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The map label for this gene is mazG [H]

Identifier: 193213596

GI number: 193213596

Start: 2156074

End: 2156889

Strand: Direct

Name: mazG [H]

Synonym: Cpar_1957

Alternate gene names: 193213596

Gene position: 2156074-2156889 (Clockwise)

Preceding gene: 193213592

Following gene: 193213597

Centisome position: 94.18

GC content: 59.8

Gene sequence:

>816_bases
ATGAAGCACGAAGCGAACCCGTCCATCGAAATCCTCAAGGAGTCCGTTCTCAACCACAACGCCGTCACGCCTGCCGAGCA
CTTCGAGCGGGTGGTGAACCTCGTGCGGGTGCTGCGTTCGGAGTGCCCGTGGGATCGCAAGCAGACGCCGGAGTCGCTGG
CGCATCTCTTGCTCGAAGAGAGCTATGAGCTGGTGCACGCCATCGACACGGGCGACGATCCGGAGCTGAAAAAGGAGCTG
GGCGATCTCTTCCTGCACGTCTGCTTTCAGGTGCTGCTGGCCGACGAGGCGGGCAAATTCTCGTTCGTCGATGTCTTCGA
GGCGCTTTGCCACAAGCTCATCAGCCGCCACCCGCACGTGTTTGGGGATGTGAAGGCCGACACGGAGCAGGCGGTACTCG
GCAACTGGGAAAATCTGAAAATGAAGGAGGGGCGCAAGAGCCTGCTGGAAGGGGTGCCGAACGCGATGTCCGAACTGCTG
CGGGCCTACCGGGTGCAGAAAAAGGTGGCGGGCGTCGGCTTCGATTGGCCAAGTGACGAAGGCGTGCTCGACAAGCTCAC
CGAGGAGATCGGCGAATTGCGTCATGCGGCGGACAAGAGCGAGCGTGAGGAGGAGTTCGGCGACCTGCTCTTCACCATCG
TCAACTACAGCCGCTTCATCGACACCAACCCCGAAGACGCTCTACGCAAGGCGACCAACAAATTCATGGATCGTTTCCGC
AAAGTCGAAGAGTCCGTGCAGGCGTCGGGAAAAAGCTGGCAGGAGTTTTCAGCCGAGGAGCTGGACTCGCTTTGGAACGA
GGCGAAAAAATCATGA

Upstream 100 bases:

>100_bases
TTCCTTGTTGTTTACGGGACAAAAGAGCCTCATTTCAATAGTACGGATTCTCCGGCCTAAATAGTAACTTTCGGCACATC
ACAACAAGCCCCCCGACATC

Downstream 100 bases:

>100_bases
TAATCTTTTATAGCCTGCATCAGCTTCCCGCAGGATATGTCACCGAGCCATCTTGCATTCGCTCACCAAAACCAACACGG
CCATGGTACAATGCTTTCGT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKHEANPSIEILKESVLNHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAGKFSFVDVFEALCHKLISRHPHVFGDVKADTEQAVLGNWENLKMKEGRKSLLEGVPNAMSELL
RAYRVQKKVAGVGFDWPSDEGVLDKLTEEIGELRHAADKSEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEESVQASGKSWQEFSAEELDSLWNEAKKS

Sequences:

>Translated_271_residues
MKHEANPSIEILKESVLNHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAGKFSFVDVFEALCHKLISRHPHVFGDVKADTEQAVLGNWENLKMKEGRKSLLEGVPNAMSELL
RAYRVQKKVAGVGFDWPSDEGVLDKLTEEIGELRHAADKSEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEESVQASGKSWQEFSAEELDSLWNEAKKS
>Mature_271_residues
MKHEANPSIEILKESVLNHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAGKFSFVDVFEALCHKLISRHPHVFGDVKADTEQAVLGNWENLKMKEGRKSLLEGVPNAMSELL
RAYRVQKKVAGVGFDWPSDEGVLDKLTEEIGELRHAADKSEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEESVQASGKSWQEFSAEELDSLWNEAKKS

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=39.6887159533074, Blast_Score=188, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30963; Mature: 30963

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHEANPSIEILKESVLNHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEE
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SYELVHAIDTGDDPELKKELGDLFLHVCFQVLLADEAGKFSFVDVFEALCHKLISRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
FGDVKADTEQAVLGNWENLKMKEGRKSLLEGVPNAMSELLRAYRVQKKVAGVGFDWPSDE
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLTEEIGELRHAADKSEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
CHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVEESVQASGKSWQEFSAEELDSLWNEAKKS
HHHHHHHHCCCCHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHEANPSIEILKESVLNHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEE
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SYELVHAIDTGDDPELKKELGDLFLHVCFQVLLADEAGKFSFVDVFEALCHKLISRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
FGDVKADTEQAVLGNWENLKMKEGRKSLLEGVPNAMSELLRAYRVQKKVAGVGFDWPSDE
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLTEEIGELRHAADKSEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
CHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVEESVQASGKSWQEFSAEELDSLWNEAKKS
HHHHHHHHCCCCHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]