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The map label for this gene is nhaA3 [H]

Identifier: 194332991

GI number: 194332991

Start: 154863

End: 156203

Strand: Reverse

Name: nhaA3 [H]

Synonym: Paes_0144

Alternate gene names: 194332991

Gene position: 156203-154863 (Counterclockwise)

Preceding gene: 194332993

Following gene: 194332989

Centisome position: 6.22

GC content: 54.06

Gene sequence:

>1341_bases
ATGACGACTGATCATCAGGCAAATGCAGAAATAACCCGGCTGCCGAAGGAATTCCTTGATCGGCTTGCCAAACCCTTTAC
GCACTTCCTGCACATCGAAGCTGCCGGCGGAGCGATTCTTCTCCTGTTCACGGTTGCTGCACTGGTTCTTTCGAACTCAC
CGTGGGCTCACATGTTTGAACAAGCATGGAAAACCAAAATAGGGCTTCAACTTGATTCGCTGGAGTATGCACGTTCTCTG
CGAGAGTGGATCAACGATGGTTTGATGACGCTTTTTTTCTTTCTTGTCGCGTTAGAGCTCAAGCGAGAGTTGGTTCTCGG
CGAGTTGAACAAACCGCGCATGGCGATGCTGTCAATTTCTGCCGCTCTGGGAGGGATGATCTTTCCAGCGGCAATCTATC
TGACTCTGCAATCAGGACAACCCGGTGAGCATGGCTGGGGCACCGTCATGGCTACCGACACGGCATTTGTTATCGGCTGC
ATGGCTCTTCTGGGATCGCGCATTCCTCAAAGCTTACGGGTGTTTATGCTCTCATTGGCGATCGTTGACGATATCGGCTC
CATTCTGGTCGTCGCTATCGGATACAGCAGCAACATTTCATGGGGAGCGTTGGCTGTTGCGGCTCTTGGCGTCGTAATCG
TGCGTGCGATAGCAATGCTGGGCTTCCGCAGTTTTCCACCCTACATCCTGATCGGCGGGATGATCTGGCTTGCTATTGAT
ACGTCCGGAATACATGCAACCATCACCGGAGTAATACTCGGGTTAATGACACCTGCGAGGCGCTGGGTCAGTGCCGATCG
TTTATACGCCATATTGGACCAGGTCGTTGCGCATCCACATGGCGGCGCCCGGGGCAGCGCAGACACAAAGGATCGGCAGA
CCTTGCAGGTAGCCGAAATTGCCGCACGCGAAACGCTCTCTCCTGTCGAACGCCTTGAGATTGCGCTCCACCCATGGATC
GGCTTTTGTATCATGCCGCTGTTTGCATTTGCCAACGCCGGTTTACCACTATCGTTGAGCGATCTCGGCAACTCGGTCAG
CATCGCGGTTTTTGCAGGTTTCGTACTCGGCAAACCTCTTGGCATTCTGTCCTTCAGCTGGCTGGCAGTGCGCACGCACA
TCGCCATGCGTCCACCGGAACTCAGTTGGAGACTGATCGCTGGCGGCAGCCTTCTCGGCGGAATCGGCTTCACCATGGCG
CTGTTTATTGCCAATATAGCGTTCGACAACAGTGTGATCACCAGCGCCAAACTTGGGATCTTCCTCGCATCCATCTTTTC
CGCAACCGCAGGTCTCTCAATGTTGAGATGGTTCCCTGCATCCGGCAAACCCGCTCAATAA

Upstream 100 bases:

>100_bases
GCGACTGAGAACGGACAATGATACCGATGATCATCACGCCCCGAAGACTATCACCCCCGGGAGTGGTCATTGTAACGACT
GGCAAACGGACATTCCTTTT

Downstream 100 bases:

>100_bases
AGTCACCACCAACCTATACAAACACACCCAAAACAGAAAAAAAGGGGACGTTCACAAGTACATAAATTTTCCAGAAAAAG
CGACCAAATCCATCATACGC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 3 [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTTDHQANAEITRLPKEFLDRLAKPFTHFLHIEAAGGAILLLFTVAALVLSNSPWAHMFEQAWKTKIGLQLDSLEYARSL
REWINDGLMTLFFFLVALELKRELVLGELNKPRMAMLSISAALGGMIFPAAIYLTLQSGQPGEHGWGTVMATDTAFVIGC
MALLGSRIPQSLRVFMLSLAIVDDIGSILVVAIGYSSNISWGALAVAALGVVIVRAIAMLGFRSFPPYILIGGMIWLAID
TSGIHATITGVILGLMTPARRWVSADRLYAILDQVVAHPHGGARGSADTKDRQTLQVAEIAARETLSPVERLEIALHPWI
GFCIMPLFAFANAGLPLSLSDLGNSVSIAVFAGFVLGKPLGILSFSWLAVRTHIAMRPPELSWRLIAGGSLLGGIGFTMA
LFIANIAFDNSVITSAKLGIFLASIFSATAGLSMLRWFPASGKPAQ

