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The map label for this gene is fabG [C]

Identifier: 192289019

GI number: 192289019

Start: 641554

End: 642447

Strand: Reverse

Name: fabG [C]

Synonym: Rpal_0589

Alternate gene names: 192289019

Gene position: 642447-641554 (Counterclockwise)

Preceding gene: 192289020

Following gene: 192289018

Centisome position: 11.18

GC content: 66.22

Gene sequence:

>894_bases
ATGAGCACGAGCCCCGAACACAAACGCACCGCGCTGGTCACCGGCGCCAATTCCGGCCTCGGCAAGGCCATCGTCACCGC
GCTGGCGGCGGACGGCCTGCGTGTCGGCCTGGTGGCGCGCGACCGCGGCCGCGGCGAGGCAGCGCTCGCCGATGTTCGCG
CCGCCACCGGCAATCAAGACCTGCACCTGTTCGTCGCCGATCTCGCCGATCAGGAGTCAATCCGGGCGCTGGCACAGGAT
GTGCGCCCGCGCTTCGACCGGCTGCATCTGCTCATCAACAACGCCGGCACCGCCTTCCCGGAGCGGCGGCTGAGCCCGCA
GGGGATCGAGCGCGCCTTCGCGATCAATCACCTCGGCCCGTTCCTGCTCACCAATCTGTTGCTCGATCTGATCAAAGCCA
GTGCGCCGGCACGGATCGTCAATGTCGGTACCCGCATCGACGCGGCGATCGATTTCGACGACCTCAACTGGGACAAGCGC
CCCTACGGCATGATGAAGGGCTACGCCCAGTCCAAGCTCGGCAATCTGCACTTCACCTTCGAACTGGCGCGCCGGCTCGA
AGGCAGCGGCGTCACCGTGAATTGTGTGTTTCCCGGCGTATTCAAGTCCAACCTCGGCGGCACCGACGGGGCGCAAGGTC
TGTTCTGGAAGCTACTCGCCAAACTCGGCGGCTGGGCGATTCCGAAGCCGGAAAGCGCGGCGCAGCGGGTGCTGTATCTG
GCGAACGCACCGGAGCTGGAGGGTGTCAGTGGCCAGTACTACGCGAACCGCAAGACGATCCCGGCCCCAGCTCAGGCGCT
CGATGCGGAAGCGAACAGGCGGCTGTGGGAGATCAGCGAGAGGATGACGGGACTGACACAGTCGCAGACCGTCGGCGACC
AGGCGGCAACTTGA

Upstream 100 bases:

>100_bases
TACGGCTGGCGGTGTGGCTGGCGATCTACTTCCTGTACGGCCGTCATCACAGCAAGCCCGCGAGGCGCTAAGCTCAGCGG
ATGACGGCCAGGAGGCCCCG

Downstream 100 bases:

>100_bases
TCGCGCAGCCCAAGCCATTGACCACCCAGCAGCCACGCAGCGGCACGCCGCGCGAAGTGCTGGGAGTGTTCTTCAAGCTC
GGGCTGACCTGTTTCGGCGG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSTSPEHKRTALVTGANSGLGKAIVTALAADGLRVGLVARDRGRGEAALADVRAATGNQDLHLFVADLADQESIRALAQD
VRPRFDRLHLLINNAGTAFPERRLSPQGIERAFAINHLGPFLLTNLLLDLIKASAPARIVNVGTRIDAAIDFDDLNWDKR
PYGMMKGYAQSKLGNLHFTFELARRLEGSGVTVNCVFPGVFKSNLGGTDGAQGLFWKLLAKLGGWAIPKPESAAQRVLYL
ANAPELEGVSGQYYANRKTIPAPAQALDAEANRRLWEISERMTGLTQSQTVGDQAAT

Sequences:

>Translated_297_residues
MSTSPEHKRTALVTGANSGLGKAIVTALAADGLRVGLVARDRGRGEAALADVRAATGNQDLHLFVADLADQESIRALAQD
VRPRFDRLHLLINNAGTAFPERRLSPQGIERAFAINHLGPFLLTNLLLDLIKASAPARIVNVGTRIDAAIDFDDLNWDKR
PYGMMKGYAQSKLGNLHFTFELARRLEGSGVTVNCVFPGVFKSNLGGTDGAQGLFWKLLAKLGGWAIPKPESAAQRVLYL
ANAPELEGVSGQYYANRKTIPAPAQALDAEANRRLWEISERMTGLTQSQTVGDQAAT
>Mature_296_residues
STSPEHKRTALVTGANSGLGKAIVTALAADGLRVGLVARDRGRGEAALADVRAATGNQDLHLFVADLADQESIRALAQDV
RPRFDRLHLLINNAGTAFPERRLSPQGIERAFAINHLGPFLLTNLLLDLIKASAPARIVNVGTRIDAAIDFDDLNWDKRP
YGMMKGYAQSKLGNLHFTFELARRLEGSGVTVNCVFPGVFKSNLGGTDGAQGLFWKLLAKLGGWAIPKPESAAQRVLYLA
NAPELEGVSGQYYANRKTIPAPAQALDAEANRRLWEISERMTGLTQSQTVGDQAAT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=299, Percent_Identity=43.4782608695652, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI10190746, Length=297, Percent_Identity=43.0976430976431, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI19923931, Length=264, Percent_Identity=43.5606060606061, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI186928839, Length=279, Percent_Identity=38.3512544802867, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI166795268, Length=279, Percent_Identity=39.426523297491, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI146231950, Length=284, Percent_Identity=39.0845070422535, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI193804850, Length=292, Percent_Identity=36.986301369863, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI7706523, Length=288, Percent_Identity=34.375, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=27.7551020408163, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=285, Percent_Identity=35.0877192982456, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI72001364, Length=290, Percent_Identity=32.4137931034483, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505416, Length=287, Percent_Identity=30.3135888501742, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17532805, Length=292, Percent_Identity=29.1095890410959, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193207620, Length=296, Percent_Identity=27.3648648648649, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17532791, Length=263, Percent_Identity=24.7148288973384, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71992402, Length=304, Percent_Identity=24.6710526315789, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535059, Length=295, Percent_Identity=24.7457627118644, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=26.6409266409266, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533172, Length=289, Percent_Identity=27.3356401384083, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115533174, Length=289, Percent_Identity=27.3356401384083, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565532, Length=203, Percent_Identity=26.1083743842365, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=25.1937984496124, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=27.6422764227642, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=250, Percent_Identity=24, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=262, Percent_Identity=25.5725190839695, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24586328, Length=282, Percent_Identity=41.4893617021277, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI22024069, Length=286, Percent_Identity=41.6083916083916, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19921754, Length=297, Percent_Identity=38.3838383838384, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI161076371, Length=287, Percent_Identity=39.7212543554007, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45553409, Length=284, Percent_Identity=35.9154929577465, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24647948, Length=284, Percent_Identity=35.9154929577465, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28573296, Length=289, Percent_Identity=39.7923875432526, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24647946, Length=284, Percent_Identity=35.9154929577465, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45554248, Length=275, Percent_Identity=38.1818181818182, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24640117, Length=275, Percent_Identity=38.1818181818182, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24656154, Length=292, Percent_Identity=33.9041095890411, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI19922628, Length=292, Percent_Identity=33.9041095890411, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24647931, Length=295, Percent_Identity=31.5254237288136, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI20129347, Length=294, Percent_Identity=29.5918367346939, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32010; Mature: 31879

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPEHKRTALVTGANSGLGKAIVTALAADGLRVGLVARDRGRGEAALADVRAATGNQD
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCC
LHLFVADLADQESIRALAQDVRPRFDRLHLLINNAGTAFPERRLSPQGIERAFAINHLGP
EEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHH
FLLTNLLLDLIKASAPARIVNVGTRIDAAIDFDDLNWDKRPYGMMKGYAQSKLGNLHFTF
HHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEHH
ELARRLEGSGVTVNCVFPGVFKSNLGGTDGAQGLFWKLLAKLGGWAIPKPESAAQRVLYL
HHHHHCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEE
ANAPELEGVSGQYYANRKTIPAPAQALDAEANRRLWEISERMTGLTQSQTVGDQAAT
ECCCCCCCCCCCEEECCCCCCCCHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure 
STSPEHKRTALVTGANSGLGKAIVTALAADGLRVGLVARDRGRGEAALADVRAATGNQD
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCC
LHLFVADLADQESIRALAQDVRPRFDRLHLLINNAGTAFPERRLSPQGIERAFAINHLGP
EEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHH
FLLTNLLLDLIKASAPARIVNVGTRIDAAIDFDDLNWDKRPYGMMKGYAQSKLGNLHFTF
HHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEHH
ELARRLEGSGVTVNCVFPGVFKSNLGGTDGAQGLFWKLLAKLGGWAIPKPESAAQRVLYL
HHHHHCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEE
ANAPELEGVSGQYYANRKTIPAPAQALDAEANRRLWEISERMTGLTQSQTVGDQAAT
ECCCCCCCCCCCEEECCCCCCCCHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]