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The map label for this gene is accC [H]

Identifier: 194333134

GI number: 194333134

Start: 310413

End: 311759

Strand: Reverse

Name: accC [H]

Synonym: Paes_0290

Alternate gene names: 194333134

Gene position: 311759-310413 (Counterclockwise)

Preceding gene: 194333135

Following gene: 194333121

Centisome position: 12.41

GC content: 49.67

Gene sequence:

>1347_bases
ATGTTGTTCAAGAAAATACTAATTGCAAATCGCGGTGAAATTGCTTTGCGCATCATGCAGACCTGCCGTGAACTGGGAAT
CAGTACGGTCGCCATCTACTCGACTGCCGATAAAAATTCCCTTCATGTCAAGTATGCCGACGAAGCCGTCTGCATCGGCC
CGCCCCTCGGAAAAGAAAGCTACCTGAACATCCCGCGGATCATGGCCGCTGCAGAGATCACCAATGCTGACGCGATTCAT
CCCGGCTATGGATTCCTTGCTGAAAATGCTGATTTCGCAGAAGTGTGCAATGCCTCGGGAATTAAATTTATCGGTCCGAC
CGCAGAGATGATCCGCAAAATGGGCGATAAAAACAGTGCCAAGGAAACCATGATCGCTGCTGGCGTCCCTGTCATTCCCG
GAAGTGACGGGTTGGTAAGGGATACAGCCCATGCACTCAAAACTGCTGAAAAAATAGGCTACCCTGTAATCATTAAGCCA
ACGGCAGGAGGCGGTGGAAAAGGAATGCGGGTGGTAAACGAACCGGAAAAAATCCAAAAAGCTCTCCTTACCTCCCAGAA
CGAAGCCCAACAGGCTTTCGGTAACAGCGGAGTCTATATTGAAAAGTTCGTAGAAAGTCCGCGCCATGTTGAAATACAGA
TCCTCGCCGACCAGCATGGCAATACGATGCATCTGGGTGAAAGAGACTGTACCATTCAACGTCGTCATCAGAAACTCATC
GAAGAGACTCCCTCACCGGTTGTCGACGAAGCGCTCCGCAATGAGATGGGCAATGCCGCTGTTGCCGCTGCAAGCGCTAT
CAATTATGAAGGCGCTGGAACCATAGAATTTCTGCTCGACAGCGACCGCAAATTCTACTTCATGGAAATGAATACCCGTA
TACAGGTTGAACATCCTGTAACGGAGGAACGCTATGATGTCGATCTGGTCAAGGAACAGATTCTTGTCGCTTCCGGCGAG
TCCATTGCCGATAGGAAATACCGGCCGAAAGGACATTCAATTGAATGCAGAATCAATGCCGAGGATCCGGAACACGGATT
CAGACCAAGTCCCGGTGAACTCCAGGTGTTTCATACGCCCGGCGGTTATGGTGTCCGTGTCGACTCTCACGGCTACGCAA
GCTACAAGATCCCGTCGAATTACGACTCCATGGTAGCCAAGCTTATTGTCACGGCCCATTCAAGAGAAGAGGCTATAGCA
AGAATGCTCAGGGCCCTGGATGAATTCATCGTTGTCGGGATAAAAACCACCATTCCTTTTCATAAGCAGCTCTTGCAGAC
TGAAGAGTTCAGAAGCGGGAACTACGACACCCACTTTCTGGAAACCTTTACCTTCAAAAAAACTTAG

Upstream 100 bases:

>100_bases
CTATCAGGAACGATCATCGATATTCTTGTCGAAAACGGCCAGCCAGTCGAGTACGATCAGGTGCTGTTCCTCGTTAAGCC
TTAATTCATAAACTATTCGA

Downstream 100 bases:

>100_bases
AAAATTCCGAGACCATCCTGCAACAAAAAAAAAGCTGTCTCCCAGAGGGGACAGCTTTTTTATTTTCCAGGCGTTATCTG
ATCCGGAAGAAAGGCTTCGG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLFKKILIANRGEIALRIMQTCRELGISTVAIYSTADKNSLHVKYADEAVCIGPPLGKESYLNIPRIMAAAEITNADAIH
PGYGFLAENADFAEVCNASGIKFIGPTAEMIRKMGDKNSAKETMIAAGVPVIPGSDGLVRDTAHALKTAEKIGYPVIIKP
TAGGGGKGMRVVNEPEKIQKALLTSQNEAQQAFGNSGVYIEKFVESPRHVEIQILADQHGNTMHLGERDCTIQRRHQKLI
EETPSPVVDEALRNEMGNAAVAAASAINYEGAGTIEFLLDSDRKFYFMEMNTRIQVEHPVTEERYDVDLVKEQILVASGE
SIADRKYRPKGHSIECRINAEDPEHGFRPSPGELQVFHTPGGYGVRVDSHGYASYKIPSNYDSMVAKLIVTAHSREEAIA
RMLRALDEFIVVGIKTTIPFHKQLLQTEEFRSGNYDTHFLETFTFKKT

Sequences:

