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The map label for this gene is mrcA [H]

Identifier: 193213506

GI number: 193213506

Start: 2050956

End: 2053271

Strand: Direct

Name: mrcA [H]

Synonym: Cpar_1867

Alternate gene names: 193213506

Gene position: 2050956-2053271 (Clockwise)

Preceding gene: 193213505

Following gene: 193213507

Centisome position: 89.59

GC content: 58.38

Gene sequence:

>2316_bases
GTGAGCACGAAAAGCAAAAAGACGAAAAAGAAAAGAAGCAAAACCAAAAAGCGCGGTACGAACATCACCATGAAAATCGC
CGGACTACTCCTTGTTATCATTATCGGTGCCGGCTCGCTGTTCGGCATCAGCCTGTTCAAAGGGCTACCGAGCCTTGAAG
AGCTTGAAAATCCCAAACCGAACCTGGCCTCGCTGGTCTACTCCGAAGACGGCGTCCTGCTGCACAAGTTCTTTCTGGAA
AACAGAACCTTCGTGCCGCTCAAGTCGATCTCCAAGTGGGTGCCAAAGGCCCTGATCGCCACCGAGGATGTGGCATTCTA
CCAGCACTGGGGCGTCGATCTCCGCCGCCTGACCCTGGCGATGGGCGAAAATATCATCAAGGGCCGCACCCGCTGGCATG
GCGCGAGCACCATCACGCAGCAGTTGGCCAAAAACCTTTTCCTGACCCAGGAGCGCACCCTGAGCCGCAAGGCCAAGGAG
TTGATTACGGCCATAGAGCTTGAAAAAACCTACACCAAGGACGAGATTCTGGCGCTCTATCTGAACACGGTCTATTTCGG
TTCAGGAGCGTACGGCATCGAAGCTGCCGCCAACACCTATTTCGGCAAGAAGGCAAGCGAACTGACGATTCCGGAAAGTG
CCTCACTGATCGCGACCCTCAAAAATCCAACCGCATACAATCCGGCCAAGAATCCGTCGACTGCTCTTGGACGCAGAAAC
CTGATCATCGGGCTGATGGAAAAAGAGGGCTTCATCACGCACGCCCAGGCGGTCAAGGCGAAAGCCACGCCGGTCACGTT
GCACTACACGCCGAGCACCCATCACGGCCTGGCCCCCTATTTCACCGAATACATCCGCCAGAACATCAAAACGAGCTCGC
AGCTTGACGGAGTCAACGTCTATAGCGATGGCCTGACCATTCAGACCACGCTCGACAGCCGGATGCAGCGCTACGCCCAG
GAGGCCATCGCCCAACAGGCCGCGGCATTGCAGGCAGAGTTCGACAAGCGCTGGACATGCAGCGACGCGCTGAAAAAGCA
GTTCATCAAGGAGAGCCCGCAGTATCGGGAGCTGGTGAACGAAGAGGGCGTTGCGCCGGCAACGGCACTCTCGAAGCTGC
TGGCCGATAAAGTGTTCGTCAAGAATCTGCTGCACGATAAAAGCCGTGTCCAGATGGCCCTGATCTCGCTCGATCCGACC
AACGGCCATGTAAAGGCCTGGGTCGGCGGCACCAATTTCAGCCCGGATGACTACCGCTACCAGTTCGACCATGTCTGGCA
GGCCAAACGGCAGCCCGGCTCGACCTTCAAGCCGTTTGTGTATTCGGCGGCCATCGATCAGGGAATTCCGGCCAACTACA
GGATTCTCGACCAGCCGCTGGCGCTGAGAGGCGGTGACGGCTCCGTCTGGATGGCTCGCAACTCCGAAGGCCAGTCCGGC
GGCATGACCACCTTGCGTGACGCACTCCGACGCTCGCTGAATCAGGTGACCATCAGGCTTGCCTACCAGTTCCTGACCCC
GTCGGAAATCATCAGCTATGCACGCCGCATGGGCATTACCACCCCCATGCAGCCGAACCTTTCGATTGCGCTCGGCACCT
CCGAGGTCTCCCCGCTGGTGCTGGCCCAGGCATTCACGACGTTTGCCAACAACGGCACCTGGAGCGAACCGCTTCCGGTC
ACCAAAGTGCTTGACAAGCGCGGGGGCCTCATTACCGAACACAAACCGGTCAGCCATTTCGGCCTTGATCCAGCGAGCAA
CTTCGTCATGGTCACCATGCTCAAGGATGTCATCGATCGCGGTACCGGTATCGCCGTTCGGGCGCGCTACGGCTTCGACG
CCGAGGCCGGTGGCAAGACTGGCACCACCCAGAGCATGAGGGATGCGTGGTTCGCCGGCTTCACGCCGCAGCTCGTCACG
GTGGTGTGGGCAGGCTTCGACGACGAACGGGTTCATTTCACCTCGATGTCGTACGGTCAGGGCGCCAGAGCTGCGCTTCC
GGCATGGGCTTCGTTCATGAAAAAGTGCTATGACGACCCGGAACTCCATCTGGAAAACCGCTATTTCACCATGCCCGACA
ATGTGATTGCCGTGCCGATTTCAGCTGGTTCGGGCGATCAGGGAGACCTGTTCAACCGTGATGTTTATGTAGAGTACTTC
ACGCCGAAAGGCTTTGCCCGCTACCGCTCTGGCGAGCTGAACAATACGCCGCCGCCGGCCCAGCAGGAATCGGACAACCC
GCAGGACAGCACGAAAACGCAGACGGCACCGACACCGATACAAATGCCGGTGCTGACGCCTCAGGAACAGTATTAA

Upstream 100 bases:

>100_bases
GGTGCAGATACCGTGACCACCGGAGCCTGACACCAGACCATCCGACAGAAAGCGCAAAAGCACGAACCAGAATGAACCAC
CTTTTGAAATCCATGTTCAC

Downstream 100 bases:

>100_bases
ATCAACATCTTCTTTGGTTTCAACCTCAATATGGCAACAACCCTTCAATCGGTCATCGTCCTCGACTTCGGGTCTCAGTA
CACCCAGCTCATCGCGCGTC

Product: penicillin-binding protein, 1A family

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MSTKSKKTKKKRSKTKKRGTNITMKIAGLLLVIIIGAGSLFGISLFKGLPSLEELENPKPNLASLVYSEDGVLLHKFFLE
NRTFVPLKSISKWVPKALIATEDVAFYQHWGVDLRRLTLAMGENIIKGRTRWHGASTITQQLAKNLFLTQERTLSRKAKE
LITAIELEKTYTKDEILALYLNTVYFGSGAYGIEAAANTYFGKKASELTIPESASLIATLKNPTAYNPAKNPSTALGRRN
LIIGLMEKEGFITHAQAVKAKATPVTLHYTPSTHHGLAPYFTEYIRQNIKTSSQLDGVNVYSDGLTIQTTLDSRMQRYAQ
EAIAQQAAALQAEFDKRWTCSDALKKQFIKESPQYRELVNEEGVAPATALSKLLADKVFVKNLLHDKSRVQMALISLDPT
NGHVKAWVGGTNFSPDDYRYQFDHVWQAKRQPGSTFKPFVYSAAIDQGIPANYRILDQPLALRGGDGSVWMARNSEGQSG
GMTTLRDALRRSLNQVTIRLAYQFLTPSEIISYARRMGITTPMQPNLSIALGTSEVSPLVLAQAFTTFANNGTWSEPLPV
TKVLDKRGGLITEHKPVSHFGLDPASNFVMVTMLKDVIDRGTGIAVRARYGFDAEAGGKTGTTQSMRDAWFAGFTPQLVT
VVWAGFDDERVHFTSMSYGQGARAALPAWASFMKKCYDDPELHLENRYFTMPDNVIAVPISAGSGDQGDLFNRDVYVEYF
TPKGFARYRSGELNNTPPPAQQESDNPQDSTKTQTAPTPIQMPVLTPQEQY

Sequences:

