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The map label for this gene is accB [H]

Identifier: 194333135

GI number: 194333135

Start: 311776

End: 312243

Strand: Reverse

Name: accB [H]

Synonym: Paes_0291

Alternate gene names: 194333135

Gene position: 312243-311776 (Counterclockwise)

Preceding gene: 194333136

Following gene: 194333134

Centisome position: 12.43

GC content: 48.5

Gene sequence:

>468_bases
ATGAACCTGAAAGAAATTGAGCAGCTGATCGATATTATCAATAAGTCGGACATCGGCGAAGCAACAATTGAGGAAGGGGA
TTTCAAAATAACTCTCAAACGCACATCCCAGATGGCTGCCATGCCTCAAGCGCAGACATCTTTTCCCGTCATCGCGCCGC
CTTCCGCTCCGGCTGCACCGTCTCAACAGTCAGCACCAGCTCCTGAGCCGGATAACCCTGCAAAGGAAAACCTGATTGAA
ATCCGCTCACCGATTGTCGGAACCTTTTACCGCTCACCCTCCCCGGAATCTGATGTTTTTGTCAGTAAAAACGATCACAT
TCAATCAGGCGATGTCCTCTGTATCGTAGAAGCAATGAAGCTGATGAATGAAATCGAGGCAGAACTATCAGGAACGATCA
TCGATATTCTTGTCGAAAACGGCCAGCCAGTCGAGTACGATCAGGTGCTGTTCCTCGTTAAGCCTTAA

Upstream 100 bases:

>100_bases
ATCCGTGTCGATACCCGCACCGGAGAATATATGGAAAGAGTCAAAAAGTAAGCCCCCTGACATTCCAGGGAGTGCTGCAT
TAAACCTAAAGCCAGAACAC

Downstream 100 bases:

>100_bases
TTCATAAACTATTCGAATGTTGTTCAAGAAAATACTAATTGCAAATCGCGGTGAAATTGCTTTGCGCATCATGCAGACCT
GCCGTGAACTGGGAATCAGT

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MNLKEIEQLIDIINKSDIGEATIEEGDFKITLKRTSQMAAMPQAQTSFPVIAPPSAPAAPSQQSAPAPEPDNPAKENLIE
IRSPIVGTFYRSPSPESDVFVSKNDHIQSGDVLCIVEAMKLMNEIEAELSGTIIDILVENGQPVEYDQVLFLVKP

Sequences:

>Translated_155_residues
MNLKEIEQLIDIINKSDIGEATIEEGDFKITLKRTSQMAAMPQAQTSFPVIAPPSAPAAPSQQSAPAPEPDNPAKENLIE
IRSPIVGTFYRSPSPESDVFVSKNDHIQSGDVLCIVEAMKLMNEIEAELSGTIIDILVENGQPVEYDQVLFLVKP
>Mature_155_residues
MNLKEIEQLIDIINKSDIGEATIEEGDFKITLKRTSQMAAMPQAQTSFPVIAPPSAPAAPSQQSAPAPEPDNPAKENLIE
IRSPIVGTFYRSPSPESDVFVSKNDHIQSGDVLCIVEAMKLMNEIEAELSGTIIDILVENGQPVEYDQVLFLVKP

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=156, Percent_Identity=39.7435897435897, Blast_Score=123, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16903; Mature: 16903

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKEIEQLIDIINKSDIGEATIEEGDFKITLKRTSQMAAMPQAQTSFPVIAPPSAPAAP
CCHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCHHHCCCCCCCCCCEEECCCCCCCC
SQQSAPAPEPDNPAKENLIEIRSPIVGTFYRSPSPESDVFVSKNDHIQSGDVLCIVEAMK
CCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCCCCCEEHHHHHHH
LMNEIEAELSGTIIDILVENGQPVEYDQVLFLVKP
HHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure
MNLKEIEQLIDIINKSDIGEATIEEGDFKITLKRTSQMAAMPQAQTSFPVIAPPSAPAAP
CCHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCHHHCCCCCCCCCCEEECCCCCCCC
SQQSAPAPEPDNPAKENLIEIRSPIVGTFYRSPSPESDVFVSKNDHIQSGDVLCIVEAMK
CCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCCCCCEEHHHHHHH
LMNEIEAELSGTIIDILVENGQPVEYDQVLFLVKP
HHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]