>Translated_448_residues
MLFKKILIANRGEIALRIMQTCRELGISTVAIYSTADKNSLHVKYADEAVCIGPPLGKESYLNIPRIMAAAEITNADAIH
PGYGFLAENADFAEVCNASGIKFIGPTAEMIRKMGDKNSAKETMIAAGVPVIPGSDGLVRDTAHALKTAEKIGYPVIIKP
TAGGGGKGMRVVNEPEKIQKALLTSQNEAQQAFGNSGVYIEKFVESPRHVEIQILADQHGNTMHLGERDCTIQRRHQKLI
EETPSPVVDEALRNEMGNAAVAAASAINYEGAGTIEFLLDSDRKFYFMEMNTRIQVEHPVTEERYDVDLVKEQILVASGE
SIADRKYRPKGHSIECRINAEDPEHGFRPSPGELQVFHTPGGYGVRVDSHGYASYKIPSNYDSMVAKLIVTAHSREEAIA
RMLRALDEFIVVGIKTTIPFHKQLLQTEEFRSGNYDTHFLETFTFKKT
>Mature_448_residues
MLFKKILIANRGEIALRIMQTCRELGISTVAIYSTADKNSLHVKYADEAVCIGPPLGKESYLNIPRIMAAAEITNADAIH
PGYGFLAENADFAEVCNASGIKFIGPTAEMIRKMGDKNSAKETMIAAGVPVIPGSDGLVRDTAHALKTAEKIGYPVIIKP
TAGGGGKGMRVVNEPEKIQKALLTSQNEAQQAFGNSGVYIEKFVESPRHVEIQILADQHGNTMHLGERDCTIQRRHQKLI
EETPSPVVDEALRNEMGNAAVAAASAINYEGAGTIEFLLDSDRKFYFMEMNTRIQVEHPVTEERYDVDLVKEQILVASGE
SIADRKYRPKGHSIECRINAEDPEHGFRPSPGELQVFHTPGGYGVRVDSHGYASYKIPSNYDSMVAKLIVTAHSREEAIA
RMLRALDEFIVVGIKTTIPFHKQLLQTEEFRSGNYDTHFLETFTFKKT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=47.380410022779, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=46.7415730337079, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=46.7415730337079, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=46.7415730337079, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=48.1900452488688, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=48.1900452488688, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=48.1900452488688, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=31.9688109161793, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=31.9688109161793, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=31.9688109161793, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=31.9688109161793, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=31.9688109161793, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=30.9338521400778, Blast_Score=239, Evalue=5e-63,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=54.627539503386, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=47.2727272727273, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=459, Percent_Identity=44.4444444444444, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.8325791855204, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=29.938900203666, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=28.0943025540275, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=28.0943025540275, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=42.6666666666667, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.9732142857143, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=44.4196428571429, Blast_Score=348, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=34.051724137931, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=32.0537428023033, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=45.8049886621315, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=458, Percent_Identity=45.4148471615721, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=458, Percent_Identity=45.4148471615721, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=458, Percent_Identity=45.4148471615721, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=458, Percent_Identity=45.4148471615721, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=458, Percent_Identity=45.4148471615721, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=459, Percent_Identity=45.3159041394335, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=459, Percent_Identity=45.3159041394335, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=459, Percent_Identity=45.3159041394335, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=459, Percent_Identity=45.3159041394335, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=459, Percent_Identity=45.3159041394335, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=44.6913580246914, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=31.4629258517034, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=31.4629258517034, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=31.4629258517034, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=31.4629258517034, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49466; Mature: 49466

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKKILIANRGEIALRIMQTCRELGISTVAIYSTADKNSLHVKYADEAVCIGPPLGKES
CCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCCCCCC
YLNIPRIMAAAEITNADAIHPGYGFLAENADFAEVCNASGIKFIGPTAEMIRKMGDKNSA
CCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCCEEECCHHHHHHHHCCCCCH
KETMIAAGVPVIPGSDGLVRDTAHALKTAEKIGYPVIIKPTAGGGGKGMRVVNEPEKIQK
HHHEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCHHHHHH
ALLTSQNEAQQAFGNSGVYIEKFVESPRHVEIQILADQHGNTMHLGERDCTIQRRHQKLI
HHHCCCCHHHHHHCCCCCEEEHHHCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHH
EETPSPVVDEALRNEMGNAAVAAASAINYEGAGTIEFLLDSDRKFYFMEMNTRIQVEHPV
HHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEEECCC
TEERYDVDLVKEQILVASGESIADRKYRPKGHSIECRINAEDPEHGFRPSPGELQVFHTP
CCCCCCHHHHHHHHHEECCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECC
GGYGVRVDSHGYASYKIPSNYDSMVAKLIVTAHSREEAIARMLRALDEFIVVGIKTTIPF
CCEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCCHH
HKQLLQTEEFRSGNYDTHFLETFTFKKT
HHHHHHHHHHCCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MLFKKILIANRGEIALRIMQTCRELGISTVAIYSTADKNSLHVKYADEAVCIGPPLGKES
CCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCCCCCC
YLNIPRIMAAAEITNADAIHPGYGFLAENADFAEVCNASGIKFIGPTAEMIRKMGDKNSA
CCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCCEEECCHHHHHHHHCCCCCH
KETMIAAGVPVIPGSDGLVRDTAHALKTAEKIGYPVIIKPTAGGGGKGMRVVNEPEKIQK
HHHEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCHHHHHH
ALLTSQNEAQQAFGNSGVYIEKFVESPRHVEIQILADQHGNTMHLGERDCTIQRRHQKLI
HHHCCCCHHHHHHCCCCCEEEHHHCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHH
EETPSPVVDEALRNEMGNAAVAAASAINYEGAGTIEFLLDSDRKFYFMEMNTRIQVEHPV
HHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEEECCC
TEERYDVDLVKEQILVASGESIADRKYRPKGHSIECRINAEDPEHGFRPSPGELQVFHTP
CCCCCCHHHHHHHHHEECCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECC
GGYGVRVDSHGYASYKIPSNYDSMVAKLIVTAHSREEAIARMLRALDEFIVVGIKTTIPF
CCEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCCHH
HKQLLQTEEFRSGNYDTHFLETFTFKKT
HHHHHHHHHHCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]