>Translated_771_residues
MSTKSKKTKKKRSKTKKRGTNITMKIAGLLLVIIIGAGSLFGISLFKGLPSLEELENPKPNLASLVYSEDGVLLHKFFLE
NRTFVPLKSISKWVPKALIATEDVAFYQHWGVDLRRLTLAMGENIIKGRTRWHGASTITQQLAKNLFLTQERTLSRKAKE
LITAIELEKTYTKDEILALYLNTVYFGSGAYGIEAAANTYFGKKASELTIPESASLIATLKNPTAYNPAKNPSTALGRRN
LIIGLMEKEGFITHAQAVKAKATPVTLHYTPSTHHGLAPYFTEYIRQNIKTSSQLDGVNVYSDGLTIQTTLDSRMQRYAQ
EAIAQQAAALQAEFDKRWTCSDALKKQFIKESPQYRELVNEEGVAPATALSKLLADKVFVKNLLHDKSRVQMALISLDPT
NGHVKAWVGGTNFSPDDYRYQFDHVWQAKRQPGSTFKPFVYSAAIDQGIPANYRILDQPLALRGGDGSVWMARNSEGQSG
GMTTLRDALRRSLNQVTIRLAYQFLTPSEIISYARRMGITTPMQPNLSIALGTSEVSPLVLAQAFTTFANNGTWSEPLPV
TKVLDKRGGLITEHKPVSHFGLDPASNFVMVTMLKDVIDRGTGIAVRARYGFDAEAGGKTGTTQSMRDAWFAGFTPQLVT
VVWAGFDDERVHFTSMSYGQGARAALPAWASFMKKCYDDPELHLENRYFTMPDNVIAVPISAGSGDQGDLFNRDVYVEYF
TPKGFARYRSGELNNTPPPAQQESDNPQDSTKTQTAPTPIQMPVLTPQEQY
>Mature_770_residues
STKSKKTKKKRSKTKKRGTNITMKIAGLLLVIIIGAGSLFGISLFKGLPSLEELENPKPNLASLVYSEDGVLLHKFFLEN
RTFVPLKSISKWVPKALIATEDVAFYQHWGVDLRRLTLAMGENIIKGRTRWHGASTITQQLAKNLFLTQERTLSRKAKEL
ITAIELEKTYTKDEILALYLNTVYFGSGAYGIEAAANTYFGKKASELTIPESASLIATLKNPTAYNPAKNPSTALGRRNL
IIGLMEKEGFITHAQAVKAKATPVTLHYTPSTHHGLAPYFTEYIRQNIKTSSQLDGVNVYSDGLTIQTTLDSRMQRYAQE
AIAQQAAALQAEFDKRWTCSDALKKQFIKESPQYRELVNEEGVAPATALSKLLADKVFVKNLLHDKSRVQMALISLDPTN
GHVKAWVGGTNFSPDDYRYQFDHVWQAKRQPGSTFKPFVYSAAIDQGIPANYRILDQPLALRGGDGSVWMARNSEGQSGG
MTTLRDALRRSLNQVTIRLAYQFLTPSEIISYARRMGITTPMQPNLSIALGTSEVSPLVLAQAFTTFANNGTWSEPLPVT
KVLDKRGGLITEHKPVSHFGLDPASNFVMVTMLKDVIDRGTGIAVRARYGFDAEAGGKTGTTQSMRDAWFAGFTPQLVTV
VWAGFDDERVHFTSMSYGQGARAALPAWASFMKKCYDDPELHLENRYFTMPDNVIAVPISAGSGDQGDLFNRDVYVEYFT
PKGFARYRSGELNNTPPPAQQESDNPQDSTKTQTAPTPIQMPVLTPQEQY

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=611, Percent_Identity=31.5875613747954, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1786343, Length=604, Percent_Identity=30.6291390728477, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1788867, Length=641, Percent_Identity=26.8330733229329, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789601, Length=224, Percent_Identity=36.1607142857143, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 85461; Mature: 85330

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKSKKTKKKRSKTKKRGTNITMKIAGLLLVIIIGAGSLFGISLFKGLPSLEELENPKP
CCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCC
NLASLVYSEDGVLLHKFFLENRTFVPLKSISKWVPKALIATEDVAFYQHWGVDLRRLTLA
CHHEEEECCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MGENIIKGRTRWHGASTITQQLAKNLFLTQERTLSRKAKELITAIELEKTYTKDEILALY
HCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHE
LNTVYFGSGAYGIEAAANTYFGKKASELTIPESASLIATLKNPTAYNPAKNPSTALGRRN
EHHHEECCCCCCHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHCCCC
LIIGLMEKEGFITHAQAVKAKATPVTLHYTPSTHHGLAPYFTEYIRQNIKTSSQLDGVNV
EEEEEECCCCCEEHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEE
YSDGLTIQTTLDSRMQRYAQEAIAQQAAALQAEFDKRWTCSDALKKQFIKESPQYRELVN
ECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHC
EEGVAPATALSKLLADKVFVKNLLHDKSRVQMALISLDPTNGHVKAWVGGTNFSPDDYRY
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCEE
QFDHVWQAKRQPGSTFKPFVYSAAIDQGIPANYRILDQPLALRGGDGSVWMARNSEGQSG
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEECCCCCEEEEECCCCCCC
GMTTLRDALRRSLNQVTIRLAYQFLTPSEIISYARRMGITTPMQPNLSIALGTSEVSPLV
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHH
LAQAFTTFANNGTWSEPLPVTKVLDKRGGLITEHKPVSHFGLDPASNFVMVTMLKDVIDR
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCCCCHHCCCCCCCCEEHHHHHHHHHHC
GTGIAVRARYGFDAEAGGKTGTTQSMRDAWFAGFTPQLVTVVWAGFDDERVHFTSMSYGQ
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHEEHEEECCCCCCEEEEEECCCCC
GARAALPAWASFMKKCYDDPELHLENRYFTMPDNVIAVPISAGSGDQGDLFNRDVYVEYF
CCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEEE
TPKGFARYRSGELNNTPPPAQQESDNPQDSTKTQTAPTPIQMPVLTPQEQY
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure 
STKSKKTKKKRSKTKKRGTNITMKIAGLLLVIIIGAGSLFGISLFKGLPSLEELENPKP
CCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCC
NLASLVYSEDGVLLHKFFLENRTFVPLKSISKWVPKALIATEDVAFYQHWGVDLRRLTLA
CHHEEEECCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MGENIIKGRTRWHGASTITQQLAKNLFLTQERTLSRKAKELITAIELEKTYTKDEILALY
HCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHE
LNTVYFGSGAYGIEAAANTYFGKKASELTIPESASLIATLKNPTAYNPAKNPSTALGRRN
EHHHEECCCCCCHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHCCCC
LIIGLMEKEGFITHAQAVKAKATPVTLHYTPSTHHGLAPYFTEYIRQNIKTSSQLDGVNV
EEEEEECCCCCEEHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEE
YSDGLTIQTTLDSRMQRYAQEAIAQQAAALQAEFDKRWTCSDALKKQFIKESPQYRELVN
ECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHC
EEGVAPATALSKLLADKVFVKNLLHDKSRVQMALISLDPTNGHVKAWVGGTNFSPDDYRY
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCEE
QFDHVWQAKRQPGSTFKPFVYSAAIDQGIPANYRILDQPLALRGGDGSVWMARNSEGQSG
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEECCCCCEEEEECCCCCCC
GMTTLRDALRRSLNQVTIRLAYQFLTPSEIISYARRMGITTPMQPNLSIALGTSEVSPLV
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHH
LAQAFTTFANNGTWSEPLPVTKVLDKRGGLITEHKPVSHFGLDPASNFVMVTMLKDVIDR
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCCCCHHCCCCCCCCEEHHHHHHHHHHC
GTGIAVRARYGFDAEAGGKTGTTQSMRDAWFAGFTPQLVTVVWAGFDDERVHFTSMSYGQ
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHEEHEEECCCCCCEEEEEECCCCC
GARAALPAWASFMKKCYDDPELHLENRYFTMPDNVIAVPISAGSGDQGDLFNRDVYVEYF
CCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEEE
TPKGFARYRSGELNNTPPPAQQESDNPQDSTKTQTAPTPIQMPVLTPQEQY
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA