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The map label for this gene is mutL [H]

Identifier: 190571443

GI number: 190571443

Start: 1125823

End: 1127652

Strand: Reverse

Name: mutL [H]

Synonym: WPa_1056

Alternate gene names: 190571443

Gene position: 1127652-1125823 (Counterclockwise)

Preceding gene: 190571444

Following gene: 190571442

Centisome position: 76.07

GC content: 34.86

Gene sequence:

>1830_bases
ATGGCAATAGTTCTTTTAGATACAAAAACCATAAATCGTATAGCAGCAGGAGAGGTAATAGAAAGGCCTGCAAGTGTGGT
AAAGGAATTAGTGGAAAATGCAATAGATGCCAGAAGCTCAGAGATAGAAATTAAGATAGAAAGTGGTGGGCGTAACCTCA
TTACTGTAATCGATGATGGTAGCGGAGTAAAAAAGGATGATTTAGAACTTGCGTTTATGCGCCATGCTACTTCAAAATTG
AGTGACAGTGAATTGATAGAGATCAAGCATCTTGGCTTTAGAGGAGAAGCTTTGCCTTCAATTGCAGCAGTAAGCAGAAT
AAAATTATCATCTAAGGCAAGCAAAGCAGATCAAGCATGGTCTATAAGGTATGAGGGGGGAGAAAAAATAGGAGAGCTTG
TTCCTTATCCTTTATCGATAGGAACATATATTGAAGTACGAGATTTATTTTTTGCCACACCAAATAGACTAAAATTTCTC
AAAACCGAAAGGGCAGAAACACAAAGCATTGTTGATATTGTAAACAACTTAGCAATGATCAATTATGGAATTGAGTTTAC
TCTTATCTCCGATAATAAGAAGCTTCTTAAGTATGCTAAGCAGAACTCATTATTTAGCAGGCTATGCGAAGTAGAAGAAG
AATTTCATGAAAACTCTTTGCAAATTAGTGAAGAAGAAGATGGCATTAGACTTACAGGATACATCTGTAAACCTACTGTC
AATCGTAGCAATTCAACTCAGATCTATACATTTGTTAATGGTAGACCAATTAAAGATAATCTACTTATTGGTGCAATTCG
TTATGCGTATCACGACCTTATTCCAAGCAATAGATATCCTTTTGCAGCGCTGCACTTAGAGATACCGTATGATCAAGTTG
ATGTAAATGTGCATCCAAATAAATCAGAGGTAAGGTTTCAGAACAAGAGGCTAATATATGAAATAGTGAGAAGAGGGCTA
ATAAAAGTGCTATCAAAGAGAATAGATCTTGCAGAAACTGTATTGGCCCAGAATGGAACAACAACGAATCATCTATCATC
AGATCCTTTTAGTAGGTCTAGTCTTAAAAATGAATTTTATGGAAGAAGGTCGGATCCTTTTGAAAACCAGTTAATGAGAA
AATTTACTTCTCCAAATATAGAGACAAAAAGCTTATCAGAACATTCAAAATCGTTTGATTATACTGGTATGCAAAAATCT
CCTCCACGAGCAGAAACTACAATTTTGGAAAGGAAACAAACCGATCTAATAAGGGACTATCCACTTGGGTTTGCACACTG
TCAAATCTACAATACTTATATTATTGCCGAGGTAAGAGACAAACTAATTATAGTAGATCAGCATGCAGCCCATGAAAGAC
TAGTATACGAGTGCTTAAAGGAGAAATCAAGTATAAAAAGACAAAAACTTCTTTTGCCTGAAATGGTTGAAATCAAAAGT
CAAGCCGGTATGGAAATGATAGAAGTTTATAAGGATAAGCTTTTCGAAATGGGCTTTGATATCGAAATTAAATCAGAAAA
TGCGATCATAGTAAAAGAAATACCTGCAATCTTAGGGTCAATAGATGTGAAGAAAATGCTAATTGATATAGTGGATAGAT
TAATAGAAATAGAAGATACTCTACCTATAGAGGATAAAATAAATAAAATACTAGCTACAATTGCTTGTCATGGATCAATT
AGAGCAGGTAGAAAGATGAAATTAGAGGAGATGAATGAGTTGTTGAGGCAAATAGAAAAAACACCATATTCTGGACAATG
CAATCACGGAAGACCAACCTATATAGAAATGAAATTAAGCGATATTGAAAAGTTATTTGAGCGAAGGTAA

Upstream 100 bases:

>100_bases
CTGCATCTATATTGTCGATTTCTAATAGTGAAATTGCAGATAGATTAAAAAAATGGAGAGAGGGGCAAACTAAAGCAGTA
AAAGAAAAACCAACATTATA

Downstream 100 bases:

>100_bases
GAAATTGTCACAAATGTGTATAGATTATACAACCCTAGTTTCGTCATCTCAAAACTCAGATACACAATTGTTCGAACATT
GCAATTTGCAGGTAATTTGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MAIVLLDTKTINRIAAGEVIERPASVVKELVENAIDARSSEIEIKIESGGRNLITVIDDGSGVKKDDLELAFMRHATSKL
SDSELIEIKHLGFRGEALPSIAAVSRIKLSSKASKADQAWSIRYEGGEKIGELVPYPLSIGTYIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYGIEFTLISDNKKLLKYAKQNSLFSRLCEVEEEFHENSLQISEEEDGIRLTGYICKPTV
NRSNSTQIYTFVNGRPIKDNLLIGAIRYAYHDLIPSNRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGL
IKVLSKRIDLAETVLAQNGTTTNHLSSDPFSRSSLKNEFYGRRSDPFENQLMRKFTSPNIETKSLSEHSKSFDYTGMQKS
PPRAETTILERKQTDLIRDYPLGFAHCQIYNTYIIAEVRDKLIIVDQHAAHERLVYECLKEKSSIKRQKLLLPEMVEIKS
QAGMEMIEVYKDKLFEMGFDIEIKSENAIIVKEIPAILGSIDVKKMLIDIVDRLIEIEDTLPIEDKINKILATIACHGSI
RAGRKMKLEEMNELLRQIEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR

Sequences:

>Translated_609_residues
MAIVLLDTKTINRIAAGEVIERPASVVKELVENAIDARSSEIEIKIESGGRNLITVIDDGSGVKKDDLELAFMRHATSKL
SDSELIEIKHLGFRGEALPSIAAVSRIKLSSKASKADQAWSIRYEGGEKIGELVPYPLSIGTYIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYGIEFTLISDNKKLLKYAKQNSLFSRLCEVEEEFHENSLQISEEEDGIRLTGYICKPTV
NRSNSTQIYTFVNGRPIKDNLLIGAIRYAYHDLIPSNRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGL
IKVLSKRIDLAETVLAQNGTTTNHLSSDPFSRSSLKNEFYGRRSDPFENQLMRKFTSPNIETKSLSEHSKSFDYTGMQKS
PPRAETTILERKQTDLIRDYPLGFAHCQIYNTYIIAEVRDKLIIVDQHAAHERLVYECLKEKSSIKRQKLLLPEMVEIKS
QAGMEMIEVYKDKLFEMGFDIEIKSENAIIVKEIPAILGSIDVKKMLIDIVDRLIEIEDTLPIEDKINKILATIACHGSI
RAGRKMKLEEMNELLRQIEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR
>Mature_608_residues
AIVLLDTKTINRIAAGEVIERPASVVKELVENAIDARSSEIEIKIESGGRNLITVIDDGSGVKKDDLELAFMRHATSKLS
DSELIEIKHLGFRGEALPSIAAVSRIKLSSKASKADQAWSIRYEGGEKIGELVPYPLSIGTYIEVRDLFFATPNRLKFLK
TERAETQSIVDIVNNLAMINYGIEFTLISDNKKLLKYAKQNSLFSRLCEVEEEFHENSLQISEEEDGIRLTGYICKPTVN
RSNSTQIYTFVNGRPIKDNLLIGAIRYAYHDLIPSNRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGLI
KVLSKRIDLAETVLAQNGTTTNHLSSDPFSRSSLKNEFYGRRSDPFENQLMRKFTSPNIETKSLSEHSKSFDYTGMQKSP
PRAETTILERKQTDLIRDYPLGFAHCQIYNTYIIAEVRDKLIIVDQHAAHERLVYECLKEKSSIKRQKLLLPEMVEIKSQ
AGMEMIEVYKDKLFEMGFDIEIKSENAIIVKEIPAILGSIDVKKMLIDIVDRLIEIEDTLPIEDKINKILATIACHGSIR
AGRKMKLEEMNELLRQIEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=343, Percent_Identity=34.6938775510204, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4505913, Length=356, Percent_Identity=28.0898876404494, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI310128478, Length=356, Percent_Identity=28.0898876404494, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4505911, Length=323, Percent_Identity=28.1733746130031, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI189458898, Length=323, Percent_Identity=28.1733746130031, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI189458896, Length=311, Percent_Identity=28.9389067524116, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI310128480, Length=308, Percent_Identity=26.6233766233766, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI263191589, Length=252, Percent_Identity=29.7619047619048, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992162, Length=359, Percent_Identity=25.0696378830084, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI91992160, Length=359, Percent_Identity=25.0696378830084, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=438, Percent_Identity=35.1598173515982, Blast_Score=246, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=316, Percent_Identity=31.0126582278481, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=24.2339832869081, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323819, Length=359, Percent_Identity=33.983286908078, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=347, Percent_Identity=26.8011527377522, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=172, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323063, Length=379, Percent_Identity=25.3298153034301, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=32.258064516129, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=25.6338028169014, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69535; Mature: 69404

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVLLDTKTINRIAAGEVIERPASVVKELVENAIDARSSEIEIKIESGGRNLITVIDDG
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECC
SGVKKDDLELAFMRHATSKLSDSELIEIKHLGFRGEALPSIAAVSRIKLSSKASKADQAW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
SIRYEGGEKIGELVPYPLSIGTYIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCCHHHHCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
NYGIEFTLISDNKKLLKYAKQNSLFSRLCEVEEEFHENSLQISEEEDGIRLTGYICKPTV
EECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCC
NRSNSTQIYTFVNGRPIKDNLLIGAIRYAYHDLIPSNRYPFAALHLEIPYDQVDVNVHPN
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKRLIYEIVRRGLIKVLSKRIDLAETVLAQNGTTTNHLSSDPFSRSSLKNEFY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
GRRSDPFENQLMRKFTSPNIETKSLSEHSKSFDYTGMQKSPPRAETTILERKQTDLIRDY
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PLGFAHCQIYNTYIIAEVRDKLIIVDQHAAHERLVYECLKEKSSIKRQKLLLPEMVEIKS
CCCEEEEEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAGMEMIEVYKDKLFEMGFDIEIKSENAIIVKEIPAILGSIDVKKMLIDIVDRLIEIEDT
HCCHHHHHHHHHHHHHCCCCEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCCC
LPIEDKINKILATIACHGSIRAGRKMKLEEMNELLRQIEKTPYSGQCNHGRPTYIEMKLS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
DIEKLFERR
HHHHHHHCC
>Mature Secondary Structure 
AIVLLDTKTINRIAAGEVIERPASVVKELVENAIDARSSEIEIKIESGGRNLITVIDDG
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECC
SGVKKDDLELAFMRHATSKLSDSELIEIKHLGFRGEALPSIAAVSRIKLSSKASKADQAW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
SIRYEGGEKIGELVPYPLSIGTYIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCCHHHHCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
NYGIEFTLISDNKKLLKYAKQNSLFSRLCEVEEEFHENSLQISEEEDGIRLTGYICKPTV
EECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCC
NRSNSTQIYTFVNGRPIKDNLLIGAIRYAYHDLIPSNRYPFAALHLEIPYDQVDVNVHPN
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKRLIYEIVRRGLIKVLSKRIDLAETVLAQNGTTTNHLSSDPFSRSSLKNEFY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
GRRSDPFENQLMRKFTSPNIETKSLSEHSKSFDYTGMQKSPPRAETTILERKQTDLIRDY
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PLGFAHCQIYNTYIIAEVRDKLIIVDQHAAHERLVYECLKEKSSIKRQKLLLPEMVEIKS
CCCEEEEEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAGMEMIEVYKDKLFEMGFDIEIKSENAIIVKEIPAILGSIDVKKMLIDIVDRLIEIEDT
HCCHHHHHHHHHHHHHCCCCEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCCC
LPIEDKINKILATIACHGSIRAGRKMKLEEMNELLRQIEKTPYSGQCNHGRPTYIEMKLS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
DIEKLFERR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA