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The map label for this gene is moeA [H]

Identifier: 193212997

GI number: 193212997

Start: 1463022

End: 1464248

Strand: Direct

Name: moeA [H]

Synonym: Cpar_1347

Alternate gene names: 193212997

Gene position: 1463022-1464248 (Clockwise)

Preceding gene: 193212996

Following gene: 193212998

Centisome position: 63.91

GC content: 62.67

Gene sequence:

>1227_bases
ATGATTACCGTTCAGGAAGCTCACCAAATTATCGCCGCGACGGTGCAACGACTGGGCGCAACCGTCTCCGTTCCGCTGCA
CCAGCTCCGTGGCCGCGTACTGGCCGAGGAGGTTCGCGCAGGCTTCCCGATGCCGCGCTTCACCAACGCCGCGATGGACG
GCTTTGCCGTGCGATTCGATGAGATTGCCGGAACATCCGACAGCGCACCCGTCACGCTCCCGGTCTCGCAGGAGCTGGCC
GCCGGAGCGCTCGCCGTTGCGCCGCTCGAAGCTGGAAGCTGCGCGCGCATCATGACCGGCGCGCCTGTACCCGACGGAGC
CGACACCGTAGTGCCGTTCGAGCAGACCAGCGGGTTCGAGAGAGAAACCGTGGAGTTCTACAAAGCTCCGAAAAAAGGCG
CGAACATCCGGCACACGGGCGAAGAGGTTAAGATCGGCGAGCTGCTCATGGCCGCAGGAACCCGCCTCACACCAGCGGAG
ACCGGCCTGCTCGGCACCTTTGGACACGGCTCTGCGCTCGTGAGGCCACAACCGAAAATCTCGATCATCACGGTCGGCAA
CGAGCTGCGCCTACCCGGAGAAAAGGCTGAGCCACTCGCGATCTACAACAGCAATCTGGCGATGCTGGCCGCCTGCCTTG
AAGCCGCAGGAGCGCAGATCGTCGAAATGCACCAGTTGAGAGATGATCGTAAAGCGATTCGCGAGGCGCTCACTTCGGCG
ATTGACGAGTCGGACATGGTCATCACCGCAGGCGGTATTTCGACCGGCCAGTACGACTTCATGCACGAAACACTCGGCGA
ACTTGGCGTAGAGCAGAAGTTCTGGAAGGTGGCACAGAAGCCCGGCAAGCCTTTCTACTTCGGATCGACCGCTGCGGGCA
CACTCTGCTTTGCGTTGCCGGGAAACCCGATTTCCGCGCTGGTCTGCCTGCTCGAATACGCCCTGCCCGCCCTCGCGCTG
ATGCAGGGTGCGACTCCGGCCCCGAAATTCACCGCGCTGCTCGACGAGCCCTTCCCCGCCGACCGCAAGCGCTACCGCTT
TCTGTTCGGCACAACGAAAATCGACGACGGCGTGCTCCGCTGCCGCGTTTCGCAGCAAACCGACTCCCACATGCTCACCG
CGCTCAGTGAAGCTGATTGCCTGATCGAAGCCGAAACATCACCCGAACCGATCCCCGCTGGCTCAGTAGTCACCTGCGCG
TGGCTGCCGTGGGCGAACGCTTTTTGA

Upstream 100 bases:

>100_bases
TCTGCCTGCCGGGCAGCGCGGGCGCGGCCAGCGACGCGCTCGAAGTGCTGCTGCCCGCGATATTCCACGCCTTTCCGATG
CTCCGGGGGGAGGGCCACGC

Downstream 100 bases:

>100_bases
TTCGAGACGACACGATGTTCCATCCCTTTGAAATAGCCGTTGGCGGCCTCTCCGGCTCGGGCAAAACCACCCTCGTTGAA
AAGCTGATCCGGCGTTTTTC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MITVQEAHQIIAATVQRLGATVSVPLHQLRGRVLAEEVRAGFPMPRFTNAAMDGFAVRFDEIAGTSDSAPVTLPVSQELA
AGALAVAPLEAGSCARIMTGAPVPDGADTVVPFEQTSGFERETVEFYKAPKKGANIRHTGEEVKIGELLMAAGTRLTPAE
TGLLGTFGHGSALVRPQPKISIITVGNELRLPGEKAEPLAIYNSNLAMLAACLEAAGAQIVEMHQLRDDRKAIREALTSA
IDESDMVITAGGISTGQYDFMHETLGELGVEQKFWKVAQKPGKPFYFGSTAAGTLCFALPGNPISALVCLLEYALPALAL
MQGATPAPKFTALLDEPFPADRKRYRFLFGTTKIDDGVLRCRVSQQTDSHMLTALSEADCLIEAETSPEPIPAGSVVTCA
WLPWANAF

Sequences:

>Translated_408_residues
MITVQEAHQIIAATVQRLGATVSVPLHQLRGRVLAEEVRAGFPMPRFTNAAMDGFAVRFDEIAGTSDSAPVTLPVSQELA
AGALAVAPLEAGSCARIMTGAPVPDGADTVVPFEQTSGFERETVEFYKAPKKGANIRHTGEEVKIGELLMAAGTRLTPAE
TGLLGTFGHGSALVRPQPKISIITVGNELRLPGEKAEPLAIYNSNLAMLAACLEAAGAQIVEMHQLRDDRKAIREALTSA
IDESDMVITAGGISTGQYDFMHETLGELGVEQKFWKVAQKPGKPFYFGSTAAGTLCFALPGNPISALVCLLEYALPALAL
MQGATPAPKFTALLDEPFPADRKRYRFLFGTTKIDDGVLRCRVSQQTDSHMLTALSEADCLIEAETSPEPIPAGSVVTCA
WLPWANAF
>Mature_408_residues
MITVQEAHQIIAATVQRLGATVSVPLHQLRGRVLAEEVRAGFPMPRFTNAAMDGFAVRFDEIAGTSDSAPVTLPVSQELA
AGALAVAPLEAGSCARIMTGAPVPDGADTVVPFEQTSGFERETVEFYKAPKKGANIRHTGEEVKIGELLMAAGTRLTPAE
TGLLGTFGHGSALVRPQPKISIITVGNELRLPGEKAEPLAIYNSNLAMLAACLEAAGAQIVEMHQLRDDRKAIREALTSA
IDESDMVITAGGISTGQYDFMHETLGELGVEQKFWKVAQKPGKPFYFGSTAAGTLCFALPGNPISALVCLLEYALPALAL
MQGATPAPKFTALLDEPFPADRKRYRFLFGTTKIDDGVLRCRVSQQTDSHMLTALSEADCLIEAETSPEPIPAGSVVTCA
WLPWANAF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=304, Percent_Identity=33.8815789473684, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI66932975, Length=304, Percent_Identity=33.8815789473684, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1787049, Length=392, Percent_Identity=35.7142857142857, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=31.2312312312312, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=339, Percent_Identity=24.7787610619469, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136978, Length=403, Percent_Identity=29.0322580645161, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24638841, Length=403, Percent_Identity=29.0322580645161, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43449; Mature: 43449

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVQEAHQIIAATVQRLGATVSVPLHQLRGRVLAEEVRAGFPMPRFTNAAMDGFAVRFD
CCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEH
EIAGTSDSAPVTLPVSQELAAGALAVAPLEAGSCARIMTGAPVPDGADTVVPFEQTSGFE
HHCCCCCCCCEEECCCHHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECHHCCCCC
RETVEFYKAPKKGANIRHTGEEVKIGELLMAAGTRLTPAETGLLGTFGHGSALVRPQPKI
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCE
SIITVGNELRLPGEKAEPLAIYNSNLAMLAACLEAAGAQIVEMHQLRDDRKAIREALTSA
EEEEECCEEECCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IDESDMVITAGGISTGQYDFMHETLGELGVEQKFWKVAQKPGKPFYFGSTAAGTLCFALP
CCCCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
GNPISALVCLLEYALPALALMQGATPAPKFTALLDEPFPADRKRYRFLFGTTKIDDGVLR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCEEE
CRVSQQTDSHMLTALSEADCLIEAETSPEPIPAGSVVTCAWLPWANAF
EEECCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MITVQEAHQIIAATVQRLGATVSVPLHQLRGRVLAEEVRAGFPMPRFTNAAMDGFAVRFD
CCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEH
EIAGTSDSAPVTLPVSQELAAGALAVAPLEAGSCARIMTGAPVPDGADTVVPFEQTSGFE
HHCCCCCCCCEEECCCHHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECHHCCCCC
RETVEFYKAPKKGANIRHTGEEVKIGELLMAAGTRLTPAETGLLGTFGHGSALVRPQPKI
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCE
SIITVGNELRLPGEKAEPLAIYNSNLAMLAACLEAAGAQIVEMHQLRDDRKAIREALTSA
EEEEECCEEECCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IDESDMVITAGGISTGQYDFMHETLGELGVEQKFWKVAQKPGKPFYFGSTAAGTLCFALP
CCCCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
GNPISALVCLLEYALPALALMQGATPAPKFTALLDEPFPADRKRYRFLFGTTKIDDGVLR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCEEE
CRVSQQTDSHMLTALSEADCLIEAETSPEPIPAGSVVTCAWLPWANAF
EEECCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]