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The map label for this gene is moaC [H]

Identifier: 193212996

GI number: 193212996

Start: 1462084

End: 1463025

Strand: Direct

Name: moaC [H]

Synonym: Cpar_1346

Alternate gene names: 193212996

Gene position: 1462084-1463025 (Clockwise)

Preceding gene: 193212989

Following gene: 193212997

Centisome position: 63.87

GC content: 64.23

Gene sequence:

>942_bases
ATGGAATTCACCCACATCGACGACAACGGCATGGTCAGCATGGTTGACGTGTCGGGCAAGCCGCCAACGCGCCGACAAGC
CAGCGCCTCCGGCTGGATCGTCATGAACCCCGAGACCATCGCGCTGCTCCGTGAACGCGAGCTGCCGAAGGGCAACGTGC
TGGCCGCGGCCAAGATCGCGGGCATCCAGGCCGCCAAGCAGACCGCGCACCTGATTCCGCTCTGCCACCAGCTCAACCTC
TCGTGGGTCGATATCGAATTCGAAATCGACGCGGATCGCATCGGCATCAAGGCGAGCGTCATCACGCGCGAGGCGACGGG
CGTAGAGATGGAAGCGCTGACCGCGGTGTCGGTTGCAGCGCTGACGATTTACGACATGTGCAAAGCGGTAGATAAAACGA
TGGAGATCACCGGCGTGCGGCTTGACCGCAAAACCGGCGGTAAGCAGTCGCTCGCGACGGAGCATCGCCCGAAGTGCGCC
GTGCTGGTGCTGTCAGACTCGATTGCGGCAGGCATGGCAACTGACCGTTCAGGACGAATTCTGAGGGAAGGACTTGAAAA
CGCCGGATGCCCAGTCGAGGAACTGACGATCATTCCGGACGAAGCAGCAGAATTGCTTGCAACAGTCAACGGATGGATCG
AAAATGGCGTGGAGCTGATCGTCACCTCCGGCGGGACCGGCCTCGGGCCGCGCGACGTGACCATCGACACGCTCACGCCG
AAGTTCACCCGCCGCCTGCCCGGCGTCGAGCAGGAGTTGCTCCGGTGGGGGCAAGGCAAAACGCGCACCGCAATGCTCTC
GCGCCTTGCCGCCGGGCTGATCGGCGACACGCTGGTCGTCTGCCTGCCGGGCAGCGCGGGCGCGGCCAGCGACGCGCTCG
AAGTGCTGCTGCCCGCGATATTCCACGCCTTTCCGATGCTCCGGGGGGAGGGCCACGCATGA

Upstream 100 bases:

>100_bases
CAGAATGCAAAAAAGGATGAAGAATCCCTATATTGCCCGGGAAACCGCTTTTCACTCCTGCGCCAACCGGATGCGGGATC
GCGCCTAAAAACGATTTTTC

Downstream 100 bases:

>100_bases
TTACCGTTCAGGAAGCTCACCAAATTATCGCCGCGACGGTGCAACGACTGGGCGCAACCGTCTCCGTTCCGCTGCACCAG
CTCCGTGGCCGCGTACTGGC

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MEFTHIDDNGMVSMVDVSGKPPTRRQASASGWIVMNPETIALLRERELPKGNVLAAAKIAGIQAAKQTAHLIPLCHQLNL
SWVDIEFEIDADRIGIKASVITREATGVEMEALTAVSVAALTIYDMCKAVDKTMEITGVRLDRKTGGKQSLATEHRPKCA
VLVLSDSIAAGMATDRSGRILREGLENAGCPVEELTIIPDEAAELLATVNGWIENGVELIVTSGGTGLGPRDVTIDTLTP
KFTRRLPGVEQELLRWGQGKTRTAMLSRLAAGLIGDTLVVCLPGSAGAASDALEVLLPAIFHAFPMLRGEGHA

Sequences:

>Translated_313_residues
MEFTHIDDNGMVSMVDVSGKPPTRRQASASGWIVMNPETIALLRERELPKGNVLAAAKIAGIQAAKQTAHLIPLCHQLNL
SWVDIEFEIDADRIGIKASVITREATGVEMEALTAVSVAALTIYDMCKAVDKTMEITGVRLDRKTGGKQSLATEHRPKCA
VLVLSDSIAAGMATDRSGRILREGLENAGCPVEELTIIPDEAAELLATVNGWIENGVELIVTSGGTGLGPRDVTIDTLTP
KFTRRLPGVEQELLRWGQGKTRTAMLSRLAAGLIGDTLVVCLPGSAGAASDALEVLLPAIFHAFPMLRGEGHA
>Mature_313_residues
MEFTHIDDNGMVSMVDVSGKPPTRRQASASGWIVMNPETIALLRERELPKGNVLAAAKIAGIQAAKQTAHLIPLCHQLNL
SWVDIEFEIDADRIGIKASVITREATGVEMEALTAVSVAALTIYDMCKAVDKTMEITGVRLDRKTGGKQSLATEHRPKCA
VLVLSDSIAAGMATDRSGRILREGLENAGCPVEELTIIPDEAAELLATVNGWIENGVELIVTSGGTGLGPRDVTIDTLTP
KFTRRLPGVEQELLRWGQGKTRTAMLSRLAAGLIGDTLVVCLPGSAGAASDALEVLLPAIFHAFPMLRGEGHA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=159, Percent_Identity=35.8490566037736, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI66932975, Length=159, Percent_Identity=35.8490566037736, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787001, Length=149, Percent_Identity=51.6778523489933, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787000, Length=171, Percent_Identity=30.4093567251462, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566331, Length=155, Percent_Identity=43.8709677419355, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17564954, Length=171, Percent_Identity=32.1637426900585, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574490, Length=155, Percent_Identity=47.0967741935484, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574492, Length=144, Percent_Identity=47.9166666666667, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17136978, Length=147, Percent_Identity=31.2925170068027, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24638841, Length=147, Percent_Identity=31.2925170068027, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33319; Mature: 33319

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTHIDDNGMVSMVDVSGKPPTRRQASASGWIVMNPETIALLRERELPKGNVLAAAKIA
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHEEEEHHCCCCCCCEEEHHHHH
GIQAAKQTAHLIPLCHQLNLSWVDIEFEIDADRIGIKASVITREATGVEMEALTAVSVAA
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LTIYDMCKAVDKTMEITGVRLDRKTGGKQSLATEHRPKCAVLVLSDSIAAGMATDRSGRI
HHHHHHHHHHHHHHEEEEEEEECCCCCCHHHCCCCCCCEEEEEEECCHHHCCCCCCCCHH
LREGLENAGCPVEELTIIPDEAAELLATVNGWIENGVELIVTSGGTGLGPRDVTIDTLTP
HHHHHHHCCCCHHHEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCH
KFTRRLPGVEQELLRWGQGKTRTAMLSRLAAGLIGDTLVVCLPGSAGAASDALEVLLPAI
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
FHAFPMLRGEGHA
HHHHHHCCCCCCC
>Mature Secondary Structure
MEFTHIDDNGMVSMVDVSGKPPTRRQASASGWIVMNPETIALLRERELPKGNVLAAAKIA
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHEEEEHHCCCCCCCEEEHHHHH
GIQAAKQTAHLIPLCHQLNLSWVDIEFEIDADRIGIKASVITREATGVEMEALTAVSVAA
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LTIYDMCKAVDKTMEITGVRLDRKTGGKQSLATEHRPKCAVLVLSDSIAAGMATDRSGRI
HHHHHHHHHHHHHHEEEEEEEECCCCCCHHHCCCCCCCEEEEEEECCHHHCCCCCCCCHH
LREGLENAGCPVEELTIIPDEAAELLATVNGWIENGVELIVTSGGTGLGPRDVTIDTLTP
HHHHHHHCCCCHHHEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCH
KFTRRLPGVEQELLRWGQGKTRTAMLSRLAAGLIGDTLVVCLPGSAGAASDALEVLLPAI
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
FHAFPMLRGEGHA
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]