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The map label for this gene is kefC [H]

Identifier: 194333504

GI number: 194333504

Start: 708315

End: 709475

Strand: Reverse

Name: kefC [H]

Synonym: Paes_0669

Alternate gene names: 194333504

Gene position: 709475-708315 (Counterclockwise)

Preceding gene: 194333505

Following gene: 194333497

Centisome position: 28.23

GC content: 49.7

Gene sequence:

>1161_bases
GTGACTAATTTTGTATTCACAGATATCGCCCTTGTCGTCATCGCTGCGACACTGCTTGGCTGGCTCTCTCTGTTGACCAG
ACAGCCGATTATCATCGCCTATATTCTTGCAGGGGTTCTGCTCGGTCCCTGGGGATTCAAAGTGATCACAGAAATCCAGT
TTATCAATGAAGTGTCCGATATCGGCATCACACTGCTCCTGTTTCTTGCCGGTCTGTCTCTTCATCCTGGAAAACTGTTT
GAGTTGTTCGGAAAAACCTTCTTCCTCACTCTTTTCACCAGCACTGTTTTTGCCGGTGTAACAGGCGCTATTCTTTACGG
TTTCGGTGCAACGGCCACCGAAGCCATCATCACCGGCGTAGCCATGATGTTTTCGAGCACCATTCTTGTGGTCAAACTCA
TGCCGACAAACACACTCCATCAGAAACATATGGGTGCTGTAGCTATCGCCGTACTCATCATGCAGGATATTTTAGCCGTT
CTTGCTATCGCTTTTATCAAAGGAGGCAGCGGTTCGACTCTTCTCGGGTGGATCACCAGTATGGCCGCAGGCATTCTGCT
CGCTTTTGCGGCAATTGTCGCTGAACGATACGCCATCAGAAAAATCATTTCGCAAGTCCAGCGCTATAATGAACTTCTGA
ACCTGGTCACTCTGGCATGGTGCTTCGCACTTGCCCTGCTTGCCGAAAAAATCGGTTTAAGCCACGAAATAGGAGCCTTT
ATTGCAGGAGTCTCTCTGGCCAACGGACCCATCTCGAATTTTCTTGCCGAAGGCCTGAAGTTTTTCAGGGATTTTTTTCT
TGTCCTTTTCTTCTTCACTCTCGGCGCGAAACTTGACTTTTCATTGCTGATTACTGTCCTCAAACCGGCCCTCCTGTTAA
CGACGGCACTGCTGTTTCTCAAGCCCTTGATCTACTGGTCGGGATTCCGCCTGACGGGTGAGACAATGAAATTCAGCCGT
GAAATGGGGTTCAGGCTCGGGCAGAACAGCGAATTCGCCCTGATCATCGCCGTTATCGCCGCCGAATCGGGAGTGCTCAG
CCAGGCAAACTCTCAACTCATCCAGCTGGTTACCATCCTTACGATGACAATCTCGTCCTACATTCTGGTCTTTTTCTTTC
CCACGCCACTGGGAACGAGCAAGCCGCTCAAAATCGACTGA

Upstream 100 bases:

>100_bases
TTGGTGTGCAGAGCAACCCTGCGTCCTGAAATCAGGTATTGCATGAATAAGCGCACGCTACCTGCAAGCGTTCCCTGAGA
CCTTAAAACATGTATCATTG

Downstream 100 bases:

>100_bases
TAAAAAAAGCCCGGTTACGCTCTTGGCTAACCGGGCTTATCACGAAAAAAAGTCAGGTGCTTGTCACAAAAAGTCTATTC
AAGAACAAGATCAATGGTCC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTNFVFTDIALVVIAATLLGWLSLLTRQPIIIAYILAGVLLGPWGFKVITEIQFINEVSDIGITLLLFLAGLSLHPGKLF
ELFGKTFFLTLFTSTVFAGVTGAILYGFGATATEAIITGVAMMFSSTILVVKLMPTNTLHQKHMGAVAIAVLIMQDILAV
LAIAFIKGGSGSTLLGWITSMAAGILLAFAAIVAERYAIRKIISQVQRYNELLNLVTLAWCFALALLAEKIGLSHEIGAF
IAGVSLANGPISNFLAEGLKFFRDFFLVLFFFTLGAKLDFSLLITVLKPALLLTTALLFLKPLIYWSGFRLTGETMKFSR
EMGFRLGQNSEFALIIAVIAAESGVLSQANSQLIQLVTILTMTISSYILVFFFPTPLGTSKPLKID

