELPIIALTGNTDSKNIAIVKQSGMNAHLGKPVSKDDLVSVFCHWLKDKTSES
HHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
SLPNNHSTANTTAMDTLLKDVEKEQILNSETIEMLRETGGNELLEELIRIYIDDAQKLID
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GIVEAEKNNDNHALNQLSHTLKGSSGSVGAQKMHIFATHLNHLSKIGDQKDYSQWVSSLH
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RIFEETIVEFENLKTSN
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIRDDAMTKQSLQDMLWAKTRNTLEHAEPNIPVMGIFGLIGFPLFFYVWAYVFPQPYENL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GFRLIIALLSIPWVLYHRLPSHFKAIFPVYMIISCWIMIPFFFSFMLLKNDWNMVWAIST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
MAGLSLLILLLNDWVLLTVLIVSAYAAAEISVSFLYGSTTGYADFQLEYIPLFLFGIVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEHHHHHHHHHHHHHH
IIFSHKRQIAQQSKISLLHSLSGSIAHEMRNPLSTITNAMGSIQTILPDKPKAGEHNSHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NLSRSGLISLHSVIDESSEIVTRANKIIDSILASMQGKSIDPANFKRLSIKTTTSYAINS
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEECC
YSYASRDEKELIHDSTIDDFEFFGDKDLFSYVIFNLLKNALHYKNSPGFRIDIFSIKGPI
CCCCCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
DNIIKIRDTGPGIASGKLHMIFDSFYTSGKKGGIGLGLSFCKRVIEAFGGTIVCDSKEKE
CCEEEEECCCCCCCCCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCC
WTEFTITLPDYTSKETEKLKKNALSEKKILVVDDNATTRTFHSKLLTEWKCRVDQAINGV
CEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAIQNITDNEYDLVLMDIEMPVLDGDEATQQIRSEIDTNASLEYYLKNVPIIGISSLPQE
HHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEECCCCCHH
TGRKRSINSGMNDFIPKPLTKNDIINLFEKYFFSEKNPVIYETSPCLEESTILLVDDNTT
HCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCC
SRKFMSIMLERMGAHVIQAENGQEAIECLEQKTVDLVFMDMEMPVLNGVEATKIIRSGKP
HHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCEEEEEECCCCHHCCCHHHHHHHCCCC
FTRFSKFRELPIIALTGNTDSKNIAIVKQSGMNAHLGKPVSKDDLVSVFCHWLKDKTSES
HHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
SLPNNHSTANTTAMDTLLKDVEKEQILNSETIEMLRETGGNELLEELIRIYIDDAQKLID
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GIVEAEKNNDNHALNQLSHTLKGSSGSVGAQKMHIFATHLNHLSKIGDQKDYSQWVSSLH
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RIFEETIVEFENLKTSN
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]