Sequences:

>Translated_446_residues
MTTDHQANAEITRLPKEFLDRLAKPFTHFLHIEAAGGAILLLFTVAALVLSNSPWAHMFEQAWKTKIGLQLDSLEYARSL
REWINDGLMTLFFFLVALELKRELVLGELNKPRMAMLSISAALGGMIFPAAIYLTLQSGQPGEHGWGTVMATDTAFVIGC
MALLGSRIPQSLRVFMLSLAIVDDIGSILVVAIGYSSNISWGALAVAALGVVIVRAIAMLGFRSFPPYILIGGMIWLAID
TSGIHATITGVILGLMTPARRWVSADRLYAILDQVVAHPHGGARGSADTKDRQTLQVAEIAARETLSPVERLEIALHPWI
GFCIMPLFAFANAGLPLSLSDLGNSVSIAVFAGFVLGKPLGILSFSWLAVRTHIAMRPPELSWRLIAGGSLLGGIGFTMA
LFIANIAFDNSVITSAKLGIFLASIFSATAGLSMLRWFPASGKPAQ
>Mature_445_residues
TTDHQANAEITRLPKEFLDRLAKPFTHFLHIEAAGGAILLLFTVAALVLSNSPWAHMFEQAWKTKIGLQLDSLEYARSLR
EWINDGLMTLFFFLVALELKRELVLGELNKPRMAMLSISAALGGMIFPAAIYLTLQSGQPGEHGWGTVMATDTAFVIGCM
ALLGSRIPQSLRVFMLSLAIVDDIGSILVVAIGYSSNISWGALAVAALGVVIVRAIAMLGFRSFPPYILIGGMIWLAIDT
SGIHATITGVILGLMTPARRWVSADRLYAILDQVVAHPHGGARGSADTKDRQTLQVAEIAARETLSPVERLEIALHPWIG
FCIMPLFAFANAGLPLSLSDLGNSVSIAVFAGFVLGKPLGILSFSWLAVRTHIAMRPPELSWRLIAGGSLLGGIGFTMAL
FIANIAFDNSVITSAKLGIFLASIFSATAGLSMLRWFPASGKPAQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=424, Percent_Identity=38.9150943396226, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 47938; Mature: 47807

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDHQANAEITRLPKEFLDRLAKPFTHFLHIEAAGGAILLLFTVAALVLSNSPWAHMFE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
QAWKTKIGLQLDSLEYARSLREWINDGLMTLFFFLVALELKRELVLGELNKPRMAMLSIS
HHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AALGGMIFPAAIYLTLQSGQPGEHGWGTVMATDTAFVIGCMALLGSRIPQSLRVFMLSLA
HHHHHHHHHEEEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHH
IVDDIGSILVVAIGYSSNISWGALAVAALGVVIVRAIAMLGFRSFPPYILIGGMIWLAID
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEEE
TSGIHATITGVILGLMTPARRWVSADRLYAILDQVVAHPHGGARGSADTKDRQTLQVAEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AARETLSPVERLEIALHPWIGFCIMPLFAFANAGLPLSLSDLGNSVSIAVFAGFVLGKPL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEHHHHHHHHHCCCH
GILSFSWLAVRTHIAMRPPELSWRLIAGGSLLGGIGFTMALFIANIAFDNSVITSAKLGI
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLASIFSATAGLSMLRWFPASGKPAQ
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTDHQANAEITRLPKEFLDRLAKPFTHFLHIEAAGGAILLLFTVAALVLSNSPWAHMFE
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
QAWKTKIGLQLDSLEYARSLREWINDGLMTLFFFLVALELKRELVLGELNKPRMAMLSIS
HHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AALGGMIFPAAIYLTLQSGQPGEHGWGTVMATDTAFVIGCMALLGSRIPQSLRVFMLSLA
HHHHHHHHHEEEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHH
IVDDIGSILVVAIGYSSNISWGALAVAALGVVIVRAIAMLGFRSFPPYILIGGMIWLAID
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEEE
TSGIHATITGVILGLMTPARRWVSADRLYAILDQVVAHPHGGARGSADTKDRQTLQVAEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AARETLSPVERLEIALHPWIGFCIMPLFAFANAGLPLSLSDLGNSVSIAVFAGFVLGKPL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEHHHHHHHHHCCCH
GILSFSWLAVRTHIAMRPPELSWRLIAGGSLLGGIGFTMALFIANIAFDNSVITSAKLGI
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLASIFSATAGLSMLRWFPASGKPAQ
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA