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The map label for this gene is guaA [H]

Identifier: 193213507

GI number: 193213507

Start: 2053302

End: 2054852

Strand: Direct

Name: guaA [H]

Synonym: Cpar_1868

Alternate gene names: 193213507

Gene position: 2053302-2054852 (Clockwise)

Preceding gene: 193213506

Following gene: 193213509

Centisome position: 89.69

GC content: 61.25

Gene sequence:

>1551_bases
ATGGCAACAACCCTTCAATCGGTCATCGTCCTCGACTTCGGGTCTCAGTACACCCAGCTCATCGCGCGTCGCATCCGTGA
AATCGGCATCTACTCCGAGATTTTTCCCTACCACACCAGCGCCGAGGAGCTGAAAAAACACCAGCCGAAAGCGATCATCC
TTTCCGGCGGCCCGAACAGCGTGTACGACGAAACCGCCTTCATGCCCGATCCGGAGGTGTTCAGCCTCGGCGTGCCGGTG
CTCGGCATCTGCTATGGCCTGCAAGCAATCGCCAAGCACTTCGGCGGCAACGTCGAAAGCTCGTCGAAGCAGGAGTTCGG
CCGCGCCAAGATGCTGGTGAGCCACGACGAGCGCGAGAGCATGCTGTTCAAGGACATTCCGGACTCGGACGTCTGGATGA
GCCACGGCGACAAGGTGACCAAACTGCCCGACGGCTTCCGCGTTACAGCCAGCACGGCCAATGCCGAGATGTGCGCCATC
GAGAGCTTCGGCAGCAAGGCTGCGCTGAAGGTGTTCGGCTTGCAGTTCCACCCTGAGGTGCAGCACTCGCTCTACGGCAA
GCAGCTCCTTTCGAACTTCCTGATCGACATCGCGGGCATCACGCCCGACTGGTCGCCGAAGAGCTTTATCCAGCACCAGA
TCGAGGAGATCAAGCGGGTTGCGGGCGACTCGACCGTGGTGTGCGGCATCAGCGGCGGCGTCGATTCCACGGTGGCTGCC
GTGCTGGTCAGCAAAGCGATTGGCGACAAGCTGCACTGCGTCTTTGTGGATAACGGCCTGCTCCGAAAGGACGAAGCGAC
AAAGGTGATGGAGTTCCTCAAGCCGCTCGGCCTGAAGGTGACGCTCGCCGACGCCAGCGACCTCTTTCTGGGACGACTCA
AAGGCGTGGCTTCGCCGGAGAAGAAGCGCAAGATCATCGGCCGCACCTTCATCCGCGTGTTTGAAGAGAACATCCACGAC
GAGAAGTTCCTCGTGCAGGGCACGCTCTACCCGGACGTCATCGAGAGCGTCAGCGTCAAGGGGCCGTCTGAAACCATCAA
GTCGCACCACAACGTCGGCGGCCTGCCGAAGCGCATGAAGCTCAAGCTCATCGAGCCGCTGCGCGAGCTGTTCAAGGACG
AAGTCCGCGCCGTCGGACGCGAGCTTGGCATCGCCGAGGACATCCTGATGCGCCACCCCTTCCCCGGCCCTGGCCTCGCC
GTGCGCGTGCTCGGCTCGTTGACGAAGGAGCGCCTCGACGTGCTGCGCGAAGCCGACCAGATTTTCATCGACGAACTCAA
AGAGAGCGGCTTGTACCAGAAAGTGTGGCAGGCCTTCTCGGTGCTCCTGCCGGTGCAGTCGGTTGGCGTCATGGGCGACA
AACGCACCTACGAAAACGTCCTCGCATTGCGCGCCGTCGAATCCACCGACGGCATGACCGCCGACTGGGCGCATTTGCCG
CACGACTTCCTCTCAAAAGTCTCGAACCGAATCATCAACGAAGTCCGAGGCATCAACCGCGTGGCGTACGATATTTCGTC
CAAGCCACCGGCGACGATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CAGCACGAAAACGCAGACGGCACCGACACCGATACAAATGCCGGTGCTGACGCCTCAGGAACAGTATTAAATCAACATCT
TCTTTGGTTTCAACCTCAAT

Downstream 100 bases:

>100_bases
AGAAAAAGAGAGATTTCTGGAGATATGAAAAAACCCCGTCGATTTCGGCGGGGTTTTTTGTTGAGGGGAAGGAATGGTTA
GCCAAAATGATTTTTGATGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MATTLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTSAEELKKHQPKAIILSGGPNSVYDETAFMPDPEVFSLGVPV
LGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVSHDERESMLFKDIPDSDVWMSHGDKVTKLPDGFRVTASTANAEMCAI
ESFGSKAALKVFGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
VLVSKAIGDKLHCVFVDNGLLRKDEATKVMEFLKPLGLKVTLADASDLFLGRLKGVASPEKKRKIIGRTFIRVFEENIHD
EKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLA
VRVLGSLTKERLDVLREADQIFIDELKESGLYQKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HDFLSKVSNRIINEVRGINRVAYDISSKPPATIEWE

Sequences:

>Translated_516_residues
MATTLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTSAEELKKHQPKAIILSGGPNSVYDETAFMPDPEVFSLGVPV
LGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVSHDERESMLFKDIPDSDVWMSHGDKVTKLPDGFRVTASTANAEMCAI
ESFGSKAALKVFGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
VLVSKAIGDKLHCVFVDNGLLRKDEATKVMEFLKPLGLKVTLADASDLFLGRLKGVASPEKKRKIIGRTFIRVFEENIHD
EKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLA
VRVLGSLTKERLDVLREADQIFIDELKESGLYQKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HDFLSKVSNRIINEVRGINRVAYDISSKPPATIEWE
>Mature_515_residues
ATTLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTSAEELKKHQPKAIILSGGPNSVYDETAFMPDPEVFSLGVPVL
GICYGLQAIAKHFGGNVESSSKQEFGRAKMLVSHDERESMLFKDIPDSDVWMSHGDKVTKLPDGFRVTASTANAEMCAIE
SFGSKAALKVFGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAAV
LVSKAIGDKLHCVFVDNGLLRKDEATKVMEFLKPLGLKVTLADASDLFLGRLKGVASPEKKRKIIGRTFIRVFEENIHDE
KFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAV
RVLGSLTKERLDVLREADQIFIDELKESGLYQKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLPH
DFLSKVSNRIINEVRGINRVAYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=554, Percent_Identity=38.2671480144404, Blast_Score=325, Evalue=9e-89,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=53.3460803059273, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71992717, Length=577, Percent_Identity=35.1819757365685, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71992710, Length=577, Percent_Identity=35.1819757365685, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI133901714, Length=577, Percent_Identity=34.8353552859619, Blast_Score=296, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=53.6121673003802, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=34.8457350272232, Blast_Score=298, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57137; Mature: 57005

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTSAEELKKHQPKAIILSGGPNS
CCCCHHHHHEEECCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCEEEEECCCCC
VYDETAFMPDPEVFSLGVPVLGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVSHDERES
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHH
MLFKDIPDSDVWMSHGDKVTKLPDGFRVTASTANAEMCAIESFGSKAALKVFGLQFHPEV
HHHHCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCEEEHHHCCCCCEEHHCCCCCCCHH
QHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
VLVSKAIGDKLHCVFVDNGLLRKDEATKVMEFLKPLGLKVTLADASDLFLGRLKGVASPE
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCH
KKRKIIGRTFIRVFEENIHDEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHH
LKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSLTKERLDVLREADQ
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFIDELKESGLYQKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCHHHHCC
HDFLSKVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure 
ATTLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTSAEELKKHQPKAIILSGGPNS
CCCHHHHHEEECCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCEEEEECCCCC
VYDETAFMPDPEVFSLGVPVLGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVSHDERES
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHH
MLFKDIPDSDVWMSHGDKVTKLPDGFRVTASTANAEMCAIESFGSKAALKVFGLQFHPEV
HHHHCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCEEEHHHCCCCCEEHHCCCCCCCHH
QHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
VLVSKAIGDKLHCVFVDNGLLRKDEATKVMEFLKPLGLKVTLADASDLFLGRLKGVASPE
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCH
KKRKIIGRTFIRVFEENIHDEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHH
LKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSLTKERLDVLREADQ
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFIDELKESGLYQKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCHHHHCC
HDFLSKVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]