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The map label for this gene is ubiE [H]

Identifier: 194333273

GI number: 194333273

Start: 463191

End: 463940

Strand: Reverse

Name: ubiE [H]

Synonym: Paes_0429

Alternate gene names: 194333273

Gene position: 463940-463191 (Counterclockwise)

Preceding gene: 194333274

Following gene: 194333268

Centisome position: 18.46

GC content: 48.8

Gene sequence:

>750_bases
ATGGCAAACAAAGCTGAAACATCGCCAAACCGGCCCCAGGAAACGGCAAAATCGCTTTTCCGGACGAAGTCACACGCATC
GATCCAGCATATGTTCGATGAGGTTGCTCCTACCTACGATTTCCTGAACCATCTGCTCAGTCTGGGTATCGACAACTACT
GGCGAGCCTTTGCTGCGGCAAAAGCAAAAAAACTGATCGGTGCAAACCCGGCACCCGACATTCTCGATGTAGCAACCGGA
ACCGGCGACCTTGCAAAGGAGATGTCGAAACTCCAGGGAGCCAGAGTGACAGGTATGGACCTGTCACCGGAAATGCTTGC
CATTGCGGAAAAAAAATATCCGCAGATACGTTTTGTACAAGGCTACGCGGAAAAACTCAACTTCGATACAGCATCATTCG
ACATTGTCAGCGCTGGTTTCGGAGCAAGAAATTTTGAGGATCTTACCAAAGGGCTGAAAGAGTTTCACCGGGTTCTCAAA
CCAGGCGGTCACGCGCTGATCATCGAGCCGATGATCCCGAGAAATCCCGTCATGAAAAAGCTCTACCTCATCTACTTCAA
AAAAGTGCTCCCGAAGATCGCCAGCATGGTCAGCAAATCCAGTTTTGCTTACGACTACCTTCCCCATTCTGTCGAATCCT
TTCCTCAGGACAAAGAATTCACGGCAATCCTGAAGAGCGCAGGGTTTCAGTCTGCGGAATTTATCCCTATGACGTTTGAG
ACCTCGATACTCTATATCGCAAAAAAATAA

Upstream 100 bases:

>100_bases
GCATGCCATATGGGCTATCAATCCTGTTTTTACCGCAAGACCAAAGATGATCTCTCCATGGAGATCTGTGATACCCTGAT
GTTTAACCCTGAAGACGTGT

Downstream 100 bases:

>100_bases
GCTGAAACCGGACAGGCTCACCGCAGCCCGTCCGGGCTTGGCTGATTCTCACATGGCAAAGCAACATACCGTCCACAGGC
CCTGCTCACAAGGCCGCTGA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MANKAETSPNRPQETAKSLFRTKSHASIQHMFDEVAPTYDFLNHLLSLGIDNYWRAFAAAKAKKLIGANPAPDILDVATG
TGDLAKEMSKLQGARVTGMDLSPEMLAIAEKKYPQIRFVQGYAEKLNFDTASFDIVSAGFGARNFEDLTKGLKEFHRVLK
PGGHALIIEPMIPRNPVMKKLYLIYFKKVLPKIASMVSKSSFAYDYLPHSVESFPQDKEFTAILKSAGFQSAEFIPMTFE
TSILYIAKK

Sequences:

>Translated_249_residues
MANKAETSPNRPQETAKSLFRTKSHASIQHMFDEVAPTYDFLNHLLSLGIDNYWRAFAAAKAKKLIGANPAPDILDVATG
TGDLAKEMSKLQGARVTGMDLSPEMLAIAEKKYPQIRFVQGYAEKLNFDTASFDIVSAGFGARNFEDLTKGLKEFHRVLK
PGGHALIIEPMIPRNPVMKKLYLIYFKKVLPKIASMVSKSSFAYDYLPHSVESFPQDKEFTAILKSAGFQSAEFIPMTFE
TSILYIAKK
>Mature_248_residues
ANKAETSPNRPQETAKSLFRTKSHASIQHMFDEVAPTYDFLNHLLSLGIDNYWRAFAAAKAKKLIGANPAPDILDVATGT
GDLAKEMSKLQGARVTGMDLSPEMLAIAEKKYPQIRFVQGYAEKLNFDTASFDIVSAGFGARNFEDLTKGLKEFHRVLKP
GGHALIIEPMIPRNPVMKKLYLIYFKKVLPKIASMVSKSSFAYDYLPHSVESFPQDKEFTAILKSAGFQSAEFIPMTFET
SILYIAKK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=254, Percent_Identity=30.7086614173228, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994983, Length=241, Percent_Identity=33.6099585062241, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17557039, Length=234, Percent_Identity=29.0598290598291, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323526, Length=253, Percent_Identity=33.596837944664, Blast_Score=128, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24641702, Length=263, Percent_Identity=27.7566539923954, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27763; Mature: 27632

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKAETSPNRPQETAKSLFRTKSHASIQHMFDEVAPTYDFLNHLLSLGIDNYWRAFAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHH
KAKKLIGANPAPDILDVATGTGDLAKEMSKLQGARVTGMDLSPEMLAIAEKKYPQIRFVQ
HHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEHHH
GYAEKLNFDTASFDIVSAGFGARNFEDLTKGLKEFHRVLKPGGHALIIEPMIPRNPVMKK
HHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
LYLIYFKKVLPKIASMVSKSSFAYDYLPHSVESFPQDKEFTAILKSAGFQSAEFIPMTFE
HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEC
TSILYIAKK
CEEEEEECC
>Mature Secondary Structure 
ANKAETSPNRPQETAKSLFRTKSHASIQHMFDEVAPTYDFLNHLLSLGIDNYWRAFAAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHH
KAKKLIGANPAPDILDVATGTGDLAKEMSKLQGARVTGMDLSPEMLAIAEKKYPQIRFVQ
HHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEHHH
GYAEKLNFDTASFDIVSAGFGARNFEDLTKGLKEFHRVLKPGGHALIIEPMIPRNPVMKK
HHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
LYLIYFKKVLPKIASMVSKSSFAYDYLPHSVESFPQDKEFTAILKSAGFQSAEFIPMTFE
HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEC
TSILYIAKK
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]