Sequences:

>Translated_386_residues
MTNFVFTDIALVVIAATLLGWLSLLTRQPIIIAYILAGVLLGPWGFKVITEIQFINEVSDIGITLLLFLAGLSLHPGKLF
ELFGKTFFLTLFTSTVFAGVTGAILYGFGATATEAIITGVAMMFSSTILVVKLMPTNTLHQKHMGAVAIAVLIMQDILAV
LAIAFIKGGSGSTLLGWITSMAAGILLAFAAIVAERYAIRKIISQVQRYNELLNLVTLAWCFALALLAEKIGLSHEIGAF
IAGVSLANGPISNFLAEGLKFFRDFFLVLFFFTLGAKLDFSLLITVLKPALLLTTALLFLKPLIYWSGFRLTGETMKFSR
EMGFRLGQNSEFALIIAVIAAESGVLSQANSQLIQLVTILTMTISSYILVFFFPTPLGTSKPLKID
>Mature_385_residues
TNFVFTDIALVVIAATLLGWLSLLTRQPIIIAYILAGVLLGPWGFKVITEIQFINEVSDIGITLLLFLAGLSLHPGKLFE
LFGKTFFLTLFTSTVFAGVTGAILYGFGATATEAIITGVAMMFSSTILVVKLMPTNTLHQKHMGAVAIAVLIMQDILAVL
AIAFIKGGSGSTLLGWITSMAAGILLAFAAIVAERYAIRKIISQVQRYNELLNLVTLAWCFALALLAEKIGLSHEIGAFI
AGVSLANGPISNFLAEGLKFFRDFFLVLFFFTLGAKLDFSLLITVLKPALLLTTALLFLKPLIYWSGFRLTGETMKFSRE
MGFRLGQNSEFALIIAVIAAESGVLSQANSQLIQLVTILTMTISSYILVFFFPTPLGTSKPLKID

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=377, Percent_Identity=25.9946949602122, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786232, Length=346, Percent_Identity=30.3468208092486, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789749, Length=337, Percent_Identity=28.7833827893175, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786685, Length=371, Percent_Identity=28.8409703504043, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 41798; Mature: 41667

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFVFTDIALVVIAATLLGWLSLLTRQPIIIAYILAGVLLGPWGFKVITEIQFINEVSD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IGITLLLFLAGLSLHPGKLFELFGKTFFLTLFTSTVFAGVTGAILYGFGATATEAIITGV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AMMFSSTILVVKLMPTNTLHQKHMGAVAIAVLIMQDILAVLAIAFIKGGSGSTLLGWITS
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MAAGILLAFAAIVAERYAIRKIISQVQRYNELLNLVTLAWCFALALLAEKIGLSHEIGAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IAGVSLANGPISNFLAEGLKFFRDFFLVLFFFTLGAKLDFSLLITVLKPALLLTTALLFL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KPLIYWSGFRLTGETMKFSREMGFRLGQNSEFALIIAVIAAESGVLSQANSQLIQLVTIL
HHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TMTISSYILVFFFPTPLGTSKPLKID
HHHHHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure 
TNFVFTDIALVVIAATLLGWLSLLTRQPIIIAYILAGVLLGPWGFKVITEIQFINEVSD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IGITLLLFLAGLSLHPGKLFELFGKTFFLTLFTSTVFAGVTGAILYGFGATATEAIITGV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AMMFSSTILVVKLMPTNTLHQKHMGAVAIAVLIMQDILAVLAIAFIKGGSGSTLLGWITS
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MAAGILLAFAAIVAERYAIRKIISQVQRYNELLNLVTLAWCFALALLAEKIGLSHEIGAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IAGVSLANGPISNFLAEGLKFFRDFFLVLFFFTLGAKLDFSLLITVLKPALLLTTALLFL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KPLIYWSGFRLTGETMKFSREMGFRLGQNSEFALIIAVIAAESGVLSQANSQLIQLVTIL
HHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TMTISSYILVFFFPTPLGTSKPLKID
HHHHHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA