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The map label for this gene is folE [H]

Identifier: 193212943

GI number: 193212943

Start: 1405989

End: 1406681

Strand: Direct

Name: folE [H]

Synonym: Cpar_1293

Alternate gene names: 193212943

Gene position: 1405989-1406681 (Clockwise)

Preceding gene: 193212942

Following gene: 193212963

Centisome position: 61.42

GC content: 54.55

Gene sequence:

>693_bases
ATGAAGTCAAAATACATGAAACAGGAAAAAACAGTGTCACCTATCGTGGAGAATAACCGATCTGCAGAATCACGCCTTTC
GCAATGCGATCTCGATGAGTGCTTTGATGAAGCTTGCGACCATCAGGAAGAGGAACGCCTCAGCTTGATGGGCAATGCCG
TATACAGCCTTCTGCAAGGTATTGGAGAGGATCCGGAGCGTGAAGGGCTGCTTATGACCCCGGAGCGGGTAGCCAAATCT
CTGCGATTTCTGACCAAAGGCTACGAGCAGGATCCGGAAGAGTTGCTGATGAAGGCGCTCTTTACCGAGTCGTATGATGA
AATGGTGCTGGTCAAAGATATTGACCTCTACTCGATGTGCGAGCACCACATGCTCCCCTTCTTCGGCAAGGCGCACGTGG
CCTACATTCCCGACGGCAAAATCGTAGGACTGTCCAAGATTCCGAGAGTAGTTGAGGTGTTCGCCCGGCGGCTTCAGGTG
CAGGAGCGCCTGACACAGCAGATTCGGGATGCAATCCAGAACGTGCTCAACCCACGCGGCGTGGCAGTGGTGATCGAAGC
GACTCACATGTGCATGGTGATGCGTGGCGTCGAAAAGCAGAACTCGGTGACCACGACCTCGGCCATGTCGGGCGACTTCA
TGACAAGCCAGTCCACGCGGAGCGAGTTCCTGCGCCTGATCGGCAGCCACTAA

Upstream 100 bases:

>100_bases
CTTCAGAACCACGTCCCGACAACGGAAATTCTGGCTGTTGTCGTGTGGGACATCCTCGAAACGCGACTGGAAACCATTAC
CAAACAGGAGGTTAGCCTCC

Downstream 100 bases:

>100_bases
CGTCGCGCCGGACAATCACCGCAGCACATAACAATGAAGAACCCCGCTTCTCTGATGAACTTTCGAGAAGCGGGGTTCTT
CATTGTTCCAGCCACTCTTC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKSKYMKQEKTVSPIVENNRSAESRLSQCDLDECFDEACDHQEEERLSLMGNAVYSLLQGIGEDPEREGLLMTPERVAKS
LRFLTKGYEQDPEELLMKALFTESYDEMVLVKDIDLYSMCEHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQV
QERLTQQIRDAIQNVLNPRGVAVVIEATHMCMVMRGVEKQNSVTTTSAMSGDFMTSQSTRSEFLRLIGSH

Sequences:

>Translated_230_residues
MKSKYMKQEKTVSPIVENNRSAESRLSQCDLDECFDEACDHQEEERLSLMGNAVYSLLQGIGEDPEREGLLMTPERVAKS
LRFLTKGYEQDPEELLMKALFTESYDEMVLVKDIDLYSMCEHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQV
QERLTQQIRDAIQNVLNPRGVAVVIEATHMCMVMRGVEKQNSVTTTSAMSGDFMTSQSTRSEFLRLIGSH
>Mature_230_residues
MKSKYMKQEKTVSPIVENNRSAESRLSQCDLDECFDEACDHQEEERLSLMGNAVYSLLQGIGEDPEREGLLMTPERVAKS
LRFLTKGYEQDPEELLMKALFTESYDEMVLVKDIDLYSMCEHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQV
QERLTQQIRDAIQNVLNPRGVAVVIEATHMCMVMRGVEKQNSVTTTSAMSGDFMTSQSTRSEFLRLIGSH

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=190, Percent_Identity=54.7368421052632, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI4503949, Length=190, Percent_Identity=54.7368421052632, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI66932970, Length=158, Percent_Identity=50, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI66932972, Length=149, Percent_Identity=52.3489932885906, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1788476, Length=190, Percent_Identity=44.2105263157895, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17560486, Length=186, Percent_Identity=57.5268817204301, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6321706, Length=184, Percent_Identity=52.7173913043478, Blast_Score=211, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24656782, Length=197, Percent_Identity=53.8071065989848, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24656791, Length=197, Percent_Identity=53.8071065989848, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24656796, Length=197, Percent_Identity=53.8071065989848, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26171; Mature: 26171

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKYMKQEKTVSPIVENNRSAESRLSQCDLDECFDEACDHQEEERLSLMGNAVYSLLQG
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IGEDPEREGLLMTPERVAKSLRFLTKGYEQDPEELLMKALFTESYDEMVLVKDIDLYSMC
CCCCCCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHH
EHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQVQERLTQQIRDAIQNVLNPRG
HHHCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VAVVIEATHMCMVMRGVEKQNSVTTTSAMSGDFMTSQSTRSEFLRLIGSH
EEEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSKYMKQEKTVSPIVENNRSAESRLSQCDLDECFDEACDHQEEERLSLMGNAVYSLLQG
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IGEDPEREGLLMTPERVAKSLRFLTKGYEQDPEELLMKALFTESYDEMVLVKDIDLYSMC
CCCCCCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHH
EHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQVQERLTQQIRDAIQNVLNPRG
HHHCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VAVVIEATHMCMVMRGVEKQNSVTTTSAMSGDFMTSQSTRSEFLRLIGSH
EEEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]