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The map label for this gene is purE [H]

Identifier: 190571444

GI number: 190571444

Start: 1127652

End: 1128152

Strand: Reverse

Name: purE [H]

Synonym: WPa_1057

Alternate gene names: 190571444

Gene position: 1128152-1127652 (Counterclockwise)

Preceding gene: 190571453

Following gene: 190571443

Centisome position: 76.1

GC content: 36.93

Gene sequence:

>501_bases
ATGTCTAATACAGAAAAAATGAAAAAGGATGTTGCTGTAATTATGGGAAGCGAGTCGGATTATGGCACTATGGTGCATGC
TATTAACCTATTAAAAGAATTGGAAATTTCACATGATGTATTTATAATATCCGCACACAGAACACCAGAGAGACTCTTTA
ATTTTACTAAGTCTGCTCAAGAAAAAGGCTTTAAGGTTATTATAGCTGGTGCAGGAGGAGCGGCTCATTTACCTGGTATG
ACTGCATCGCTTACTTATTTACCTGTTATCGGTATTCCTGTGCATAGCAAGCAATTAAATGGGCTAGATAGTCTATTATC
TATAGTGCAGATGCCAAAAGGTGTTCCAGTTGCAACAATGTCTATAGGAGAGAGTGGAGCATGCAATGCCGCTATTACTG
CTGCATCTATATTGTCGATTTCTAATAGTGAAATTGCAGATAGATTAAAAAAATGGAGAGAGGGGCAAACTAAAGCAGTA
AAAGAAAAACCAACATTATAA

Upstream 100 bases:

>100_bases
ATTTTTAAAGTTTCTATTTAATAAGAATGCTATATCATATTCGTAATTTAATTTAAATATCTGTTGCTTCTGAAATACTA
TTTGGTTAGTAAATAAAATC

Downstream 100 bases:

>100_bases
TGGCAATAGTTCTTTTAGATACAAAAACCATAAATCGTATAGCAGCAGGAGAGGTAATAGAAAGGCCTGCAAGTGTGGTA
AAGGAATTAGTGGAAAATGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSNTEKMKKDVAVIMGSESDYGTMVHAINLLKELEISHDVFIISAHRTPERLFNFTKSAQEKGFKVIIAGAGGAAHLPGM
TASLTYLPVIGIPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGESGACNAAITAASILSISNSEIADRLKKWREGQTKAV
KEKPTL

Sequences:

>Translated_166_residues
MSNTEKMKKDVAVIMGSESDYGTMVHAINLLKELEISHDVFIISAHRTPERLFNFTKSAQEKGFKVIIAGAGGAAHLPGM
TASLTYLPVIGIPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGESGACNAAITAASILSISNSEIADRLKKWREGQTKAV
KEKPTL
>Mature_165_residues
SNTEKMKKDVAVIMGSESDYGTMVHAINLLKELEISHDVFIISAHRTPERLFNFTKSAQEKGFKVIIAGAGGAAHLPGMT
ASLTYLPVIGIPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGESGACNAAITAASILSISNSEIADRLKKWREGQTKAVK
EKPTL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=55.1948051948052, Blast_Score=159, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=48.7012987012987, Blast_Score=141, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17716; Mature: 17585

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTEKMKKDVAVIMGSESDYGTMVHAINLLKELEISHDVFIISAHRTPERLFNFTKSAQ
CCCHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
EKGFKVIIAGAGGAAHLPGMTASLTYLPVIGIPVHSKQLNGLDSLLSIVQMPKGVPVATM
HCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCEEEE
SIGESGACNAAITAASILSISNSEIADRLKKWREGQTKAVKEKPTL
ECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure 
SNTEKMKKDVAVIMGSESDYGTMVHAINLLKELEISHDVFIISAHRTPERLFNFTKSAQ
CCHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
EKGFKVIIAGAGGAAHLPGMTASLTYLPVIGIPVHSKQLNGLDSLLSIVQMPKGVPVATM
HCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCEEEE
SIGESGACNAAITAASILSISNSEIADRLKKWREGQTKAVKEKPTL
ECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]