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The map label for this gene is zitB [H]

Identifier: 190571497

GI number: 190571497

Start: 1193026

End: 1193922

Strand: Reverse

Name: zitB [H]

Synonym: WPa_1114

Alternate gene names: 190571497

Gene position: 1193922-1193026 (Counterclockwise)

Preceding gene: 190571500

Following gene: 190571496

Centisome position: 80.54

GC content: 34.0

Gene sequence:

>897_bases
ATGACAGCAGTGCACAATGGCAAACACTCAATAGCAGAGTCCAAGCGCTTAATTTATTCCATAATAATAGTCGCAATAAC
AATGCTTATGGAGATAGCAGGTGGAGTAATTTCACATTCGCTTGCTCTACTATCAGATGCAGGACATATGCTCACTGATC
TTTTTGCCTTGGTTTTAAGCTGGATAGCACACAAATTTTCAGCTAAGAAATCTGATTTACAGAGGTCATATGGGTATCAC
AGATTGCAGATAATTGCAGCATTTGTTAATGGTTTAACTCTATTTTTCATTGCAGCGGTCATTATAATTGAATCAATAAA
GAGATTCATTTGTCCGGTCAATGTTGAATGGAAAGTAATGCTAATAATTGCCACACTTGGCCTGATCTCTAACATTATAG
TCTTTTTTATATTACATAGTAAATGCGAAAGTAATATAAACATAAAAAGTGCTGTATTGCATGTTATCGGAGATATTTTA
GGTTCTGTAGCTGCTATACTTGCATCCATAATTATCATGTTTACCGGATGGCAAATAGTGGACCCTATTTTGTCAGTATT
TGTCAGTGTAATAATCTTAAACAGTGGCTATAAAATTCTCAAGAATTCTTGCCATATACTCCTTGAAGGTACACCTGAGA
GTGTATCTGCTGAGGAGATAAAAAGTGAGATTGTATCTAAGTTACCTGAAGTGATAGATGTGCATCATATACATGCATGG
TCACTATCTGATAATTATTTTATACTTACTATGCATGCCAAGATAAAGCAAAATGGGCAACATACTAATATTCTGTATGA
GATAAAAAAAATACTATTAAATAGATTTGAAATTGCACACTCTACAGTTGAAATTGAATACGATGAGTGCGTAGACAGTA
AAATACTTAAGCATTGA

Upstream 100 bases:

>100_bases
GGGTAATTAGCTCAGTTGGTAGAGCACTTGCTTGACGTGCAAGGGGTCGCTGGTTCGAGCCCAGTGTTACCCACGATTTT
TGCTCATAAAAAGATTTTAT

Downstream 100 bases:

>100_bases
CATCTATAGGCTATTTGTTATTACTACAATATCATAATATTATAGAGAGTAGACTATGATAGGTGTTTCCCAAATACAAT
TTCCTGGAAAGGATTCTTAC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTAVHNGKHSIAESKRLIYSIIIVAITMLMEIAGGVISHSLALLSDAGHMLTDLFALVLSWIAHKFSAKKSDLQRSYGYH
RLQIIAAFVNGLTLFFIAAVIIIESIKRFICPVNVEWKVMLIIATLGLISNIIVFFILHSKCESNINIKSAVLHVIGDIL
GSVAAILASIIIMFTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPESVSAEEIKSEIVSKLPEVIDVHHIHAW
SLSDNYFILTMHAKIKQNGQHTNILYEIKKILLNRFEIAHSTVEIEYDECVDSKILKH

Sequences:

