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The map label for this gene is ribA [H]

Identifier: 190571630

GI number: 190571630

Start: 1326874

End: 1327959

Strand: Direct

Name: ribA [H]

Synonym: WPa_1254

Alternate gene names: 190571630

Gene position: 1326874-1327959 (Clockwise)

Preceding gene: 190571627

Following gene: 190571631

Centisome position: 89.51

GC content: 32.69

Gene sequence:

>1086_bases
ATGTTTATAGGAAATCAAAGTAGAAATAAAGTAGAAAGGGCCATCAGTGAAGTCAGGCGTGGTCTTCCAATTTTAATATA
TGATGATGAAAATAACTATCTATTGCTTGCTGCTGCTGAAACTTTAGAAAAAAATTTATTTAGTCAATATAAGCTTATAT
CAGGTAATGTGTATGTTACTTTGACTGCAAGTAAGGTAAAATACATATGTCAGAGTAAAGAACATAGTAGCAAACGTCTG
TTGATAAGCAATTTTGATGAACTGCTCCATTTAATAAACTGTTCAAAGGAAGGTAGCATAAAAGAGTTGCAATGCTCAAA
GACAATAGATGCGTATGCTGTTGCCTTGCTTAAGTTCTCAGAATTATTGCCATACGCGTTAGTGGCTGATATGACTTTTG
AGAATAAACATGAAATGCGAAATTGGTGTGAAGAAAATGACATTATTGCACTAAATACGTTACTTGTGAATGATTTTCAA
CAAAATCATAGTGTGTATGAAGTGTGCAAAACATCATTATTTTTAAAGCAGACTCAAGAAGTAGATATCATATCTTATAG
AACCAAAAGTGGCGGAAGAGAACATTATGCAATTATCATTGGCAATCCAGATAAAGATAATGAGCCATTAGTGAGAATTC
ATTCTGCATGCTATACAGGAGACTTATTAGACAGCTTATCATGTGATTGCAGAAGCCAGTTACATCAAGCGATTCAAATA
ATGACCGACTTTGGGAATGGCATTATATTATACTTGATGCAAGATGGGAGAGGCATTGGTTTAACTAATAAGTTAAGAGC
ATACAGTATGCAAAGAAAATATAATCTTGATACTGTTGATGCAAATAGAGTATTGGGTTTTGAAGATGATGAAAGGAGCT
TTGCTGTTGCAGCTAAAATACTTAAGAAATTGAACATTAACAAAATACAATTACTTACAAACAATGGTAGAAAGTTATCA
GAGTTGAAAAATAACGGTATAGAAGTTACAAAGTGTGTACCACTTATTATGGAACGCAATGAATATAATCATTCATATAT
GGAAACAAAATTTGGCAAGTTAGGCCATGGATTAAGGGTTTATTAG

Upstream 100 bases:

>100_bases
GGTGGAATTGGTAGACACGCAGCGTTGAGGTCGCTGTGGCTCACAAAGCCTTGGAAGTTCAAGTCTTCTCGACCGCACCA
AGTTGTTTGGTGTAGGTGAA

Downstream 100 bases:

>100_bases
CTTTTTTGTTATAACTACTTTGTTAGCTTGCTATGTTAATTAATATAAGTTAAGATTTTTAAGAATATTGAGATGCTGAA
ATTTTTAAAACAAGAAAAAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MFIGNQSRNKVERAISEVRRGLPILIYDDENNYLLLAAAETLEKNLFSQYKLISGNVYVTLTASKVKYICQSKEHSSKRL
LISNFDELLHLINCSKEGSIKELQCSKTIDAYAVALLKFSELLPYALVADMTFENKHEMRNWCEENDIIALNTLLVNDFQ
QNHSVYEVCKTSLFLKQTQEVDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQI
MTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKILKKLNINKIQLLTNNGRKLS
ELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLRVY

Sequences:

>Translated_361_residues
MFIGNQSRNKVERAISEVRRGLPILIYDDENNYLLLAAAETLEKNLFSQYKLISGNVYVTLTASKVKYICQSKEHSSKRL
LISNFDELLHLINCSKEGSIKELQCSKTIDAYAVALLKFSELLPYALVADMTFENKHEMRNWCEENDIIALNTLLVNDFQ
QNHSVYEVCKTSLFLKQTQEVDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQI
MTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKILKKLNINKIQLLTNNGRKLS
ELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLRVY
>Mature_361_residues
MFIGNQSRNKVERAISEVRRGLPILIYDDENNYLLLAAAETLEKNLFSQYKLISGNVYVTLTASKVKYICQSKEHSSKRL
LISNFDELLHLINCSKEGSIKELQCSKTIDAYAVALLKFSELLPYALVADMTFENKHEMRNWCEENDIIALNTLLVNDFQ
QNHSVYEVCKTSLFLKQTQEVDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQI
MTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKILKKLNINKIQLLTNNGRKLS
ELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLRVY

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=174, Percent_Identity=43.6781609195402, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=35.632183908046, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 41245; Mature: 41245

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIGNQSRNKVERAISEVRRGLPILIYDDENNYLLLAAAETLEKNLFSQYKLISGNVYVT
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHHHHHHEEEEECCEEEE
LTASKVKYICQSKEHSSKRLLISNFDELLHLINCSKEGSIKELQCSKTIDAYAVALLKFS
EEHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ELLPYALVADMTFENKHEMRNWCEENDIIALNTLLVNDFQQNHSVYEVCKTSLFLKQTQE
HHCCHHHHHCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHCCC
VDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQI
EEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEHHHHHCHHHHHHCCHHHHHHHHHHHHH
MTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKI
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHH
LKKLNINKIQLLTNNGRKLSELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLRV
HHHCCCCEEEEEECCCCCHHHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
Y
C
>Mature Secondary Structure
MFIGNQSRNKVERAISEVRRGLPILIYDDENNYLLLAAAETLEKNLFSQYKLISGNVYVT
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHHHHHHEEEEECCEEEE
LTASKVKYICQSKEHSSKRLLISNFDELLHLINCSKEGSIKELQCSKTIDAYAVALLKFS
EEHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ELLPYALVADMTFENKHEMRNWCEENDIIALNTLLVNDFQQNHSVYEVCKTSLFLKQTQE
HHCCHHHHHCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHCCC
VDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQI
EEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEHHHHHCHHHHHHCCHHHHHHHHHHHHH
MTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKI
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHH
LKKLNINKIQLLTNNGRKLSELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLRV
HHHCCCCEEEEEECCCCCHHHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]