>Translated_298_residues
MTAVHNGKHSIAESKRLIYSIIIVAITMLMEIAGGVISHSLALLSDAGHMLTDLFALVLSWIAHKFSAKKSDLQRSYGYH
RLQIIAAFVNGLTLFFIAAVIIIESIKRFICPVNVEWKVMLIIATLGLISNIIVFFILHSKCESNINIKSAVLHVIGDIL
GSVAAILASIIIMFTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPESVSAEEIKSEIVSKLPEVIDVHHIHAW
SLSDNYFILTMHAKIKQNGQHTNILYEIKKILLNRFEIAHSTVEIEYDECVDSKILKH
>Mature_297_residues
TAVHNGKHSIAESKRLIYSIIIVAITMLMEIAGGVISHSLALLSDAGHMLTDLFALVLSWIAHKFSAKKSDLQRSYGYHR
LQIIAAFVNGLTLFFIAAVIIIESIKRFICPVNVEWKVMLIIATLGLISNIIVFFILHSKCESNINIKSAVLHVIGDILG
SVAAILASIIIMFTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPESVSAEEIKSEIVSKLPEVIDVHHIHAWS
LSDNYFILTMHAKIKQNGQHTNILYEIKKILLNRFEIAHSTVEIEYDECVDSKILKH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI289803013, Length=292, Percent_Identity=29.1095890410959, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803009, Length=292, Percent_Identity=29.1095890410959, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803007, Length=292, Percent_Identity=29.1095890410959, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803003, Length=292, Percent_Identity=29.1095890410959, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI64762489, Length=295, Percent_Identity=28.8135593220339, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI21361112, Length=311, Percent_Identity=25.08038585209, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI52352805, Length=293, Percent_Identity=27.6450511945392, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI21359890, Length=307, Percent_Identity=27.3615635179153, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI20070323, Length=315, Percent_Identity=27.3015873015873, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI14210520, Length=222, Percent_Identity=27.027027027027, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI52351208, Length=136, Percent_Identity=33.0882352941176, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI222080086, Length=125, Percent_Identity=32, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40255009, Length=125, Percent_Identity=32, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=42.0863309352518, Blast_Score=214, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI193210990, Length=296, Percent_Identity=27.7027027027027, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17555796, Length=289, Percent_Identity=29.0657439446367, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=289, Percent_Identity=29.0657439446367, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=27.5409836065574, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324892, Length=155, Percent_Identity=27.0967741935484, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=182, Percent_Identity=31.8681318681319, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=32.5396825396825, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583858, Length=315, Percent_Identity=27.9365079365079, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24584409, Length=143, Percent_Identity=32.8671328671329, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574430, Length=143, Percent_Identity=32.8671328671329, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24585900, Length=133, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585898, Length=133, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585896, Length=133, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921672, Length=133, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656728, Length=154, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656724, Length=154, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656720, Length=154, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656715, Length=154, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357035, Length=154, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=35.2380952380952, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667550, Length=92, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24667546, Length=92, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33201; Mature: 33070

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVHNGKHSIAESKRLIYSIIIVAITMLMEIAGGVISHSLALLSDAGHMLTDLFALVLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WIAHKFSAKKSDLQRSYGYHRLQIIAAFVNGLTLFFIAAVIIIESIKRFICPVNVEWKVM
HHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LIIATLGLISNIIVFFILHSKCESNINIKSAVLHVIGDILGSVAAILASIIIMFTGWQIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DPILSVFVSVIILNSGYKILKNSCHILLEGTPESVSAEEIKSEIVSKLPEVIDVHHIHAW
HHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
SLSDNYFILTMHAKIKQNGQHTNILYEIKKILLNRFEIAHSTVEIEYDECVDSKILKH
EECCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
TAVHNGKHSIAESKRLIYSIIIVAITMLMEIAGGVISHSLALLSDAGHMLTDLFALVLS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WIAHKFSAKKSDLQRSYGYHRLQIIAAFVNGLTLFFIAAVIIIESIKRFICPVNVEWKVM
HHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LIIATLGLISNIIVFFILHSKCESNINIKSAVLHVIGDILGSVAAILASIIIMFTGWQIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DPILSVFVSVIILNSGYKILKNSCHILLEGTPESVSAEEIKSEIVSKLPEVIDVHHIHAW
HHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
SLSDNYFILTMHAKIKQNGQHTNILYEIKKILLNRFEIAHSTVEIEYDECVDSKILKH
EECCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]